Aliases for ZNF134 Gene

Aliases for ZNF134 Gene

  • Zinc Finger Protein 134 2 3 4 5
  • Zinc Finger Protein 134 (Clone PHZ-15) 2 3
  • PHZ-15 2 3
  • ZNF134 5

External Ids for ZNF134 Gene

Previous GeneCards Identifiers for ZNF134 Gene

  • GC19P059024
  • GC19P058579
  • GC19P062801
  • GC19P062817
  • GC19P058126
  • GC19P054438

Summaries for ZNF134 Gene

GeneCards Summary for ZNF134 Gene

ZNF134 (Zinc Finger Protein 134) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF304.

UniProtKB/Swiss-Prot Summary for ZNF134 Gene

Additional gene information for ZNF134 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF134 Gene

Genomics for ZNF134 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF134 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF134 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF134

Top Transcription factor binding sites by QIAGEN in the ZNF134 gene promoter:
  • COUP
  • COUP-TF1
  • FOXL1
  • FOXO4
  • HNF-4alpha1
  • HNF-4alpha2
  • HTF
  • POU2F1
  • POU2F1a

Genomic Locations for ZNF134 Gene

Genomic Locations for ZNF134 Gene
10,492 bases
Plus strand
9,124 bases
Plus strand

Genomic View for ZNF134 Gene

Genes around ZNF134 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF134 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF134 Gene

Proteins for ZNF134 Gene

  • Protein details for ZNF134 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 134
    Protein Accession:
    Secondary Accessions:
    • Q9Y4B2

    Protein attributes for ZNF134 Gene

    427 amino acids
    Molecular mass:
    48480 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF134 Gene


neXtProt entry for ZNF134 Gene

Post-translational modifications for ZNF134 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF134 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF134 Gene

Domains & Families for ZNF134 Gene

Gene Families for ZNF134 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF134 Gene

  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZNF134 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 134 (Q5U5N5_HUMAN)
  • ZNF134 protein (Q6PJ68_HUMAN)
  • ZNF134 protein (Q6PJU4_HUMAN)
  • Zinc finger protein 134 (ZN134_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF134: view

Function for ZNF134 Gene

Molecular function for ZNF134 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 134 (C2H2 type,Kruppel-like),tightly linked to a full size LTR of human endogenous retroviruses HERV-K

Phenotypes From GWAS Catalog for ZNF134 Gene

Gene Ontology (GO) - Molecular Function for ZNF134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF134: view
genes like me logo Genes that share phenotypes with ZNF134: view

Animal Model Products

CRISPR Products

miRNA for ZNF134 Gene

miRTarBase miRNAs that target ZNF134

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF134

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF134 Gene

Localization for ZNF134 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF134 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF134 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with ZNF134: view

Pathways & Interactions for ZNF134 Gene

PathCards logo

SuperPathways for ZNF134 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF134: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF134 Gene

Drugs & Compounds for ZNF134 Gene

(1) Drugs for ZNF134 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 431
genes like me logo Genes that share compounds with ZNF134: view

Transcripts for ZNF134 Gene

mRNA/cDNA for ZNF134 Gene

8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF134

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF134 Gene

No ASD Table

Relevant External Links for ZNF134 Gene

GeneLoc Exon Structure for

Expression for ZNF134 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF134 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF134 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF134

SOURCE GeneReport for Unigene cluster for ZNF134 Gene:


Evidence on tissue expression from TISSUES for ZNF134 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZNF134: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF134 Gene

Orthologs for ZNF134 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF134 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF134 30 31
  • 99.45 (n)
(Canis familiaris)
Mammalia ZNF134 30 31
  • 86.62 (n)
(Bos Taurus)
Mammalia ZNF134 30 31
  • 84.78 (n)
Species where no ortholog for ZNF134 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF134 Gene

Gene Tree for ZNF134 (if available)
Gene Tree for ZNF134 (if available)
Evolutionary constrained regions (ECRs) for ZNF134: view image

Paralogs for ZNF134 Gene

(498) SIMAP similar genes for ZNF134 Gene using alignment to 6 proteins:

  • ZN134_HUMAN
  • M0R246_HUMAN
  • Q5U5N5_HUMAN
  • Q6PJ68_HUMAN
  • Q6PJU4_HUMAN Pseudogenes for ZNF134 Gene

genes like me logo Genes that share paralogs with ZNF134: view

Variants for ZNF134 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF134 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10413455 - p.Ala46Thr
rs10414451 - p.Ile30Thr
rs34034473 - p.Ser207Arg

Additional dbSNP identifiers (rs#s) for ZNF134 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF134 Gene

Variant ID Type Subtype PubMed ID
esv3575120 CNV gain 25503493

Variation tolerance for ZNF134 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF134 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF134 Gene

Disorders for ZNF134 Gene

No disorders were found for ZNF134 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF134 Gene

Publications for ZNF134 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  4. Mycobacterial and HIV infections up-regulated human zinc finger protein 134, a novel positive regulator of HIV-1 LTR activity and viral propagation. (PMID: 25144775) Benjamin R … Banerjee S (PloS one 2014) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF134 Gene

Sources for ZNF134 Gene