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Aliases for ZNF107 Gene

Aliases for ZNF107 Gene

  • Zinc Finger Protein 107 2 3 3 5
  • Zinc Finger Protein 588 2 3 4
  • ZNF588 3 4
  • ZFD25 3 4
  • C2H2 Type Zinc-Finger Protein 3
  • Zinc Finger Protein 107 (Y8) 2
  • Zinc Finger Protein (ZFD25) 3
  • Zinc Finger Protein ZFD25 4
  • Smap-7 3
  • Y8 3

External Ids for ZNF107 Gene

Previous HGNC Symbols for ZNF107 Gene

  • ZNF588

Previous GeneCards Identifiers for ZNF107 Gene

  • GC07U990127
  • GC07P063764
  • GC07P064126
  • GC07P060507

Summaries for ZNF107 Gene

Entrez Gene Summary for ZNF107 Gene

  • This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for ZNF107 Gene

ZNF107 (Zinc Finger Protein 107) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF43.

UniProtKB/Swiss-Prot for ZNF107 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF107 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF107 Gene

Genomics for ZNF107 Gene

GeneHancer (GH) Regulatory Elements for ZNF107 Gene

Promoters and enhancers for ZNF107 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J064664 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 698 +0.4 372 3.2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 ZNF107 CCT6P3 GTF2IP14 ZNF736 LOC441239 ERV3-1 SEPHS1P1 ZNF138 MIR6839
GH07J065373 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.5 +708.2 708172 2.1 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 FOS SP3 ZNF92 GTF2IP14 GUSB CCT6P3 CCT6P1 ZNF107 ERV3-1 ENSG00000238124
GH07J064562 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.3 -103.2 -103182 1.8 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 POLR2B ZNF680 ZNF107 CCT6P3 GTF2IP14 ZNF736 GABPAP ZNF117 LOC644387 BNIP3P42
GH07J064685 Enhancer 0.7 ENCODE 37.5 +21.8 21816 5.3 ELF3 SOX13 FOXA2 CEBPG ZNF644 ZSCAN9 E2F1 CTBP1 POLR2A CREM BNIP3P11 ZNF107 SEPHS1P1 GC07P064707
GH07J064995 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.1 +335.8 335802 11.8 MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 RCOR2 ZNF117 CCT6P3 GTF2IP14 ERV3-1 INTS4P1 CCT6P1 ZNF736 VKORC1L1 ENSG00000227113 GUSB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF107 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF107 gene promoter:

Genomic Locations for ZNF107 Gene

Genomic Locations for ZNF107 Gene
chr7:64,666,083-64,711,582
(GRCh38/hg38)
Size:
45,500 bases
Orientation:
Plus strand
chr7:64,126,511-64,171,404
(GRCh37/hg19)

Genomic View for ZNF107 Gene

Genes around ZNF107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF107 Gene

Proteins for ZNF107 Gene

  • Protein details for ZNF107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UII5-ZN107_HUMAN
    Recommended name:
    Zinc finger protein 107
    Protein Accession:
    Q9UII5

    Protein attributes for ZNF107 Gene

    Size:
    783 amino acids
    Molecular mass:
    90673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF107 Gene

Post-translational modifications for ZNF107 Gene

  • Ubiquitination at posLast=133133
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF107 Gene

Domains & Families for ZNF107 Gene

Gene Families for ZNF107 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF107 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UII5

UniProtKB/Swiss-Prot:

ZN107_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF107: view

Function for ZNF107 Gene

Molecular function for ZNF107 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF107: view
genes like me logo Genes that share phenotypes with ZNF107: view

Animal Model Products

miRNA for ZNF107 Gene

miRTarBase miRNAs that target ZNF107

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF107 Gene

Localization for ZNF107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF107 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF107 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF107: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF107 Gene

Pathways & Interactions for ZNF107 Gene

SuperPathways for ZNF107 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF107: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF107 Gene

Drugs & Compounds for ZNF107 Gene

No Compound Related Data Available

Transcripts for ZNF107 Gene

Unigene Clusters for ZNF107 Gene

Zinc finger protein 107:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF107 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - -

Relevant External Links for ZNF107 Gene

GeneLoc Exon Structure for
ZNF107
ECgene alternative splicing isoforms for
ZNF107

Expression for ZNF107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF107 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF107 Gene

This gene is overexpressed in Bone marrow stromal cell (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF107 Gene



Protein tissue co-expression partners for ZNF107 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF107 Gene:

ZNF107

SOURCE GeneReport for Unigene cluster for ZNF107 Gene:

Hs.732661

mRNA Expression by UniProt/SwissProt for ZNF107 Gene:

Q9UII5-ZN107_HUMAN
Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney and pancreas. Weakly expressed in aorta, liver and lung.

Evidence on tissue expression from TISSUES for ZNF107 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ZNF107: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF107 Gene

Orthologs for ZNF107 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF107 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF107 33
  • 99.37 (n)
rat
(Rattus norvegicus)
Mammalia Zfp748 33
  • 66.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp458 34
  • 50 (a)
ManyToMany
Zfp457 34
  • 48 (a)
ManyToMany
Zfp759 34
  • 46 (a)
ManyToMany
Zfp738 34
  • 45 (a)
ManyToMany
A530054K11Rik 34
  • 41 (a)
ManyToMany
Zfp748 34
  • 39 (a)
ManyToMany
AA987161 34
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 38 (a)
ManyToMany
Species where no ortholog for ZNF107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF107 Gene

ENSEMBL:
Gene Tree for ZNF107 (if available)
TreeFam:
Gene Tree for ZNF107 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF107: view image

Paralogs for ZNF107 Gene

(399) SIMAP similar genes for ZNF107 Gene using alignment to 3 proteins:

  • ZN107_HUMAN
  • C9JSF9_HUMAN
  • Q8WVL4_HUMAN
genes like me logo Genes that share paralogs with ZNF107: view

Variants for ZNF107 Gene

Sequence variations from dbSNP and Humsavar for ZNF107 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000051627 -- 64,665,365(+) T/A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000055405 -- 64,686,110(+) C/T genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000068088 -- 64,668,305(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000068303 -- 64,700,130(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000068714 -- 64,708,543(+) C/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF107 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv437e215 CNV deletion 23714750
esv23182 CNV gain 19812545
esv2422405 CNV duplication 17116639
esv2764000 CNV gain+loss 21179565
esv3571879 CNV loss 25503493
nsv1018445 CNV gain 25217958
nsv1027615 CNV gain 25217958
nsv464518 CNV gain 19166990
nsv607312 CNV gain 21841781
nsv970856 CNV duplication 23825009

Variation tolerance for ZNF107 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF107 Gene

Human Gene Mutation Database (HGMD)
ZNF107
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF107 Gene

Disorders for ZNF107 Gene

Additional Disease Information for ZNF107

No disorders were found for ZNF107 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF107 Gene

Publications for ZNF107 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Cloning and characterization of a novel human gene encoding a zinc finger protein with 25 fingers. (PMID: 10673043) Li XA … Yutani C (Biochimica et biophysica acta 1999) 3 4 58
  3. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid EJ … Szpirer C (The EMBO journal 1993) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF107 Gene

Sources for ZNF107 Gene

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