This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. ... See more...

Aliases for ZNF136 Gene

Aliases for ZNF136 Gene

  • Zinc Finger Protein 136 2 3 4 5
  • PHZ-20 2 3
  • Zinc Finger Protein 136 (Clone PHZ-20) 2
  • ZNF136 5

External Ids for ZNF136 Gene

Previous GeneCards Identifiers for ZNF136 Gene

  • GC19P012405
  • GC19P012496
  • GC19P012119
  • GC19P012134
  • GC19P012037
  • GC19P012273
  • GC19P011848

Summaries for ZNF136 Gene

Entrez Gene Summary for ZNF136 Gene

  • This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

GeneCards Summary for ZNF136 Gene

ZNF136 (Zinc Finger Protein 136) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is ZNF627.

UniProtKB/Swiss-Prot Summary for ZNF136 Gene

  • May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.

Additional gene information for ZNF136 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF136 Gene

Genomics for ZNF136 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF136 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF136 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF136

Top Transcription factor binding sites by QIAGEN in the ZNF136 gene promoter:
  • GCNF
  • GCNF-1
  • GCNF-2
  • p300
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1

Genomic Locations for ZNF136 Gene

Genomic Locations for ZNF136 Gene
chr19:12,163,047-12,189,881
(GRCh38/hg38)
Size:
26,835 bases
Orientation:
Plus strand
chr19:12,273,872-12,300,064
(GRCh37/hg19)
Size:
26,193 bases
Orientation:
Plus strand

Genomic View for ZNF136 Gene

Genes around ZNF136 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF136 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF136 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF136 Gene

Proteins for ZNF136 Gene

  • Protein details for ZNF136 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52737-ZN136_HUMAN
    Recommended name:
    Zinc finger protein 136
    Protein Accession:
    P52737

    Protein attributes for ZNF136 Gene

    Size:
    540 amino acids
    Molecular mass:
    62784 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF136 Gene

Post-translational modifications for ZNF136 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF136 Gene

No data available for DME Specific Peptides for ZNF136 Gene

Domains & Families for ZNF136 Gene

Gene Families for ZNF136 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF136 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF136 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 136 (ZN136_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52737

UniProtKB/Swiss-Prot:

ZN136_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF136: view

Function for ZNF136 Gene

Molecular function for ZNF136 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.
GENATLAS Biochemistry:
zinc finger protein 136 (C2H2 type,Kruppel-like,KRAB subfamily)

Phenotypes From GWAS Catalog for ZNF136 Gene

Gene Ontology (GO) - Molecular Function for ZNF136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity TAS 7649249
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF136: view
genes like me logo Genes that share phenotypes with ZNF136: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF136 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF136
  • Consensus sequence: YTKGATAHAGTATTCTWGGTNGGCA Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF136

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF136 Gene

Localization for ZNF136 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF136 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF136 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF136: view

Pathways & Interactions for ZNF136 Gene

genes like me logo Genes that share pathways with ZNF136: view

Pathways by source for ZNF136 Gene

2 Reactome pathways for ZNF136 Gene
1 KEGG pathway for ZNF136 Gene

Gene Ontology (GO) - Biological Process for ZNF136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 7649249
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 7649249
genes like me logo Genes that share ontologies with ZNF136: view

No data available for SIGNOR curated interactions for ZNF136 Gene

Drugs & Compounds for ZNF136 Gene

No Compound Related Data Available

Transcripts for ZNF136 Gene

mRNA/cDNA for ZNF136 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF136

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF136 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for ZNF136 Gene

GeneLoc Exon Structure for
ZNF136

Expression for ZNF136 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF136 Gene

Protein differential expression in normal tissues from HIPED for ZNF136 Gene

This gene is overexpressed in Bone (58.8) and Plasma (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF136 Gene



Protein tissue co-expression partners for ZNF136 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF136

SOURCE GeneReport for Unigene cluster for ZNF136 Gene:

Hs.479874

mRNA Expression by UniProt/SwissProt for ZNF136 Gene:

P52737-ZN136_HUMAN
Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for ZNF136 Gene

  • Lung(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ZNF136: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF136 Gene

Orthologs for ZNF136 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF136 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF136 30
  • 99.75 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 52 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG11762 32
  • 41 (a)
D19A 32
  • 32 (a)
CG11695 32
  • 31 (a)
Species where no ortholog for ZNF136 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF136 Gene

ENSEMBL:
Gene Tree for ZNF136 (if available)
TreeFam:
Gene Tree for ZNF136 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF136: view image

Paralogs for ZNF136 Gene

(512) SIMAP similar genes for ZNF136 Gene using alignment to 5 proteins:

  • ZN136_HUMAN
  • C9J2Q9_HUMAN
  • C9JJK8_HUMAN
  • C9JR58_HUMAN
  • F8WES0_HUMAN
genes like me logo Genes that share paralogs with ZNF136: view

Variants for ZNF136 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF136 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs193921014 Uncertain Significance: Malignant tumor of prostate 12,187,261(+) T/G MISSENSE_VARIANT
rs10425995 - p.Tyr107Cys

Additional dbSNP identifiers (rs#s) for ZNF136 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF136 Gene

Variant ID Type Subtype PubMed ID
esv2677508 CNV deletion 23128226
nsv510754 CNV deletion 20534489
nsv578619 CNV loss 21841781
nsv833753 CNV loss 17160897
nsv961179 CNV duplication 23825009

Variation tolerance for ZNF136 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF136 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF136

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF136 Gene

Disorders for ZNF136 Gene

No disorders were found for ZNF136 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF136 Gene

Publications for ZNF136 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PMID: 7649249) Vissing H … Thiesen HJ (FEBS letters 1995) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for ZNF136 Gene

Sources for ZNF136 Gene