Aliases for ZNF135 Gene

Aliases for ZNF135 Gene

  • Zinc Finger Protein 135 2 3 4 5
  • Zinc Finger Protein 61 2 3 4
  • Zinc Finger Protein 135 (Clone PHZ-17) 2 3
  • ZNF78L1 3 4
  • PHZ-17 2 3
  • ZNF61 3 4
  • Zinc Finger Protein 78-Like 1 (PT3) 3
  • Zinc Finger Protein 78-Like 1 4
  • ZNF135 5
  • PT3 3

External Ids for ZNF135 Gene

Previous HGNC Symbols for ZNF135 Gene

  • ZNF61
  • ZNF78L1

Previous GeneCards Identifiers for ZNF135 Gene

  • GC19P059476
  • GC19P059025
  • GC19P063246
  • GC19P063263
  • GC19P063060
  • GC19P063264
  • GC19P058571
  • GC19P054881
  • GC19P058573
  • GC19P058577
  • GC19P058587
  • GC19P058602

Summaries for ZNF135 Gene

GeneCards Summary for ZNF135 Gene

ZNF135 (Zinc Finger Protein 135) is a Protein Coding gene. Diseases associated with ZNF135 include Ureteral Benign Neoplasm. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot Summary for ZNF135 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.

Additional gene information for ZNF135 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF135 Gene

Genomics for ZNF135 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF135 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF135 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF135

Top Transcription factor binding sites by QIAGEN in the ZNF135 gene promoter:
  • AREB6
  • ARP-1
  • Elk-1
  • HOXA5
  • p53
  • Pax-2
  • Pax-2a
  • Pax-2b
  • Zic3

Genomic Locations for ZNF135 Gene

Genomic Locations for ZNF135 Gene
chr19:58,059,227-58,086,310
(GRCh38/hg38)
Size:
27,084 bases
Orientation:
Plus strand
chr19:58,570,607-58,597,677
(GRCh37/hg19)
Size:
27,071 bases
Orientation:
Plus strand

Genomic View for ZNF135 Gene

Genes around ZNF135 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF135 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF135 Gene

Proteins for ZNF135 Gene

  • Protein details for ZNF135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52742-ZN135_HUMAN
    Recommended name:
    Zinc finger protein 135
    Protein Accession:
    P52742
    Secondary Accessions:
    • B4DHH9
    • E9PEV2
    • F5GYY9
    • I3L0B3
    • Q5U5L3
    • Q8N1I7

    Protein attributes for ZNF135 Gene

    Size:
    658 amino acids
    Molecular mass:
    75261 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50254.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: May be due to competing acceptor splice site.

    Alternative splice isoforms for ZNF135 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF135 Gene

Post-translational modifications for ZNF135 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF135 Gene

Domains & Families for ZNF135 Gene

Gene Families for ZNF135 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF135 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF135 Gene

GenScript: Design optimal peptide antigens:
  • Zinc-finger protein (ZNFpT3) (Q15936_HUMAN)
  • cDNA FLJ40692 fis, clone THYMU2024748, highly similar to ZINC FINGER PROTEIN 135 (Q8N1I7_HUMAN)
  • cDNA FLJ36883 fis, clone BLADE2000389, highly similar to ZINC FINGER PROTEIN 135 (Q8N9M3_HUMAN)
  • Zinc finger protein 78-like 1 (ZN135_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52742

UniProtKB/Swiss-Prot:

ZN135_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF135: view

Function for ZNF135 Gene

Molecular function for ZNF135 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 135 (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF135 Gene

Gene Ontology (GO) - Molecular Function for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF135: view
genes like me logo Genes that share phenotypes with ZNF135: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF135

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF135 Gene

Localization for ZNF135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF135 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF135 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IEA --
genes like me logo Genes that share ontologies with ZNF135: view

Pathways & Interactions for ZNF135 Gene

genes like me logo Genes that share pathways with ZNF135: view

Pathways by source for ZNF135 Gene

2 Reactome pathways for ZNF135 Gene
1 KEGG pathway for ZNF135 Gene

Interacting Proteins for ZNF135 Gene

Gene Ontology (GO) - Biological Process for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with ZNF135: view

No data available for SIGNOR curated interactions for ZNF135 Gene

Drugs & Compounds for ZNF135 Gene

No Compound Related Data Available

Transcripts for ZNF135 Gene

mRNA/cDNA for ZNF135 Gene

7 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF135

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF135 Gene

No ASD Table

Relevant External Links for ZNF135 Gene

GeneLoc Exon Structure for
ZNF135

Expression for ZNF135 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF135 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF135

SOURCE GeneReport for Unigene cluster for ZNF135 Gene:

Hs.85863

Evidence on tissue expression from TISSUES for ZNF135 Gene

  • Nervous system(4.7)
  • Blood(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with ZNF135: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF135 Gene

Orthologs for ZNF135 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF135 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF135 30 31
  • 99.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC102154493 30
  • 85.49 (n)
-- 31
  • 48 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia ZNF135 30 31
  • 84.88 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp712 31
  • 45 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia ZNF135 31
  • 37 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG12299 32
  • 41 (a)
CG9797 32
  • 40 (a)
CG9215 32
  • 37 (a)
CG10543 32
  • 34 (a)
CG3032 32
  • 32 (a)
CG7987 32
  • 31 (a)
Worm
(Caenorhabditis elegans)
Secernentea M03D4.4 32
  • 33 (a)
Species where no ortholog for ZNF135 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ZNF135 Gene

ENSEMBL:
Gene Tree for ZNF135 (if available)
TreeFam:
Gene Tree for ZNF135 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF135: view image

Paralogs for ZNF135 Gene

Paralogs for ZNF135 Gene

(534) SIMAP similar genes for ZNF135 Gene using alignment to 3 proteins:

  • ZN135_HUMAN
  • M0R0N7_HUMAN
  • Q8N9M3_HUMAN
genes like me logo Genes that share paralogs with ZNF135: view

Variants for ZNF135 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF135 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
724935 Likely Benign: not provided 58,067,642(+) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
726216 Likely Benign: not provided 58,059,287(+) G/C MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
726932 Benign: not provided 58,063,481(+) C/T SYNONYMOUS_VARIANT
746583 Likely Benign: not provided 58,067,073(+) G/T NONSENSE,INTRON_VARIANT
781538 Benign: not provided 58,066,946(+) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF135 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF135 Gene

Variant ID Type Subtype PubMed ID
nsv1066059 CNV gain 25217958
nsv1134817 CNV deletion 24896259
nsv458836 CNV gain 19166990
nsv580403 CNV gain 21841781
nsv828656 CNV gain 20364138
nsv833885 CNV loss 17160897
nsv961254 CNV duplication 23825009

Variation tolerance for ZNF135 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF135 Gene

Human Gene Mutation Database (HGMD)
ZNF135
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF135

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF135 Gene

Disorders for ZNF135 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF135 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ureteral benign neoplasm
  • neoplasm of ureter
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF135

genes like me logo Genes that share disorders with ZNF135: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF135 Gene

Publications for ZNF135 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF135 Gene

Sources for ZNF135 Gene