The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017] See more...

Aliases for ZNF141 Gene

Aliases for ZNF141 Gene

  • Zinc Finger Protein 141 2 3 4 5
  • Zinc Finger Protein 141 (Clone PHZ-44) 2 3
  • PHZ-44 2 3
  • D4S90 3 4
  • ZNF141 5

External Ids for ZNF141 Gene

Previous HGNC Symbols for ZNF141 Gene

  • D4S90

Previous GeneCards Identifiers for ZNF141 Gene

  • GC04P000321
  • GC04P000203
  • GC04P000204
  • GC04P000044
  • GC04P000303

Summaries for ZNF141 Gene

Entrez Gene Summary for ZNF141 Gene

  • The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]

GeneCards Summary for ZNF141 Gene

ZNF141 (Zinc Finger Protein 141) is a Protein Coding gene. Diseases associated with ZNF141 include Polydactyly, Postaxial, Type A6 and Polydactyly, Postaxial, Type A1. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF732.

UniProtKB/Swiss-Prot Summary for ZNF141 Gene

  • May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF141 Gene

Genomics for ZNF141 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF141 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF141 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF141

Top Transcription factor binding sites by QIAGEN in the ZNF141 gene promoter:
  • Bach1
  • c-Myb
  • GR
  • GR-alpha
  • HSF1 (long)
  • HSF1short
  • USF-1
  • USF1
  • ZID

Genomic Locations for ZNF141 Gene

Genomic Locations for ZNF141 Gene
chr4:337,814-384,868
(GRCh38/hg38)
Size:
47,055 bases
Orientation:
Plus strand
chr4:331,596-378,653
(GRCh37/hg19)
Size:
47,058 bases
Orientation:
Plus strand

Genomic View for ZNF141 Gene

Genes around ZNF141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF141 Gene

Proteins for ZNF141 Gene

  • Protein details for ZNF141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15928-ZN141_HUMAN
    Recommended name:
    Zinc finger protein 141
    Protein Accession:
    Q15928
    Secondary Accessions:
    • Q6DK07

    Protein attributes for ZNF141 Gene

    Size:
    474 amino acids
    Molecular mass:
    55249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF141 Gene

Post-translational modifications for ZNF141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF141 Gene

Domains & Families for ZNF141 Gene

Gene Families for ZNF141 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF141 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF141 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 141 (Clone pHZ-44), isoform CRA_c (D6RIY0_HUMAN)
  • Zinc finger protein 141 (ZN141_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15928

UniProtKB/Swiss-Prot:

ZN141_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF141: view

Function for ZNF141 Gene

Molecular function for ZNF141 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor. Plays a role in limb development.
GENATLAS Biochemistry:
zinc finger protein 141,C2H2 type,Kruppel-like,KRAB subfamily

Phenotypes From GWAS Catalog for ZNF141 Gene

Gene Ontology (GO) - Molecular Function for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF141: view
genes like me logo Genes that share phenotypes with ZNF141: view

Human Phenotype Ontology for ZNF141 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF141

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF141 Gene

Localization for ZNF141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF141 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF141 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF141: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF141 Gene

Pathways & Interactions for ZNF141 Gene

genes like me logo Genes that share pathways with ZNF141: view

Pathways by source for ZNF141 Gene

2 Reactome pathways for ZNF141 Gene
1 KEGG pathway for ZNF141 Gene

Gene Ontology (GO) - Biological Process for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
GO:0006366 transcription by RNA polymerase II TAS 8268908
GO:0007275 multicellular organism development IEA --
GO:0009653 anatomical structure morphogenesis TAS 8268908
GO:0035108 limb morphogenesis IMP 23160277
genes like me logo Genes that share ontologies with ZNF141: view

No data available for SIGNOR curated interactions for ZNF141 Gene

Drugs & Compounds for ZNF141 Gene

No Compound Related Data Available

Transcripts for ZNF141 Gene

mRNA/cDNA for ZNF141 Gene

5 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF141

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF141 Gene

No ASD Table

Relevant External Links for ZNF141 Gene

GeneLoc Exon Structure for
ZNF141

Expression for ZNF141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF141 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF141

SOURCE GeneReport for Unigene cluster for ZNF141 Gene:

Hs.654355

mRNA Expression by UniProt/SwissProt for ZNF141 Gene:

Q15928-ZN141_HUMAN
Tissue specificity: Ubiquitously low expression.

