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The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]
ZNF10 (Zinc Finger Protein 10) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF180.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 17512541 |
GO:0043565 | sequence-specific DNA binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,IDA | 23665872 |
GO:0032991 | protein-containing complex | IDA | 17512541 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
|
2 | Herpes simplex virus 1 infection |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF10 30 |
|
||
Dog (Canis familiaris) |
Mammalia | ZNF10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZNF10 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | ZNF10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
ZNF302 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11147259 | - | p.Gln227Arg |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1590n100 | CNV | gain | 25217958 |
dgv1593n100 | CNV | gain | 25217958 |
dgv1594n100 | CNV | gain | 25217958 |
dgv1595n100 | CNV | gain | 25217958 |
dgv1596n100 | CNV | gain | 25217958 |
dgv1597n100 | CNV | gain | 25217958 |
dgv220n27 | CNV | gain | 19166990 |
dgv3060n54 | CNV | gain | 21841781 |
dgv534e212 | CNV | gain | 25503493 |
dgv950e59 | CNV | duplication | 20981092 |
esv27162 | CNV | gain+loss | 19812545 |
esv2759923 | CNV | loss | 17122850 |
esv2760921 | CNV | gain | 21179565 |
esv2763014 | CNV | gain | 21179565 |
esv3631326 | CNV | loss | 21293372 |
esv3631327 | CNV | gain | 21293372 |
esv3631329 | CNV | gain | 21293372 |
esv3631330 | CNV | gain | 21293372 |
nsv1046905 | CNV | loss | 25217958 |
nsv1054203 | CNV | gain | 25217958 |
nsv442301 | CNV | gain | 18776908 |
nsv455818 | CNV | loss | 19166990 |
nsv470337 | CNV | loss | 18288195 |
nsv518970 | CNV | gain | 19592680 |
nsv561145 | CNV | gain | 21841781 |
nsv561148 | CNV | loss | 21841781 |
nsv561149 | CNV | gain | 21841781 |
nsv9050 | CNV | gain | 18304495 |
No disorders were found for ZNF10 Gene.