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ZNF133 Gene(Protein Coding)

Zinc Finger Protein 133

GCID:
GC20P018264
GIFtS:
41
Genes Participants
UDN Logo

Aliases for ZNF133 Gene

Aliases for ZNF133 Gene

  • Zinc Finger Protein 133 2 3 3 5
  • Zinc Finger Protein 133 (Clone PHZ-13) 2 3
  • Zinc Finger Protein 150 (PHZ-66) 2 3
  • ZNF150 3 4
  • Zinc Finger Protein 150 4
  • PHZ-13 3
  • PHZ-66 3

External Ids for ZNF133 Gene

Previous HGNC Symbols for ZNF133 Gene

  • ZNF150

Previous GeneCards Identifiers for ZNF133 Gene

  • GC20P018257
  • GC20P018217

Summaries for ZNF133 Gene

GeneCards Summary for ZNF133 Gene

ZNF133 (Zinc Finger Protein 133) is a Protein Coding gene. Diseases associated with ZNF133 include Corneal Dystrophy, Posterior Polymorphous, 1 and Osteoblastoma. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is HKR1.

UniProtKB/Swiss-Prot for ZNF133 Gene

  • May be involved in transcriptional regulation as a repressor.

Gene Wiki entry for ZNF133 Gene

Additional gene information for ZNF133 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF133 Gene

Genomics for ZNF133 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ZNF133 Gene

Promoters and enhancers for ZNF133 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20J018287 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.3 316 2.4 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF133 ENSG00000237259 DZANK1 POLR3F GCNT1P1 GC20M018295 RN7SKP74
GH20J018267 Promoter/Enhancer 0.7 EPDnew ENCODE 650.3 -20.1 -20112 0.4 ZNF133 ENSG00000237259 LOC105372551 RNU2-56P
GH20J018298 Promoter 0.5 EPDnew 650.4 +9.8 9762 0.1 ZNF133 DZANK1 POLR3F GC20M018295 RN7SKP74 ENSG00000237259
GH20J018136 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 21.8 -149.7 -149665 3.7 CLOCK SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B KAT14 PET117 ZNF133 LOC100270804 LOC100286962 LOC100529052 GC20P018220
GH20J018587 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.4 +300.0 299990 1.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 ZNF143 KLF13 DTD1 LOC100270804 ZNF133 SMIM26 LOC100286962 SEC23B RN7SL638P ENSG00000284776
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF133 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF133 gene promoter:
  • c-Jun
  • ATF-2
  • MRF-2
  • HNF-4alpha2
  • HNF-4alpha1
  • COUP-TF1
  • COUP-TF
  • COUP
  • CUTL1
  • Lmo2

Genomic Locations for ZNF133 Gene

Genomic Locations for ZNF133 Gene
chr20:18,288,283-18,316,996
(GRCh38/hg38)
Size:
28,714 bases
Orientation:
Plus strand
chr20:18,269,121-18,297,640
(GRCh37/hg19)
Size:
28,520 bases
Orientation:
Plus strand

Genomic View for ZNF133 Gene

Genes around ZNF133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF133 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF133 Gene

Proteins for ZNF133 Gene

Products:

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  • Protein details for ZNF133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52736-ZN133_HUMAN
    Recommended name:
    Zinc finger protein 133
    Protein Accession:
    P52736
    Secondary Accessions:
    • A8K5S4
    • B4DHU7
    • B4DIB8
    • B7ZAS1
    • F5H289
    • J3KQ11
    • J3KQJ0
    • Q53XU1
    • Q5JXV8
    • Q9BUV2
    • Q9H443

    Protein attributes for ZNF133 Gene

    Size:
    654 amino acids
    Molecular mass:
    73388 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF133 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF133 Gene

Post-translational modifications for ZNF133 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF133 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF133 Gene

Domains & Families for ZNF133 Gene

Gene Families for ZNF133 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF133 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF133 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52736

UniProtKB/Swiss-Prot:

ZN133_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF133: view

Function for ZNF133 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZNF133 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor.
GENATLAS Biochemistry:
zinc finger protein 133 (C2H2 type,Kruppel-like,KRAB subfamily)

