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Aliases for ZNF124 Gene

Aliases for ZNF124 Gene

  • Zinc Finger Protein 124 2 3 5
  • Zinc Finger Protein HZF-16 3 4
  • Zinc Finger Protein 124 (HZF-16) 2
  • HZF-16 3
  • HZF16 3
  • ZK7 3

External Ids for ZNF124 Gene

Previous GeneCards Identifiers for ZNF124 Gene

  • GC01P245157
  • GC01P242540
  • GC01P243386
  • GC01M244265
  • GC01M244098
  • GC01M243645
  • GC01M245386
  • GC01M247285
  • GC01M217713

Summaries for ZNF124 Gene

Entrez Gene Summary for ZNF124 Gene

  • This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]

GeneCards Summary for ZNF124 Gene

ZNF124 (Zinc Finger Protein 124) is a Protein Coding gene. Diseases associated with ZNF124 include Dandy-Walker Complex. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF124 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF124 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF124 Gene

Genomics for ZNF124 Gene

GeneHancer (GH) Regulatory Elements for ZNF124 Gene

Promoters and enhancers for ZNF124 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I247170 Promoter 1.3 EPDnew Ensembl 556.7 +1.0 1037 1.6 ZNF830 PKNOX1 NRF1 MNT ZNF124 GC01P247173 GC01P247174 ZNF496 FGFR3P6
GH01I247173 Enhancer 0.6 FANTOM5 ENCODE 550.8 -0.8 -832 0.3 L3MBTL2 MAX RUNX3 ENSG00000224014 GC01P247173 GC01P247174 ZNF124 ZNF496 ENSG00000259865 NLRP3 AHCTF1
GH01I246564 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 +603.0 602952 9.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 CNST TFB2M ZNF670-ZNF695 ZNF669 AHCTF1 ZNF496 ZNF124 SMYD3 LINC01341 ENSG00000225300
GH01I247126 Enhancer 0.8 Ensembl 31.9 +45.1 45100 2.5 BCOR HDAC1 PKNOX1 MLX ARNT ETV1 TAL1 TCF12 NCOR1 CBFA2T2 ZNF124 ENSG00000259865 FGFR3P6
GH01I247110 Promoter/Enhancer 1.5 Ensembl ENCODE 15 +60.3 60337 2.8 PKNOX1 ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 SP5 MXD4 REST C1orf229 ZNF124 ZNF669 ZNF695 ENSG00000227671
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF124 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF124 gene promoter:

Genomic Locations for ZNF124 Gene

Genomic Locations for ZNF124 Gene
50,464 bases
Minus strand

Genomic View for ZNF124 Gene

Genes around ZNF124 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF124 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF124 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF124 Gene

Proteins for ZNF124 Gene

  • Protein details for ZNF124 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 124
    Protein Accession:
    Secondary Accessions:
    • B3KNP3
    • J3KSE1
    • Q15974
    • Q4VAJ7
    • Q5T2V4

    Protein attributes for ZNF124 Gene

    351 amino acids
    Molecular mass:
    40217 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF124 Gene


neXtProt entry for ZNF124 Gene

Post-translational modifications for ZNF124 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF124 Gene

Domains & Families for ZNF124 Gene

Gene Families for ZNF124 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF124 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF124: view

Function for ZNF124 Gene

Molecular function for ZNF124 Gene

GENATLAS Biochemistry:
zinc finger protein 127 (C2H2 type,Kruppel-like),from a hepatoblastoma cell line
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF124 Gene

Gene Ontology (GO) - Molecular Function for ZNF124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF124: view
genes like me logo Genes that share phenotypes with ZNF124: view

Animal Model Products

CRISPR Products

miRNA for ZNF124 Gene

miRTarBase miRNAs that target ZNF124

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF124 Gene

Localization for ZNF124 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF124 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF124 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF124: view

Pathways & Interactions for ZNF124 Gene

SuperPathways for ZNF124 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF124: view

Pathways by source for ZNF124 Gene

2 Reactome pathways for ZNF124 Gene

Gene Ontology (GO) - Biological Process for ZNF124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF124: view

