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Aliases for ZNF138 Gene

Aliases for ZNF138 Gene

  • Zinc Finger Protein 138 2 3 5
  • Zinc Finger Protein 138 (Clone PHZ-32) 2 3
  • PHZ-32 3

External Ids for ZNF138 Gene

Previous GeneCards Identifiers for ZNF138 Gene

  • GC07P062894
  • GC07P063652
  • GC07P063684
  • GC07P063085
  • GC07P063698
  • GC07P063892
  • GC07P064254
  • GC07P060636

Summaries for ZNF138 Gene

GeneCards Summary for ZNF138 Gene

ZNF138 (Zinc Finger Protein 138) is a Protein Coding gene. Diseases associated with ZNF138 include Split-Hand/Foot Malformation 1. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot for ZNF138 Gene

  • May be involved in transcriptional regulation as a repressor.

Additional gene information for ZNF138 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF138 Gene

Genomics for ZNF138 Gene

GeneHancer (GH) Regulatory Elements for ZNF138 Gene

Promoters and enhancers for ZNF138 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I064792 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.9 -0.2 -245 2.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 POLR2B ZNF138 EEF1DP4 GABPAP GTF2IP14 ERV3-1 ZNF107 ENSG00000234338 ENSG00000277206
GH07I065749 Promoter/Enhancer 1.5 Ensembl ENCODE 10 +956.7 956721 2.8 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 CCT6P1 VKORC1L1 ENSG00000244657 LOC100996437 ENSG00000230189 LINC00174 ENSG00000229180 LOC84214 LOC100420547 GTF2IP9
GH07I064664 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.4 -127.9 -127933 3.2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 ZNF107 CCT6P3 GTF2IP14 ZNF736 LOC441239 ERV3-1 SEPHS1P1 ZNF138 MIR6839
GH07I064569 Enhancer 0.6 Ensembl ENCODE 5.5 -224.5 -224487 1 CTCF ZNF48 EZH2 LOC100129293 ZNF107 ZNF680P1 ZNF138 LOC100133092
GH07I064541 Enhancer 0.6 Ensembl ENCODE 5.5 -252.6 -252577 1.2 FOSL1 JUND RUNX3 ZNF107 ZNF680P1 ZNF138 BNIP3P42 ZNF680 HNRNPCP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF138 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF138 Gene

Genomic Locations for ZNF138 Gene
59,413 bases
Plus strand

Genomic View for ZNF138 Gene

Genes around ZNF138 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF138 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF138 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF138 Gene

Proteins for ZNF138 Gene

  • Protein details for ZNF138 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 138
    Protein Accession:
    Secondary Accessions:
    • B4DFX2
    • B4DP87
    • E9PHI7
    • E9PHK7

    Protein attributes for ZNF138 Gene

    262 amino acids
    Molecular mass:
    30592 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF138 Gene


neXtProt entry for ZNF138 Gene

Post-translational modifications for ZNF138 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF138 Gene

Domains & Families for ZNF138 Gene

Gene Families for ZNF138 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF138 Gene

Suggested Antigen Peptide Sequences for ZNF138 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF138: view

Function for ZNF138 Gene

Molecular function for ZNF138 Gene

GENATLAS Biochemistry:
zinc finger protein 138 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor.

Gene Ontology (GO) - Molecular Function for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 7557990
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF138: view
genes like me logo Genes that share phenotypes with ZNF138: view

miRNA for ZNF138 Gene

miRTarBase miRNAs that target ZNF138

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF138 Gene

Localization for ZNF138 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF138 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF138 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS 7557990
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF138: view

Pathways & Interactions for ZNF138 Gene

SuperPathways for ZNF138 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF138: view

Pathways by source for ZNF138 Gene

2 Reactome pathways for ZNF138 Gene

Gene Ontology (GO) - Biological Process for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 7557990
genes like me logo Genes that share ontologies with ZNF138: view

No data available for SIGNOR curated interactions for ZNF138 Gene

Drugs & Compounds for ZNF138 Gene

No Compound Related Data Available

Transcripts for ZNF138 Gene

Unigene Clusters for ZNF138 Gene

Zinc finger protein 138:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF138 Gene

ExUns: 1 ^ 2 ^ 3

Relevant External Links for ZNF138 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF138 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF138 Gene

Protein differential expression in normal tissues from HIPED for ZNF138 Gene

This gene is overexpressed in Breast (56.3) and Prostate (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF138 Gene

Protein tissue co-expression partners for ZNF138 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF138 Gene:


SOURCE GeneReport for Unigene cluster for ZNF138 Gene:


Evidence on tissue expression from TISSUES for ZNF138 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF138: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF138 Gene

Orthologs for ZNF138 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF138 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 54 (a)
(Mus musculus)
Mammalia Zfp493 34
  • 28 (a)
(Bos Taurus)
Mammalia -- 34
  • 27 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 24 (a)
-- 34
  • 18 (a)
(Canis familiaris)
Mammalia -- 34
  • 20 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 20 (a)
-- 34
  • 19 (a)
-- 34
  • 18 (a)
-- 34
  • 15 (a)
-- 34
  • 14 (a)
-- 34
  • 14 (a)
-- 34
  • 13 (a)
-- 34
  • 13 (a)
Species where no ortholog for ZNF138 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF138 Gene

Gene Tree for ZNF138 (if available)
Gene Tree for ZNF138 (if available)

Paralogs for ZNF138 Gene

(485) SIMAP similar genes for ZNF138 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF138: view

Variants for ZNF138 Gene

Sequence variations from dbSNP and Humsavar for ZNF138 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000048354 -- 64,807,940(+) TT/T intron_variant
rs1000064909 -- 64,830,597(+) A/G intron_variant
rs1000079610 -- 64,815,318(+) C/T intron_variant
rs1000148791 -- 64,814,087(+) C/T 5_prime_UTR_variant, intron_variant
rs1000181768 -- 64,850,312(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF138 Gene

Variant ID Type Subtype PubMed ID
nsv970859 CNV duplication 23825009
nsv970858 CNV duplication 23825009
nsv970857 CNV duplication 23825009
nsv607314 CNV gain 21841781
nsv607313 CNV loss 21841781
nsv607312 CNV gain 21841781
nsv508457 CNV deletion 20534489
nsv464518 CNV gain 19166990
nsv436564 CNV deletion 17901297
nsv1137583 CNV deletion 24896259
nsv1026390 CNV gain 25217958
nsv1022042 CNV gain 25217958
esv3613425 CNV loss 21293372
esv3571879 CNV loss 25503493
esv3541774 CNV deletion 23714750
esv33896 CNV gain 17666407
esv2764000 CNV gain+loss 21179565
esv2677316 CNV deletion 23128226
esv2675483 CNV deletion 23128226
esv2478591 CNV insertion 19546169
esv2422405 CNV duplication 17116639
esv23796 CNV loss 19812545
dgv1099e201 CNV deletion 23290073

Variation tolerance for ZNF138 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF138 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF138 Gene

Disorders for ZNF138 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF138 Gene - From: DISEASES

Disorder Aliases PubMed IDs
split-hand/foot malformation 1
  • shfm1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF138

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF138: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF138 Gene

Publications for ZNF138 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N … Bergen AW (PloS one 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 3 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF138 Gene

Sources for ZNF138 Gene

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