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Aliases for ZNF117 Gene

Aliases for ZNF117 Gene

  • Zinc Finger Protein 117 2 3 3 5
  • Provirus-Linked Krueppel 3 4
  • Zinc Finger Protein HPF9 3 4
  • Krueppel-Related Zinc Finger Protein 3
  • Zinc Finger Protein 117 (HPF9) 2
  • H-Plk 3
  • H-PLK 4
  • HPF9 3

External Ids for ZNF117 Gene

Previous GeneCards Identifiers for ZNF117 Gene

  • GC07U990128
  • GC07M063078
  • GC07M063835
  • GC07M063848
  • GC07M063881
  • GC07M064074
  • GC07M064434
  • GC07M060814

Summaries for ZNF117 Gene

Entrez Gene Summary for ZNF117 Gene

  • This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Readthrough transcription occurs between this gene and the upstream endogenous retrovirus group 3 member 1 (ERV3-1) locus, and may result in additional transcript variants encoding the zinc finger protein. [provided by RefSeq, Jan 2017]

GeneCards Summary for ZNF117 Gene

ZNF117 (Zinc Finger Protein 117) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZNF107.

UniProtKB/Swiss-Prot for ZNF117 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF117 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF117 Gene

Genomics for ZNF117 Gene

GeneHancer (GH) Regulatory Elements for ZNF117 Gene

Promoters and enhancers for ZNF117 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J064995 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 668.2 +4.8 4799 11.8 MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 RCOR2 ZNF117 CCT6P3 GTF2IP14 ERV3-1 INTS4P1 CCT6P1 ZNF736 VKORC1L1 ENSG00000227113 GUSB
GH07J064990 Promoter 0.7 EPDnew 661.8 +15.7 15745 0.1 ZNF701 SETDB1 ZNF117 GUSB ZNF107 ERV3-1 ZNF736 LOC441239 LOC84214 VN1R43P
GH07J064902 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14 +103.2 103240 2.3 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF273 EEF1DP4 ZNF117 GTF2IP14 LOC441239 VN1R42P
GH07J065037 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 11.6 -32.4 -32435 2.9 HDAC1 TAF9B RB1 NFRKB KLF17 SIN3A YY1 ZNF335 POLR2B EGR1 CCT6P3 ENSG00000239985 LOC441241 LOC105375330 ZNF92 GTF2IP14 INTS4P1 VKORC1L1 ZNF117 GC07P065067
GH07J065872 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 8.9 -866.8 -866787 1.9 ARNT SIN3A DMAP1 YY1 GTF3C2 ZNF213 ZFP91 SP3 SP5 MXD4 VKORC1L1 LOC100996437 RABGEF1 LOC84214 ENSG00000244657 LOC100420547 ENSG00000229180 ENSG00000232546 GUSB LINC00174
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF117 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF117 gene promoter:
  • p53
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • LUN-1
  • TBP
  • POU2F1a
  • POU2F1

Genomic Locations for ZNF117 Gene

Genomic Locations for ZNF117 Gene
34,909 bases
Minus strand
34,909 bases
Minus strand

Genomic View for ZNF117 Gene

Genes around ZNF117 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF117 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF117 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF117 Gene

Proteins for ZNF117 Gene

  • Protein details for ZNF117 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 117
    Protein Accession:
    Secondary Accessions:
    • Q02313
    • Q7Z7Q7

    Protein attributes for ZNF117 Gene

    483 amino acids
    Molecular mass:
    56376 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA36010.1; Type=Erroneous termination; Positions=428; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AAA58666.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAG41761.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ZNF117 Gene

Post-translational modifications for ZNF117 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF117 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF117 Gene

Domains & Families for ZNF117 Gene

Gene Families for ZNF117 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF117 Gene


Suggested Antigen Peptide Sequences for ZNF117 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF117: view

Function for ZNF117 Gene

Molecular function for ZNF117 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 117 (HPF9),KRAB subfamily (C2H2 type,Kruppel-like)

