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The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple tr... See more...
Aliases for ZMYND8 Gene
Aliases for ZMYND8 Gene
External Ids for ZMYND8 Gene
- HGNC: 9397
- Entrez Gene: 23613
- Ensembl: ENSG00000101040
- OMIM: 615713
- UniProtKB: Q9ULU4
Previous HGNC Symbols for ZMYND8 Gene
- PRKCBP1
Previous GeneCards Identifiers for ZMYND8 Gene
- GC20M045272
- GC20M045837
- GC20M042581
Summaries for ZMYND8 Gene
-
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZMYND8 Gene
ZMYND8 (Zinc Finger MYND-Type Containing 8) is a Protein Coding gene. Diseases associated with ZMYND8 include Cutaneous T Cell Lymphoma. Among its related pathways are Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include repressing transcription factor binding. An important paralog of this gene is ZMYND11.
UniProtKB/Swiss-Prot Summary for ZMYND8 Gene
-
May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.
Additional gene information for ZMYND8 Gene
- Monarch Initiative
- Search for ZMYND8 at DataMed
- Search for ZMYND8 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZMYND8 Gene
Genomics for ZMYND8 Gene
GeneHancer (GH) Regulatory Elements for ZMYND8 Gene
Promoters and enhancers for ZMYND8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZMYND8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZMYND8 gene promoter:
-
- Bach2
- C/EBPalpha
- CBF(2)
- CBF-B
- E47
- FOXJ2
- FOXJ2 (long isoform)
- Olf-1
- USF-1
- USF1
Genomic Locations for ZMYND8 Gene
Genomic Locations for ZMYND8 Gene
- chr20:47,209,214-47,356,889
- (GRCh38/hg38)
- Size:
- 147,676 bases
- Orientation:
- Minus strand
- chr20:45,837,859-45,985,567
- (GRCh37/hg19)
- Size:
- 147,709 bases
- Orientation:
- Minus strand
Genomic View for ZMYND8 Gene
Genes around ZMYND8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by HGNC
- 20q13.12 by Entrez Gene
- 20q13.12 by Ensembl
ZMYND8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZMYND8 Gene
Proteins for ZMYND8 Gene
-
Protein details for ZMYND8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULU4-PKCB1_HUMAN
- Recommended name:
- Protein kinase C-binding protein 1
- Protein Accession:
- Q9ULU4
- B3KVL2
- B7Z2A8
- B7Z3E0
- B7Z680
- B7ZM62
- E1P5U5
- F5H0X3
- H7C0U2
- J3KPU3
- Q13517
- Q2HXV1
- Q2HXV2
- Q2HXV3
- Q2HXV4
- Q2HXV7
- Q2HXV8
- Q2HXV9
- Q2HXW0
- Q2HXW1
- Q2HXW2
- Q4JJ94
- Q4JJ95
- Q5TH09
- Q5TH11
- Q6MZM1
- Q8WXC5
- Q9H1F3
- Q9H1F4
- Q9H1F5
- Q9H1L8
- Q9H1L9
- Q9H2G5
- Q9NYN3
- Q9UIX6
Protein attributes for ZMYND8 Gene
- Size:
- 1186 amino acids
- Molecular mass:
- 131692 Da
- Quaternary structure:
-
- Interacts in vitro with PRKCB1 (PubMed:11003709). Interacts with KDM5D and KDM1A (PubMed:27477906). Interacts with histone H3 (via N-terminus) that is both methylated at 'Lys-4' (H3K4me1) and acetylated at 'Lys-14' (H3K14ac), and with histone H3 (via N-terminus) unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-14' (H3K14ac) (PubMed:27477906). Interacts (via PHD-type Zinc finger, Bromo and PWWP domains) with DBN1 (via ADF-H domain); the interaction leads to sequestering of ZMYND8 in the cytoplasm (PubMed:28966017).
