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Aliases for ZNF132 Gene

Aliases for ZNF132 Gene

  • Zinc Finger Protein 132 2 3 5
  • Zinc Finger Protein 132 (Clone PHZ-12) 2
  • PHZ-12 3

External Ids for ZNF132 Gene

Previous GeneCards Identifiers for ZNF132 Gene

  • GC19M059842
  • GC19M059398
  • GC19M063620
  • GC19M063635
  • GC19M058944
  • GC19M055257

Summaries for ZNF132 Gene

GeneCards Summary for ZNF132 Gene

ZNF132 (Zinc Finger Protein 132) is a Protein Coding gene. Diseases associated with ZNF132 include Split-Hand/Foot Malformation 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF304.

UniProtKB/Swiss-Prot for ZNF132 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF132 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF132 Gene

Genomics for ZNF132 Gene

GeneHancer (GH) Regulatory Elements for ZNF132 Gene

Promoters and enhancers for ZNF132 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I058439 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 575.5 +0.1 108 2.1 HDGF PKNOX1 MXI1 MAX SIN3A BMI1 KLF5 YY1 ETS1 POLR2A ZNF132 LOC100419848 ZNF584 ENSG00000232098 LOC105372483 ENSG00000268912 PIR40092 ZNF324B
GH19I057599 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 56.4 +840.2 840185 1.5 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 KLF13 ZNF530 ZNF606 ZNF549 ZNF135 ZNF417 ZNF132 ZNF418 ZNF446 ZNF17 LOC105372482
GH19I058379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 50.7 +59.1 59137 2.9 ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF837 LOC100128398 ZNF606 ZNF329 ZNF135 TRIM28 ZNF132 ZNF446 ZSCAN18 ZNF548
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 49.2 +257.0 256986 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 48.4 +113.4 113351 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 PIR44424 LOC105372480 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF132 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF132 gene promoter:

Genomic Locations for ZNF132 Gene

Genomic Locations for ZNF132 Gene
7,416 bases
Minus strand

Genomic View for ZNF132 Gene

Genes around ZNF132 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF132 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF132 Gene

Proteins for ZNF132 Gene

  • Protein details for ZNF132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 132
    Protein Accession:
    Secondary Accessions:
    • Q32MI9

    Protein attributes for ZNF132 Gene

    706 amino acids
    Molecular mass:
    80623 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF132 Gene


neXtProt entry for ZNF132 Gene

Post-translational modifications for ZNF132 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF132 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF132 Gene

Domains & Families for ZNF132 Gene

Gene Families for ZNF132 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF132 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF132: view

Function for ZNF132 Gene

Molecular function for ZNF132 Gene

GENATLAS Biochemistry:
zinc finger protein 132 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF132 Gene

Gene Ontology (GO) - Molecular Function for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 7557990
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF132: view
genes like me logo Genes that share phenotypes with ZNF132: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF132 Gene

Localization for ZNF132 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF132 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF132 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF132: view

Pathways & Interactions for ZNF132 Gene

SuperPathways for ZNF132 Gene

No Data Available

Interacting Proteins for ZNF132 Gene

Gene Ontology (GO) - Biological Process for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF132: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF132 Gene

Drugs & Compounds for ZNF132 Gene

No Compound Related Data Available

Transcripts for ZNF132 Gene

mRNA/cDNA for ZNF132 Gene

Unigene Clusters for ZNF132 Gene

Zinc finger protein 132:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF132 Gene

No ASD Table

Relevant External Links for ZNF132 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF132 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF132 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF132 Gene:


SOURCE GeneReport for Unigene cluster for ZNF132 Gene:

genes like me logo Genes that share expression patterns with ZNF132: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF132 Gene

Orthologs for ZNF132 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF132 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF132 33 34
  • 99.24 (n)
(Canis familiaris)
Mammalia ZNF132 33 34
  • 86.04 (n)
(Bos Taurus)
Mammalia ZNF132 33 34
  • 81.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15436 35
  • 42 (a)
(Caenorhabditis elegans)
Secernentea F35H8.3 35
  • 36 (a)
Species where no ortholog for ZNF132 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF132 Gene

Gene Tree for ZNF132 (if available)
Gene Tree for ZNF132 (if available)

Paralogs for ZNF132 Gene

(504) SIMAP similar genes for ZNF132 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF132: view

Variants for ZNF132 Gene

Sequence variations from dbSNP and Humsavar for ZNF132 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000304254 -- 58,435,991(-) T/G intron_variant
rs1000786057 -- 58,438,288(-) C/T intron_variant
rs1000863909 -- 58,441,361(-) T/G upstream_transcript_variant
rs1001683642 -- 58,440,848(-) C/A upstream_transcript_variant
rs1002080233 -- 58,435,030(-) C/G/T coding_sequence_variant, missense_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF132 Gene

Variant ID Type Subtype PubMed ID
esv999478 CNV insertion 20482838
nsv1057077 CNV gain 25217958
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for ZNF132 Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF132 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF132 Gene

Disorders for ZNF132 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF132 Gene - From: DISEASES

Disorder Aliases PubMed IDs
split-hand/foot malformation 1
  • shfm1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF132

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF132: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF132 Gene

Publications for ZNF132 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4 58
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 44 58
  4. Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis. (PMID: 21445975) Abildgaard MO … Sørensen KD (International journal of cancer 2012) 3 58
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3 58

Products for ZNF132 Gene

Sources for ZNF132 Gene

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