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Aliases for ZNF114 Gene

Aliases for ZNF114 Gene

  • Zinc Finger Protein 114 2 3 5

External Ids for ZNF114 Gene

Previous GeneCards Identifiers for ZNF114 Gene

  • GC19U990132
  • GC19P053467
  • GC19P048775
  • GC19P045156
  • GC19P048675
  • GC19P048172

Summaries for ZNF114 Gene

GeneCards Summary for ZNF114 Gene

ZNF114 (Zinc Finger Protein 114) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF114 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF114 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF114 Gene

Genomics for ZNF114 Gene

GeneHancer (GH) Regulatory Elements for ZNF114 Gene

Promoters and enhancers for ZNF114 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I048269 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 559.5 +0.7 657 3 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF121 ZNF143 RUNX3 SP5 ZNF114 LOC105372429 CCDC114 CARD8-AS1 TMEM143
GH19I048172 Promoter 0.5 EPDnew 550.2 -97.9 -97892 0.1 LIG1 ZSWIM9 ZNF114 ENSG00000280353
GH19I048328 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 5 +61.6 61567 5.8 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 YBX1 ZNF2 YY1 POLR2B BICRA GRWD1 TMEM143 SNRNP70 NOP53-AS1 CA11 NOP53 KDELR1 RPL18 ZSWIM9
GH19I048308 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.6 +39.9 39908 3.1 ELF3 RB1 ZFP64 ARID4B SIN3A RAD21 ZNF48 RARA ZNF335 CREM CCDC114 KDELR1 NOP53 NOP53-AS1 CYTH2 RPL18 BAX BICRA GRWD1 ZNF114
GH19I048243 Enhancer 0.9 Ensembl ENCODE dbSUPER 5.9 -25.4 -25369 2 JUN GABPB1 ELF1 SPI1 CARD8-AS1 CARD8 ZNF114 PLA2G4C PIR59935 GC19M048250 PIR40942
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF114 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF114 gene promoter:

Genomic Locations for ZNF114 Gene

Genomic Locations for ZNF114 Gene
17,510 bases
Plus strand

Genomic View for ZNF114 Gene

Genes around ZNF114 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF114 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF114 Gene

Proteins for ZNF114 Gene

  • Protein details for ZNF114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 114
    Protein Accession:
    Secondary Accessions:
    • A8K6B0
    • Q08AQ6

    Protein attributes for ZNF114 Gene

    417 amino acids
    Molecular mass:
    47747 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF114 Gene


neXtProt entry for ZNF114 Gene

Post-translational modifications for ZNF114 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF114 Gene

Domains & Families for ZNF114 Gene

Gene Families for ZNF114 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF114 Gene

Suggested Antigen Peptide Sequences for ZNF114 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF114: view

Function for ZNF114 Gene

Molecular function for ZNF114 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF114: view

Phenotypes for ZNF114 Gene

genes like me logo Genes that share phenotypes with ZNF114: view

miRNA for ZNF114 Gene

miRTarBase miRNAs that target ZNF114

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF114 Gene

Localization for ZNF114 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF114 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF114 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with ZNF114: view

Pathways & Interactions for ZNF114 Gene

SuperPathways for ZNF114 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF114: view

Pathways by source for ZNF114 Gene

2 Reactome pathways for ZNF114 Gene

Gene Ontology (GO) - Biological Process for ZNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF114: view

No data available for SIGNOR curated interactions for ZNF114 Gene

Drugs & Compounds for ZNF114 Gene

No Compound Related Data Available

Transcripts for ZNF114 Gene

Unigene Clusters for ZNF114 Gene

Zinc finger protein 114:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF114 Gene

No ASD Table

Relevant External Links for ZNF114 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF114 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF114 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF114 Gene

This gene is overexpressed in Thyroid (x6.9).

NURSA nuclear receptor signaling pathways regulating expression of ZNF114 Gene:


SOURCE GeneReport for Unigene cluster for ZNF114 Gene:


Evidence on tissue expression from TISSUES for ZNF114 Gene

  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF114: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF114 Gene

Orthologs for ZNF114 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF114 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF114 34 33
  • 98.63 (n)
(Canis familiaris)
Mammalia ZNF114 33 34
  • 72.06 (n)
(Bos Taurus)
Mammalia ZNF114 33 34
  • 69.02 (n)
Species where no ortholog for ZNF114 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF114 Gene

Gene Tree for ZNF114 (if available)
Gene Tree for ZNF114 (if available)

Paralogs for ZNF114 Gene

(465) SIMAP similar genes for ZNF114 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF114: view

No data available for Paralogs for ZNF114 Gene

Variants for ZNF114 Gene

Sequence variations from dbSNP and Humsavar for ZNF114 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000291817 -- 48,277,490(+) T/C intron_variant
rs1000617838 -- 48,276,335(+) T/C intron_variant
rs1000849279 -- 48,271,094(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000852077 -- 48,281,378(+) C/A intron_variant
rs1000874244 -- 48,273,412(+) TTTTCTTTTCTTTTCT/TTTTCTTTTCT genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF114 Gene

Variant ID Type Subtype PubMed ID
dgv3614n100 CNV gain 25217958
dgv3616n100 CNV loss 25217958
esv2657727 CNV deletion 23128226
esv2672581 CNV deletion 23128226
esv3305559 CNV mobile element insertion 20981092
esv34181 CNV loss 18971310
esv3447587 CNV insertion 20981092
esv3644581 CNV loss 21293372
nsv1057454 CNV loss 25217958
nsv1065106 CNV gain 25217958
nsv469623 CNV loss 16826518
nsv833854 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for ZNF114 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF114 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF114 Gene

Disorders for ZNF114 Gene

Additional Disease Information for ZNF114

No disorders were found for ZNF114 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF114 Gene

Publications for ZNF114 Gene

  1. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3 58

Products for ZNF114 Gene

Sources for ZNF114 Gene

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