Gene Ontology (GO) - Molecular Function for ZNF117 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 2023909
GO:0008270 zinc ion binding NAS 2505992
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF117: view
genes like me logo Genes that share phenotypes with ZNF117: view

Animal Model Products

miRNA for ZNF117 Gene

miRTarBase miRNAs that target ZNF117

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF117 Gene

Localization for ZNF117 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF117 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF117 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF117 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF117: view

Pathways & Interactions for ZNF117 Gene

SuperPathways for ZNF117 Gene

No Data Available

Interacting Proteins for ZNF117 Gene

Gene Ontology (GO) - Biological Process for ZNF117 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF117: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF117 Gene

Drugs & Compounds for ZNF117 Gene

No Compound Related Data Available

Transcripts for ZNF117 Gene

mRNA/cDNA for ZNF117 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(161) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF117 Gene

Zinc finger protein 117:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF117 Gene

No ASD Table

Relevant External Links for ZNF117 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF117 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF117 Gene

Protein differential expression in normal tissues from HIPED for ZNF117 Gene

This gene is overexpressed in Stomach (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF117 Gene

Protein tissue co-expression partners for ZNF117 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF117 Gene:


SOURCE GeneReport for Unigene cluster for ZNF117 Gene:

genes like me logo Genes that share expression patterns with ZNF117: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF117 Gene

Orthologs for ZNF117 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF117 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF117 34
  • 90 (a)
(Bos Taurus)
Mammalia -- 34
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 42 (a)
-- 34
  • 37 (a)
(Mus musculus)
Mammalia Zfp87 34
  • 39 (a)
(Canis familiaris)
Mammalia -- 34
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
-- 34
  • 38 (a)
-- 34
  • 35 (a)
-- 34
  • 31 (a)
-- 34
  • 30 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 26 (a)
Species where no ortholog for ZNF117 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF117 Gene

Gene Tree for ZNF117 (if available)
Gene Tree for ZNF117 (if available)
Evolutionary constrained regions (ECRs) for ZNF117: view image

Paralogs for ZNF117 Gene

(508) SIMAP similar genes for ZNF117 Gene using alignment to 1 proteins:

  • ZN117_HUMAN
genes like me logo Genes that share paralogs with ZNF117: view

Variants for ZNF117 Gene

Sequence variations from dbSNP and Humsavar for ZNF117 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000023149 -- 64,980,008(-) G/T intron_variant
rs1000315821 -- 64,989,997(-) G/C 5_prime_UTR_variant
rs1000366499 -- 64,990,290(-) C/T 5_prime_UTR_variant
rs1000699567 -- 64,991,348(-) T/A/C upstream_transcript_variant
rs1000802503 -- 64,986,268(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF117 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv226e55 CNV loss 17911159
esv2422405 CNV duplication 17116639
nsv1019180 CNV loss 25217958
nsv1022042 CNV gain 25217958
nsv464518 CNV gain 19166990
nsv473467 CNV novel sequence insertion 20440878
nsv607312 CNV gain 21841781
nsv970505 CNV duplication 23825009

Variation tolerance for ZNF117 Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.23; 97.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF117 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF117 Gene

Disorders for ZNF117 Gene

Additional Disease Information for ZNF117

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF117 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF117 Gene

Publications for ZNF117 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Localization of the human KRAB finger gene ZNF117 (HPF9) to chromosome 7q11.2. (PMID: 1427907) Bellefroid EJ … Martial JA (Genomics 1992) 2 3 58
  3. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid EJ … Martial JA (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 58
  4. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. (PMID: 2115127) Kato N … Cohen M (Molecular and cellular biology 1990) 3 4 58
  5. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. (PMID: 2505992) Bellefroid EJ … Martial JA (DNA (Mary Ann Liebert, Inc.) 1989) 3 4 58

Products for ZNF117 Gene

Sources for ZNF117 Gene

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