- SequenceCaution:
-
- Sequence=AAC72244.1; Type=Frameshift; Positions=816; Evidence={ECO:0000305}; Sequence=BAA86439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ZMYND8 Gene
Protein Expression for ZMYND8 Gene
Post-translational modifications for ZMYND8 Gene
Other Protein References for ZMYND8 Gene
- ENSEMBL proteins:
-
- ENSP00000392964
- ENSP00000262975
- ENSP00000439800
- ENSP00000479806
- ENSP00000335537
- ENSP00000394379
- ENSP00000420095
- ENSP00000393806
- ENSP00000482048
- ENSP00000312237
- ENSP00000418495
- ENSP00000413727
- ENSP00000396725
- ENSP00000443086
- ENSP00000379577
- ENSP00000479197
- ENSP00000418210
- ENSP00000361093
- ENSP00000354166
- ENSP00000348246
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PKCB1 Antibody and Immunotag™ RACK7 Polyclonal Antibody
- Atlas Antibodies Anti-ZMYND8 Antibody
- Novus Biologicals Antibodies for ZMYND8
-
Abcam antibodies for ZMYND8
- Invitrogen Antibodies for ZMYND8 (AFLGC-ZMYND8)
-
Boster Bio Antibodies for ZMYND8
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZMYND8
Protein Products
-
OriGene Purified Proteins for ZMYND8
- Search Origene for MassSpec and Protein Over-expression Lysates for ZMYND8
- Origene Custom Protein Services for ZMYND8
-
Abcam proteins for ZMYND8
Assay Products
- Aviva Systems Biology PKCb1 ELISA Kit (Human) (OKDD00467)
No data available for DME Specific Peptides for ZMYND8 Gene
Domains & Families for ZMYND8 Gene
Gene Families for ZMYND8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZMYND8 Gene
Suggested Antigen Peptide Sequences for ZMYND8 Gene
- GenScript: Design optimal peptide antigens:
-
- ZMYND8 protein (A6H8Y8_HUMAN)
- ZMYND8 protein (B7ZM62_HUMAN)
- Zinc finger MYND domain-containing protein 8 (PKCB1_HUMAN)
- ZMYND8 protein (Q569J9_HUMAN)
- Protein kinase C binding protein 1 (Q5TH11_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZMYND8 Gene
Function for ZMYND8 Gene
Molecular function for ZMYND8 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.
Phenotypes From GWAS Catalog for ZMYND8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003714 | transcription corepressor activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 15095401 |
| GO:0008270 | zinc ion binding | IDA | 28966017 |
| GO:0019904 | protein domain specific binding | IDA | 28966017 |
| GO:0035064 | methylated histone binding | IDA | 27477906 |
Phenotypes for ZMYND8 Gene
- MGI mutant phenotypes for ZMYND8:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZMYND8:
-
- Decreased viability
- Increased cell death HMECs cells
- Increased Nanog expression
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased hepcidin::fluc mRNA expression
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for ZMYND8 Gene
- MGI Knock Outs for ZMYND8:
-
- Zmynd8 Zmynd8<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for ZMYND8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZMYND8
- genomics-online: gRNA clones - Search for available ZMYND8 gRNA products
- Overview of 189 available ZMYND8 gene related products
- Applied Biological Materials (abm): CRISPR Clones for ZMYND8 - Select products 50% OFF >
- * ZMYND8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ZMYND8 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZMYND8
miRNA for ZMYND8 Gene
- miRTarBase miRNAs that target ZMYND8
-
- hsa-mir-548d-5p (MIRT037778)
- hsa-mir-421 (MIRT039404)
- hsa-mir-92a-3p (MIRT049407)
- hsa-mir-18a-5p (MIRT050675)
- hsa-mir-142-3p (MIRT439226)
- hsa-mir-3140-3p (MIRT615847)
- hsa-mir-30e-5p (MIRT726058)
- hsa-mir-30d-5p (MIRT726059)
- hsa-mir-30c-5p (MIRT726060)
- hsa-mir-30b-5p (MIRT726061)
- hsa-mir-30a-5p (MIRT726062)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ZMYND8
- Browse OriGene Inhibitory RNA Products For ZMYND8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMYND8
- genomics-online: shRNA clones - Search for available ZMYND8 shRNA products
- Overview of 189 available ZMYND8 gene related products
Clone Products
-
-
- MG211857
- MR211857
- MR211857L3
- MR211857L3V
- MR211857L4
- MR211857L4V
- MR230239
- MR231627
- MR231655
- MR231676
- MR231711
- RC212828
- RC212828L1
- RC212828L1V
- RC212828L2
- RC212828L2V
- RC212828L3
- RC212828L3V
- RC212828L4
- RC212828L4V
- RC215969
- RC215969L3
- RC215969L3V
- RC215969L4
- RC215969L4V
- RC221394
- RC221394L3
- RC221394L3V
- RC221394L4
- RC221394L4V
- RC236112
- RC239745
- RC239786
- RC239921
- RC239958
- RC239976
- RC239998
- RC240001
