Aliases for ZMYND8 Gene
Aliases for ZMYND8 Gene
External Ids for ZMYND8 Gene
- HGNC: 9397
- Entrez Gene: 23613
- Ensembl: ENSG00000101040
- OMIM: 615713
- UniProtKB: Q9ULU4
Previous HGNC Symbols for ZMYND8 Gene
- PRKCBP1
Previous GeneCards Identifiers for ZMYND8 Gene
- GC20M045272
- GC20M045837
- GC20M042581
Summaries for ZMYND8 Gene
-
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZMYND8 Gene
ZMYND8 (Zinc Finger MYND-Type Containing 8) is a Protein Coding gene. Diseases associated with ZMYND8 include Cutaneous T Cell Lymphoma. Among its related pathways are Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include repressing transcription factor binding and RNA polymerase II transcription corepressor activity. An important paralog of this gene is TAF1.
UniProtKB/Swiss-Prot for ZMYND8 Gene
-
May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.
Additional gene information for ZMYND8 Gene
- Monarch Initiative
- Search for ZMYND8 at DataMed
- Search for ZMYND8 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYND8 Gene
Genomics for ZMYND8 Gene
GeneHancer (GH) Regulatory Elements for ZMYND8 Gene
Promoters and enhancers for ZMYND8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZMYND8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZMYND8 gene promoter:
Regulatory Element Products
Genomic Locations for ZMYND8 Gene
Genomic Locations for ZMYND8 Gene
- chr20:47,209,214-47,356,889
- (GRCh38/hg38)
- Size:
- 147,676 bases
- Orientation:
- Minus strand
- chr20:45,837,859-45,985,567
- (GRCh37/hg19)
Genomic View for ZMYND8 Gene
Genes around ZMYND8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
ZMYND8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZMYND8 Gene
Proteins for ZMYND8 Gene
-
Protein details for ZMYND8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULU4-PKCB1_HUMAN
- Recommended name:
- Protein kinase C-binding protein 1
- Protein Accession:
- Q9ULU4
- B3KVL2
- B7Z2A8
- B7Z3E0
- B7Z680
- B7ZM62
- E1P5U5
- F5H0X3
- H7C0U2
- J3KPU3
- Q13517
- Q2HXV1
- Q2HXV2
- Q2HXV3
- Q2HXV4
- Q2HXV7
- Q2HXV8
- Q2HXV9
- Q2HXW0
- Q2HXW1
- Q2HXW2
- Q4JJ94
- Q4JJ95
- Q5TH09
- Q5TH11
- Q6MZM1
- Q8WXC5
- Q9H1F3
- Q9H1F4
- Q9H1F5
- Q9H1L8
- Q9H1L9
- Q9H2G5
- Q9NYN3
- Q9UIX6
Protein attributes for ZMYND8 Gene
- Size:
- 1186 amino acids
- Molecular mass:
- 131692 Da
- Quaternary structure:
-
- Interacts in vitro with PRKCB1 (PubMed:11003709). Interacts with KDM5D and KDM1A. Interacts with histone H3 (via N-terminus) that is both methylated at Lys-4 (H3K4me1) and acetylated at Lys-14 (H3K14ac), and with histone H3 (via N-terminus) unmodified at Lys-4 (H3K4me0) and acetylated at Lys-14 (H3K14ac).
