This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] See more...

Aliases for ZNF107 Gene

Aliases for ZNF107 Gene

  • Zinc Finger Protein 107 2 3 4 5
  • Zinc Finger Protein 588 2 3 4
  • ZFD25 2 3 4
  • ZNF588 3 4
  • Smap-7 2 3
  • C2H2 Type Zinc-Finger Protein 3
  • Zinc Finger Protein 107 (Y8) 2
  • Zinc Finger Protein (ZFD25) 3
  • Zinc Finger Protein ZFD25 4
  • ZNF107 5
  • Y8 3

External Ids for ZNF107 Gene

Previous HGNC Symbols for ZNF107 Gene

  • ZNF588

Previous GeneCards Identifiers for ZNF107 Gene

  • GC07U990127
  • GC07P063764
  • GC07P064126
  • GC07P060507
  • GC07P064666

Summaries for ZNF107 Gene

Entrez Gene Summary for ZNF107 Gene

  • This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for ZNF107 Gene

ZNF107 (Zinc Finger Protein 107) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot Summary for ZNF107 Gene

Additional gene information for ZNF107 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF107 Gene

Genomics for ZNF107 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF107 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF107 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF107

Top Transcription factor binding sites by QIAGEN in the ZNF107 gene promoter:
  • NRSF form 2
  • p53

Genomic Locations for ZNF107 Gene

Genomic Locations for ZNF107 Gene
chr7:64,665,010-64,711,582
(GRCh38/hg38)
Size:
46,573 bases
Orientation:
Plus strand
chr7:64,126,511-64,171,404
(GRCh37/hg19)
Size:
44,894 bases
Orientation:
Plus strand

Genomic View for ZNF107 Gene

Genes around ZNF107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF107 Gene

Proteins for ZNF107 Gene

  • Protein details for ZNF107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UII5-ZN107_HUMAN
    Recommended name:
    Zinc finger protein 107
    Protein Accession:
    Q9UII5

    Protein attributes for ZNF107 Gene

    Size:
    783 amino acids
    Molecular mass:
    90673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF107 Gene

Post-translational modifications for ZNF107 Gene

  • Ubiquitination at Lys133
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF107 Gene

Domains & Families for ZNF107 Gene

Gene Families for ZNF107 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF107 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF107 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61041, highly similar to Zinc finger protein 588 (B4E1P7_HUMAN)
  • Zinc finger protein 588, isoform CRA_b (C9JSF9_HUMAN)
  • ZNF107 protein (Q8WVL4_HUMAN)
  • SMAP-7 (Q9H3U2_HUMAN)
  • Zinc finger protein ZFD25 (ZN107_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UII5

UniProtKB/Swiss-Prot:

ZN107_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF107: view

Function for ZNF107 Gene

Molecular function for ZNF107 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF107 Gene

Gene Ontology (GO) - Molecular Function for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA --
GO:0003700 DNA-binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF107: view
genes like me logo Genes that share phenotypes with ZNF107: view

Animal Model Products

CRISPR Products

miRNA for ZNF107 Gene

miRTarBase miRNAs that target ZNF107

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF107

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF107 Gene

Localization for ZNF107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF107 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF107 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF107: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF107 Gene

Pathways & Interactions for ZNF107 Gene

PathCards logo

SuperPathways for ZNF107 Gene

genes like me logo Genes that share pathways with ZNF107: view

Pathways by source for ZNF107 Gene

1 KEGG pathway for ZNF107 Gene

Gene Ontology (GO) - Biological Process for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF107: view

No data available for SIGNOR curated interactions for ZNF107 Gene

Drugs & Compounds for ZNF107 Gene

No Compound Related Data Available

Transcripts for ZNF107 Gene

mRNA/cDNA for ZNF107 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF107

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF107 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - -

Relevant External Links for ZNF107 Gene

GeneLoc Exon Structure for
ZNF107

Expression for ZNF107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF107 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF107 Gene

This gene is overexpressed in Bone marrow stromal cell (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF107 Gene



Protein tissue co-expression partners for ZNF107 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF107

SOURCE GeneReport for Unigene cluster for ZNF107 Gene:

Hs.732661

mRNA Expression by UniProt/SwissProt for ZNF107 Gene:

Q9UII5-ZN107_HUMAN
Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney and pancreas. Weakly expressed in aorta, liver and lung.

Evidence on tissue expression from TISSUES for ZNF107 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ZNF107: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF107 Gene

Orthologs for ZNF107 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF107 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF107 30
  • 99.37 (n)
Rat
(Rattus norvegicus)
Mammalia Zfp748 30
  • 66.1 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 54 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Zfp458 31
  • 50 (a)
ManyToMany
Zfp457 31
  • 48 (a)
ManyToMany
Zfp759 31
  • 46 (a)
ManyToMany
Zfp738 31
  • 45 (a)
ManyToMany
A530054K11Rik 31
  • 41 (a)
ManyToMany
Zfp748 31
  • 39 (a)
ManyToMany
AA987161 31
  • 37 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 42 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 41 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 38 (a)
ManyToMany
Species where no ortholog for ZNF107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF107 Gene

ENSEMBL:
Gene Tree for ZNF107 (if available)
TreeFam:
Gene Tree for ZNF107 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF107: view image

Paralogs for ZNF107 Gene

(399) SIMAP similar genes for ZNF107 Gene using alignment to 3 proteins:

  • ZN107_HUMAN
  • C9JSF9_HUMAN
  • Q8WVL4_HUMAN
genes like me logo Genes that share paralogs with ZNF107: view

Variants for ZNF107 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF107 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
623424 Uncertain Significance: Severe Myopia 64,708,308(+) ATG/A FRAMESHIFT_VARIANT
709064 Likely Benign: not provided 64,707,124(+) T/G MISSENSE_VARIANT
713598 Benign: not provided 64,708,051(+) G/A MISSENSE_VARIANT
717331 Likely Benign: not provided 64,707,505(+) A/G MISSENSE_VARIANT
768151 Benign: not provided 64,708,263(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF107 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF107 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv437e215 CNV deletion 23714750
esv23182 CNV gain 19812545
esv2422405 CNV duplication 17116639
esv2764000 CNV gain+loss 21179565
esv3571879 CNV loss 25503493
nsv1018445 CNV gain 25217958
nsv1027615 CNV gain 25217958
nsv464518 CNV gain 19166990
nsv607312 CNV gain 21841781
nsv970856 CNV duplication 23825009

Variation tolerance for ZNF107 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF107 Gene

Human Gene Mutation Database (HGMD)
ZNF107
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF107 Gene

Disorders for ZNF107 Gene

Additional Disease Information for ZNF107

No disorders were found for ZNF107 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF107 Gene

Publications for ZNF107 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Cloning and characterization of a novel human gene encoding a zinc finger protein with 25 fingers. (PMID: 10673043) Li XA … Yutani C (Biochimica et biophysica acta 1999) 3 4
  3. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid EJ … Szpirer C (The EMBO journal 1993) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZNF107 Gene

Sources for ZNF107 Gene