Aliases for ZNF138 Gene

Aliases for ZNF138 Gene

  • Zinc Finger Protein 138 2 3 4 5
  • Zinc Finger Protein 138 (Clone PHZ-32) 2 3
  • PHZ-32 2 3
  • ZNF138 5

External Ids for ZNF138 Gene

Previous GeneCards Identifiers for ZNF138 Gene

  • GC07P062894
  • GC07P063652
  • GC07P063684
  • GC07P063085
  • GC07P063698
  • GC07P063892
  • GC07P064254
  • GC07P060636

Summaries for ZNF138 Gene

GeneCards Summary for ZNF138 Gene

ZNF138 (Zinc Finger Protein 138) is a Protein Coding gene. Diseases associated with ZNF138 include Split-Hand/Foot Malformation 1. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF93.

UniProtKB/Swiss-Prot Summary for ZNF138 Gene

Additional gene information for ZNF138 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF138 Gene

Genomics for ZNF138 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF138 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF138 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF138

Genomic Locations for ZNF138 Gene

Genomic Locations for ZNF138 Gene
chr7:64,794,388-64,860,823
(GRCh38/hg38)
Size:
66,436 bases
Orientation:
Plus strand
chr7:64,254,766-64,294,054
(GRCh37/hg19)
Size:
39,289 bases
Orientation:
Plus strand

Genomic View for ZNF138 Gene

Genes around ZNF138 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF138 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF138 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF138 Gene

Proteins for ZNF138 Gene

  • Protein details for ZNF138 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52744-ZN138_HUMAN
    Recommended name:
    Zinc finger protein 138
    Protein Accession:
    P52744
    Secondary Accessions:
    • B4DFX2
    • B4DP87
    • E9PHI7
    • E9PHK7

    Protein attributes for ZNF138 Gene

    Size:
    262 amino acids
    Molecular mass:
    30592 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF138 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF138 Gene

Post-translational modifications for ZNF138 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF138 Gene

Domains & Families for ZNF138 Gene

Gene Families for ZNF138 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF138 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF138 Gene

GenScript: Design optimal peptide antigens:
  • ZNF138 protein (A2RRP7_HUMAN)
  • Zinc finger protein 138 (ZN138_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52744

UniProtKB/Swiss-Prot:

ZN138_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF138: view

Function for ZNF138 Gene

Molecular function for ZNF138 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor.
GENATLAS Biochemistry:
zinc finger protein 138 (C2H2 type,Kruppel-like)

Gene Ontology (GO) - Molecular Function for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF138: view
genes like me logo Genes that share phenotypes with ZNF138: view

Animal Model Products

CRISPR Products

miRNA for ZNF138 Gene

miRTarBase miRNAs that target ZNF138

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF138

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF138 Gene

Localization for ZNF138 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF138 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF138 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF138: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF138 Gene

Pathways & Interactions for ZNF138 Gene

PathCards logo

SuperPathways for ZNF138 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF138: view

Pathways by source for ZNF138 Gene

2 Reactome pathways for ZNF138 Gene

Gene Ontology (GO) - Biological Process for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF138: view

No data available for SIGNOR curated interactions for ZNF138 Gene

Drugs & Compounds for ZNF138 Gene

No Compound Related Data Available

Transcripts for ZNF138 Gene

mRNA/cDNA for ZNF138 Gene

13 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF138

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF138 Gene

ExUns: 1 ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for ZNF138 Gene

GeneLoc Exon Structure for
ZNF138

Expression for ZNF138 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF138 Gene

Protein differential expression in normal tissues from HIPED for ZNF138 Gene

This gene is overexpressed in Breast (56.3) and Prostate (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF138 Gene



Protein tissue co-expression partners for ZNF138 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF138

SOURCE GeneReport for Unigene cluster for ZNF138 Gene:

Hs.184080

Evidence on tissue expression from TISSUES for ZNF138 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF138: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF138 Gene

Orthologs for ZNF138 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF138 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 54 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Zfp493 31
  • 28 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 27 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 24 (a)
ManyToMany
-- 31
  • 18 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 20 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 20 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
-- 31
  • 18 (a)
ManyToMany
-- 31
  • 15 (a)
ManyToMany
-- 31
  • 14 (a)
ManyToMany
-- 31
  • 14 (a)
ManyToMany
-- 31
  • 13 (a)
ManyToMany
-- 31
  • 13 (a)
ManyToMany
Species where no ortholog for ZNF138 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF138 Gene

ENSEMBL:
Gene Tree for ZNF138 (if available)
TreeFam:
Gene Tree for ZNF138 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF138: view image

Paralogs for ZNF138 Gene

Paralogs for ZNF138 Gene

(485) SIMAP similar genes for ZNF138 Gene using alignment to 5 proteins:

  • ZN138_HUMAN
  • A2RRP7_HUMAN
  • C9JHF6_HUMAN
  • E7EWC5_HUMAN
  • J3QSS9_HUMAN
genes like me logo Genes that share paralogs with ZNF138: view

Variants for ZNF138 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF138 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs10949946 - p.Gly62Glu

Additional dbSNP identifiers (rs#s) for ZNF138 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF138 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
esv23796 CNV loss 19812545
esv2422405 CNV duplication 17116639
esv2478591 CNV insertion 19546169
esv2675483 CNV deletion 23128226
esv2677316 CNV deletion 23128226
esv2764000 CNV gain+loss 21179565
esv33896 CNV gain 17666407
esv3541774 CNV deletion 23714750
esv3571879 CNV loss 25503493
esv3613425 CNV loss 21293372
nsv1022042 CNV gain 25217958
nsv1026390 CNV gain 25217958
nsv1137583 CNV deletion 24896259
nsv436564 CNV deletion 17901297
nsv464518 CNV gain 19166990
nsv508457 CNV deletion 20534489
nsv607312 CNV gain 21841781
nsv607313 CNV loss 21841781
nsv607314 CNV gain 21841781
nsv970857 CNV duplication 23825009
nsv970858 CNV duplication 23825009
nsv970859 CNV duplication 23825009

Variation tolerance for ZNF138 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF138 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF138

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF138 Gene

Disorders for ZNF138 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF138 Gene - From: DISEASES

Disorder Aliases PubMed IDs
split-hand/foot malformation 1
  • shfm1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF138

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF138: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF138 Gene

Publications for ZNF138 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N … Bergen AW (PloS one 2009) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF138 Gene

  • Signalway Proteins for ZNF138

Sources for ZNF138 Gene