Aliases for ZMYND12 Gene

Aliases for ZMYND12 Gene

  • Zinc Finger MYND-Type Containing 12 2 3 5
  • Zinc Finger MYND Domain-Containing Protein 12 3 4
  • Zinc Finger, MYND Domain Containing 12 3
  • DKFZp434N2435 2
  • ZMYND12 5

External Ids for ZMYND12 Gene

Previous GeneCards Identifiers for ZMYND12 Gene

  • GC01M042359
  • GC01M042309
  • GC01M042565
  • GC01M042668
  • GC01M042896
  • GC01M041016

Summaries for ZMYND12 Gene

GeneCards Summary for ZMYND12 Gene

ZMYND12 (Zinc Finger MYND-Type Containing 12) is a Protein Coding gene. Diseases associated with ZMYND12 include Cone-Rod Dystrophy 18. An important paralog of this gene is PDCD2L.

Additional gene information for ZMYND12 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZMYND12 Gene

Genomics for ZMYND12 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZMYND12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J042454 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.2 228 3.9 HNRNPL CREB1 PRDM10 ZNF629 REST TFE3 ZNF692 POLR2A BACH1 LARP7 CCDC30 PPCS ZMYND12 lnc-PPCS-1 SZT2 PPIH SVBP P3H1 HYI FOXJ3
GH01J042461 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 14.5 -6.9 -6893 2.5 SP1 CREB1 PRDM10 ZNF629 RFX1 ZHX2 LARP7 PRDM1 ZNF143 ZIC2 CCDC30 HSALNG0003002 SZT2 ZMYND12 P3H1 PPIH MED8 ZNF691 PPCS
GH01J042419 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 24.7 +35.6 35566 7.4 PRDM10 ZNF629 ZNF692 ZIC2 POLR2A PATZ1 ZNF341 ZNF561 ZBTB44 RAD21 ZMYND12 SVBP PPIH CCDC30 PPCS RNU6-536P ENSG00000236180 CLDN19 YBX1 piR-30960
GH01J042430 Enhancer 0.8 Ensembl ENCODE 25.9 +25.0 25026 1.9 IKZF2 SP1 RELB FOXA2 KDM6A JUND IKZF1 HNF4A RXRA TBX21 MN308723 ZMYND12 PPCS ENSG00000236180 RNU6-536P CCDC30 P3H1 YBX1 lnc-PPCS-4 RIMKLA
GH01J042784 Promoter/Enhancer 0.8 FANTOM5 Ensembl 25.5 -328.9 -328934 1.2 RBFOX2 PKNOX1 ZBTB33 ENSG00000228452 TMEM269 TMEM269-DT SVBP ZMYND12 CFAP57 YBX1 lnc-SVBP-4 ENSG00000283580 ERMAP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZMYND12 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZMYND12

Top Transcription factor binding sites by QIAGEN in the ZMYND12 gene promoter:
  • CUTL1
  • Elk-1
  • En-1
  • HEN1
  • Pax-4a
  • RFX1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • YY1

Genomic Locations for ZMYND12 Gene

Genomic Locations for ZMYND12 Gene
chr1:42,430,329-42,456,267
(GRCh38/hg38)
Size:
25,939 bases
Orientation:
Minus strand
chr1:42,896,000-42,921,938
(GRCh37/hg19)
Size:
25,939 bases
Orientation:
Minus strand

Genomic View for ZMYND12 Gene

Genes around ZMYND12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYND12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYND12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND12 Gene

Proteins for ZMYND12 Gene

  • Protein details for ZMYND12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0C1-ZMY12_HUMAN
    Recommended name:
    Zinc finger MYND domain-containing protein 12
    Protein Accession:
    Q9H0C1
    Secondary Accessions:
    • Q5VUS6
    • Q8TC87
    • Q96M51

    Protein attributes for ZMYND12 Gene

    Size:
    365 amino acids
    Molecular mass:
    41818 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZMYND12 Gene

Post-translational modifications for ZMYND12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMYND12 Gene

No data available for DME Specific Peptides for ZMYND12 Gene

Domains & Families for ZMYND12 Gene

Gene Families for ZMYND12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZMYND12 Gene

InterPro:
Blocks:
  • Zn-finger, MYND type
ProtoNet:

Suggested Antigen Peptide Sequences for ZMYND12 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger MYND domain-containing protein 12 (ZMY12_HUMAN)
genes like me logo Genes that share domains with ZMYND12: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZMYND12 Gene

Function for ZMYND12 Gene

Phenotypes From GWAS Catalog for ZMYND12 Gene

Gene Ontology (GO) - Molecular Function for ZMYND12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYND12: view
genes like me logo Genes that share phenotypes with ZMYND12: view

Animal Model Products

CRISPR Products

miRNA for ZMYND12 Gene

miRTarBase miRNAs that target ZMYND12

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMYND12

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMYND12 Gene

Localization for ZMYND12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMYND12 gene
Compartment Confidence
cytosol 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZMYND12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with ZMYND12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ZMYND12 Gene

Pathways & Interactions for ZMYND12 Gene

PathCards logo

SuperPathways for ZMYND12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYND12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZMYND12 Gene

Drugs & Compounds for ZMYND12 Gene

No Compound Related Data Available

Transcripts for ZMYND12 Gene

mRNA/cDNA for ZMYND12 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMYND12

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for ZMYND12 Gene

GeneLoc Exon Structure for
ZMYND12

Expression for ZMYND12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZMYND12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ZMYND12 Gene

This gene is overexpressed in Testis (x11.1).

Protein differential expression in normal tissues from HIPED for ZMYND12 Gene

This gene is overexpressed in Plasma (57.9) and Ovary (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZMYND12 Gene



Protein tissue co-expression partners for ZMYND12 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZMYND12

SOURCE GeneReport for Unigene cluster for ZMYND12 Gene:

Hs.294009
genes like me logo Genes that share expression patterns with ZMYND12: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMYND12 Gene

Orthologs for ZMYND12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZMYND12 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZMYND12 30 31
  • 99.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZMYND12 30 31
  • 88.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZMYND12 30 31
  • 87.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zmynd12 30
  • 84.16 (n)
Mouse
(Mus musculus)
Mammalia Zmynd12 30 17 31
  • 83.89 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZMYND12 31
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZMYND12 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZMYND12 30
  • 60.54 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zmynd12 30
  • 61.43 (n)
Str.3332 30
Zebrafish
(Danio rerio)
Actinopterygii zymnd12 30 31
  • 51.5 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3655 31
  • 37 (a)
OneToOne
Species where no ortholog for ZMYND12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZMYND12 Gene

ENSEMBL:
Gene Tree for ZMYND12 (if available)
TreeFam:
Gene Tree for ZMYND12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZMYND12: view image

Paralogs for ZMYND12 Gene

Paralogs for ZMYND12 Gene

genes like me logo Genes that share paralogs with ZMYND12: view

Variants for ZMYND12 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZMYND12 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1034268 - p.Phe316Leu

Additional dbSNP identifiers (rs#s) for ZMYND12 Gene

Variation tolerance for ZMYND12 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMYND12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMYND12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZMYND12 Gene

Disorders for ZMYND12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMYND12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cone-rod dystrophy 18
  • cord18
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZMYND12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMYND12 Gene

Publications for ZMYND12 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZMYND12 Gene

Sources for ZMYND12 Gene