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Aliases for ZNF106 Gene

Aliases for ZNF106 Gene

  • Zinc Finger Protein 106 2 3 5
  • SH3-Domain Binding Protein 3 2 3
  • Zinc Finger Protein 474 3 4
  • ZFP106 3 4
  • SH3BP3 3 4
  • ZNF474 3 4
  • Zinc Finger Protein 106 Homolog (Mouse) 2
  • Zfp-106 4

External Ids for ZNF106 Gene

Previous HGNC Symbols for ZNF106 Gene

  • ZFP106

Previous GeneCards Identifiers for ZNF106 Gene

  • GC19U990126
  • GC15M042707

Summaries for ZNF106 Gene

GeneCards Summary for ZNF106 Gene

ZNF106 (Zinc Finger Protein 106) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include opioid peptide activity. An important paralog of this gene is FBXW10.

Gene Wiki entry for ZNF106 Gene

Additional gene information for ZNF106 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF106 Gene

Genomics for ZNF106 Gene

GeneHancer (GH) Regulatory Elements for ZNF106 Gene

Promoters and enhancers for ZNF106 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I042490 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 0.0 -39 2.5 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF106 SNAP23 LRRC57 TMEM87A GANC HAUS2 RPS3AP47 ENSG00000261684
GH15I042455 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 550.3 +34.0 33964 3.9 SP1 USF1 POLR2A SIN3A EBF1 ZNF106 CAPN3 GANC TMEM87A MIR627 LRRC57 GC15P042438
GH15I042489 Promoter 0.5 EPDnew 550.8 +1.9 1913 0.1 SNAP23 ZNF106 HAUS2 LRRC57 GANC TMEM87A GC15P042438
GH15I042360 Enhancer 0.4 FANTOM5 dbSUPER 2.5 +130.4 130376 0.3 CAPN3 ZNF106 STARD9 ENSG00000258461 GC15M042373
GH15I042471 Enhancer 0.8 ENCODE 0.4 +19.4 19419 0.2 HDGF CTCF KLF1 ARNT ARID4B ZNF384 CEBPG ZSCAN9 RAD21 RFX5 GANC TMEM87A ZNF106 GC15P042438
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF106 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF106 Gene

Genomic Locations for ZNF106 Gene
chr15:42,412,437-42,491,197
(GRCh38/hg38)
Size:
78,761 bases
Orientation:
Minus strand
chr15:42,705,021-42,783,321
(GRCh37/hg19)

Genomic View for ZNF106 Gene

Genes around ZNF106 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF106 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF106 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF106 Gene

Proteins for ZNF106 Gene

  • Protein details for ZNF106 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2Y7-ZN106_HUMAN
    Recommended name:
    Zinc finger protein 106
    Protein Accession:
    Q9H2Y7
    Secondary Accessions:
    • B4DZ40
    • E9PE29
    • Q6NSD9
    • Q6PEK1
    • Q86T43
    • Q86T45
    • Q86T50
    • Q86T58
    • Q86TA9
    • Q96M37
    • Q9H7B8

    Protein attributes for ZNF106 Gene

    Size:
    1883 amino acids
    Molecular mass:
    208883 Da
    Quaternary structure:
    • Interacts with KNOP1.
    SequenceCaution:
    • Sequence=AAH58023.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70244.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14976.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD91134.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF106 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF106 Gene

Post-translational modifications for ZNF106 Gene

  • Ubiquitination at isoforms=243, isoforms=356, isoforms=539, and isoforms=775

No data available for DME Specific Peptides for ZNF106 Gene

Domains & Families for ZNF106 Gene

Gene Families for ZNF106 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ZNF106 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF106: view

No data available for UniProtKB/Swiss-Prot for ZNF106 Gene

Function for ZNF106 Gene

Phenotypes From GWAS Catalog for ZNF106 Gene

Gene Ontology (GO) - Molecular Function for ZNF106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0017124 SH3 domain binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF106: view
genes like me logo Genes that share phenotypes with ZNF106: view

Animal Models for ZNF106 Gene

MGI Knock Outs for ZNF106:

Animal Model Products

CRISPR Products

miRNA for ZNF106 Gene

miRTarBase miRNAs that target ZNF106

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF106 Gene

Localization for ZNF106 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF106 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF106 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol IBA --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with ZNF106: view

Pathways & Interactions for ZNF106 Gene

SuperPathways for ZNF106 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008286 insulin receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with ZNF106: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF106 Gene

Drugs & Compounds for ZNF106 Gene

No Compound Related Data Available

Transcripts for ZNF106 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF106 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11:
SP12: - - -
SP13: - - - - -
SP14:

ExUns: 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1: - -
SP2: - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11: -
SP12:
SP13:
SP14:

Relevant External Links for ZNF106 Gene

GeneLoc Exon Structure for
ZNF106
ECgene alternative splicing isoforms for
ZNF106

Expression for ZNF106 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF106 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF106 Gene

This gene is overexpressed in Muscle - Skeletal (x12.3) and Heart - Left Ventricle (x6.9).

