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Aliases for ZNF131 Gene

Aliases for ZNF131 Gene

  • Zinc Finger Protein 131 2 3 3 5
  • Zinc Finger And BTB Domain Containing 35 2 3
  • Zinc Finger Protein 131 (Clone PHZ-10) 2 3
  • ZBTB35 3
  • PHZ-10 3

External Ids for ZNF131 Gene

Previous GeneCards Identifiers for ZNF131 Gene

  • GC05P043425
  • GC05M044298
  • GC05P043161
  • GC05P043206
  • GC05P043198
  • GC05U900556
  • GC05P043066
  • GC05P043069
  • GC05P043071
  • GC05P043073
  • GC05P043088
  • GC05P043098
  • GC05P043110
  • GC05P043120
  • GC05P043104
  • GC05P043128
  • GC05P043138
  • GC05P043146
  • GC05P043153
  • GC05P043160
  • GC05P043170
  • GC05P043174

Summaries for ZNF131 Gene

GeneCards Summary for ZNF131 Gene

ZNF131 (Zinc Finger Protein 131) is a Protein Coding gene. Diseases associated with ZNF131 include Joubert Syndrome 1. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZBTB17.

UniProtKB/Swiss-Prot for ZNF131 Gene

  • Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.

Additional gene information for ZNF131 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF131 Gene

Genomics for ZNF131 Gene

GeneHancer (GH) Regulatory Elements for ZNF131 Gene

Promoters and enhancers for ZNF131 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J043033 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 684.1 -26.7 -26703 10.3 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZFP41 ZNF610 ZNF585B GLIS1 NBN ZNF131 ENSG00000249492 TMEM267 ENSG00000260786 ANXA2R EEF1A1P19 RPL29P12 LOC153684 ENSG00000272382 PAIP1
GH05J043063 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 681.4 +1.2 1178 5.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF131 LOC648987 PIR50097 LOC100132356 LOC100506639 SELENOP EEF1A1P19 RPL29P12 ANXA2R ENSG00000260786
GH05J043119 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 698.5 +56.5 56530 3.6 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZNF131 RPL29P12 EEF1A1P19 ENSG00000249492 TMEM267 ENSG00000272382 NIM1K PIR55971 GC05P043130
GH05J043482 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 76.4 +419.8 419831 5.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF585B GLIS1 NBN TMEM267 ENSG00000249492 ZNF131 EEF1A1P19 RPL29P12 C5orf34 NNT CCL28 HMGCS1 ENSG00000248240
GH05J043311 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 51.5 +248.3 248321 4.2 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN HMGCS1 ZNF131 TMEM267 ENSG00000249492 EEF1A1P19 LOC648987 SERBP1P6 ANXA2R ENSG00000272382 RPL29P12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF131 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF131 gene promoter:
  • AhR
  • ATF
  • POU2F1a
  • POU2F1
  • LyF-1
  • USF-1
  • USF1
  • N-Myc
  • Roaz
  • Pax-6

Genomic Locations for ZNF131 Gene

Genomic Locations for ZNF131 Gene
chr5:43,065,176-43,192,021
(GRCh38/hg38)
Size:
126,846 bases
Orientation:
Plus strand
chr5:43,065,278-43,192,123
(GRCh37/hg19)
Size:
126,846 bases
Orientation:
Plus strand

Genomic View for ZNF131 Gene

Genes around ZNF131 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF131 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF131 Gene

Proteins for ZNF131 Gene

  • Protein details for ZNF131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52739-ZN131_HUMAN
    Recommended name:
    Zinc finger protein 131
    Protein Accession:
    P52739
    Secondary Accessions:
    • B4DRL3
    • Q6PIF0

    Protein attributes for ZNF131 Gene

    Size:
    623 amino acids
    Molecular mass:
    71422 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF131 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF131 Gene

Post-translational modifications for ZNF131 Gene

  • Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination.
  • Ubiquitinated.
  • Ubiquitination at isoforms=2220
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF131 Gene

Domains & Families for ZNF131 Gene

Gene Families for ZNF131 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF131 Gene

Suggested Antigen Peptide Sequences for ZNF131 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52739

UniProtKB/Swiss-Prot:

ZN131_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF131: view

Function for ZNF131 Gene

Molecular function for ZNF131 Gene

UniProtKB/Swiss-Prot Function:
Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
GENATLAS Biochemistry:
zinc finger protein 131 (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF131 Gene

