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Aliases for ZMYM4 Gene

Aliases for ZMYM4 Gene

  • Zinc Finger MYM-Type Containing 4 2 3 5
  • Zinc Finger Protein 262 2 3 4
  • ZNF262 3 4
  • Zinc Finger MYM-Type Protein 4 3
  • Cell Death Inhibiting RNA 3
  • Zinc Finger, MYM-Type 4 3
  • ZNF198L3 3
  • KIAA0425 4
  • CDIR 3
  • MYM 3

External Ids for ZMYM4 Gene

Previous HGNC Symbols for ZMYM4 Gene

  • ZNF262

Previous GeneCards Identifiers for ZMYM4 Gene

  • GC01P035404
  • GC01P035507
  • GC01P035734
  • GC01P033853

Summaries for ZMYM4 Gene

GeneCards Summary for ZMYM4 Gene

ZMYM4 (Zinc Finger MYM-Type Containing 4) is a Protein Coding gene. An important paralog of this gene is ZMYM6.

UniProtKB/Swiss-Prot for ZMYM4 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization.

Additional gene information for ZMYM4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYM4 Gene

Genomics for ZMYM4 Gene

GeneHancer (GH) Regulatory Elements for ZMYM4 Gene

Promoters and enhancers for ZMYM4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J035267 Promoter/Enhancer 1.5 Ensembl ENCODE 660.9 +0.2 231 2.8 HDGF PKNOX1 ARNT ZFP64 SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZMYM4 SFPQ ZMYM6 LOC653160 ZMYM1 ENSG00000201542 ENSG00000201868 ENSG00000230163 TMEM35B TRAPPC3
GH01J036154 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 76.1 +888.0 887953 4.5 PKNOX1 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 ZNF143 ZNF548 MAP7D1 TRAPPC3 SFPQ AGO3 ZMYM4 RPL5P4 THRAP3 COL8A2 EVA1B AGO4
GH01J035882 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 37.3 +617.0 616957 6.2 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 ZNF143 AGO1 AGO3 ZMYM4 SFPQ LOC653160 ZMYM6 ZMYM1 TEKT2 LOC100128093 ADPRHL2
GH01J035553 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 32.7 +288.2 288152 6 MLX FEZF1 DMAP1 YBX1 YY1 ZNF213 ZNF143 SP3 NFYC ZFP41 KIAA0319L NCDN ZMYM4 SFPQ ZMYM1 ZMYM6 AGO3 LOC100419802 ENSG00000232335 RPL12P45
GH01J036266 Enhancer 0.9 dbSUPER 85.6 +997.9 997926 0.8 ZNF493 ZFP64 MZF1 ZEB1 ZNF121 ZNF23 ZNF213 ZFP91 KLF7 ZNF654 ZMYM4 AGO3 RPL5P4 THRAP3 EVA1B COL8A2 LOC105378647 TRAPPC3 AGO4 UBE2V2P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZMYM4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZMYM4 gene promoter:

Genomic Locations for ZMYM4 Gene

Genomic Locations for ZMYM4 Gene
153,345 bases
Plus strand

Genomic View for ZMYM4 Gene

Genes around ZMYM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYM4 Gene

Proteins for ZMYM4 Gene

  • Protein details for ZMYM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger MYM-type protein 4
    Protein Accession:
    Secondary Accessions:
    • A0JP19
    • A0JP20
    • O43308
    • Q5T5E1
    • Q5T5E2
    • Q7L3Q4

    Protein attributes for ZMYM4 Gene

    1548 amino acids
    Molecular mass:
    172788 Da
    Quaternary structure:
    No Data Available
    • The 3-UTR region of the mRNA encoding this protein contains a motif called CDIR (for cell death inhibiting RNA) that binds HNRPD/AUF1 and HSPB1/HSP27. It is able to inhibit interferon-gamma induced apoptosis.
    • Sequence=CAI22686.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22687.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMYM4 Gene


neXtProt entry for ZMYM4 Gene

Post-translational modifications for ZMYM4 Gene

  • Ubiquitination at isoforms=2, 3, 41479, isoforms=2, 3, 41341, isoforms=2, 3, 41127, and isoforms=2, 4140
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZMYM4 Gene

Domains & Families for ZMYM4 Gene

Gene Families for ZMYM4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZMYM4 Gene

Suggested Antigen Peptide Sequences for ZMYM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZMYM4: view

No data available for UniProtKB/Swiss-Prot for ZMYM4 Gene

Function for ZMYM4 Gene

Molecular function for ZMYM4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization.

