The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008] See more...

Aliases for ZNF14 Gene

Aliases for ZNF14 Gene

  • Zinc Finger Protein 14 2 3 4 5
  • Gonadotropin-Inducible Ovary Transcription Repressor 4 3 4
  • Zinc Finger Protein 14 (KOX 6) 2 3
  • Zinc Finger Protein KOX6 3 4
  • GIOT-4 3 4
  • KOX6 3 4
  • Gonadotropin Inducible Transcription Repressor-4 3
  • GIOT4 4

External Ids for ZNF14 Gene

Previous GeneCards Identifiers for ZNF14 Gene

  • GC19M020315
  • GC19M020212
  • GC19M019666
  • GC19M019682
  • GC19M019821
  • GC19M019384

Summaries for ZNF14 Gene

Entrez Gene Summary for ZNF14 Gene

  • The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF14 Gene

ZNF14 (Zinc Finger Protein 14) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF700.

UniProtKB/Swiss-Prot Summary for ZNF14 Gene

Additional gene information for ZNF14 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF14 Gene

Genomics for ZNF14 Gene

GeneHancer (GH) Regulatory Elements for ZNF14 Gene

Promoters and enhancers for ZNF14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF14 gene promoter:
  • ATF-2
  • CP2
  • CRE-BP1
  • GCNF
  • GCNF-1
  • GCNF-2
  • HTF
  • NF-1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ZNF14 Gene

Genomic Locations for ZNF14 Gene
chr19:19,710,472-19,733,112
(GRCh38/hg38)
Size:
22,641 bases
Orientation:
Minus strand
chr19:19,821,280-19,843,921
(GRCh37/hg19)
Size:
22,642 bases
Orientation:
Minus strand

Genomic View for ZNF14 Gene

Genes around ZNF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF14 Gene

Proteins for ZNF14 Gene

  • Protein details for ZNF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17017-ZNF14_HUMAN
    Recommended name:
    Zinc finger protein 14
    Protein Accession:
    P17017
    Secondary Accessions:
    • B9EGA4
    • Q9ULZ5

    Protein attributes for ZNF14 Gene

    Size:
    642 amino acids
    Molecular mass:
    75353 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF14 Gene

Post-translational modifications for ZNF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF14 Gene

Domains & Families for ZNF14 Gene

Gene Families for ZNF14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF14 Gene

Suggested Antigen Peptide Sequences for ZNF14 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX6 (ZNF14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17017

UniProtKB/Swiss-Prot:

ZNF14_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF14: view

Function for ZNF14 Gene

Molecular function for ZNF14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 14 (KOX6) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF14 Gene

Gene Ontology (GO) - Molecular Function for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF14: view
genes like me logo Genes that share phenotypes with ZNF14: view

Animal Model Products

CRISPR Products

miRNA for ZNF14 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF14 Gene

Localization for ZNF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF14 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF14: view

Pathways & Interactions for ZNF14 Gene

genes like me logo Genes that share pathways with ZNF14: view

Pathways by source for ZNF14 Gene

2 Reactome pathways for ZNF14 Gene
1 KEGG pathway for ZNF14 Gene

Gene Ontology (GO) - Biological Process for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF14: view

No data available for SIGNOR curated interactions for ZNF14 Gene

Drugs & Compounds for ZNF14 Gene

No Compound Related Data Available

Transcripts for ZNF14 Gene

mRNA/cDNA for ZNF14 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF14

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF14 Gene

No ASD Table

Relevant External Links for ZNF14 Gene

GeneLoc Exon Structure for
ZNF14
ECgene alternative splicing isoforms for
ZNF14

Expression for ZNF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF14 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF14 Gene:

ZNF14

SOURCE GeneReport for Unigene cluster for ZNF14 Gene:

Hs.659932

Evidence on tissue expression from TISSUES for ZNF14 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF14: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF14 Gene

Orthologs for ZNF14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF14 33 32
  • 99.17 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5595 32
  • 67.55 (n)
Zfp976 17
cow
(Bos Taurus)
Mammalia -- 33
  • 57 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6254 34
  • 33 (a)
CG8301 34
  • 29 (a)
CG4707 34
  • 28 (a)
Species where no ortholog for ZNF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF14 Gene

ENSEMBL:
Gene Tree for ZNF14 (if available)
TreeFam:
Gene Tree for ZNF14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF14: view image

Paralogs for ZNF14 Gene

(492) SIMAP similar genes for ZNF14 Gene using alignment to 1 proteins:

  • ZNF14_HUMAN

Pseudogenes.org Pseudogenes for ZNF14 Gene

genes like me logo Genes that share paralogs with ZNF14: view

Variants for ZNF14 Gene

Sequence variations from dbSNP and Humsavar for ZNF14 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000068576 -- 19,731,982(-) T/C intron_variant
rs1000145008 -- 19,715,917(-) G/A intron_variant
rs1000194803 -- 19,718,329(-) G/A intron_variant
rs1000227738 -- 19,718,025(-) T/ intron_variant
rs1000408433 -- 19,728,869(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF14 Gene

Variant ID Type Subtype PubMed ID
dgv1731n106 CNV deletion 24896259
dgv3455n100 CNV gain 25217958
dgv6300n54 CNV gain 21841781
dgv6301n54 CNV gain 21841781
dgv6302n54 CNV loss 21841781
dgv80n73 CNV deletion 24416366
esv22084 CNV gain+loss 19812545
esv2676150 CNV deletion 23128226
esv2718294 CNV deletion 23290073
esv33361 CNV loss 17666407
esv3381770 CNV insertion 20981092
esv33937 CNV loss 17666407
esv3556149 CNV deletion 23714750
esv3643856 CNV loss 21293372
nsv1070659 CNV deletion 25765185
nsv1109172 CNV deletion 24896259
nsv1150655 CNV deletion 26484159
nsv2436 CNV deletion 18451855
nsv436259 CNV deletion 17901297
nsv498894 CNV loss 21111241
nsv509726 CNV insertion 20534489
nsv512566 CNV loss 21212237
nsv514892 CNV gain+loss 21397061
nsv519533 CNV gain 19592680
nsv578788 CNV gain 21841781
nsv578793 CNV loss 21841781
nsv578794 CNV loss 21841781
nsv578796 CNV loss 21841781
nsv819368 CNV gain 19587683
nsv821501 CNV deletion 20802225
nsv828479 CNV loss 20364138
nsv828480 CNV gain+loss 20364138

Variation tolerance for ZNF14 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF14 Gene

Disorders for ZNF14 Gene

Additional Disease Information for ZNF14

No disorders were found for ZNF14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF14 Gene

Publications for ZNF14 Gene

  1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 56
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  3. TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. (PMID: 27609421) Banks CA … Washburn MP (Molecular & cellular proteomics : MCP 2016) 3 56
  4. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis MC … He K (Human molecular genetics 2015) 3 56
  5. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 56

Products for ZNF14 Gene

Sources for ZNF14 Gene