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Aliases for ZNF142 Gene

Aliases for ZNF142 Gene

  • Zinc Finger Protein 142 2 3 5
  • Zinc Finger Protein 142 (Clone PHZ-49) 2 3
  • HA4654 3 4
  • KIAA0236 4
  • PHZ-49 3

External Ids for ZNF142 Gene

Previous GeneCards Identifiers for ZNF142 Gene

  • GC02M217518
  • GC02M218224
  • GC02M219466
  • GC02M219705
  • GC02M219328
  • GC02M219210
  • GC02M211356

Summaries for ZNF142 Gene

Entrez Gene Summary for ZNF142 Gene

  • The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for ZNF142 Gene

ZNF142 (Zinc Finger Protein 142) is a Protein Coding gene. An important paralog of this gene is ZNF462.

UniProtKB/Swiss-Prot for ZNF142 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF142 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF142 Gene

Genomics for ZNF142 Gene

GeneHancer (GH) Regulatory Elements for ZNF142 Gene

Promoters and enhancers for ZNF142 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I218658 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 68 2.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 SLC30A9 E2F8 BCS1L ZNF142 CNOT9 NHEJ1 USP37 AAMP SLC23A3 STK11IP PLCD4 RNF25
GH02I219569 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 47.7 -911.9 -911876 4 PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 INHA OBSL1 ZNF142 RNF25 NHEJ1 SLC23A3 STK36 STK11IP GLB1L DNPEP
GH02I219495 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.6 -838.4 -838371 5 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ENSG00000268603 GC02M219493 GMPPA ZNF142 STK36 RNF25 CNOT9 USP37 NHEJ1 STK11IP
GH02I218908 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.1 -249.9 -249943 2.4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B CNOT9 STK36 ZNF142 USP37 AAMP OBSL1 NHEJ1 CDK5R2 ENSG00000235024 ENSG00000269068
GH02I219368 Enhancer 1.1 Ensembl ENCODE 30.6 -709.7 -709651 2.4 FOXA2 FEZF1 ZNF2 GATA2 ZNF416 KLF7 RXRA YY2 REST TSHZ1 LOC105373883 ZNF142 STK36 CNOT9 RNF25 ENSG00000269068 STK11IP ENSG00000268896 ANKZF1 OBSL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF142 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF142 gene promoter:

Genomic Locations for ZNF142 Gene

Genomic Locations for ZNF142 Gene
chr2:218,637,916-218,659,655
(GRCh38/hg38)
Size:
21,740 bases
Orientation:
Minus strand
chr2:219,502,639-219,524,378
(GRCh37/hg19)

Genomic View for ZNF142 Gene

Genes around ZNF142 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF142 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF142 Gene

Proteins for ZNF142 Gene

  • Protein details for ZNF142 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52746-ZN142_HUMAN
    Recommended name:
    Zinc finger protein 142
    Protein Accession:
    P52746
    Secondary Accessions:
    • Q92510

    Protein attributes for ZNF142 Gene

    Size:
    1687 amino acids
    Molecular mass:
    187880 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13242.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF142 Gene

Post-translational modifications for ZNF142 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF142 Gene

Domains & Families for ZNF142 Gene

Gene Families for ZNF142 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF142 Gene

Suggested Antigen Peptide Sequences for ZNF142 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52746

UniProtKB/Swiss-Prot:

ZN142_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF142: view

Function for ZNF142 Gene

Molecular function for ZNF142 Gene

GENATLAS Biochemistry:
zinc finger protein 142 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF142 Gene

Gene Ontology (GO) - Molecular Function for ZNF142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF142: view
genes like me logo Genes that share phenotypes with ZNF142: view

Animal Models for ZNF142 Gene

MGI Knock Outs for ZNF142:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF142 Gene

Localization for ZNF142 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF142 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF142 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF142: view

Pathways & Interactions for ZNF142 Gene

SuperPathways for ZNF142 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF142: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF142 Gene

Drugs & Compounds for ZNF142 Gene

No Compound Related Data Available

Transcripts for ZNF142 Gene

Unigene Clusters for ZNF142 Gene

Zinc finger protein 142:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF142 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for ZNF142 Gene

GeneLoc Exon Structure for
ZNF142
ECgene alternative splicing isoforms for
ZNF142

Expression for ZNF142 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF142 Gene

Protein differential expression in normal tissues from HIPED for ZNF142 Gene

This gene is overexpressed in Adipocyte (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF142 Gene



Protein tissue co-expression partners for ZNF142 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF142 Gene:

ZNF142

SOURCE GeneReport for Unigene cluster for ZNF142 Gene:

Hs.657969

Evidence on tissue expression from TISSUES for ZNF142 Gene

  • Bone marrow(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ZNF142: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF142 Gene

Orthologs for ZNF142 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF142 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF142 33 34
  • 95.79 (n)
cow
(Bos Taurus)
Mammalia ZNF142 33 34
  • 86.49 (n)
dog
(Canis familiaris)
Mammalia ZNF142 33 34
  • 85.54 (n)
mouse
(Mus musculus)
Mammalia Zfp142 33 16 34
  • 85.2 (n)
rat
(Rattus norvegicus)
Mammalia Zfp142 33
  • 84.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF142 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF142 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF142 33 34
  • 66.46 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF142 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf142 33
  • 60.59 (n)
zebrafish
(Danio rerio)
Actinopterygii znf142 33 34
  • 54.29 (n)
Dr.17315 33
fruit fly
(Drosophila melanogaster)
Insecta hb 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hbl-1 34
  • 12 (a)
OneToMany
Species where no ortholog for ZNF142 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF142 Gene

ENSEMBL:
Gene Tree for ZNF142 (if available)
TreeFam:
Gene Tree for ZNF142 (if available)

Paralogs for ZNF142 Gene

Paralogs for ZNF142 Gene

genes like me logo Genes that share paralogs with ZNF142: view

Variants for ZNF142 Gene

Sequence variations from dbSNP and Humsavar for ZNF142 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1057516954 likely-pathogenic, GRACILE syndrome 218,661,547(-) T/C upstream_transcript_variant
rs1057517412 likely-pathogenic, GRACILE syndrome 218,661,501(-) CCC/CC upstream_transcript_variant
rs121908572 pathogenic, Leigh syndrome due to mitochondrial complex III deficiency 218,661,283(-) C/T upstream_transcript_variant
rs121908575 pathogenic, Mitochondrial complex III deficiency 218,661,120(-) C/G/T upstream_transcript_variant
rs121908576 pathogenic, likely-pathogenic, Mitochondrial complex III deficiency, not provided, BCS1L-Related Disorders, GRACILE syndrome 218,661,153(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF142 Gene

Variant ID Type Subtype PubMed ID
esv2662860 CNV deletion 23128226
esv3594346 CNV loss 21293372
esv3594347 CNV loss 21293372

Variation tolerance for ZNF142 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.28; 88.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF142 Gene

Human Gene Mutation Database (HGMD)
ZNF142
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF142

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF142 Gene

Disorders for ZNF142 Gene

Additional Disease Information for ZNF142

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF142 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF142 Gene

Publications for ZNF142 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58
  3. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF142 Gene

Sources for ZNF142 Gene

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