Aliases for ZNF136 Gene
External Ids for ZNF136 Gene
Previous GeneCards Identifiers for ZNF136 Gene
This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
GeneCards Summary for ZNF136 Gene
ZNF136 (Zinc Finger Protein 136) is a Protein Coding gene. Diseases associated with ZNF136 include Noonan Syndrome 2. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is ZNF627.
UniProtKB/Swiss-Prot for ZNF136 Gene
May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.