Aliases for ZNF112 Gene

Aliases for ZNF112 Gene

  • Zinc Finger Protein 112 2 3 4 5
  • Zinc Finger Protein 228 2 3 4
  • ZFP112 3 4
  • ZNF228 3 4
  • Zinc Finger Protein 112 Homolog (Mouse) 2
  • Zinc Finger Protein 112 Homolog 3
  • Zinc Finger Protein 112 (Y14) 3
  • Zfp-112 4

External Ids for ZNF112 Gene

Previous HGNC Symbols for ZNF112 Gene

  • ZFP112
  • ZNF228

Previous GeneCards Identifiers for ZNF112 Gene

  • GC19U990130
  • GC00U934196
  • GC19M044832

Summaries for ZNF112 Gene

GeneCards Summary for ZNF112 Gene

ZNF112 (Zinc Finger Protein 112) is a Protein Coding gene. Diseases associated with ZNF112 include Myeloid And Lymphoid Neoplasms Associated With Fgfr1 Abnormalities and Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of Pdgfra, Pdgfrb, And Fgfr1. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF226.

UniProtKB/Swiss-Prot Summary for ZNF112 Gene

Additional gene information for ZNF112 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF112 Gene

Genomics for ZNF112 Gene

GeneHancer (GH) Regulatory Elements for ZNF112 Gene

Promoters and enhancers for ZNF112 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF112 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF112

Genomic Locations for ZNF112 Gene

Genomic Locations for ZNF112 Gene
chr19:44,326,553-44,367,217
(GRCh38/hg38)
Size:
40,665 bases
Orientation:
Minus strand
chr19:44,830,706-44,871,377
(GRCh37/hg19)
Size:
40,672 bases
Orientation:
Minus strand

Genomic View for ZNF112 Gene

Genes around ZNF112 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF112 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF112 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF112 Gene

Proteins for ZNF112 Gene

  • Protein details for ZNF112 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJU3-ZN112_HUMAN
    Recommended name:
    Zinc finger protein 112
    Protein Accession:
    Q9UJU3
    Secondary Accessions:
    • A4FU53
    • Q9HCA7

    Protein attributes for ZNF112 Gene

    Size:
    913 amino acids
    Molecular mass:
    105842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF112 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF112 Gene

Post-translational modifications for ZNF112 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF112 Gene

Domains & Families for ZNF112 Gene

Gene Families for ZNF112 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF112 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF112 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 112 homolog (Mouse) (Q0VG01_HUMAN)
  • Zinc finger protein 228 (ZF112_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJU3

UniProtKB/Swiss-Prot:

ZN112_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF112: view

Function for ZNF112 Gene

Molecular function for ZNF112 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF112 Gene

Gene Ontology (GO) - Molecular Function for ZNF112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF112: view
genes like me logo Genes that share phenotypes with ZNF112: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF112

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF112 Gene

Localization for ZNF112 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF112 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF112 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF112: view

Pathways & Interactions for ZNF112 Gene

genes like me logo Genes that share pathways with ZNF112: view

Pathways by source for ZNF112 Gene

2 Reactome pathways for ZNF112 Gene
1 KEGG pathway for ZNF112 Gene

Interacting Proteins for ZNF112 Gene

;

Gene Ontology (GO) - Biological Process for ZNF112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF112: view

No data available for SIGNOR curated interactions for ZNF112 Gene

Drugs & Compounds for ZNF112 Gene

No Compound Related Data Available

Transcripts for ZNF112 Gene

mRNA/cDNA for ZNF112 Gene

7 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF112

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF112 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2:
SP3: -
SP4: - -

Relevant External Links for ZNF112 Gene

GeneLoc Exon Structure for
ZNF112

Expression for ZNF112 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF112 Gene

Protein differential expression in normal tissues from HIPED for ZNF112 Gene

This gene is overexpressed in Testis (46.6) and CD8 Tcells (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF112 Gene



Protein tissue co-expression partners for ZNF112 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF112

Evidence on tissue expression from TISSUES for ZNF112 Gene

  • Liver(4)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ZNF112: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF112 Gene

Orthologs for ZNF112 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF112 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP112 30
  • 98.97 (n)
ZNF112 31
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP112 30
  • 89.43 (n)
cow
(Bos Taurus)
Mammalia ZFP112 30
  • 85.63 (n)
ZNF112 31
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp112 17 31 30
  • 75.17 (n)
rat
(Rattus norvegicus)
Mammalia Zfp112 30
  • 73.87 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 52 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-367f21.5 31
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5245 31
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tag-146 31
  • 23 (a)
ManyToMany
C27A12.2 31
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9363 31
  • 27 (a)
ManyToMany
Species where no ortholog for ZNF112 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF112 Gene

ENSEMBL:
Gene Tree for ZNF112 (if available)
TreeFam:
Gene Tree for ZNF112 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF112: view image

Paralogs for ZNF112 Gene

Paralogs for ZNF112 Gene

(547) SIMAP similar genes for ZNF112 Gene using alignment to 6 proteins:

  • ZN112_HUMAN
  • F5GWS7_HUMAN
  • K7EIR6_HUMAN
  • K7EN57_HUMAN
  • K7ENS0_HUMAN
  • K7EQV5_HUMAN

Pseudogenes.org Pseudogenes for ZNF112 Gene

genes like me logo Genes that share paralogs with ZNF112: view

Variants for ZNF112 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF112 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769019 Benign: not provided 44,327,931(-) C/T SYNONYMOUS_VARIANT
769020 Benign: not provided 44,329,009(-) T/A MISSENSE_VARIANT
rs386352382 Uncertain Significance: not provided 44,328,788(-) T/C MISSENSE_VARIANT
rs10419604 - p.Thr287Lys
rs11673395 - p.Pro54Ser

Additional dbSNP identifiers (rs#s) for ZNF112 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF112 Gene

Variant ID Type Subtype PubMed ID
esv1016841 CNV insertion 17803354
esv2718619 CNV deletion 23290073
nsv1123261 CNV deletion 24896259
nsv515911 CNV loss 19592680
nsv579855 CNV loss 21841781
nsv579856 CNV gain 21841781
nsv960851 CNV duplication 23825009

Variation tolerance for ZNF112 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.83; 83.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF112 Gene

Human Gene Mutation Database (HGMD)
ZNF112
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF112

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF112 Gene

Disorders for ZNF112 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF112 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myeloid and lymphoid neoplasms associated with fgfr1 abnormalities
myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1
  • myeloid and lymphoid neoplasms with eosinophilia and abnormalities of platelet-derived growth factor receptor alpha , platelet-derived growth factor receptor beta , and fibroblast growth factor receptor-1 are a group of hematologic neoplasms
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF112

genes like me logo Genes that share disorders with ZNF112: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF112 Gene

Publications for ZNF112 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 54
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for ZNF112 Gene

Sources for ZNF112 Gene