No data available for SIGNOR curated interactions for ZNF124 Gene

Drugs & Compounds for ZNF124 Gene

No Compound Related Data Available

Transcripts for ZNF124 Gene

Unigene Clusters for ZNF124 Gene

Zinc finger protein 124:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF124 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for ZNF124 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF124 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF124 Gene

Protein differential expression in normal tissues from HIPED for ZNF124 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.5) and Heart (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF124 Gene

Protein tissue co-expression partners for ZNF124 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF124 Gene:


SOURCE GeneReport for Unigene cluster for ZNF124 Gene:

genes like me logo Genes that share expression patterns with ZNF124: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF124 Gene

Orthologs for ZNF124 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF124 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF124 33 34
  • 91.58 (n)
(Mus musculus)
Mammalia LOC102637111 33
  • 70.66 (n)
Gm20422 34
  • 20 (a)
Gm20541 16
(Canis familiaris)
Mammalia ZNF124 34
  • 34 (a)
(Monodelphis domestica)
Mammalia ZNF124 34
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
(Danio rerio)
Actinopterygii ZNF557 34
  • 32 (a)
Species where no ortholog for ZNF124 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF124 Gene

Gene Tree for ZNF124 (if available)
Gene Tree for ZNF124 (if available)

Paralogs for ZNF124 Gene

(503) SIMAP similar genes for ZNF124 Gene using alignment to 2 proteins: Pseudogenes for ZNF124 Gene

genes like me logo Genes that share paralogs with ZNF124: view

No data available for Paralogs for ZNF124 Gene

Variants for ZNF124 Gene

Sequence variations from dbSNP and Humsavar for ZNF124 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000084169 -- 247,163,587(-) C/G intron_variant
rs1000114198 -- 247,124,895(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000163293 -- 247,121,485(-) T/C downstream_transcript_variant
rs1000274956 -- 247,139,908(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000330848 -- 247,128,291(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF124 Gene

Variant ID Type Subtype PubMed ID
dgv335e59 CNV duplication 20981092
dgv891n54 CNV loss 21841781
dgv892n54 CNV gain 21841781
dgv894n54 CNV loss 21841781
dgv895n54 CNV loss 21841781
dgv896n54 CNV gain+loss 21841781
esv1201683 CNV deletion 17803354
esv1225151 OTHER inversion 17803354
esv1441492 OTHER inversion 17803354
esv24532 CNV gain+loss 19812545
esv2675826 CNV deletion 23128226
esv2727629 CNV deletion 23290073
esv2727640 CNV deletion 23290073
esv2727651 CNV deletion 23290073
esv2727662 CNV deletion 23290073
esv2727673 CNV deletion 23290073
esv3308500 CNV mobile element insertion 20981092
esv33129 CNV gain+loss 17666407
esv3365909 CNV insertion 20981092
esv3550299 CNV deletion 23714750
esv3589499 CNV loss 21293372
esv3589507 CNV loss 21293372
esv3589508 CNV loss 21293372
esv3589509 CNV loss 21293372
nsv1014012 CNV loss 25217958
nsv1122471 CNV deletion 24896259
nsv472596 CNV novel sequence insertion 20440878
nsv499487 OTHER inversion 21111241
nsv509779 CNV insertion 20534489
nsv513639 OTHER inversion 21212237
nsv5287 CNV insertion 18451855
nsv549549 CNV loss 21841781
nsv549567 CNV loss 21841781
nsv549582 CNV gain 21841781
nsv549585 CNV loss 21841781
nsv7192 OTHER inversion 18451855
nsv821373 CNV deletion 20802225
nsv833126 CNV loss 17160897
nsv945438 CNV duplication 23825009
nsv954060 CNV deletion 24416366

Variation tolerance for ZNF124 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF124 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF124 Gene

Disorders for ZNF124 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF124 Gene - From: GeneCards

Disorder Aliases PubMed IDs
dandy-walker complex
  • dandy-walker syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF124

genes like me logo Genes that share disorders with ZNF124: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF124 Gene

Publications for ZNF124 Gene

  1. A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines. (PMID: 7916577) Saleh M … Evans GA (American journal of human genetics 1993) 2 3 4 58
  2. Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (PMID: 21314694) Kendler KS … Gejman PV (Alcoholism, clinical and experimental research 2011) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZNF124 Gene

Sources for ZNF124 Gene

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