This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell de... See more...

Aliases for ZNF124 Gene

Aliases for ZNF124 Gene

  • Zinc Finger Protein 124 2 3 4 5
  • Zinc Finger Protein HZF-16 3 4
  • HZF-16 2 3
  • HZF16 2 3
  • Zinc Finger Protein 124 (HZF-16) 2
  • ZNF124 5
  • ZK7 3

External Ids for ZNF124 Gene

Previous GeneCards Identifiers for ZNF124 Gene

  • GC01P245157
  • GC01P242540
  • GC01P243386
  • GC01M244265
  • GC01M244098
  • GC01M243645
  • GC01M245386
  • GC01M247285
  • GC01M217713

Summaries for ZNF124 Gene

Entrez Gene Summary for ZNF124 Gene

  • This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]

GeneCards Summary for ZNF124 Gene

ZNF124 (Zinc Finger Protein 124) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF20.

UniProtKB/Swiss-Prot Summary for ZNF124 Gene

Additional gene information for ZNF124 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF124 Gene

Genomics for ZNF124 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF124 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF124 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF124

Top Transcription factor binding sites by QIAGEN in the ZNF124 gene promoter:
  • aMEF-2
  • AML1a
  • AREB6
  • FOXI1
  • HEN1
  • HFH-3
  • MEF-2A
  • Msx-1
  • NCX
  • Pax-4a

Genomic Locations for ZNF124 Gene

Genomic Locations for ZNF124 Gene
chr1:247,121,975-247,172,379
(GRCh38/hg38)
Size:
50,405 bases
Orientation:
Minus strand
chr1:247,285,277-247,335,318
(GRCh37/hg19)
Size:
50,042 bases
Orientation:
Minus strand

Genomic View for ZNF124 Gene

Genes around ZNF124 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF124 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF124 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF124 Gene

Proteins for ZNF124 Gene

  • Protein details for ZNF124 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15973-ZN124_HUMAN
    Recommended name:
    Zinc finger protein 124
    Protein Accession:
    Q15973
    Secondary Accessions:
    • B3KNP3
    • J3KSE1
    • Q15974
    • Q4VAJ7
    • Q5T2V4

    Protein attributes for ZNF124 Gene

    Size:
    351 amino acids
    Molecular mass:
    40217 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF124 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF124 Gene

Post-translational modifications for ZNF124 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF124 Gene

Domains & Families for ZNF124 Gene

Gene Families for ZNF124 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF124 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF124 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 124 (Q5T2V5_HUMAN)
  • Zinc finger protein 16 (Q6RFS2_HUMAN)
  • Zinc finger protein HZF-16 (ZN124_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15973

UniProtKB/Swiss-Prot:

ZN124_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF124: view

Function for ZNF124 Gene

Molecular function for ZNF124 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 127 (C2H2 type,Kruppel-like),from a hepatoblastoma cell line

Phenotypes From GWAS Catalog for ZNF124 Gene

Gene Ontology (GO) - Molecular Function for ZNF124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS 7916577
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF124: view
genes like me logo Genes that share phenotypes with ZNF124: view

Animal Model Products

CRISPR Products

miRNA for ZNF124 Gene

miRTarBase miRNAs that target ZNF124

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF124

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF124 Gene

Localization for ZNF124 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF124 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF124 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF124: view

Pathways & Interactions for ZNF124 Gene

genes like me logo Genes that share pathways with ZNF124: view

Pathways by source for ZNF124 Gene

2 Reactome pathways for ZNF124 Gene
1 KEGG pathway for ZNF124 Gene

Gene Ontology (GO) - Biological Process for ZNF124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF124: view

No data available for SIGNOR curated interactions for ZNF124 Gene

Drugs & Compounds for ZNF124 Gene

No Compound Related Data Available

Transcripts for ZNF124 Gene

mRNA/cDNA for ZNF124 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF124

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF124 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for ZNF124 Gene