- SequenceCaution:
-
- Sequence=AAC72244.1; Type=Frameshift; Positions=816; Evidence={ECO:0000305}; Sequence=BAA86439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ZMYND8 Gene
Protein Expression for ZMYND8 Gene
Post-translational modifications for ZMYND8 Gene
Other Protein References for ZMYND8 Gene
- ENSEMBL proteins:
-
- ENSP00000262975
- ENSP00000312237
- ENSP00000335537
- ENSP00000348246
- ENSP00000354166
- ENSP00000361093
- ENSP00000379577
- ENSP00000392964
- ENSP00000393806
- ENSP00000394379
- ENSP00000396725
- ENSP00000413727
- ENSP00000418495
- ENSP00000420095
- ENSP00000439800
- ENSP00000443086
- ENSP00000479197
- ENSP00000479806
- ENSP00000482048
- ENSP00000418210
- REFSEQ proteins:
-
- NP_001268698.1
- NP_001268700.1
- NP_001268701.1
- NP_001268702.1
- NP_001268703.1
- NP_001268704.1
- NP_001268705.1
- NP_001268706.1
- NP_001268707.1
- NP_001268708.1
- NP_001268709.1
- NP_001268710.1
- NP_001268711.1
- NP_001268712.1
- NP_001268713.1
- NP_036540.3
- NP_898868.1
- NP_898869.1
- XP_005260413.1
- XP_005260415.1
- XP_005260417.1
- XP_005260419.1
- XP_005260421.1
- XP_005260423.1
- XP_006723823.1
- XP_006723825.1
- XP_006723826.1
- XP_006723829.1
- XP_011527051.1
- XP_011527053.1
- XP_011527054.1
- XP_011527055.1
- XP_011527056.1
- XP_016883249.1
- XP_016883250.1
- XP_016883251.1
- XP_016883252.1
- XP_016883253.1
- XP_016883254.1
- XP_016883255.1
- XP_016883256.1
- XP_016883257.1
- XP_016883258.1
- XP_016883259.1
- XP_016883260.1
- XP_016883261.1
- XP_016883262.1
- XP_016883263.1
- XP_016883264.1
- XP_016883265.1
- XP_016883266.1
- XP_016883267.1
- XP_016883268.1
- XP_016883269.1
Antibody Products
- Novus Biologicals Antibodies for ZMYND8
-
Abcam antibodies for ZMYND8
- Invitrogen Antibodies for ZMYND8
- GeneTex ZMYND8 antibody for ZMYND8
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZMYND8
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZMYND8
- Origene Custom Protein Services for ZMYND8
- Search GeneTex for Proteins for ZMYND8
-
Abcam proteins for ZMYND8
Assay Products
No data available for DME Specific Peptides for ZMYND8 Gene
Domains & Families for ZMYND8 Gene
Gene Families for ZMYND8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZMYND8 Gene
Suggested Antigen Peptide Sequences for ZMYND8 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZMYND8 Gene
Function for ZMYND8 Gene
Molecular function for ZMYND8 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.
Phenotypes From GWAS Catalog for ZMYND8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
| GO:0001106 | RNA polymerase II transcription corepressor activity | ISS | -- |
| GO:0003682 | chromatin binding | IBA | -- |
| GO:0003712 | transcription cofactor activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 15095401 |
Phenotypes for ZMYND8 Gene
- MGI mutant phenotypes for ZMYND8:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZMYND8:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Increased cell death HMECs cells
- Increased Nanog expression
- Decreased viability
Animal Models for ZMYND8 Gene
- MGI Knock Outs for ZMYND8:
-
- Zmynd8 tm1a(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZMYND8
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZMYND8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZMYND8 gene
- Search ViGene Biosciences for ZMYND8
CRISPR Products
-
OriGene CRISPR knockouts for ZMYND8
- genomics-online: gRNA clones - Search results for 180 available ZMYND8 gene related products
- Overview of 180 available ZMYND8 gene related products
-
Recommended
- Applied Biological Materials CRISPR for ZMYND8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZMYND8
- GenScript: Design CRISPR guide RNA sequences for ZMYND8
miRNA for ZMYND8 Gene
- miRTarBase miRNAs that target ZMYND8
-
- hsa-mir-548d-5p (MIRT037778)
- hsa-mir-421 (MIRT039404)
- hsa-mir-92a-3p (MIRT049407)
- hsa-mir-18a-5p (MIRT050675)
- hsa-mir-142-3p (MIRT439226)
- hsa-mir-3140-3p (MIRT615847)
- hsa-mir-30e-5p (MIRT726058)
- hsa-mir-30d-5p (MIRT726059)
- hsa-mir-30c-5p (MIRT726060)
- hsa-mir-30b-5p (MIRT726061)
- hsa-mir-30a-5p (MIRT726062)
miRNA Products
- Search ViGene Biosciences for ZMYND8
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ZMYND8
- Browse OriGene Inhibitory RNA Products For ZMYND8
- genomics-online: shRNA clones - Search results for 180 available ZMYND8 gene related products
- Overview of 180 available ZMYND8 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for ZMYND8 gene
Clone Products
-
OriGene ORF clones in human for ZMYND8
- RG215969
- RC215969L2
- RC215969L1
- RC215969
- RG212828
- RC212828L2
- RC212828L1
- RC212828
- RG221394
- RC221394L2
- RC221394L1
- RC221394
- RC239998
- RC240044
- RC240001
- RC239958
