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Aliases for ZNF135 Gene

Aliases for ZNF135 Gene

  • Zinc Finger Protein 135 2 3 5
  • Zinc Finger Protein 61 2 3 4
  • Zinc Finger Protein 135 (Clone PHZ-17) 2 3
  • ZNF78L1 3 4
  • ZNF61 3 4
  • Zinc Finger Protein 78-Like 1 (PT3) 3
  • Zinc Finger Protein 78-Like 1 4
  • PHZ-17 3
  • PT3 3

External Ids for ZNF135 Gene

Previous HGNC Symbols for ZNF135 Gene

  • ZNF61
  • ZNF78L1

Previous GeneCards Identifiers for ZNF135 Gene

  • GC19P059476
  • GC19P059025
  • GC19P063246
  • GC19P063263
  • GC19P063060
  • GC19P063264
  • GC19P058571
  • GC19P054881
  • GC19P058573
  • GC19P058577
  • GC19P058587
  • GC19P058602

Summaries for ZNF135 Gene

GeneCards Summary for ZNF135 Gene

ZNF135 (Zinc Finger Protein 135) is a Protein Coding gene. Diseases associated with ZNF135 include Causalgia. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF184.

UniProtKB/Swiss-Prot for ZNF135 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.

Additional gene information for ZNF135 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF135 Gene

Genomics for ZNF135 Gene

GeneHancer (GH) Regulatory Elements for ZNF135 Gene

Promoters and enhancers for ZNF135 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I058058 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 573.1 +0.1 82 2 NRF1 BACH1 SIN3A GABPA ETS1 POLR2A ZNF143 CHD2 ZNF135 GC19P058062 PIR58539 GC19P058067 ZSCAN1
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 75.2 +267.6 267632 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I057599 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 64.2 -459.2 -459202 1.5 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 KLF13 ZNF530 ZNF606 ZNF549 ZNF135 ZNF417 ZNF132 ZNF418 ZNF446 ZNF17 LOC105372482
GH19I058379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 56.5 +321.8 321846 2.9 ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF837 LOC100128398 ZNF606 ZNF329 ZNF135 TRIM28 ZNF132 ZNF446 ZSCAN18 ZNF548
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 46.7 +124.0 123997 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF135 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF135 gene promoter:

Genomic Locations for ZNF135 Gene

Genomic Locations for ZNF135 Gene
chr19:58,059,239-58,086,310
(GRCh38/hg38)
Size:
27,072 bases
Orientation:
Plus strand
chr19:58,570,607-58,597,677
(GRCh37/hg19)

Genomic View for ZNF135 Gene

Genes around ZNF135 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF135 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF135 Gene

Proteins for ZNF135 Gene

  • Protein details for ZNF135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52742-ZN135_HUMAN
    Recommended name:
    Zinc finger protein 135
    Protein Accession:
    P52742
    Secondary Accessions:
    • B4DHH9
    • E9PEV2
    • F5GYY9
    • I3L0B3
    • Q5U5L3
    • Q8N1I7

    Protein attributes for ZNF135 Gene

    Size:
    658 amino acids
    Molecular mass:
    75261 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50254.1; Type=Frameshift; Positions=207, 558, 563; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF135 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF135 Gene

Post-translational modifications for ZNF135 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF135 Gene

Domains & Families for ZNF135 Gene

Gene Families for ZNF135 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

P52742

UniProtKB/Swiss-Prot:

ZN135_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF135: view

Function for ZNF135 Gene

Molecular function for ZNF135 Gene

GENATLAS Biochemistry:
zinc finger protein 135 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS,IBA 7557990
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF135: view
genes like me logo Genes that share phenotypes with ZNF135: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF135 Gene

Localization for ZNF135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF135 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF135 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS 7557990
genes like me logo Genes that share ontologies with ZNF135: view

Pathways & Interactions for ZNF135 Gene

SuperPathways for ZNF135 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF135: view

Pathways by source for ZNF135 Gene

2 Reactome pathways for ZNF135 Gene

Gene Ontology (GO) - Biological Process for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 7557990
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with ZNF135: view

No data available for SIGNOR curated interactions for ZNF135 Gene

Drugs & Compounds for ZNF135 Gene

No Compound Related Data Available

Transcripts for ZNF135 Gene

Unigene Clusters for ZNF135 Gene

Zinc finger protein 135:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF135 Gene

No ASD Table

Relevant External Links for ZNF135 Gene

GeneLoc Exon Structure for
ZNF135
ECgene alternative splicing isoforms for
ZNF135

Expression for ZNF135 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF135 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF135 Gene:

ZNF135

SOURCE GeneReport for Unigene cluster for ZNF135 Gene:

Hs.85863

Evidence on tissue expression from TISSUES for ZNF135 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF135: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF135 Gene

Orthologs for ZNF135 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF135 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF135 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia LOC102154493 33
  • 85.49 (n)
-- 34
  • 48 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia ZNF135 33 34
  • 84.88 (n)
mouse
(Mus musculus)
Mammalia Zfp712 34
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia ZNF135 34
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12299 35
  • 41 (a)
CG9797 35
  • 40 (a)
CG9215 35
  • 37 (a)
CG10543 35
  • 34 (a)
CG3032 35
  • 32 (a)
CG7987 35
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea M03D4.4 35
  • 33 (a)
Species where no ortholog for ZNF135 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF135 Gene

ENSEMBL:
Gene Tree for ZNF135 (if available)
TreeFam:
Gene Tree for ZNF135 (if available)

Paralogs for ZNF135 Gene

(534) SIMAP similar genes for ZNF135 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF135: view

Variants for ZNF135 Gene

Sequence variations from dbSNP and Humsavar for ZNF135 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000007384 -- 58,062,497(+) C/G intron_variant
rs1000038573 -- 58,062,733(+) C/T intron_variant
rs1000100401 -- 58,062,260(+) C/T intron_variant
rs1001012788 -- 58,069,879(+) T/C downstream_transcript_variant
rs1001044296 -- 58,066,522(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF135 Gene

Variant ID Type Subtype PubMed ID
nsv961254 CNV duplication 23825009
nsv833885 CNV loss 17160897
nsv828656 CNV gain 20364138
nsv580403 CNV gain 21841781
nsv458836 CNV gain 19166990
nsv1134817 CNV deletion 24896259
nsv1066059 CNV gain 25217958

Variation tolerance for ZNF135 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF135 Gene

Human Gene Mutation Database (HGMD)
ZNF135
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF135

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF135 Gene

Disorders for ZNF135 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF135 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
causalgia
  • complex regional pain syndrome, type ii
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF135

genes like me logo Genes that share disorders with ZNF135: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF135 Gene

Publications for ZNF135 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4 58
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3 58
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A … Wanker EE (Science signaling 2011) 3 58

Products for ZNF135 Gene

Sources for ZNF135 Gene

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