- RC240013
- RC240017
- RC240029
- RC240032
- RC240044
- RC240048
- RC240067
- RG212828
- RG215969
- RG221394
- RR212873
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZMYND8
- Addgene plasmids for ZMYND8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZMYND8
- Applied Biological Materials (abm): Clones for ZMYND8 - Select products 50% OFF >
- * ZMYND8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ZMYND8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for ZMYND8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZMYND8 Gene
Localization for ZMYND8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZMYND8 Gene
- Nucleus. Cytoplasm. Note=Sequestered in the cytoplasm through the interaction with DBN1. {ECO:0000269 PubMed:28966017}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 2 |
| cytosol | 1 |
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,ISS | -- |
| GO:0005737 | cytoplasm | IMP | 28966017 |
| GO:0043197 | dendritic spine | IEA | -- |
| GO:0043198 | dendritic shaft | IEA | -- |
Pathways & Interactions for ZMYND8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrated Breast Cancer Pathway | ||
Pathways by source for ZMYND8 Gene
1 BioSystems pathway for ZMYND8 Gene
Interacting Proteins for ZMYND8 Gene
Selected Interacting proteins:
Q9ULU4-PKCB1_HUMAN
ENSP00000420095
for ZMYND8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZMYND8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0030336 | negative regulation of cell migration | IMP | 27477906 |
| GO:0051491 | positive regulation of filopodium assembly | IEA | -- |
| GO:0060999 | positive regulation of dendritic spine development | IEA | -- |
| GO:0098815 | modulation of excitatory postsynaptic potential | IEA | -- |
No data available for SIGNOR curated interactions for ZMYND8 Gene
Transcripts for ZMYND8 Gene
mRNA/cDNA for ZMYND8 Gene
- (20) REFSEQ mRNAs :
- (43) Additional mRNA sequences :
- (415) Selected AceView cDNA sequences:
- (21) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262975 4139 bps (ENST00000262975.8)
- ENST00000311275 5362 bps (ENST00000311275.11)
- ENST00000352431 3832 bps (ENST00000352431.6)
- ENST00000355972 5542 bps (ENST00000355972.8)
- ENST00000360911 4991 bps (ENST00000360911.7)
CRISPR Products
-
OriGene CRISPR knockouts for ZMYND8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZMYND8
- genomics-online: gRNA clones - Search for available ZMYND8 gRNA products
- Overview of 189 available ZMYND8 gene related products
- Applied Biological Materials (abm): CRISPR Clones for ZMYND8 - Select products 50% OFF >
- * ZMYND8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ZMYND8 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZMYND8
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ZMYND8
- Browse OriGene Inhibitory RNA Products For ZMYND8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMYND8
- genomics-online: shRNA clones - Search for available ZMYND8 shRNA products
- Overview of 189 available ZMYND8 gene related products
Clone Products
-
-
- MG211857
- MR211857
- MR211857L3
- MR211857L3V
- MR211857L4
- MR211857L4V
- MR230239
- MR231627
- MR231655
- MR231676
- MR231711
- RC212828
- RC212828L1
- RC212828L1V
- RC212828L2
- RC212828L2V
- RC212828L3
- RC212828L3V
- RC212828L4
- RC212828L4V
- RC215969
- RC215969L3
- RC215969L3V
- RC215969L4
- RC215969L4V
- RC221394
- RC221394L3
- RC221394L3V
- RC221394L4
- RC221394L4V
- RC236112
- RC239745
- RC239786
- RC239921
- RC239958
- RC239976
- RC239998
- RC240001
- RC240013
- RC240017
- RC240029
- RC240032
- RC240044
- RC240048
- RC240067
- RG212828
- RG215969
- RG221394
- RR212873
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZMYND8
- Addgene plasmids for ZMYND8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZMYND8
- Applied Biological Materials (abm): Clones for ZMYND8 - Select products 50% OFF >
- * ZMYND8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ZMYND8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for ZMYND8 Gene
This gene is overexpressed in Adrenal (17.7), Peripheral blood mononuclear cells (16.5), and Placenta (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZMYND8 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZMYND8 Gene:
ZMYND8SOURCE GeneReport for Unigene cluster for ZMYND8 Gene:
Hs.446240mRNA Expression by UniProt/SwissProt for ZMYND8 Gene:
Q9ULU4-PKCB1_HUMAN
Tissue specificity:
Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).