- RC239745
- RC239786
- RC240029
- RC240013
- RC239976
- RC240067
- RC240017
- RC240048
- RC240032
- RC239921
- RC236112
- RC215969L2V
- RC215969L1V
- RC212828L2V
- RC212828L1V
- RC221394L2V
- RC221394L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for ZMYND8 in any vector
- NM_001281777.2
- XM_006723763.1
- NM_183047.3
- NM_001281780.2
- XM_005260364.2
- NM_001281783.2
- XM_005260366.2
- NM_012408.5
- XM_006723760.2
- NM_001281773.2
- XM_005260360.3
- NM_001281776.2
- XM_005260362.2
- NM_183048.3
- NM_001281779.2
- XM_011528753.1
- NM_001281782.2
- XM_006723766.1
- NM_001281769.1
- XM_011528749.1
- NM_001281772.2
- XM_011528750.1
- NM_001281775.2
- XM_006723762.2
- NM_001281778.2
- XM_011528752.1
- NM_001281781.2
- XM_011528754.1
- NM_001281784.2
- XM_011528755.1
- XM_005260356.3
- NM_001281771.2
- XM_005260358.2
- NM_001281774.2
- XM_011528751.1
- Sino Biological Human cDNA Clone for ZMYND8
- VectorBuilder custom plasmid, inducible vectors for ZMYND8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZMYND8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ZMYND8
- genomics-online: cdna clones - Search results for 180 available ZMYND8 gene related products
- Overview of 180 available ZMYND8 gene related products
-
Recommended
- orf clones - Search results for 180 available ZMYND8 gene related products
- Overview of 180 available ZMYND8 gene related products
-
Recommended
- Applied Biological Materials Clones for ZMYND8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZMYND8
-
ViGene Biosciences adenoviral particle packaged cDNA for ZMYND8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZMYND8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZMYND8 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZMYND8 Gene
Localization for ZMYND8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZMYND8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 2 |
| cytosol | 1 |
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,ISS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0043197 | dendritic spine | IEA | -- |
| GO:0043198 | dendritic shaft | IEA | -- |
Pathways & Interactions for ZMYND8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrated Breast Cancer Pathway | ||
Pathways by source for ZMYND8 Gene
1 BioSystems pathway for ZMYND8 Gene
Interacting Proteins for ZMYND8 Gene
Selected Interacting proteins:
Q9ULU4-PKCB1_HUMAN
ENSP00000418210
for ZMYND8 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0030336 | negative regulation of cell migration | IMP | 27477906 |
| GO:0051491 | positive regulation of filopodium assembly | IEA | -- |
| GO:0060999 | positive regulation of dendritic spine development | IEA | -- |
No data available for SIGNOR curated interactions for ZMYND8 Gene
Transcripts for ZMYND8 Gene
mRNA/cDNA for ZMYND8 Gene
- (54) REFSEQ mRNAs :
- (38) Additional mRNA sequences :
- (415) Selected AceView cDNA sequences:
- (21) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZMYND8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZMYND8
- genomics-online: gRNA clones - Search results for 180 available ZMYND8 gene related products
- Overview of 180 available ZMYND8 gene related products
-
Recommended
- Applied Biological Materials CRISPR for ZMYND8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZMYND8
- GenScript: Design CRISPR guide RNA sequences for ZMYND8
miRNA Products
- Search ViGene Biosciences for ZMYND8
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ZMYND8
- Browse OriGene Inhibitory RNA Products For ZMYND8
- genomics-online: shRNA clones - Search results for 180 available ZMYND8 gene related products
- Overview of 180 available ZMYND8 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for ZMYND8 gene
Clone Products
-
OriGene ORF clones in human for ZMYND8
- RG215969
- RC215969L2
- RC215969L1
- RC215969
- RG212828
- RC212828L2
- RC212828L1
- RC212828
- RG221394
- RC221394L2
- RC221394L1
- RC221394
- RC239998
- RC240044
- RC240001
- RC239958
- RC239745
- RC239786
- RC240029
- RC240013
- RC239976
- RC240067
- RC240017
- RC240048
- RC240032
- RC239921
- RC236112
- RC215969L2V
- RC215969L1V
- RC212828L2V
- RC212828L1V
- RC221394L2V
- RC221394L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for ZMYND8 in any vector
- NM_001281777.2
- XM_006723763.1
- NM_183047.3
- NM_001281780.2
- XM_005260364.2
- NM_001281783.2
- XM_005260366.2
- NM_012408.5
- XM_006723760.2
- NM_001281773.2
- XM_005260360.3
- NM_001281776.2
- XM_005260362.2
- NM_183048.3
- NM_001281779.2
- XM_011528753.1
- NM_001281782.2
- XM_006723766.1
- NM_001281769.1
- XM_011528749.1
- NM_001281772.2
- XM_011528750.1
- NM_001281775.2
- XM_006723762.2
- NM_001281778.2
- XM_011528752.1
- NM_001281781.2
