Aliases for ZNF114 Gene

Aliases for ZNF114 Gene

  • Zinc Finger Protein 114 2 3 4 5
  • Zinc Finger Protein 114 (Y18) 3
  • MGC17986 2
  • ZNF114 5

External Ids for ZNF114 Gene

Previous GeneCards Identifiers for ZNF114 Gene

  • GC19U990132
  • GC19P053467
  • GC19P048775
  • GC19P045156
  • GC19P048675
  • GC19P048172

Summaries for ZNF114 Gene

GeneCards Summary for ZNF114 Gene

ZNF114 (Zinc Finger Protein 114) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF626.

UniProtKB/Swiss-Prot Summary for ZNF114 Gene

Additional gene information for ZNF114 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF114 Gene

Genomics for ZNF114 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF114 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF114 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF114

Top Transcription factor binding sites by QIAGEN in the ZNF114 gene promoter:
  • E47
  • GATA-1
  • ITF-2
  • NF-1
  • NF-1/L
  • Tal-1
  • Tal-1beta

Genomic Locations for ZNF114 Gene

Genomic Locations for ZNF114 Gene
chr19:48,270,081-48,287,608
(GRCh38/hg38)
Size:
17,528 bases
Orientation:
Plus strand
chr19:48,675,575-48,790,865
(GRCh37/hg19)
Size:
115,291 bases
Orientation:
Plus strand

Genomic View for ZNF114 Gene

Genes around ZNF114 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF114 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF114 Gene

Proteins for ZNF114 Gene

  • Protein details for ZNF114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC26-ZN114_HUMAN
    Recommended name:
    Zinc finger protein 114
    Protein Accession:
    Q8NC26
    Secondary Accessions:
    • A8K6B0
    • Q08AQ6

    Protein attributes for ZNF114 Gene

    Size:
    417 amino acids
    Molecular mass:
    47747 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF114 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF114 Gene

Post-translational modifications for ZNF114 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF114 Gene

Domains & Families for ZNF114 Gene

Gene Families for ZNF114 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF114 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF114 Gene

GenScript: Design optimal peptide antigens:
  • ZNF114 protein (Q8N4J1_HUMAN)
  • Zinc finger protein 114 (ZN114_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NC26

UniProtKB/Swiss-Prot:

ZN114_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF114: view

Function for ZNF114 Gene

Molecular function for ZNF114 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF114: view
genes like me logo Genes that share phenotypes with ZNF114: view

Animal Model Products

CRISPR Products

miRNA for ZNF114 Gene

miRTarBase miRNAs that target ZNF114

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF114

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF114 Gene

Localization for ZNF114 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF114 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF114 gene
Compartment Confidence
extracellular 4
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ZNF114: view

Pathways & Interactions for ZNF114 Gene

genes like me logo Genes that share pathways with ZNF114: view

Pathways by source for ZNF114 Gene

2 Reactome pathways for ZNF114 Gene
1 KEGG pathway for ZNF114 Gene

Gene Ontology (GO) - Biological Process for ZNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF114: view

No data available for SIGNOR curated interactions for ZNF114 Gene

Drugs & Compounds for ZNF114 Gene

No Compound Related Data Available

Transcripts for ZNF114 Gene

mRNA/cDNA for ZNF114 Gene

6 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF114

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF114 Gene

No ASD Table

Relevant External Links for ZNF114 Gene

GeneLoc Exon Structure for
ZNF114

Expression for ZNF114 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF114 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF114 Gene

This gene is overexpressed in Thyroid (x6.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF114

SOURCE GeneReport for Unigene cluster for ZNF114 Gene:

Hs.511883

Evidence on tissue expression from TISSUES for ZNF114 Gene

  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF114: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF114 Gene

Orthologs for ZNF114 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF114 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF114 30 31
  • 98.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF114 30 31
  • 72.06 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF114 30 31
  • 69.02 (n)
OneToOne
Species where no ortholog for ZNF114 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF114 Gene

ENSEMBL:
Gene Tree for ZNF114 (if available)
TreeFam:
Gene Tree for ZNF114 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF114: view image

Paralogs for ZNF114 Gene

(465) SIMAP similar genes for ZNF114 Gene using alignment to 5 proteins:

  • ZN114_HUMAN
  • M0QXN8_HUMAN
  • M0R0H2_HUMAN
  • M0R0V4_HUMAN
  • Q8N4J1_HUMAN
genes like me logo Genes that share paralogs with ZNF114: view

Variants for ZNF114 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF114 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769027 Benign: not provided 48,286,244(+) T/C MISSENSE_VARIANT
785630 Benign: not provided 48,286,338(+) A/G SYNONYMOUS_VARIANT
rs16981956 - p.Val207Ala
rs35802964 - p.His99Asn

Additional dbSNP identifiers (rs#s) for ZNF114 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF114 Gene

Variant ID Type Subtype PubMed ID
dgv3614n100 CNV gain 25217958
dgv3616n100 CNV loss 25217958
esv2657727 CNV deletion 23128226
esv2672581 CNV deletion 23128226
esv3305559 CNV mobile element insertion 20981092
esv34181 CNV loss 18971310
esv3447587 CNV insertion 20981092
esv3644581 CNV loss 21293372
nsv1057454 CNV loss 25217958
nsv1065106 CNV gain 25217958
nsv469623 CNV loss 16826518
nsv833854 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for ZNF114 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF114 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF114

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF114 Gene

Disorders for ZNF114 Gene

No disorders were found for ZNF114 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF114 Gene

Publications for ZNF114 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  3. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for ZNF114 Gene

  • Signalway Proteins for ZNF114

Sources for ZNF114 Gene