This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results i... See more...

Aliases for ZMYND15 Gene

Aliases for ZMYND15 Gene

  • Zinc Finger MYND-Type Containing 15 2 3 5
  • Zinc Finger MYND Domain-Containing Protein 15 3 4
  • DKFZp434N127 2
  • ZMYND15 5
  • SPGF14 3

External Ids for ZMYND15 Gene

Previous GeneCards Identifiers for ZMYND15 Gene

  • GC17P004594
  • GC17P004850
  • GC17P004849
  • GC17P004590
  • GC17P004644
  • GC17P004531

Summaries for ZMYND15 Gene

Entrez Gene Summary for ZMYND15 Gene

  • This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for ZMYND15 Gene

ZMYND15 (Zinc Finger MYND-Type Containing 15) is a Protein Coding gene. Diseases associated with ZMYND15 include Spermatogenic Failure 14 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. Gene Ontology (GO) annotations related to this gene include histone deacetylase binding. An important paralog of this gene is SMYD4.

UniProtKB/Swiss-Prot Summary for ZMYND15 Gene

  • Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZMYND15 Gene

Genomics for ZMYND15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZMYND15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZMYND15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZMYND15

Top Transcription factor binding sites by QIAGEN in the ZMYND15 gene promoter:
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for ZMYND15 Gene

Genomic Locations for ZMYND15 Gene
chr17:4,739,833-4,746,119
(GRCh38/hg38)
Size:
6,287 bases
Orientation:
Plus strand
chr17:4,643,319-4,649,411
(GRCh37/hg19)
Size:
6,093 bases
Orientation:
Plus strand

Genomic View for ZMYND15 Gene

Genes around ZMYND15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYND15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYND15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND15 Gene

Proteins for ZMYND15 Gene

  • Protein details for ZMYND15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H091-ZMY15_HUMAN
    Recommended name:
    Zinc finger MYND domain-containing protein 15
    Protein Accession:
    Q9H091
    Secondary Accessions:
    • B4DXY5
    • I3L296

    Protein attributes for ZMYND15 Gene

    Size:
    742 amino acids
    Molecular mass:
    81860 Da
    Quaternary structure:
    • Interacts with HDAC1, HDAC3, HDAC6 and, to a lesser extent, with HDAC7.

    Alternative splice isoforms for ZMYND15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYND15 Gene

Post-translational modifications for ZMYND15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMYND15 Gene

No data available for DME Specific Peptides for ZMYND15 Gene

Domains & Families for ZMYND15 Gene

Gene Families for ZMYND15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZMYND15 Gene

InterPro:
Blocks:
  • Zn-finger, MYND type
ProtoNet:

Suggested Antigen Peptide Sequences for ZMYND15 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60403, highly similar to Zinc finger MYND domain-containing protein 15 (B4DXY5_HUMAN)
  • Zinc finger MYND domain-containing protein 15 (ZMY15_HUMAN)
genes like me logo Genes that share domains with ZMYND15: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZMYND15 Gene

Function for ZMYND15 Gene

Molecular function for ZMYND15 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.

Phenotypes From GWAS Catalog for ZMYND15 Gene

Gene Ontology (GO) - Molecular Function for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042826 histone deacetylase binding IEA,IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYND15: view
genes like me logo Genes that share phenotypes with ZMYND15: view

Human Phenotype Ontology for ZMYND15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMYND15

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZMYND15 Gene

Localization for ZMYND15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYND15 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMYND15 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
plasma membrane 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZMYND15: view

Pathways & Interactions for ZMYND15 Gene

PathCards logo

SuperPathways for ZMYND15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0007286 spermatid development IEA,IBA 21873635
GO:0030154 cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZMYND15: view

No data available for Pathways by source and SIGNOR curated interactions for ZMYND15 Gene

Drugs & Compounds for ZMYND15 Gene

No Compound Related Data Available

Transcripts for ZMYND15 Gene

mRNA/cDNA for ZMYND15 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMYND15

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND15 Gene

No ASD Table

Relevant External Links for ZMYND15 Gene

GeneLoc Exon Structure for
ZMYND15

Expression for ZMYND15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZMYND15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ZMYND15 Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for ZMYND15 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (60.0) and Liver (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZMYND15 Gene



Protein tissue co-expression partners for ZMYND15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZMYND15

SOURCE GeneReport for Unigene cluster for ZMYND15 Gene:

Hs.47223

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMYND15 Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
Regions:
Pelvis:
  • ovary
  • testicle
genes like me logo Genes that share expression patterns with ZMYND15: view

No data available for mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for ZMYND15 Gene

Orthologs for ZMYND15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZMYND15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZMYND15 30 31
  • 98.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZMYND15 30 31
  • 87.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZMYND15 30 31
  • 86.36 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zmynd15 30 17 31
  • 83.9 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zmynd15 30
  • 83.83 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZMYND15 31
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZMYND15 31
  • 44 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G70150 30
  • 39.29 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0481000 30
  • 40.16 (n)
Species where no ortholog for ZMYND15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZMYND15 Gene

ENSEMBL:
Gene Tree for ZMYND15 (if available)
TreeFam:
Gene Tree for ZMYND15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZMYND15: view image

Paralogs for ZMYND15 Gene

Paralogs for ZMYND15 Gene

genes like me logo Genes that share paralogs with ZMYND15: view

Variants for ZMYND15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZMYND15 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
715430 Likely Benign: not provided 4,745,333(+) G/A MISSENSE_VARIANT
738160 Likely Benign: not provided 4,741,763(+) T/C SYNONYMOUS_VARIANT
777098 Benign: not provided 4,743,360(+) G/A MISSENSE_VARIANT
790174 Benign: not provided 4,740,923(+) A/G SYNONYMOUS_VARIANT
812589 Uncertain Significance: Male infertility; Spermatogenic failure 14 4,745,381(+) G/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ZMYND15 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZMYND15 Gene

Variant ID Type Subtype PubMed ID
nsv1952 CNV insertion 18451855
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897

Variation tolerance for ZMYND15 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMYND15 Gene

Human Gene Mutation Database (HGMD)
ZMYND15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMYND15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND15 Gene

Disorders for ZMYND15 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZMYND15 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZMY15_HUMAN
  • Spermatogenic failure 14 (SPGF14) [MIM:615842]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:24431330}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with ZMYND15: view

No data available for Genatlas for ZMYND15 Gene

Publications for ZMYND15 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia. (PMID: 24431330) Ayhan Ö … Tolun A (Journal of medical genetics 2014) 3 4
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. (PMID: 20675388) Yan W … Charo IF (The Journal of biological chemistry 2010) 3

Products for ZMYND15 Gene

Sources for ZMYND15 Gene