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Aliases for ZNF14 Gene

Aliases for ZNF14 Gene

  • Zinc Finger Protein 14 2 3 3 5
  • Gonadotropin-Inducible Ovary Transcription Repressor 4 3 4
  • Zinc Finger Protein 14 (KOX 6) 2 3
  • Zinc Finger Protein KOX6 3 4
  • GIOT-4 3 4
  • KOX6 3 4
  • Gonadotropin Inducible Transcription Repressor-4 3
  • GIOT4 4

External Ids for ZNF14 Gene

Previous GeneCards Identifiers for ZNF14 Gene

  • GC19M020315
  • GC19M020212
  • GC19M019666
  • GC19M019682
  • GC19M019821
  • GC19M019384

Summaries for ZNF14 Gene

Entrez Gene Summary for ZNF14 Gene

  • The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF14 Gene

ZNF14 (Zinc Finger Protein 14) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF14 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF14 Gene

Genomics for ZNF14 Gene

GeneHancer (GH) Regulatory Elements for ZNF14 Gene

Promoters and enhancers for ZNF14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J019731 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 665 +0.3 311 2 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 POLR2B ZNF207 ZNF14 PIRC98
GH19J019374 Enhancer 1.2 Ensembl ENCODE dbSUPER 28.7 +357.9 357949 0.9 ZNF493 MZF1 ZBTB40 ZNF155 ZNF213 ZNF138 SCRT2 KLF7 ZNF202 OVOL3 NR2C2AP ATP13A1 ENSG00000268030 ENSG00000267481 ZNF90 UPF1 ZNF253 MAU2 ZNF14 ZNF506
GH19J019319 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.7 +412.2 412211 2.6 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A YY1 POLR2B ZNF766 ZNF213 MAU2 SUGP1 GATAD2A ATP13A1 ENSG00000267693 ENSG00000268938 ZNF506 ZNF14 MEF2B NR2C2AP
GH19J019058 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +670.6 670585 7.3 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B SLC25A42 UPF1 IQCN MAU2 ENSG00000268030 ENSG00000268938 ATP13A1 ENSG00000269191 NR2C2AP ELL
GH19J019201 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12 +530.1 530145 2.1 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 GTF3C2 E2F8 ZFP91 NR2C2AP ATP13A1 UPF1 ENSG00000268030 ZNF90 MAU2 ENSG00000268938 IQCN ENSG00000267481 ENSG00000269191
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF14 gene promoter:
  • CRE-BP1
  • ATF-2
  • GCNF-2
  • GCNF-1
  • GCNF
  • CP2
  • PPAR-gamma1
  • PPAR-gamma2
  • HTF
  • NF-1

Genomic Locations for ZNF14 Gene

Genomic Locations for ZNF14 Gene
22,642 bases
Minus strand
22,642 bases
Minus strand

Genomic View for ZNF14 Gene

Genes around ZNF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF14 Gene

Proteins for ZNF14 Gene

  • Protein details for ZNF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 14
    Protein Accession:
    Secondary Accessions:
    • B9EGA4
    • Q9ULZ5

    Protein attributes for ZNF14 Gene

    642 amino acids
    Molecular mass:
    75353 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF14 Gene

Post-translational modifications for ZNF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF14 Gene

Domains & Families for ZNF14 Gene

Gene Families for ZNF14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF14 Gene

Suggested Antigen Peptide Sequences for ZNF14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF14: view

Function for ZNF14 Gene

Molecular function for ZNF14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 14 (KOX6) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF14 Gene

Gene Ontology (GO) - Molecular Function for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF14: view
genes like me logo Genes that share phenotypes with ZNF14: view

Animal Model Products

miRNA for ZNF14 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF14 Gene

Localization for ZNF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF14 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF14: view

Pathways & Interactions for ZNF14 Gene

SuperPathways for ZNF14 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF14: view

Pathways by source for ZNF14 Gene

2 Reactome pathways for ZNF14 Gene

Gene Ontology (GO) - Biological Process for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF14: view

No data available for SIGNOR curated interactions for ZNF14 Gene

Drugs & Compounds for ZNF14 Gene

No Compound Related Data Available

Transcripts for ZNF14 Gene

mRNA/cDNA for ZNF14 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF14 Gene

Zinc finger protein 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF14 Gene

No ASD Table

Relevant External Links for ZNF14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF14 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF14 Gene:


SOURCE GeneReport for Unigene cluster for ZNF14 Gene:


Evidence on tissue expression from TISSUES for ZNF14 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF14: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF14 Gene

Orthologs for ZNF14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF14 34 33
  • 99.17 (n)
(Mus musculus)
Mammalia Gm5595 33
  • 67.55 (n)
Zfp976 16
(Bos Taurus)
Mammalia -- 34
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6254 35
  • 33 (a)
CG8301 35
  • 29 (a)
CG4707 35
  • 28 (a)
Species where no ortholog for ZNF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF14 Gene

Gene Tree for ZNF14 (if available)
Gene Tree for ZNF14 (if available)
Evolutionary constrained regions (ECRs) for ZNF14: view image

Paralogs for ZNF14 Gene

(492) SIMAP similar genes for ZNF14 Gene using alignment to 1 proteins:

  • ZNF14_HUMAN Pseudogenes for ZNF14 Gene

genes like me logo Genes that share paralogs with ZNF14: view

Variants for ZNF14 Gene

Sequence variations from dbSNP and Humsavar for ZNF14 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000068576 -- 19,731,982(-) T/C intron_variant
rs1000145008 -- 19,715,917(-) G/A intron_variant
rs1000194803 -- 19,718,329(-) G/A intron_variant
rs1000227738 -- 19,718,025(-) T/ intron_variant
rs1000408433 -- 19,728,869(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF14 Gene

Variant ID Type Subtype PubMed ID
nsv828480 CNV gain+loss 20364138
nsv828479 CNV loss 20364138
nsv821501 CNV deletion 20802225
nsv819368 CNV gain 19587683
nsv578796 CNV loss 21841781
nsv578794 CNV loss 21841781
nsv578793 CNV loss 21841781
nsv578788 CNV gain 21841781
nsv519533 CNV gain 19592680
nsv514892 CNV gain+loss 21397061
nsv512566 CNV loss 21212237
nsv509726 CNV insertion 20534489
nsv498894 CNV loss 21111241
nsv436259 CNV deletion 17901297
nsv2436 CNV deletion 18451855
nsv1150655 CNV deletion 26484159
nsv1109172 CNV deletion 24896259
nsv1070659 CNV deletion 25765185
esv3643856 CNV loss 21293372
esv3556149 CNV deletion 23714750
esv33937 CNV loss 17666407
esv3381770 CNV insertion 20981092
esv33361 CNV loss 17666407
esv2718294 CNV deletion 23290073
esv2676150 CNV deletion 23128226
esv22084 CNV gain+loss 19812545
dgv80n73 CNV deletion 24416366
dgv6302n54 CNV loss 21841781
dgv6301n54 CNV gain 21841781
dgv6300n54 CNV gain 21841781
dgv3455n100 CNV gain 25217958
dgv1731n106 CNV deletion 24896259

Variation tolerance for ZNF14 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF14 Gene

Disorders for ZNF14 Gene

Additional Disease Information for ZNF14

No disorders were found for ZNF14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF14 Gene

Publications for ZNF14 Gene

  1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58
  2. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis MC … He K (Human molecular genetics 2015) 3 58
  3. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF14 Gene

Sources for ZNF14 Gene

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