Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF141 Gene

Aliases for ZNF141 Gene

  • Zinc Finger Protein 141 2 3 5
  • Zinc Finger Protein 141 (Clone PHZ-44) 2 3
  • D4S90 3 4
  • PHZ-44 3

External Ids for ZNF141 Gene

Previous HGNC Symbols for ZNF141 Gene

  • D4S90

Previous GeneCards Identifiers for ZNF141 Gene

  • GC04P000321
  • GC04P000203
  • GC04P000204
  • GC04P000044
  • GC04P000303

Summaries for ZNF141 Gene

Entrez Gene Summary for ZNF141 Gene

  • The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]

GeneCards Summary for ZNF141 Gene

ZNF141 (Zinc Finger Protein 141) is a Protein Coding gene. Diseases associated with ZNF141 include Polydactyly, Postaxial, Type A6 and Postaxial Polydactyly Type A, Bilateral. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF732.

UniProtKB/Swiss-Prot for ZNF141 Gene

  • May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

Additional gene information for ZNF141 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF141 Gene

Genomics for ZNF141 Gene

GeneHancer (GH) Regulatory Elements for ZNF141 Gene

Promoters and enhancers for ZNF141 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I000335 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 -0.3 -272 3.1 HDGF PKNOX1 SMAD1 NFIB RB1 SIN3A KLF5 ZBTB7B ZBTB40 RFX5 ENSG00000248564 ZNF141 ENSG00000251535 ZNF721
GH04I000050 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.8 -284.1 -284148 6.1 PKNOX1 CBX3 ZSCAN4 SIN3A IRF4 YY1 ETS1 ZNF335 ZNF350 ZNF143 ZNF595 PIGG PCGF3 ZNF718 ZNF141 GAK ENSG00000272588 LOC100129917 IDUA GC04P000106
GH04I001009 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 18.4 +673.4 673431 3.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF48 GLIS2 CBX5 ZNF143 FOS FGFRL1 LOC100129917 ZNF141 ZNF718 ZNF876P CTBP1-AS2 ZNF732 LOC100288172 ABCA11P IDUA
GH04I000704 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.1 +368.4 368448 2.6 HDGF PKNOX1 CLOCK SMAD1 ARNT SIN3A YBX1 ZNF2 POLR2B ZNF207 PCGF3 CRIPAK LOC100129917 ZNF718 PIGG ZNF141 ENSG00000272588 PDE6B ENSG00000281016 ZNF732
GH04I001041 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.4 +704.0 703979 1.6 PKNOX1 ATF1 RB1 ZSCAN4 EGR1 ATF7 EGR2 HDAC8 ZNF592 SP1 GC04M001019 LOC105374343 CRIPAK LOC100129917 ZNF141 CTBP1-AS2 ZNF718 ZNF876P ZNF732 LOC100288172
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF141 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF141 gene promoter:

Genomic Locations for ZNF141 Gene

Genomic Locations for ZNF141 Gene
47,058 bases
Plus strand

Genomic View for ZNF141 Gene

Genes around ZNF141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF141 Gene

Proteins for ZNF141 Gene

  • Protein details for ZNF141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 141
    Protein Accession:
    Secondary Accessions:
    • Q6DK07

    Protein attributes for ZNF141 Gene

    474 amino acids
    Molecular mass:
    55249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF141 Gene

Post-translational modifications for ZNF141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF141 Gene

Domains & Families for ZNF141 Gene

Gene Families for ZNF141 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF141 Gene

Suggested Antigen Peptide Sequences for ZNF141 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF141: view

Function for ZNF141 Gene

Molecular function for ZNF141 Gene

GENATLAS Biochemistry:
zinc finger protein 141,C2H2 type,Kruppel-like,KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

Phenotypes From GWAS Catalog for ZNF141 Gene

Gene Ontology (GO) - Molecular Function for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF141: view
genes like me logo Genes that share phenotypes with ZNF141: view

Human Phenotype Ontology for ZNF141 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF141 Gene

Localization for ZNF141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF141 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF141 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF141: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF141 Gene

Pathways & Interactions for ZNF141 Gene

SuperPathways for ZNF141 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF141: view

Pathways by source for ZNF141 Gene

2 Reactome pathways for ZNF141 Gene

Gene Ontology (GO) - Biological Process for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 8268908
GO:0007275 multicellular organism development IEA --
GO:0009653 anatomical structure morphogenesis TAS 8268908
genes like me logo Genes that share ontologies with ZNF141: view

No data available for SIGNOR curated interactions for ZNF141 Gene

Drugs & Compounds for ZNF141 Gene

No Compound Related Data Available

Transcripts for ZNF141 Gene

Unigene Clusters for ZNF141 Gene

Zinc finger protein 141:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF141 Gene

No ASD Table

Relevant External Links for ZNF141 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF141 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF141 Gene:


SOURCE GeneReport for Unigene cluster for ZNF141 Gene:


mRNA Expression by UniProt/SwissProt for ZNF141 Gene:

Tissue specificity: Ubiquitously low expression.