Protein differential expression in normal tissues from HIPED for ZNF106 Gene

This gene is overexpressed in Bone (31.0), Lung (23.4), and Monocytes (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF106 Gene



Protein tissue co-expression partners for ZNF106 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF106 Gene:

ZNF106

Evidence on tissue expression from TISSUES for ZNF106 Gene

  • Muscle(4.7)
  • Liver(4.3)
  • Nervous system(4)
  • Skin(3.4)
  • Heart(3.3)
genes like me logo Genes that share expression patterns with ZNF106: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF106 Gene

Orthologs for ZNF106 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF106 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP106 33
  • 99.75 (n)
ZNF106 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF106 33 34
  • 89.84 (n)
dog
(Canis familiaris)
Mammalia ZNF106 33 34
  • 89.81 (n)
mouse
(Mus musculus)
Mammalia Zfp106 33 16 34
  • 82.67 (n)
rat
(Rattus norvegicus)
Mammalia LOC688018 33
  • 81.93 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF106 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFP106 33
  • 66.87 (n)
ZNF106 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF106 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf106 33
  • 59.08 (n)
Str.16042 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9777 33
zebrafish
(Danio rerio)
Actinopterygii znf106a 34
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14322 34
  • 18 (a)
OneToMany
Species where no ortholog for ZNF106 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF106 Gene

ENSEMBL:
Gene Tree for ZNF106 (if available)
TreeFam:
Gene Tree for ZNF106 (if available)

Paralogs for ZNF106 Gene

Paralogs for ZNF106 Gene

(2) SIMAP similar genes for ZNF106 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF106 Gene

genes like me logo Genes that share paralogs with ZNF106: view

Variants for ZNF106 Gene

Sequence variations from dbSNP and Humsavar for ZNF106 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs112661890 uncertain-significance, Limb-Girdle Muscular Dystrophy, Recessive, Limb-girdle muscular dystrophy, type 2A 42,411,984(-) G/A downstream_transcript_variant
rs772498665 uncertain-significance, Limb-girdle muscular dystrophy, type 2A, Limb-Girdle Muscular Dystrophy, Recessive 42,412,307(-) T/C downstream_transcript_variant
rs774244796 uncertain-significance, Limb-Girdle Muscular Dystrophy, Recessive, Limb-girdle muscular dystrophy, type 2A 42,412,206(-) GGGG/GGG downstream_transcript_variant
rs780202767 uncertain-significance, Limb-Girdle Muscular Dystrophy, Recessive, Limb-girdle muscular dystrophy, type 2A 42,412,254(-) ACTCA/ACTCACTCA downstream_transcript_variant
rs886051152 uncertain-significance, Limb-Girdle Muscular Dystrophy, Recessive, Limb-girdle muscular dystrophy, type 2A 42,412,216(-) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF106 Gene

Variant ID Type Subtype PubMed ID
nsv832987 CNV gain 17160897
nsv832986 CNV loss 17160897
nsv827311 CNV loss 20364138
nsv819827 CNV loss 19587683
nsv528725 CNV gain 19592680
nsv1508 CNV insertion 18451855
nsv1108952 CNV deletion 24896259
esv3636271 CNV loss 21293372
esv3636268 CNV loss 21293372
esv3636267 CNV loss 21293372
esv2749623 CNV deletion 23290073
esv2669606 CNV deletion 23128226
esv2665670 CNV deletion 23128226
esv22587 CNV loss 19812545

Variation tolerance for ZNF106 Gene

Residual Variation Intolerance Score: 4.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF106 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF106

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF106 Gene

Disorders for ZNF106 Gene

Additional Disease Information for ZNF106

No disorders were found for ZNF106 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF106 Gene

Publications for ZNF106 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1. (PMID: 15656981) Grasberger H … Bell GI (Gene 2005) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF106 Gene

Sources for ZNF106 Gene

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