GeneLoc Exon Structure for
ZNF124

Expression for ZNF124 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF124 Gene

Protein differential expression in normal tissues from HIPED for ZNF124 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.5) and Heart (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF124 Gene



Protein tissue co-expression partners for ZNF124 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF124

SOURCE GeneReport for Unigene cluster for ZNF124 Gene:

Hs.421238

Evidence on tissue expression from TISSUES for ZNF124 Gene

  • Kidney(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with ZNF124: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF124 Gene

Orthologs for ZNF124 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF124 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF124 30 31
  • 91.58 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia LOC102637111 30
  • 70.66 (n)
Gm20422 31
  • 20 (a)
OneToOne
Gm20541 17
Dog
(Canis familiaris)
Mammalia ZNF124 31
  • 34 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF124 31
  • 32 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 33 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ZNF557 31
  • 32 (a)
OneToMany
Species where no ortholog for ZNF124 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF124 Gene

ENSEMBL:
Gene Tree for ZNF124 (if available)
TreeFam:
Gene Tree for ZNF124 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF124: view image

Paralogs for ZNF124 Gene

(503) SIMAP similar genes for ZNF124 Gene using alignment to 2 proteins:

  • ZN124_HUMAN
  • J3QKQ6_HUMAN

Pseudogenes.org Pseudogenes for ZNF124 Gene

genes like me logo Genes that share paralogs with ZNF124: view

Variants for ZNF124 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF124 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
791149 Benign: not provided 247,156,803(-) G/T NONSENSE,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF124 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF124 Gene

Variant ID Type Subtype PubMed ID
dgv335e59 CNV duplication 20981092
dgv891n54 CNV loss 21841781
dgv892n54 CNV gain 21841781
dgv894n54 CNV loss 21841781
dgv895n54 CNV loss 21841781
dgv896n54 CNV gain+loss 21841781
esv1201683 CNV deletion 17803354
esv1225151 OTHER inversion 17803354
esv1441492 OTHER inversion 17803354
esv24532 CNV gain+loss 19812545
esv2675826 CNV deletion 23128226
esv2727629 CNV deletion 23290073
esv2727640 CNV deletion 23290073
esv2727651 CNV deletion 23290073
esv2727662 CNV deletion 23290073
esv2727673 CNV deletion 23290073
esv3308500 CNV mobile element insertion 20981092
esv33129 CNV gain+loss 17666407
esv3365909 CNV insertion 20981092
esv3550299 CNV deletion 23714750
esv3589499 CNV loss 21293372
esv3589507 CNV loss 21293372
esv3589508 CNV loss 21293372
esv3589509 CNV loss 21293372
nsv1014012 CNV loss 25217958
nsv1122471 CNV deletion 24896259
nsv472596 CNV novel sequence insertion 20440878
nsv499487 OTHER inversion 21111241
nsv509779 CNV insertion 20534489
nsv513639 OTHER inversion 21212237
nsv5287 CNV insertion 18451855
nsv549549 CNV loss 21841781
nsv549567 CNV loss 21841781
nsv549582 CNV gain 21841781
nsv549585 CNV loss 21841781
nsv7192 OTHER inversion 18451855
nsv821373 CNV deletion 20802225
nsv833126 CNV loss 17160897
nsv945438 CNV duplication 23825009
nsv954060 CNV deletion 24416366

Variation tolerance for ZNF124 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF124 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF124

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF124 Gene

Disorders for ZNF124 Gene

Additional Disease Information for ZNF124

No disorders were found for ZNF124 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF124 Gene

Publications for ZNF124 Gene

  1. A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines. (PMID: 7916577) Saleh M … Evans GA (American journal of human genetics 1993) 2 3 4
  2. Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (PMID: 21314694) Kendler KS … Gejman PV (Alcoholism, clinical and experimental research 2011) 3 41
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ZNF124 Gene

Sources for ZNF124 Gene