This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] See more...

Aliases for ZNF12 Gene

Aliases for ZNF12 Gene

  • Zinc Finger Protein 12 2 3 4 5
  • Zinc Finger Protein 325 2 3 4
  • Gonadotropin-Inducible Ovary Transcription Repressor 3 3 4
  • Zinc Finger Protein KOX3 3 4
  • ZNF325 3 4
  • GIOT-3 3 4
  • KOX3 3 4
  • Gonadotropin Inducible Transcription Repressor 3 3
  • Zinc Finger Protein 11 3
  • HZF11 3
  • GIOT3 4

External Ids for ZNF12 Gene

Previous HGNC Symbols for ZNF12 Gene

  • ZNF325

Previous GeneCards Identifiers for ZNF12 Gene

  • GC07U990124
  • GC07M006474
  • GC19M009266
  • GC07M006503
  • GC07M006696
  • GC07M006599
  • GC07M006728
  • GC07M006693
  • GC07M006830
  • GC07M006844
  • GC07M006851
  • GC07M006694
  • GC07M006718
  • GC07M006732
  • GC07M006744
  • GC07M006757
  • GC07M006774
  • GC07M006787
  • GC07M006813

Summaries for ZNF12 Gene

Entrez Gene Summary for ZNF12 Gene

  • This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF12 Gene

ZNF12 (Zinc Finger Protein 12) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is RBAK.

UniProtKB/Swiss-Prot Summary for ZNF12 Gene

  • Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.

Additional gene information for ZNF12 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF12 Gene

Genomics for ZNF12 Gene

GeneHancer (GH) Regulatory Elements for ZNF12 Gene

Promoters and enhancers for ZNF12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF12 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF12

Top Transcription factor binding sites by QIAGEN in the ZNF12 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Evi-1
  • GR-alpha
  • GR-beta
  • Pax-4a
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ZNF12 Gene

Genomic Locations for ZNF12 Gene
chr7:6,688,433-6,706,969
(GRCh38/hg38)
Size:
18,537 bases
Orientation:
Minus strand
chr7:6,728,064-6,746,566
(GRCh37/hg19)
Size:
18,503 bases
Orientation:
Minus strand

Genomic View for ZNF12 Gene

Genes around ZNF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF12 Gene

Proteins for ZNF12 Gene

  • Protein details for ZNF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17014-ZNF12_HUMAN
    Recommended name:
    Zinc finger protein 12
    Protein Accession:
    P17014
    Secondary Accessions:
    • A8MYC4
    • A8WFQ8
    • B2RNQ7
    • B4DF45
    • Q6N016
    • Q8NHZ0
    • Q9H9P0
    • Q9ULZ6

    Protein attributes for ZNF12 Gene

    Size:
    697 amino acids
    Molecular mass:
    81202 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14183.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG57306.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF12 Gene

Post-translational modifications for ZNF12 Gene

  • Ubiquitination at Lys337
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF12 Gene

No data available for DME Specific Peptides for ZNF12 Gene

Domains & Families for ZNF12 Gene

Gene Families for ZNF12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF12 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF12 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 11 (Q6RFS4_HUMAN)
  • Zinc finger protein KOX3 (ZNF12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17014

UniProtKB/Swiss-Prot:

ZNF12_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF12: view

Function for ZNF12 Gene

Molecular function for ZNF12 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.
GENATLAS Biochemistry:
zinc finger protein 12 (KOX3) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF12 Gene

Gene Ontology (GO) - Molecular Function for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF12: view
genes like me logo Genes that share phenotypes with ZNF12: view

Animal Model Products

CRISPR Products

miRNA for ZNF12 Gene

miRTarBase miRNAs that target ZNF12

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF12 Gene

Localization for ZNF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF12 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 16806083
GO:0005654 nucleoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with ZNF12: view

Pathways & Interactions for ZNF12 Gene

genes like me logo Genes that share pathways with ZNF12: view

Pathways by source for ZNF12 Gene

2 Reactome pathways for ZNF12 Gene
1 KEGG pathway for ZNF12 Gene

Gene Ontology (GO) - Biological Process for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 16806083
genes like me logo Genes that share ontologies with ZNF12: view

No data available for SIGNOR curated interactions for ZNF12 Gene

Drugs & Compounds for ZNF12 Gene

No Compound Related Data Available

Transcripts for ZNF12 Gene

mRNA/cDNA for ZNF12 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF12

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2:

Relevant External Links for ZNF12 Gene

GeneLoc Exon Structure for
ZNF12

Expression for ZNF12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF12 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF12 Gene



Protein tissue co-expression partners for ZNF12 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF12

SOURCE GeneReport for Unigene cluster for ZNF12 Gene:

Hs.431471

mRNA Expression by UniProt/SwissProt for ZNF12 Gene:

P17014-ZNF12_HUMAN
Tissue specificity: Widely expressed in various adult tissues and embryonic developmental stages (isoform 3).

Evidence on tissue expression from TISSUES for ZNF12 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF12: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF12 Gene

Orthologs for ZNF12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF12 31 30
  • 99.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF12 31 30
  • 89.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF12 31
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp12 30
  • 78.76 (n)
mouse
(Mus musculus)
Mammalia Zfp12 17 31 30
  • 77.37 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 48 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR361547.1 31
  • 40 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF12 Gene

ENSEMBL:
Gene Tree for ZNF12 (if available)
TreeFam:
Gene Tree for ZNF12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF12: view image

Paralogs for ZNF12 Gene

Paralogs for ZNF12 Gene

(483) SIMAP similar genes for ZNF12 Gene using alignment to 2 proteins:

  • ZNF12_HUMAN
  • H9KV98_HUMAN

Pseudogenes.org Pseudogenes for ZNF12 Gene

genes like me logo Genes that share paralogs with ZNF12: view

Variants for ZNF12 Gene

Additional dbSNP identifiers (rs#s) for ZNF12 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF12 Gene

Variant ID Type Subtype PubMed ID
dgv1073e201 CNV deletion 23290073
esv1914954 OTHER inversion 16254605
esv2560724 CNV deletion 19546169
esv2669093 CNV deletion 23128226
esv2733934 CNV deletion 23290073
esv2752174 CNV gain 17911159
esv32852 CNV loss 17666407
esv3612042 CNV gain 21293372
esv4389 CNV loss 18987735
esv7643 CNV loss 19470904
nsv1015646 CNV loss 25217958
nsv1126774 CNV deletion 24896259
nsv436904 CNV insertion 17901297
nsv7392 OTHER inversion 18451855
nsv8038 CNV gain 18304495

Variation tolerance for ZNF12 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF12

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF12 Gene

Disorders for ZNF12 Gene

Additional Disease Information for ZNF12

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF12 Gene

Publications for ZNF12 Gene

  1. ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity. (PMID: 16806083) Zhao Y … Li Y (Biochemical and biophysical research communications 2006) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 54

Products for ZNF12 Gene

Sources for ZNF12 Gene