Gene Ontology (GO) - Molecular Function for ZNF131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 7557990
genes like me logo Genes that share ontologies with ZNF131: view
genes like me logo Genes that share phenotypes with ZNF131: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF131

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF131 Gene

Localization for ZNF131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF131 Gene

Nucleus. Note=Sumoylation does not affect nuclear localization.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF131 gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Intermediate filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 7557990
GO:0005654 nucleoplasm IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF131: view

Pathways & Interactions for ZNF131 Gene

SuperPathways for ZNF131 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 7557990
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF131: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF131 Gene

Drugs & Compounds for ZNF131 Gene

No Compound Related Data Available

Transcripts for ZNF131 Gene

mRNA/cDNA for ZNF131 Gene

(16) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(20) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF131 Gene

Zinc finger protein 131:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF131

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF131 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3:

Relevant External Links for ZNF131 Gene

GeneLoc Exon Structure for
ZNF131
ECgene alternative splicing isoforms for
ZNF131

Expression for ZNF131 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF131 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF131 Gene

This gene is overexpressed in Adrenal (38.6), Cervix (18.2), and Blymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF131 Gene



Protein tissue co-expression partners for ZNF131 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF131 Gene:

ZNF131

SOURCE GeneReport for Unigene cluster for ZNF131 Gene:

Hs.535804

mRNA Expression by UniProt/SwissProt for ZNF131 Gene:

P52739-ZN131_HUMAN
Tissue specificity: Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus.

Evidence on tissue expression from TISSUES for ZNF131 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ZNF131: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF131 Gene

Orthologs for ZNF131 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF131 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF131 34 33
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF131 34 33
  • 93.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF131 34 33
  • 93.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp131 16 34 33
  • 90.88 (n)
rat
(Rattus norvegicus)
Mammalia Zfp131 33
  • 89.57 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF131 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF131 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF131 34 33
  • 77.51 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF131 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf131 33
  • 69.63 (n)
zebrafish
(Danio rerio)
Actinopterygii znf131 34 33
  • 63.98 (n)
OneToOne
Species where no ortholog for ZNF131 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF131 Gene

ENSEMBL:
Gene Tree for ZNF131 (if available)
TreeFam:
Gene Tree for ZNF131 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF131: view image

Paralogs for ZNF131 Gene

Paralogs for ZNF131 Gene

(26) SIMAP similar genes for ZNF131 Gene using alignment to 10 proteins:

  • ZN131_HUMAN
  • D6R9I2_HUMAN
  • D6RAT8_HUMAN
  • D6RBK1_HUMAN
  • D6RD61_HUMAN
  • D6RE06_HUMAN
  • D6RFI6_HUMAN
  • D6RJ09_HUMAN
  • D6RJH2_HUMAN
  • H0Y974_HUMAN

Pseudogenes.org Pseudogenes for ZNF131 Gene

genes like me logo Genes that share paralogs with ZNF131: view

Variants for ZNF131 Gene

Sequence variations from dbSNP and Humsavar for ZNF131 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000004770 -- 43,155,349(+) G/A intron_variant
rs1000092881 -- 43,166,364(+) C/T intron_variant
rs1000117099 -- 43,146,859(+) T/A intron_variant
rs1000118960 -- 43,124,077(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000143705 -- 43,174,495(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF131 Gene

Variant ID Type Subtype PubMed ID
esv2663534 CNV deletion 23128226
esv3604890 CNV loss 21293372
esv3604891 CNV loss 21293372
nsv1117551 CNV deletion 24896259
nsv1148998 CNV insertion 26484159
nsv462126 CNV gain 19166990
nsv597925 CNV gain 21841781
nsv830274 CNV loss 17160897

Variation tolerance for ZNF131 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF131 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF131

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF131 Gene

Disorders for ZNF131 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF131 Gene - From: DISEASES

Disorder Aliases PubMed IDs
joubert syndrome 1
  • jbts1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF131

genes like me logo Genes that share disorders with ZNF131: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF131 Gene

Publications for ZNF131 Gene

  1. High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. (PMID: 18847501) Han X … Ma D (BMC genomics 2008) 3 4 22 58
  2. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131. (PMID: 23404503) Oh Y … Chung KC (The Journal of biological chemistry 2013) 3 4 58
  3. Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. (PMID: 22467880) Oh Y … Chung KC (The Journal of biological chemistry 2012) 3 4 58
  4. Nuclear trafficking of the POZ-ZF protein Znf131. (PMID: 17306895) Donaldson NS … Daniel JM (Biochimica et biophysica acta 2007) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ZNF131 Gene

Sources for ZNF131 Gene

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