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Aliases for ZNF140 Gene

Aliases for ZNF140 Gene

  • Zinc Finger Protein 140 2 3 3 5
  • Zinc Finger Protein 140 (Clone PHZ-39) 2
  • PHZ-39 3

External Ids for ZNF140 Gene

Previous GeneCards Identifiers for ZNF140 Gene

  • GC12P131178
  • GC12P133260
  • GC12P131896
  • GC12P131391
  • GC12P132267
  • GC12P133657
  • GC12P130436

Summaries for ZNF140 Gene

GeneCards Summary for ZNF140 Gene

ZNF140 (Zinc Finger Protein 140) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF565.

UniProtKB/Swiss-Prot for ZNF140 Gene

  • May be involved in transcriptional regulation as a repressor.

Additional gene information for ZNF140 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF140 Gene

Genomics for ZNF140 Gene

GeneHancer (GH) Regulatory Elements for ZNF140 Gene

Promoters and enhancers for ZNF140 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J133079 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 682 +0.9 935 2.8 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF140 GC12M133080 GC12M133081 PIR60665 PIR45490 ZNF26 EP400P1 ZNF84 GOLGA3 ZNF10
GH12J132597 Enhancer 1.2 Ensembl ENCODE 234.7 -481.4 -481373 1.8 HDGF ARNT YBX1 ZNF2 YY1 ZNF143 ZNF548 SP3 ZNF662 REST ZNF140 EP400 ZNF84 ZNF268 ZNF891 ZNF26 GOLGA3 ZNF605 ANKLE2 DDX51
GH12J132827 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 78.5 -251.2 -251204 2.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GOLGA3 ANKLE2 ZNF140 ZNF26 EP400 NOC4L CHFR ZNF891 POLE ZNF268
GH12J132886 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 64.1 -191.7 -191685 3.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 CHFR LOC101928530 ZNF140 ANKLE2 EP400 ZNF891 ZNF26 GOLGA3 ZNF268 EP400P1
GH12J133180 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 36.8 +102.0 102041 1.7 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 ZNF207 ZNF268 ZNF891 ZNF140 ZNF26 CHFR ANKLE2 ENSG00000256825 ZNF10 GOLGA3 ENSG00000255919
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF140 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF140 Gene

Genomic Locations for ZNF140 Gene
chr12:133,079,687-133,108,803
(GRCh38/hg38)
Size:
29,117 bases
Orientation:
Plus strand
chr12:133,656,424-133,684,260
(GRCh37/hg19)

Genomic View for ZNF140 Gene

Genes around ZNF140 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF140 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF140 Gene

Proteins for ZNF140 Gene

  • Protein details for ZNF140 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52738-ZN140_HUMAN
    Recommended name:
    Zinc finger protein 140
    Protein Accession:
    P52738
    Secondary Accessions:
    • D3DXJ3
    • Q05CP6
    • Q8IV75

    Protein attributes for ZNF140 Gene

    Size:
    457 amino acids
    Molecular mass:
    52996 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF140 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF140 Gene

Post-translational modifications for ZNF140 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF140 Gene

Domains & Families for ZNF140 Gene

Gene Families for ZNF140 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF140 Gene

Suggested Antigen Peptide Sequences for ZNF140 Gene

Graphical View of Domain Structure for InterPro Entry

P52738

UniProtKB/Swiss-Prot:

ZN140_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF140: view

Function for ZNF140 Gene

Molecular function for ZNF140 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor.
GENATLAS Biochemistry:
zinc finger protein 140 (C2H2 type,Kruppel-like,KRAB subfamily)

Phenotypes From GWAS Catalog for ZNF140 Gene

Gene Ontology (GO) - Molecular Function for ZNF140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 7557990
genes like me logo Genes that share ontologies with ZNF140: view
genes like me logo Genes that share phenotypes with ZNF140: view

Animal Model Products

miRNA for ZNF140 Gene

miRTarBase miRNAs that target ZNF140

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF140 Gene

Localization for ZNF140 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF140 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF140 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZNF140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF140: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF140 Gene

