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Aliases for ZNF121 Gene

Aliases for ZNF121 Gene

  • Zinc Finger Protein 121 2 3 3 5
  • Zinc Finger Protein 121 (Clone ZHC32) 2 3
  • Zinc Finger Protein 20 3 4
  • ZNF20 3 4
  • D19S204 3
  • ZHC32 3

External Ids for ZNF121 Gene

Previous HGNC Symbols for ZNF121 Gene

  • D19S204

Previous GeneCards Identifiers for ZNF121 Gene

  • GC19U990136
  • GC19M009676
  • GC19M009257

Summaries for ZNF121 Gene

GeneCards Summary for ZNF121 Gene

ZNF121 (Zinc Finger Protein 121) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF778.

UniProtKB/Swiss-Prot for ZNF121 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF121 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF121 Gene

Genomics for ZNF121 Gene

GeneHancer (GH) Regulatory Elements for ZNF121 Gene

Promoters and enhancers for ZNF121 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009583 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 662.4 +0.4 398 2.3 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 ZNF426 ZNF121 ZNF266 ZNF561 EIF3G KRI1 PPAN ZNF317 RAVER1 FBXL12
GH19J010100 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49.9 -519.8 -519842 8.3 MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPAN ANGPTL6 PPAN-P2RY11 ILF3 ZNF699 KRI1 FBXL12 ZNF317 LOC100419831 ZNF561
GH19J010379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 50.5 -796.0 -795982 1.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 TYK2 GC19P010382 ILF3 KRI1 FBXL12 PPAN RAVER1 ZNF561 DNMT1 TIMM29
GH19J010427 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 29.4 -846.0 -846020 6.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT SIN3A YBX1 ZNF143 ZNF592 MEF2D PDE4A ZNF266 ILF3 KRI1 FBXL12 RAVER1 ZNF561 PPAN EIF3G LOC100419831
GH19J009620 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 30.2 -37.3 -37276 3.2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 ZNF561 ZNF561-AS1 ZNF266 KRI1 ZNF317 PPAN FBXL12 DNMT1 RAVER1 ZNF558
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF121 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF121 Gene

Genomic Locations for ZNF121 Gene
24,193 bases
Minus strand
24,181 bases
Minus strand

Genomic View for ZNF121 Gene

Genes around ZNF121 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF121 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF121 Gene

Proteins for ZNF121 Gene

  • Protein details for ZNF121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 121
    Protein Accession:

    Protein attributes for ZNF121 Gene

    390 amino acids
    Molecular mass:
    44694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF121 Gene

Post-translational modifications for ZNF121 Gene

  • Ubiquitination at posLast=385385
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF121 Gene

No data available for DME Specific Peptides for ZNF121 Gene

Domains & Families for ZNF121 Gene

Gene Families for ZNF121 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF121 Gene


Suggested Antigen Peptide Sequences for ZNF121 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF121: view

Function for ZNF121 Gene

Molecular function for ZNF121 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 121 (clone ZHC32),KRAB subfamily

Phenotypes From GWAS Catalog for ZNF121 Gene

Gene Ontology (GO) - Molecular Function for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF121: view
genes like me logo Genes that share phenotypes with ZNF121: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF121 Gene

Localization for ZNF121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF121 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF121 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Nucleoli (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF121: view

Pathways & Interactions for ZNF121 Gene

SuperPathways for ZNF121 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF121: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF121 Gene

Drugs & Compounds for ZNF121 Gene

No Compound Related Data Available

Transcripts for ZNF121 Gene

mRNA/cDNA for ZNF121 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF121 Gene

Zinc finger protein 121:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF121 Gene

No ASD Table

Relevant External Links for ZNF121 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF121 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF121 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF121 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF121 Gene:


SOURCE GeneReport for Unigene cluster for ZNF121 Gene:


Evidence on tissue expression from TISSUES for ZNF121 Gene

  • Spleen(2)
genes like me logo Genes that share expression patterns with ZNF121: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF121 Gene

Orthologs for ZNF121 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF121 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF121 34 33
  • 99.83 (n)
(Mus musculus)
Mammalia Zfp560 34
  • 28 (a)
(Bos Taurus)
Mammalia -- 34
  • 24 (a)
Species where no ortholog for ZNF121 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF121 Gene

Gene Tree for ZNF121 (if available)
Gene Tree for ZNF121 (if available)
Evolutionary constrained regions (ECRs) for ZNF121: view image

Paralogs for ZNF121 Gene

Paralogs for ZNF121 Gene

(503) SIMAP similar genes for ZNF121 Gene using alignment to 2 proteins:

  • ZN121_HUMAN
genes like me logo Genes that share paralogs with ZNF121: view

Variants for ZNF121 Gene

Sequence variations from dbSNP and Humsavar for ZNF121 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000014409 -- 9,584,516(-) G/T 5_prime_UTR_variant
rs1000069908 -- 9,569,263(-) T/C intron_variant
rs1000093531 -- 9,582,964(-) C/T intron_variant
rs1000166167 -- 9,574,682(-) A/C intron_variant
rs1000375271 -- 9,579,683(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF121 Gene

Variant ID Type Subtype PubMed ID
esv2718156 CNV deletion 23290073
nsv1060112 CNV gain 25217958

Variation tolerance for ZNF121 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF121 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF121 Gene

Disorders for ZNF121 Gene

Additional Disease Information for ZNF121

No disorders were found for ZNF121 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF121 Gene

Publications for ZNF121 Gene

  1. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. (PMID: 8468057) Chen H … Antonarakis SE (Genomics 1993) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells. (PMID: 27988300) Luo A … Dong JT (Journal of genetics and genomics = Yi chuan xue bao 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for ZNF121 Gene

Sources for ZNF121 Gene

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