Phenotypes From GWAS Catalog for ZMYM4 Gene

Gene Ontology (GO) - Molecular Function for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding TAS 10486218
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYM4: view
genes like me logo Genes that share phenotypes with ZMYM4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMYM4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMYM4 Gene

Localization for ZMYM4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMYM4 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZMYM4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZMYM4 Gene

Pathways & Interactions for ZMYM4 Gene

SuperPathways for ZMYM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007275 multicellular organism development TAS 10486218
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with ZMYM4: view

No data available for Pathways by source and SIGNOR curated interactions for ZMYM4 Gene

Drugs & Compounds for ZMYM4 Gene

No Compound Related Data Available

Transcripts for ZMYM4 Gene

Unigene Clusters for ZMYM4 Gene

Zinc finger, MYM-type 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMYM4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP5: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31
SP1: - -

Relevant External Links for ZMYM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZMYM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMYM4 Gene

Protein differential expression in normal tissues from HIPED for ZMYM4 Gene

This gene is overexpressed in Cerebrospinal fluid (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZMYM4 Gene

Protein tissue co-expression partners for ZMYM4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZMYM4 Gene:


SOURCE GeneReport for Unigene cluster for ZMYM4 Gene:


mRNA Expression by UniProt/SwissProt for ZMYM4 Gene:

Tissue specificity: Expressed at higher level in heart, skeletal muscle, kidney and liver.

Evidence on tissue expression from TISSUES for ZMYM4 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZMYM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMYM4 Gene

Orthologs for ZMYM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZMYM4 34 33
  • 99.83 (n)
(Bos Taurus)
Mammalia ZMYM4 34 33
  • 95.24 (n)
(Canis familiaris)
Mammalia ZMYM4 34 33
  • 95.08 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
(Mus musculus)
Mammalia Zmym4 16 34 33
  • 91.76 (n)
(Rattus norvegicus)
Mammalia Zmym4 33
  • 90.99 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 26 (a)
(Gallus gallus)
Aves -- 34
  • 84 (a)
ZMYM4 33
  • 80.2 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zmym4 33
  • 70.73 (n)
(Danio rerio)
Actinopterygii zmym4 34 33
  • 56.08 (n)
si:ch211-266o15.1 34
  • 41 (a)
si:ch211-173p18.3 34
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta woc 34
  • 23 (a)
Species where no ortholog for ZMYM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYM4 Gene

Gene Tree for ZMYM4 (if available)
Gene Tree for ZMYM4 (if available)
Evolutionary constrained regions (ECRs) for ZMYM4: view image

Paralogs for ZMYM4 Gene

Paralogs for ZMYM4 Gene

(4) SIMAP similar genes for ZMYM4 Gene using alignment to 2 proteins:

  • H7C1I7_HUMAN Pseudogenes for ZMYM4 Gene

genes like me logo Genes that share paralogs with ZMYM4: view

Variants for ZMYM4 Gene

Sequence variations from dbSNP and Humsavar for ZMYM4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs191217255 A colorectal cancer sample 35,415,633(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000000642 -- 35,269,374(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000003586 -- 35,417,252(+) AAAGAAAGAAA/AAAGAAA genic_downstream_transcript_variant, intron_variant
rs1000030174 -- 35,388,550(+) T/C intron_variant
rs1000032644 -- 35,282,589(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYM4 Gene

Variant ID Type Subtype PubMed ID
esv32554 CNV loss 17666407
esv3585718 CNV loss 21293372
esv3585719 CNV loss 21293372
esv8737 CNV gain 19470904
nsv1012556 CNV gain 25217958
nsv1133838 CNV deletion 24896259
nsv508149 CNV deletion 20534489
nsv818134 CNV loss 17921354
nsv822287 CNV gain 20364138
nsv822298 CNV loss 20364138
nsv945878 CNV duplication 23825009
nsv945879 CNV duplication 23825009

Variation tolerance for ZMYM4 Gene

Residual Variation Intolerance Score: 6.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMYM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYM4 Gene

Disorders for ZMYM4 Gene

Additional Disease Information for ZMYM4

No disorders were found for ZMYM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZMYM4 Gene

Publications for ZMYM4 Gene

  1. Assignment of ZNF262 to human chromosome band 1p34-->p32 by in situ hybridization. (PMID: 10449923) Sohal J … Cross NC (Cytogenetics and cell genetics 1999) 2 3 4 58
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4 58
  3. Cell death inhibiting RNA (CDIR) derived from a 3'-untranslated region binds AUF1 and heat shock protein 27. (PMID: 12356764) Shchors K … Deiss LP (The Journal of biological chemistry 2002) 3 4 58
  4. Cloning and mapping of members of the MYM family. (PMID: 10486218) Smedley D … Shipley J (Genomics 1999) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 58

Products for ZMYM4 Gene

Sources for ZMYM4 Gene

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