Pathways & Interactions for ZNF140 Gene

SuperPathways for ZNF140 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF140: view

Pathways by source for ZNF140 Gene

2 Reactome pathways for ZNF140 Gene

Gene Ontology (GO) - Biological Process for ZNF140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11470777
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF140: view

No data available for SIGNOR curated interactions for ZNF140 Gene

Drugs & Compounds for ZNF140 Gene

No Compound Related Data Available

Transcripts for ZNF140 Gene

Unigene Clusters for ZNF140 Gene

Zinc finger protein 140:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF140 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - -

Relevant External Links for ZNF140 Gene

GeneLoc Exon Structure for
ZNF140
ECgene alternative splicing isoforms for
ZNF140

Expression for ZNF140 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF140 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF140 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF140 Gene:

ZNF140

SOURCE GeneReport for Unigene cluster for ZNF140 Gene:

Hs.181552

mRNA Expression by UniProt/SwissProt for ZNF140 Gene:

P52738-ZN140_HUMAN
Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for ZNF140 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with ZNF140: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF140 Gene

Orthologs for ZNF140 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF140 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF140 34 33
  • 99.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF140 34 33
  • 90.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF140 34 33
  • 89.57 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZAP1 34
  • 14 (a)
OneToMany
Species where no ortholog for ZNF140 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF140 Gene

ENSEMBL:
Gene Tree for ZNF140 (if available)
TreeFam:
Gene Tree for ZNF140 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF140: view image

Paralogs for ZNF140 Gene

(533) SIMAP similar genes for ZNF140 Gene using alignment to 10 proteins:

  • ZN140_HUMAN
  • F5GX08_HUMAN
  • F5H0J9_HUMAN
  • F5H3Z2_HUMAN
  • F5H4I1_HUMAN
  • F5H644_HUMAN
  • F8WAF8_HUMAN
  • I3L0D9_HUMAN
  • I3L0I7_HUMAN
  • Q05CP6_HUMAN

Pseudogenes.org Pseudogenes for ZNF140 Gene

genes like me logo Genes that share paralogs with ZNF140: view

Variants for ZNF140 Gene

Sequence variations from dbSNP and Humsavar for ZNF140 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000022810 -- 133,076,311(+) C/T upstream_transcript_variant
rs1000150634 -- 133,079,992(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000182272 -- 133,079,679(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000189625 -- 133,104,237(+) A/G intron_variant
rs1000261700 -- 133,107,249(+) A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF140 Gene

Variant ID Type Subtype PubMed ID
dgv1590n100 CNV gain 25217958
dgv1592n100 CNV gain 25217958
dgv1593n100 CNV gain 25217958
dgv1594n100 CNV gain 25217958
dgv1595n100 CNV gain 25217958
dgv3060n54 CNV gain 21841781
dgv330e199 CNV deletion 23128226
dgv534e212 CNV gain 25503493
dgv917n106 CNV deletion 24896259
esv27162 CNV gain+loss 19812545
esv2759923 CNV loss 17122850
esv2760921 CNV gain 21179565
esv3631326 CNV loss 21293372
esv3631327 CNV gain 21293372
esv3631328 CNV gain 21293372
nsv1048027 CNV gain 25217958
nsv1054933 CNV gain 25217958
nsv1071081 CNV deletion 25765185
nsv470337 CNV loss 18288195
nsv472013 CNV novel sequence insertion 20440878
nsv518970 CNV gain 19592680
nsv561145 CNV gain 21841781

Variation tolerance for ZNF140 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF140 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF140

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF140 Gene

Disorders for ZNF140 Gene

Additional Disease Information for ZNF140

No disorders were found for ZNF140 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF140 Gene

Publications for ZNF140 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PMID: 7649249) Vissing H … Thiesen HJ (FEBS letters 1995) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Impact of cytosine methylation on DNA binding specificities of human transcription factors. (PMID: 28473536) Yin Y … Taipale J (Science (New York, N.Y.) 2017) 3 58

Products for ZNF140 Gene

Sources for ZNF140 Gene

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