Aliases for ZNF132 Gene

Aliases for ZNF132 Gene

  • Zinc Finger Protein 132 2 3 4 5
  • Zinc Finger Protein 132 (Clone PHZ-12) 2
  • PHZ-12 3

External Ids for ZNF132 Gene

Previous GeneCards Identifiers for ZNF132 Gene

  • GC19M059842
  • GC19M059398
  • GC19M063620
  • GC19M063635
  • GC19M058944
  • GC19M055257

Summaries for ZNF132 Gene

GeneCards Summary for ZNF132 Gene

ZNF132 (Zinc Finger Protein 132) is a Protein Coding gene. Diseases associated with ZNF132 include Split-Hand/Foot Malformation 1. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF585B.

UniProtKB/Swiss-Prot Summary for ZNF132 Gene

Additional gene information for ZNF132 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF132 Gene

Genomics for ZNF132 Gene

GeneHancer (GH) Regulatory Elements for ZNF132 Gene

Promoters and enhancers for ZNF132 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF132 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF132

Top Transcription factor binding sites by QIAGEN in the ZNF132 gene promoter:
  • AP-1
  • ATF-2
  • Bach2
  • c-Jun
  • HSF2
  • NF-1
  • NF-1/L

Genomic Locations for ZNF132 Gene

Genomic Locations for ZNF132 Gene
chr19:58,432,807-58,440,222
(GRCh38/hg38)
Size:
7,416 bases
Orientation:
Minus strand
chr19:58,944,181-58,951,589
(GRCh37/hg19)
Size:
7,409 bases
Orientation:
Minus strand

Genomic View for ZNF132 Gene

Genes around ZNF132 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF132 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF132 Gene

Proteins for ZNF132 Gene

  • Protein details for ZNF132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52740-ZN132_HUMAN
    Recommended name:
    Zinc finger protein 132
    Protein Accession:
    P52740
    Secondary Accessions:
    • Q32MI9

    Protein attributes for ZNF132 Gene

    Size:
    706 amino acids
    Molecular mass:
    80623 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF132 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF132 Gene

Post-translational modifications for ZNF132 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF132 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF132 Gene

Domains & Families for ZNF132 Gene

Gene Families for ZNF132 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF132 Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF132 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 132 (ZN132_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52740

UniProtKB/Swiss-Prot:

ZN132_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF132: view

Function for ZNF132 Gene

Molecular function for ZNF132 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 132 (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF132 Gene

Gene Ontology (GO) - Molecular Function for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 7557990
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF132: view
genes like me logo Genes that share phenotypes with ZNF132: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF132

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF132 Gene

Localization for ZNF132 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF132 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF132 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF132: view

Pathways & Interactions for ZNF132 Gene

PathCards logo

SuperPathways for ZNF132 Gene

genes like me logo Genes that share pathways with ZNF132: view

Pathways by source for ZNF132 Gene

1 KEGG pathway for ZNF132 Gene

Gene Ontology (GO) - Biological Process for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF132: view

No data available for SIGNOR curated interactions for ZNF132 Gene

Drugs & Compounds for ZNF132 Gene

No Compound Related Data Available

Transcripts for ZNF132 Gene

mRNA/cDNA for ZNF132 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF132

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF132 Gene

No ASD Table

Relevant External Links for ZNF132 Gene

GeneLoc Exon Structure for
ZNF132

Expression for ZNF132 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF132 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF132

SOURCE GeneReport for Unigene cluster for ZNF132 Gene:

Hs.156169
genes like me logo Genes that share expression patterns with ZNF132: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF132 Gene

Orthologs for ZNF132 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF132 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF132 31 30
  • 99.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF132 31 30
  • 86.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF132 31 30
  • 81.01 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15436 32
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea F35H8.3 32
  • 36 (a)
Species where no ortholog for ZNF132 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF132 Gene

ENSEMBL:
Gene Tree for ZNF132 (if available)
TreeFam:
Gene Tree for ZNF132 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF132: view image

Paralogs for ZNF132 Gene

Paralogs for ZNF132 Gene

(504) SIMAP similar genes for ZNF132 Gene using alignment to 2 proteins:

  • ZN132_HUMAN
  • L8ECA3_HUMAN
genes like me logo Genes that share paralogs with ZNF132: view

Variants for ZNF132 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF132 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1122955 - p.Gly203Asp
rs1465789 - p.Pro252Leu

Additional dbSNP identifiers (rs#s) for ZNF132 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF132 Gene

Variant ID Type Subtype PubMed ID
esv999478 CNV insertion 20482838
nsv1057077 CNV gain 25217958
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for ZNF132 Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF132 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF132

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF132 Gene

Disorders for ZNF132 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF132 Gene - From: DISEASES

Disorder Aliases PubMed IDs
split-hand/foot malformation 1
  • shfm1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF132

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF132: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF132 Gene

Publications for ZNF132 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4 54
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41 54
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 41 54
  4. Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma. (PMID: 30578410) Jiang D … Wang M (Cell death & disease 2018) 3 54
  5. Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis. (PMID: 21445975) Abildgaard MO … Sørensen KD (International journal of cancer 2012) 3 54

Products for ZNF132 Gene

Sources for ZNF132 Gene