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF141 Gene

Germ Layers:
  • mesoderm
  • skeleton
  • digit
  • finger
  • hand
  • upper limb
genes like me logo Genes that share expression patterns with ZNF141: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Evidence on tissue expression from TISSUES for ZNF141 Gene

Orthologs for ZNF141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF141 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF141 33 34
  • 99.72 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
-- 34
  • 32 (a)
(Bos Taurus)
Mammalia -- 34
  • 44 (a)
(Canis familiaris)
Mammalia -- 34
  • 32 (a)
(Mus musculus)
Mammalia Zfp941 34
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
-- 34
  • 33 (a)
-- 34
  • 31 (a)
-- 34
  • 27 (a)
-- 34
  • 27 (a)
-- 34
  • 26 (a)
-- 34
  • 25 (a)
-- 34
  • 24 (a)
Species where no ortholog for ZNF141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF141 Gene

Gene Tree for ZNF141 (if available)
Gene Tree for ZNF141 (if available)

Paralogs for ZNF141 Gene

(533) SIMAP similar genes for ZNF141 Gene using alignment to 4 proteins: Pseudogenes for ZNF141 Gene

genes like me logo Genes that share paralogs with ZNF141: view

Variants for ZNF141 Gene

Sequence variations from dbSNP and Humsavar for ZNF141 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs587776959 conflicting-interpretations-of-pathogenicity, Postaxial polydactyly type A6, Polydactyly, postaxial A6 (PAPA6) [MIM:615226] 373,858(+) C/T coding_sequence_variant, missense_variant
rs113884485 benign, not specified 373,417(+) C/G/T coding_sequence_variant, missense_variant
rs114931928 benign, not specified 373,410(+) A/G/T coding_sequence_variant, missense_variant
rs1000004977 -- 341,508(+) A/G 5_prime_UTR_variant, intron_variant
rs1000010522 -- 350,393(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF141 Gene

Variant ID Type Subtype PubMed ID
dgv2697n106 CNV deletion 24896259
dgv5076n100 CNV gain 25217958
dgv5077n100 CNV loss 25217958
dgv8875n54 CNV loss 21841781
dgv914e199 CNV deletion 23128226
dgv971e214 CNV gain 21293372
esv2763816 CNV gain+loss 21179565
esv3599369 CNV loss 21293372
esv3893862 CNV gain 25118596
esv4769 OTHER complex 18987735
nsv1001899 CNV loss 25217958
nsv1006781 CNV gain 25217958
nsv1009336 CNV gain 25217958
nsv1074123 CNV deletion 25765185
nsv1150471 CNV deletion 26484159
nsv1161026 CNV duplication 26073780
nsv461144 CNV loss 19166990
nsv469736 CNV loss 16826518
nsv469996 CNV gain 18288195
nsv593198 CNV loss 21841781
nsv593199 CNV loss 21841781
nsv980176 CNV duplication 23825009

Variation tolerance for ZNF141 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF141 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF141 Gene

Disorders for ZNF141 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF141 Gene - From: HGMD, OMIM, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
polydactyly, postaxial, type a6
  • papa6
postaxial polydactyly type a, bilateral
  • polydactyly, postaxial
- elite association - COSMIC cancer census association via MalaCards


  • Polydactyly, postaxial A6 (PAPA6) [MIM:615226]: A condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. {ECO:0000269 PubMed:23160277}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ZNF141

genes like me logo Genes that share disorders with ZNF141: view

No data available for Genatlas for ZNF141 Gene

Publications for ZNF141 Gene

  1. A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. (PMID: 8268908) Tommerup N … Vissing H (Human molecular genetics 1993) 2 3 4 22 58
  2. Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. (PMID: 23160277) Kalsoom UE … Ahmad W (Journal of medical genetics 2013) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Advances in the molecular genetics of non-syndromic polydactyly. (PMID: 26515020) Deng H … Yuan L (Expert reviews in molecular medicine 2015) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF141 Gene

Sources for ZNF141 Gene

Loading form....