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Aliases for ZNF100 Gene

Aliases for ZNF100 Gene

  • Zinc Finger Protein 100 2 3 5
  • Zinc Finger Protein 100 (Y1) 2

External Ids for ZNF100 Gene

Previous GeneCards Identifiers for ZNF100 Gene

  • GC19U990120
  • GC19M021697
  • GC19M021906
  • GC19M021446

Summaries for ZNF100 Gene

GeneCards Summary for ZNF100 Gene

ZNF100 (Zinc Finger Protein 100) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF430.

UniProtKB/Swiss-Prot for ZNF100 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF100 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF100 Gene

Genomics for ZNF100 Gene

GeneHancer (GH) Regulatory Elements for ZNF100 Gene

Promoters and enhancers for ZNF100 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I021766 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 657.6 +0.4 414 2 PKNOX1 ATF1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 FOS ZNF100 PIR33243 RPL7AP10 MTDHP4 LOC641367 ZNF431
GH19I021396 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 31.8 +370.2 370208 2 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 ETS1 POLR2B E2F8 ZNF207 ZNF493 LOC105372321 ZNF100 RPL7AP10 ZNF431 LOC641367 ZNF43 ZNF66 MTDHP4 ENSG00000269237
GH19I020922 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 31.8 +844.1 844100 2.1 PKNOX1 RB1 ARID4B SIN3A ZNF48 ZBTB40 YY1 ZNF335 SCRT2 ZNF207 ZNF85 ZNF100 ZNF66 ZNF90 RPL7AP10 ZNF431 LOC641367 ZNF43 ZNF486 ENSG00000268416
GH19I021835 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 28.2 -68.5 -68503 2.3 HDAC1 PKNOX1 ATF1 NFRKB ARID4B SIN3A ZBTB40 ZNF48 RFX5 YY1 ZNF43 ZNF100 VN1R84P PIR62983 BNIP3P27
GH19I021019 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 22.8 +745.4 745352 4.6 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF430 ZNF100 LOC641367 ZNF714 ZNF90 BNIP3P26 RPL7AP10 ZNF66 ZNF431 ZNF486
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF100 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF100 Gene

Genomic Locations for ZNF100 Gene
chr19:21,722,766-21,767,628
(GRCh38/hg38)
Size:
44,863 bases
Orientation:
Minus strand
chr19:21,905,568-21,950,430
(GRCh37/hg19)

Genomic View for ZNF100 Gene

Genes around ZNF100 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF100 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF100 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF100 Gene

Proteins for ZNF100 Gene

  • Protein details for ZNF100 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYN0-ZN100_HUMAN
    Recommended name:
    Zinc finger protein 100
    Protein Accession:
    Q8IYN0
    Secondary Accessions:
    • Q7M4M0

    Protein attributes for ZNF100 Gene

    Size:
    542 amino acids
    Molecular mass:
    62745 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF100 Gene

Post-translational modifications for ZNF100 Gene

  • Ubiquitination at isoforms=12
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF100 Gene

Domains & Families for ZNF100 Gene

Gene Families for ZNF100 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF100 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYN0

UniProtKB/Swiss-Prot:

ZN100_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF100: view

Function for ZNF100 Gene

Molecular function for ZNF100 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF100 Gene

Gene Ontology (GO) - Molecular Function for ZNF100 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF100: view
genes like me logo Genes that share phenotypes with ZNF100: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF100 Gene

Localization for ZNF100 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF100 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF100 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF100 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF100: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF100 Gene

Pathways & Interactions for ZNF100 Gene

SuperPathways for ZNF100 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF100: view

Pathways by source for ZNF100 Gene

2 Reactome pathways for ZNF100 Gene

Interacting Proteins for ZNF100 Gene

Gene Ontology (GO) - Biological Process for ZNF100 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF100: view

No data available for SIGNOR curated interactions for ZNF100 Gene

Drugs & Compounds for ZNF100 Gene

No Compound Related Data Available

Transcripts for ZNF100 Gene

Unigene Clusters for ZNF100 Gene

Zinc finger protein 100:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF100 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: -
SP3: - - -
SP4:

Relevant External Links for ZNF100 Gene

GeneLoc Exon Structure for
ZNF100
ECgene alternative splicing isoforms for
ZNF100

Expression for ZNF100 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF100 Gene

Protein differential expression in normal tissues from HIPED for ZNF100 Gene

This gene is overexpressed in Islet of Langerhans (46.6) and Serum (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF100 Gene



Protein tissue co-expression partners for ZNF100 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF100 Gene:

ZNF100

SOURCE GeneReport for Unigene cluster for ZNF100 Gene:

Hs.365142

Evidence on tissue expression from TISSUES for ZNF100 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF100: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF100 Gene

Orthologs for ZNF100 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF100 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF100 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp493 34
  • 58 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 50 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
Species where no ortholog for ZNF100 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF100 Gene

ENSEMBL:
Gene Tree for ZNF100 (if available)
TreeFam:
Gene Tree for ZNF100 (if available)

Paralogs for ZNF100 Gene

(531) SIMAP similar genes for ZNF100 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZNF100 Gene

genes like me logo Genes that share paralogs with ZNF100: view

Variants for ZNF100 Gene

Sequence variations from dbSNP and Humsavar for ZNF100 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs193921016 uncertain-significance, Malignant tumor of prostate 21,727,905(-) CC/C coding_sequence_variant, frameshift
rs1000032191 -- 21,766,663(-) T/C intron_variant
rs1000069280 -- 21,732,476(-) G/C intron_variant
rs1000093870 -- 21,765,034(-) A/G intron_variant
rs1000238741 -- 21,738,173(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF100 Gene

Variant ID Type Subtype PubMed ID
dgv511e201 CNV deletion 23290073
dgv83e19 OTHER inversion 19470904
esv2578515 CNV loss 19546169
esv2675419 CNV deletion 23128226
esv2718335 CNV deletion 23290073
esv2718343 CNV deletion 23290073
esv3556183 CNV deletion 23714750
esv3643932 CNV loss 21293372
esv3643933 CNV gain 21293372
esv4924 OTHER complex 18987735
nsv1061327 CNV gain 25217958
nsv1063115 CNV gain 25217958
nsv1133008 OTHER inversion 24896259
nsv578969 CNV loss 21841781
nsv578970 CNV loss 21841781
nsv578971 CNV loss 21841781
nsv7306 OTHER inversion 18451855
nsv833783 CNV loss 17160897
nsv833784 CNV loss 17160897
nsv961193 CNV duplication 23825009
nsv963026 CNV duplication 23825009

Variation tolerance for ZNF100 Gene

Residual Variation Intolerance Score: 69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF100 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF100

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF100 Gene

Disorders for ZNF100 Gene

Additional Disease Information for ZNF100

No disorders were found for ZNF100 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF100 Gene

Publications for ZNF100 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death. (PMID: 23272104) Choudhury KR … Bhattacharyya NP (PloS one 2012) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF100 Gene

Sources for ZNF100 Gene

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