Aliases for ZMYND8 Gene
External Ids for ZMYND8 Gene
Previous HGNC Symbols for ZMYND8 Gene
Previous GeneCards Identifiers for ZMYND8 Gene
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZMYND8 Gene
ZMYND8 (Zinc Finger MYND-Type Containing 8) is a Protein Coding gene. Diseases associated with ZMYND8 include Cutaneous T Cell Lymphoma. Among its related pathways are Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include repressing transcription factor binding. An important paralog of this gene is ZMYND11.
UniProtKB/Swiss-Prot Summary for ZMYND8 Gene
May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.