Evidence on tissue expression from TISSUES for ZMYND8 Gene
- Nervous system(4.9)
- Eye(4.3)
- Liver(4.3)
- Intestine(2.9)
- Lung(2.9)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for ZMYND8
-
OriGene qPCR primer pairs and template standards for ZMYND8
- genomics-online: primer clones - Search for available ZMYND8 Primer products
- Overview of 189 available ZMYND8 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMYND8 Gene
Orthologs for ZMYND8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZMYND8 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZMYND8 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZMYND8 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Zmynd8 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zmynd8 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZMYND8 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ZMYND8 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZMYND8 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZMYND8 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zmynd8 32 |
|
||
| Str.16445 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.18946 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zmynd8 33 32 |
|
OneToMany | |
| prkcbp1l 33 |
|
OneToMany | |||
| wufb99d12 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG1815 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne |
- Species where no ortholog for ZMYND8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ZMYND8 Gene
- ENSEMBL:
- Gene Tree for ZMYND8 (if available)
- TreeFam:
- Gene Tree for ZMYND8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZMYND8: view image
Paralogs for ZMYND8 Gene
(5) SIMAP similar genes for ZMYND8 Gene using alignment to 13 proteins:
- PKCB1_HUMAN
- A6H8Y8_HUMAN
- B7ZM62_HUMAN
- F5H0X3_HUMAN
- H7C0U2_HUMAN
- H7C4X9_HUMAN
- J3KPU3_HUMAN
- Q2HXV1_HUMAN
- Q2HXV3_HUMAN
- Q569J9_HUMAN
- Q5TH07_HUMAN
- Q5TH08_HUMAN
- Q5TH12_HUMAN
Variants for ZMYND8 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1135401783 | uncertain-significance, Intellectual disability | 47,238,794(-) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, stop_gained | |
| rs1000010017 | -- | 47,237,962(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000038465 | -- | 47,329,016(-) | AT/ | intron_variant | |
| rs1000042682 | -- | 47,288,831(-) | G/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000063894 | -- | 47,228,988(-) | A/G | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2663936 | CNV | deletion | 23128226 |
| esv33497 | CNV | loss | 17666407 |
| esv3567997 | CNV | loss | 25503493 |
| esv3567999 | CNV | loss | 25503493 |
| esv3645968 | CNV | loss | 21293372 |
| esv990338 | CNV | deletion | 20482838 |
| nsv1061899 | CNV | loss | 25217958 |
| nsv1066814 | CNV | gain | 25217958 |
| nsv1066907 | CNV | gain | 25217958 |
| nsv1125728 | CNV | tandem duplication | 24896259 |
Residual Variation Intolerance Score:
0.946% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.09;
84.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZMYND8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZMYND8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND8 Gene
Disorders for ZMYND8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cutaneous t cell lymphoma |
|
|
Search ZMYND8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZMYND8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ZMYND8 Gene
Publications for ZMYND8 Gene
- Identification and characterization of PRKCBP1, a candidate RACK-like protein. (PMID: 11003709) Fossey SC … Bowden DW (Mammalian genome : official journal of the International Mammalian Genome Society 2000) 3 4 23 56
- The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin. (PMID: 28966017) Yao N … Zhang M (Structure (London, England : 1993) 2017) 3 4 56
- ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. (PMID: 27477906) Li N … Lee MG (Molecular cell 2016) 3 4 56
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 56
ExternalLinks
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