The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repress... See more...

Aliases for ZNF10 Gene

Aliases for ZNF10 Gene

  • Zinc Finger Protein 10 2 3 4 5
  • KOX1 2 3 4
  • Zinc Finger Protein 10 (KOX 1) 2 3
  • Zinc Finger Protein KOX1 3 4
  • ZNF10 5

External Ids for ZNF10 Gene

Previous GeneCards Identifiers for ZNF10 Gene

  • GC12P131228
  • GC12P133310
  • GC12P131897
  • GC12P131392
  • GC12P132317
  • GC12P133708
  • GC12P133709
  • GC12P133131
  • GC12P133132
  • GC12P133134

Summaries for ZNF10 Gene

Entrez Gene Summary for ZNF10 Gene

  • The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF10 Gene

ZNF10 (Zinc Finger Protein 10) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF180.

UniProtKB/Swiss-Prot Summary for ZNF10 Gene

Gene Wiki entry for ZNF10 Gene

Additional gene information for ZNF10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF10 Gene

Genomics for ZNF10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF10

Top Transcription factor binding sites by QIAGEN in the ZNF10 gene promoter:
  • CREB
  • deltaCREB

Genomic Locations for ZNF10 Gene

Genomic Locations for ZNF10 Gene
chr12:133,130,575-133,159,465
(GRCh38/hg38)
Size:
28,891 bases
Orientation:
Plus strand
chr12:133,707,161-133,736,051
(GRCh37/hg19)
Size:
28,891 bases
Orientation:
Plus strand

Genomic View for ZNF10 Gene

Genes around ZNF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF10 Gene

Proteins for ZNF10 Gene

  • Protein details for ZNF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21506-ZNF10_HUMAN
    Recommended name:
    Zinc finger protein 10
    Protein Accession:
    P21506
    Secondary Accessions:
    • B2RBS1
    • Q8TC91

    Protein attributes for ZNF10 Gene

    Size:
    573 amino acids
    Molecular mass:
    66455 Da
    Quaternary structure:
    • Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain).

neXtProt entry for ZNF10 Gene

Post-translational modifications for ZNF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF10 Gene

No data available for DME Specific Peptides for ZNF10 Gene

Domains & Families for ZNF10 Gene

Gene Families for ZNF10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF10 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF10 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX1 (ZNF10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21506

UniProtKB/Swiss-Prot:

ZNF10_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF10: view

Function for ZNF10 Gene

Molecular function for ZNF10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 10 (KOX1) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF10 Gene

Gene Ontology (GO) - Molecular Function for ZNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 17512541
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF10: view
genes like me logo Genes that share phenotypes with ZNF10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF10 Gene

Localization for ZNF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF10 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 23665872
GO:0032991 protein-containing complex IDA 17512541
genes like me logo Genes that share ontologies with ZNF10: view

Pathways & Interactions for ZNF10 Gene

genes like me logo Genes that share pathways with ZNF10: view

Pathways by source for ZNF10 Gene

2 Reactome pathways for ZNF10 Gene
1 KEGG pathway for ZNF10 Gene

Gene Ontology (GO) - Biological Process for ZNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF10: view

No data available for SIGNOR curated interactions for ZNF10 Gene

Drugs & Compounds for ZNF10 Gene

(1) Drugs for ZNF10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF10: view

Transcripts for ZNF10 Gene

mRNA/cDNA for ZNF10 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF10

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF10 Gene

No ASD Table

Relevant External Links for ZNF10 Gene

GeneLoc Exon Structure for
ZNF10

Expression for ZNF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF10 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF10 Gene

This gene is overexpressed in Pituitary (x4.2).

Protein differential expression in normal tissues from HIPED for ZNF10 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF10 Gene



Protein tissue co-expression partners for ZNF10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF10

SOURCE GeneReport for Unigene cluster for ZNF10 Gene:

Hs.573983

Evidence on tissue expression from TISSUES for ZNF10 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF10 Gene

Orthologs for ZNF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF10 30
  • 99.94 (n)
Dog
(Canis familiaris)
Mammalia ZNF10 30 31
  • 88.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF10 30 31
  • 87.62 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 44 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia ZNF10 31
  • 39 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 44 (a)
ManyToMany
ZNF302 31
  • 41 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 27 (a)
ManyToMany
Species where no ortholog for ZNF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF10 Gene

ENSEMBL:
Gene Tree for ZNF10 (if available)
TreeFam:
Gene Tree for ZNF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF10: view image

Paralogs for ZNF10 Gene

(550) SIMAP similar genes for ZNF10 Gene using alignment to 7 proteins:

  • ZNF10_HUMAN
  • F5GZ75_HUMAN
  • F5H0R3_HUMAN
  • F5H311_HUMAN
  • F5H6S6_HUMAN
  • F5H8F6_HUMAN
  • F8WD46_HUMAN

Pseudogenes.org Pseudogenes for ZNF10 Gene

genes like me logo Genes that share paralogs with ZNF10: view

Variants for ZNF10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF10 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs11147259 - p.Gln227Arg

Additional dbSNP identifiers (rs#s) for ZNF10 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF10 Gene

Variant ID Type Subtype PubMed ID
dgv1590n100 CNV gain 25217958
dgv1593n100 CNV gain 25217958
dgv1594n100 CNV gain 25217958
dgv1595n100 CNV gain 25217958
dgv1596n100 CNV gain 25217958
dgv1597n100 CNV gain 25217958
dgv220n27 CNV gain 19166990
dgv3060n54 CNV gain 21841781
dgv534e212 CNV gain 25503493
dgv950e59 CNV duplication 20981092
esv27162 CNV gain+loss 19812545
esv2759923 CNV loss 17122850
esv2760921 CNV gain 21179565
esv2763014 CNV gain 21179565
esv3631326 CNV loss 21293372
esv3631327 CNV gain 21293372
esv3631329 CNV gain 21293372
esv3631330 CNV gain 21293372
nsv1046905 CNV loss 25217958
nsv1054203 CNV gain 25217958
nsv442301 CNV gain 18776908
nsv455818 CNV loss 19166990
nsv470337 CNV loss 18288195
nsv518970 CNV gain 19592680
nsv561145 CNV gain 21841781
nsv561148 CNV loss 21841781
nsv561149 CNV gain 21841781
nsv9050 CNV gain 18304495

Variation tolerance for ZNF10 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF10 Gene

Disorders for ZNF10 Gene

Additional Disease Information for ZNF10

No disorders were found for ZNF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF10 Gene

Publications for ZNF10 Gene

  1. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W … Huang Z (Cellular and molecular life sciences : CMLS 2013) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. (PMID: 10748030) Peng H … Rauscher FJ (The Journal of biological chemistry 2000) 3 23
  4. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor. (PMID: 9278146) Moosmann P … Schaffner W (Biological chemistry 1997) 3 23
  5. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3

Products for ZNF10 Gene

Sources for ZNF10 Gene