Phenotypes From GWAS Catalog for ZNF133 Gene

Gene Ontology (GO) - Molecular Function for ZNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 7557990
GO:0005515 protein binding IPI 20195357
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF133: view
genes like me logo Genes that share phenotypes with ZNF133: view

Animal Model Products

CRISPR Products

miRNA for ZNF133 Gene

miRTarBase miRNAs that target ZNF133

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF133

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF133 Gene

Localization for ZNF133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF133 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF133 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF133: view

Pathways & Interactions for ZNF133 Gene

SuperPathways for ZNF133 Gene

PathCards logo More details on SuperPathways for ZNF133
SuperPathway Contained pathways
1 Gene Expression
Gene Expression
.48
Generic Transcription Pathway
.48
genes like me logo Genes that share pathways with ZNF133: view

Pathways by source for ZNF133 Gene

2 Reactome pathways for ZNF133 Gene

Gene Ontology (GO) - Biological Process for ZNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF133: view

No data available for SIGNOR curated interactions for ZNF133 Gene

Drugs & Compounds for ZNF133 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for ZNF133 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF133 Gene

(43) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(77) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF133 Gene

Zinc finger protein 133:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF133

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF133 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
SP1: -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4:
SP5:
SP6: - - -
SP7: - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - -
SP11:
SP12: - - - - - - - - - -
SP13:
SP14: - - - - - - - - - - - -
SP15: - -
SP16: - - - - - - - - - - - - - - - - -

Relevant External Links for ZNF133 Gene

GeneLoc Exon Structure for
ZNF133
ECgene alternative splicing isoforms for
ZNF133

Expression for ZNF133 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF133 Gene

mRNA expression in normal human tissues for ZNF133 Gene
mRNA expression by BioGPS for ZNF133 GenemRNA expression by GTEx for ZNF133 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF133 Gene:

ZNF133

SOURCE GeneReport for Unigene cluster for ZNF133 Gene:

Hs.472221

mRNA Expression by UniProt/SwissProt for ZNF133 Gene:

P52736-ZN133_HUMAN
Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for ZNF133 Gene

  • Nervous system(4.5)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF133: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF133 Gene

Orthologs for ZNF133 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF133 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF133 34 33
  • 99.54 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia ZNF133 34 33
  • 86.45 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Zfp133 33
  • 83.59 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG10543 35
  • 32 (a)
fu2 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes STP2 36
Species where no ortholog for ZNF133 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF133 Gene

ENSEMBL:
Gene Tree for ZNF133 (if available)
TreeFam:
Gene Tree for ZNF133 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF133: view image

Paralogs for ZNF133 Gene

Paralogs for ZNF133 Gene

(554) SIMAP similar genes for ZNF133 Gene using alignment to 8 proteins:

  • ZN133_HUMAN
  • B7ZAS1_HUMAN
  • F5H289_HUMAN
  • J3KQ11_HUMAN
  • J3KQJ0_HUMAN
  • Q5JXV9_HUMAN
  • Q5JXW0_HUMAN
  • Q5JXW1_HUMAN
genes like me logo Genes that share paralogs with ZNF133: view

Variants for ZNF133 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ZNF133 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000038595 -- 18,293,056(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000154269 -- 18,292,814(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000163065 -- 18,314,460(+) T/G intron_variant
rs1000175399 -- 18,305,917(+) A/T intron_variant
rs1000251502 -- 18,299,760(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF133 Gene

Variant ID Type Subtype PubMed ID
esv2751911 CNV gain 17911159
esv2758788 CNV loss 17122850
nsv1062244 CNV gain 25217958
nsv509763 CNV insertion 20534489

Variation tolerance for ZNF133 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF133 Gene

Human Gene Mutation Database (HGMD)
ZNF133
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF133

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF133 Gene

Disorders for ZNF133 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZNF133 Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF133

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF133: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF133 Gene

Publications for ZNF133 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4 58
  2. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PMID: 7649249) Vissing H … Thiesen HJ (FEBS letters 1995) 2 3 4 58
  3. PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity. (PMID: 17934332) Lee SJ … Hahn MJ (Experimental & molecular medicine 2007) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

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Sources for ZNF133 Gene

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