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The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
ZMYND8 (Zinc Finger MYND-Type Containing 8) is a Protein Coding gene. Diseases associated with ZMYND8 include Cutaneous T Cell Lymphoma and Lymphoma. Among its related pathways are Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include repressing transcription factor binding. An important paralog of this gene is ZMYND11.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003714 | transcription corepressor activity | ISS | -- |
GO:0005515 | protein binding | IPI | 15095401 |
GO:0008270 | zinc ion binding | IDA | 28966017 |
GO:0019904 | protein domain specific binding | IDA | 28966017 |
GO:0035064 | methylated histone binding | IDA | 27477906 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,ISS | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IMP | 28966017 |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0043197 | dendritic spine | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Integrated Breast Cancer Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0030336 | negative regulation of cell migration | IMP | 27477906 |
GO:0051491 | positive regulation of filopodium assembly | IEA | -- |
GO:0060999 | positive regulation of dendritic spine development | IEA | -- |
GO:0098815 | modulation of excitatory postsynaptic potential | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZMYND8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZMYND8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZMYND8 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Zmynd8 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zmynd8 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZMYND8 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZMYND8 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZMYND8 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZMYND8 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zmynd8 30 |
|
||
Str.16445 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.18946 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zmynd8 30 31 |
|
OneToMany | |
prkcbp1l 31 |
|
OneToMany | |||
wufb99d12 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG1815 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712278 | Benign: not provided | 47,282,110(-) | T/C | SYNONYMOUS_VARIANT | |
771780 | Benign: not provided | 47,239,110(-) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
777918 | Benign: not provided | 47,249,374(-) | C/G | MISSENSE_VARIANT | |
786438 | Benign: not provided | 47,276,304(-) | C/T | INTRON_VARIANT | |
786680 | Benign: not provided | 47,291,786(-) | G/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2663936 | CNV | deletion | 23128226 |
esv33497 | CNV | loss | 17666407 |
esv3567997 | CNV | loss | 25503493 |
esv3567999 | CNV | loss | 25503493 |
esv3645968 | CNV | loss | 21293372 |
esv990338 | CNV | deletion | 20482838 |
nsv1061899 | CNV | loss | 25217958 |
nsv1066814 | CNV | gain | 25217958 |
nsv1066907 | CNV | gain | 25217958 |
nsv1125728 | CNV | tandem duplication | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cutaneous t cell lymphoma |
|
|
lymphoma |
|
|
breast cancer |
|
|