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF141 Gene

Germ Layers:
  • mesoderm
Systems:
  • skeleton
Regions:
Limb:
  • digit
  • finger
  • hand
  • upper limb
genes like me logo Genes that share expression patterns with ZNF141: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Evidence on tissue expression from TISSUES for ZNF141 Gene

Orthologs for ZNF141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF141 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF141 30 31
  • 99.72 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 45 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 44 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 32 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Zfp941 31
  • 29 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 43 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
Species where no ortholog for ZNF141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF141 Gene

ENSEMBL:
Gene Tree for ZNF141 (if available)
TreeFam:
Gene Tree for ZNF141 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF141: view image

Paralogs for ZNF141 Gene

Paralogs for ZNF141 Gene

(533) SIMAP similar genes for ZNF141 Gene using alignment to 4 proteins:

  • ZN141_HUMAN
  • D6RB60_HUMAN
  • D6RIY0_HUMAN
  • Q4W5N2_HUMAN

Pseudogenes.org Pseudogenes for ZNF141 Gene

genes like me logo Genes that share paralogs with ZNF141: view

Variants for ZNF141 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF141 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
714237 Benign: not provided 373,616(+) A/G SYNONYMOUS_VARIANT,INTRON_VARIANT
715929 Benign: not provided 373,856(+) T/C SYNONYMOUS_VARIANT,INTRON_VARIANT
718907 Benign: not provided 372,823(+) G/A MISSENSE_VARIANT
721178 Likely Benign: not provided 372,924(+) C/T MISSENSE_VARIANT
771138 Benign: not provided 372,807(+) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF141 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF141 Gene

Variant ID Type Subtype PubMed ID
dgv2697n106 CNV deletion 24896259
dgv5076n100 CNV gain 25217958
dgv5077n100 CNV loss 25217958
dgv8875n54 CNV loss 21841781
dgv914e199 CNV deletion 23128226
dgv971e214 CNV gain 21293372
esv2763816 CNV gain+loss 21179565
esv3599369 CNV loss 21293372
esv3893862 CNV gain 25118596
esv4769 OTHER complex 18987735
nsv1001899 CNV loss 25217958
nsv1006781 CNV gain 25217958
nsv1009336 CNV gain 25217958
nsv1074123 CNV deletion 25765185
nsv1150471 CNV deletion 26484159
nsv1161026 CNV duplication 26073780
nsv461144 CNV loss 19166990
nsv469736 CNV loss 16826518
nsv469996 CNV gain 18288195
nsv593198 CNV loss 21841781
nsv593199 CNV loss 21841781
nsv980176 CNV duplication 23825009

Variation tolerance for ZNF141 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF141 Gene

Human Gene Mutation Database (HGMD)
ZNF141
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF141 Gene

Disorders for ZNF141 Gene

MalaCards: The human disease database

(10) MalaCards diseases for ZNF141 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN141_HUMAN
  • Polydactyly, postaxial A6 (PAPA6) [MIM:615226]: A condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. {ECO:0000269 PubMed:23160277}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with ZNF141: view

No data available for Genatlas for ZNF141 Gene

Publications for ZNF141 Gene

  1. A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. (PMID: 8268908) Tommerup N … Vissing H (Human molecular genetics 1993) 2 3 4 23
  2. Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. (PMID: 23160277) Kalsoom UE … Ahmad W (Journal of medical genetics 2013) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Advances in the molecular genetics of non-syndromic polydactyly. (PMID: 26515020) Deng H … Yuan L (Expert reviews in molecular medicine 2015) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF141 Gene

Sources for ZNF141 Gene