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Aliases for ZNF134 Gene

Aliases for ZNF134 Gene

  • Zinc Finger Protein 134 2 3 5
  • Zinc Finger Protein 134 (Clone PHZ-15) 2 3
  • PHZ-15 3

External Ids for ZNF134 Gene

Previous GeneCards Identifiers for ZNF134 Gene

  • GC19P059024
  • GC19P058579
  • GC19P062801
  • GC19P062817
  • GC19P058126
  • GC19P054438

Summaries for ZNF134 Gene

GeneCards Summary for ZNF134 Gene

ZNF134 (Zinc Finger Protein 134) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZNF304.

UniProtKB/Swiss-Prot for ZNF134 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF134 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF134 Gene

Genomics for ZNF134 Gene

GeneHancer (GH) Regulatory Elements for ZNF134 Gene

Promoters and enhancers for ZNF134 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057613 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 567.2 +0.3 274 1.8 PKNOX1 ATF1 ARID4B SIN3A ZBTB7B YY1 ETS1 ZNF280A POLR2B GLIS2 ZNF134 ZNF274 ZNF256 ZNF550 ZNF773 ZNF264 ENSG00000268392 ZNF417 ZNF543 TRIM28
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 103.4 +569.0 569003 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 95.7 +712.6 712638 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I058553 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 57 +942.9 942880 7.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CHMP2A UBE2M TRIM28 ZNF417 ZNF134 ZNF606 ZNF274 MZF1 LOC100128398 ERVK3-1
GH19I058517 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.3 +905.5 905475 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZBTB45 PIR40518 ZNF324B TRIM28 ZNF446 ZNF134 ZNF417 ZSCAN22 ZNF549 ZNF274
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF134 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF134 gene promoter:

Genomic Locations for ZNF134 Gene

Genomic Locations for ZNF134 Gene
chr19:57,614,233-57,624,723
(GRCh38/hg38)
Size:
10,491 bases
Orientation:
Plus strand
chr19:58,125,601-58,134,724
(GRCh37/hg19)

Genomic View for ZNF134 Gene

Genes around ZNF134 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF134 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF134 Gene

Proteins for ZNF134 Gene

  • Protein details for ZNF134 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52741-ZN134_HUMAN
    Recommended name:
    Zinc finger protein 134
    Protein Accession:
    P52741
    Secondary Accessions:
    • Q9Y4B2

    Protein attributes for ZNF134 Gene

    Size:
    427 amino acids
    Molecular mass:
    48480 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF134 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF134 Gene

Post-translational modifications for ZNF134 Gene

No Post-translational modifications

Other Protein References for ZNF134 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF134 Gene

Domains & Families for ZNF134 Gene

Gene Families for ZNF134 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF134 Gene

Suggested Antigen Peptide Sequences for ZNF134 Gene

Graphical View of Domain Structure for InterPro Entry

P52741

UniProtKB/Swiss-Prot:

ZN134_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF134: view

Function for ZNF134 Gene

Molecular function for ZNF134 Gene

GENATLAS Biochemistry:
zinc finger protein 134 (C2H2 type,Kruppel-like),tightly linked to a full size LTR of human endogenous retroviruses HERV-K
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF134 Gene

Gene Ontology (GO) - Molecular Function for ZNF134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 7557990
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF134: view
genes like me logo Genes that share phenotypes with ZNF134: view

miRNA for ZNF134 Gene

miRTarBase miRNAs that target ZNF134

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF134 Gene

Localization for ZNF134 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF134 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF134 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7557990
genes like me logo Genes that share ontologies with ZNF134: view

Pathways & Interactions for ZNF134 Gene

SuperPathways for ZNF134 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 7557990
genes like me logo Genes that share ontologies with ZNF134: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF134 Gene

Drugs & Compounds for ZNF134 Gene

No Compound Related Data Available

Transcripts for ZNF134 Gene

Unigene Clusters for ZNF134 Gene

Zinc finger protein 134:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF134 Gene

No ASD Table

Relevant External Links for ZNF134 Gene

GeneLoc Exon Structure for
ZNF134
ECgene alternative splicing isoforms for
ZNF134

Expression for ZNF134 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF134 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF134 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF134 Gene:

ZNF134

SOURCE GeneReport for Unigene cluster for ZNF134 Gene:

Hs.469694

Evidence on tissue expression from TISSUES for ZNF134 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF134: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF134 Gene

Orthologs for ZNF134 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF134 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF134 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia ZNF134 33 34
  • 86.62 (n)
cow
(Bos Taurus)
Mammalia ZNF134 33 34
  • 84.78 (n)
Species where no ortholog for ZNF134 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF134 Gene

ENSEMBL:
Gene Tree for ZNF134 (if available)
TreeFam:
Gene Tree for ZNF134 (if available)

Paralogs for ZNF134 Gene

(498) SIMAP similar genes for ZNF134 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF134 Gene

genes like me logo Genes that share paralogs with ZNF134: view

Variants for ZNF134 Gene

Sequence variations from dbSNP and Humsavar for ZNF134 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000788055 -- 57,617,310(+) G/A intron_variant
rs1000806093 -- 57,621,306(+) G/T coding_sequence_variant, missense_variant
rs1000923773 -- 57,617,049(+) C/T intron_variant
rs1000943843 -- 57,623,548(+) AAAAAAAAAA/AAAAAAAAA/AAAAAAAAAAA 3_prime_UTR_variant
rs1001007071 -- 57,615,675(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF134 Gene

Variant ID Type Subtype PubMed ID
esv3575120 CNV gain 25503493

Variation tolerance for ZNF134 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF134 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF134

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF134 Gene

Disorders for ZNF134 Gene

Additional Disease Information for ZNF134

No disorders were found for ZNF134 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF134 Gene

Publications for ZNF134 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4 58
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  3. Mycobacterial and HIV infections up-regulated human zinc finger protein 134, a novel positive regulator of HIV-1 LTR activity and viral propagation. (PMID: 25144775) Benjamin R … Banerjee S (PloS one 2014) 3 58
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF134 Gene

Sources for ZNF134 Gene

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