- XM_011528754.1
- NM_001281784.2
- XM_011528755.1
- XM_005260356.3
- NM_001281771.2
- XM_005260358.2
- NM_001281774.2
- XM_011528751.1
- Sino Biological Human cDNA Clone for ZMYND8
- VectorBuilder custom plasmid, inducible vectors for ZMYND8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZMYND8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ZMYND8
- genomics-online: cdna clones - Search results for 180 available ZMYND8 gene related products
- Overview of 180 available ZMYND8 gene related products
-
Recommended
- orf clones - Search results for 180 available ZMYND8 gene related products
- Overview of 180 available ZMYND8 gene related products
-
Recommended
- Applied Biological Materials Clones for ZMYND8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZMYND8 Gene
This gene is overexpressed in Adrenal (17.7), Peripheral blood mononuclear cells (16.5), and Placenta (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZMYND8 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZMYND8 Gene:
ZMYND8SOURCE GeneReport for Unigene cluster for ZMYND8 Gene:
Hs.446240mRNA Expression by UniProt/SwissProt for ZMYND8 Gene:
Q9ULU4-PKCB1_HUMAN
Tissue specificity:
Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).
Evidence on tissue expression from TISSUES for ZMYND8 Gene
- Nervous system(4.9)
- Eye(4.3)
- Liver(4.3)
- Intestine(2.9)
- Lung(2.9)
- Skin(2.3)
Primer Products
-
OriGene qPCR primer pairs for ZMYND8
- genomics-online: primer clones - Search results for 180 available ZMYND8 gene related products
- Overview of 180 available ZMYND8 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMYND8 Gene
Orthologs for ZMYND8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZMYND8 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZMYND8 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZMYND8 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Zmynd8 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zmynd8 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZMYND8 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ZMYND8 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZMYND8 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ZMYND8 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zmynd8 33 |
|
||
| Str.16445 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.18946 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zmynd8 33 34 |
|
||
| prkcbp1l 34 |
|
OneToMany | |||
| wufb99d12 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG1815 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for ZMYND8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZMYND8 Gene
(5) SIMAP similar genes for ZMYND8 Gene using alignment to 13 proteins:
Variants for ZMYND8 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000010017 | -- | 47,237,962(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000038465 | -- | 47,329,016(-) | AT/ | genic_upstream_transcript_variant, intron_variant | |
| rs1000042682 | -- | 47,288,831(-) | G/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000063894 | -- | 47,228,988(-) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000076138 | -- | 47,285,127(-) | G/A | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2663936 | CNV | deletion | 23128226 |
| esv33497 | CNV | loss | 17666407 |
| esv3567997 | CNV | loss | 25503493 |
| esv3567999 | CNV | loss | 25503493 |
| esv3645968 | CNV | loss | 21293372 |
| esv990338 | CNV | deletion | 20482838 |
| nsv1061899 | CNV | loss | 25217958 |
| nsv1066814 | CNV | gain | 25217958 |
| nsv1066907 | CNV | gain | 25217958 |
| nsv1125728 | CNV | tandem duplication | 24896259 |
Residual Variation Intolerance Score:
0.946% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.09;
84.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZMYND8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZMYND8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND8 Gene
Disorders for ZMYND8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cutaneous t cell lymphoma |
|
|
Search ZMYND8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZMYND8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ZMYND8 Gene
Publications for ZMYND8 Gene
- Identification and characterization of PRKCBP1, a candidate RACK-like protein. (PMID: 11003709) Fossey SC … Bowden DW (Mammalian genome : official journal of the International Mammalian Genome Society 2000) 3 4 22 58
- ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. (PMID: 27477906) Li N … Lee MG (Molecular cell 2016) 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for ZMYND8 Gene
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Sources for ZMYND8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems