The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants enco... See more...

Aliases for ZMYM2 Gene

Aliases for ZMYM2 Gene

  • Zinc Finger MYM-Type Containing 2 2 3 5
  • Zinc Finger Protein 198 2 3 4
  • Fused In Myeloproliferative Disorders Protein 3 4
  • Zinc Finger MYM-Type Protein 2 3 4
  • ZNF198 3 4
  • RAMP 3 4
  • FIM 3 4
  • Rearranged In Atypical Myeloproliferative Disorder Protein 4
  • Rearranged In An Atypical Myeloproliferative Disorder 3
  • Zinc Finger, MYM-Type 2 3
  • SCLL 3
  • MYM 3

External Ids for ZMYM2 Gene

Previous HGNC Symbols for ZMYM2 Gene

  • ZNF198

Previous GeneCards Identifiers for ZMYM2 Gene

  • GC13P019431
  • GC13P020532
  • GC13P001338

Summaries for ZMYM2 Gene

Entrez Gene Summary for ZMYM2 Gene

  • The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ZMYM2 Gene

ZMYM2 (Zinc Finger MYM-Type Containing 2) is a Protein Coding gene. Diseases associated with ZMYM2 include Lymphoblastic Lymphoma and 8P11 Myeloproliferative Syndrome. Among its related pathways are HIV Life Cycle and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include ubiquitin conjugating enzyme binding. An important paralog of this gene is ZMYM3.

UniProtKB/Swiss-Prot Summary for ZMYM2 Gene

Gene Wiki entry for ZMYM2 Gene

Additional gene information for ZMYM2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZMYM2 Gene

Genomics for ZMYM2 Gene

GeneHancer (GH) Regulatory Elements for ZMYM2 Gene

Promoters and enhancers for ZMYM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZMYM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZMYM2 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • HOXA5
  • MAZR
  • Nkx6-1
  • Pax-5
  • POU2F1
  • POU2F1a
  • POU3F1
  • RREB-1

Genomic Locations for ZMYM2 Gene

Genomic Locations for ZMYM2 Gene
chr13:19,957,432-20,091,845
(GRCh38/hg38)
Size:
134,414 bases
Orientation:
Plus strand
chr13:20,532,810-20,665,968
(GRCh37/hg19)
Size:
133,159 bases
Orientation:
Plus strand

Genomic View for ZMYM2 Gene

Genes around ZMYM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYM2 Gene

Proteins for ZMYM2 Gene

  • Protein details for ZMYM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBW7-ZMYM2_HUMAN
    Recommended name:
    Zinc finger MYM-type protein 2
    Protein Accession:
    Q9UBW7
    Secondary Accessions:
    • A6NDG0
    • A6NI02
    • O43212
    • O43434
    • O60898
    • Q5W0Q4
    • Q5W0T3
    • Q63HP0
    • Q8NE39
    • Q9H0V5
    • Q9H538
    • Q9UEU2

    Protein attributes for ZMYM2 Gene

    Size:
    1377 amino acids
    Molecular mass:
    154911 Da
    Quaternary structure:
    • May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.
    SequenceCaution:
    • Sequence=AAB88464.1; Type=Frameshift; Positions=330, 966, 1009, 1017; Evidence={ECO:0000305}; Sequence=AAC23591.1; Type=Frameshift; Positions=330; Evidence={ECO:0000305}; Sequence=CAA73875.1; Type=Frameshift; Positions=388, 403, 406, 409, 418; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMYM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYM2 Gene

Post-translational modifications for ZMYM2 Gene

  • Ubiquitination at Lys88, Lys1107, Lys1280, and Lys1313
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZMYM2 Gene

Domains & Families for ZMYM2 Gene

Gene Families for ZMYM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ZMYM2 Gene

Suggested Antigen Peptide Sequences for ZMYM2 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, MYM-type 2 (Q5W0Q3_HUMAN)
  • Zinc finger protein 198 (ZMYM2_HUMAN)
genes like me logo Genes that share domains with ZMYM2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZMYM2 Gene

Function for ZMYM2 Gene

Molecular function for ZMYM2 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Phenotypes From GWAS Catalog for ZMYM2 Gene

Gene Ontology (GO) - Molecular Function for ZMYM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0005515 protein binding IPI 26275350
GO:0008270 zinc ion binding NAS 9576949
GO:0031624 ubiquitin conjugating enzyme binding IPI 12776193
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYM2: view
genes like me logo Genes that share phenotypes with ZMYM2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMYM2 Gene

Localization for ZMYM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYM2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMYM2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZMYM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005829 cytosol TAS --
GO:0016605 PML body IDA 17027752
genes like me logo Genes that share ontologies with ZMYM2: view

Pathways & Interactions for ZMYM2 Gene

genes like me logo Genes that share pathways with ZMYM2: view

Gene Ontology (GO) - Biological Process for ZMYM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0008150 biological_process ND --
GO:0022604 regulation of cell morphogenesis IBA 21873635
genes like me logo Genes that share ontologies with ZMYM2: view

No data available for SIGNOR curated interactions for ZMYM2 Gene

Drugs & Compounds for ZMYM2 Gene

(2) Drugs for ZMYM2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZMYM2: view

Transcripts for ZMYM2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - - -
SP14: -

ExUns: 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ZMYM2 Gene

GeneLoc Exon Structure for
ZMYM2
ECgene alternative splicing isoforms for
ZMYM2

Expression for ZMYM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMYM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZMYM2 Gene

This gene is overexpressed in Lung (23.0), Retina (6.4), CD8 Tcells (6.3), and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZMYM2 Gene



Protein tissue co-expression partners for ZMYM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZMYM2 Gene:

ZMYM2

SOURCE GeneReport for Unigene cluster for ZMYM2 Gene:

Hs.507433

Evidence on tissue expression from TISSUES for ZMYM2 Gene

  • Nervous system(4.8)
  • Bone marrow(2.5)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with ZMYM2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMYM2 Gene

Orthologs for ZMYM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYM2 33 32
  • 99.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZMYM2 33 32
  • 95.47 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZMYM2 33
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmym2 17 33 32
  • 92.68 (n)
oppossum
(Monodelphis domestica)
Mammalia ZMYM2 33
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZMYM2 33
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zmym2 32
  • 89.91 (n)
chicken
(Gallus gallus)
Aves -- 33
  • 86 (a)
OneToMany
ZMYM2 32
  • 82.83 (n)
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.31166 32
zebrafish
(Danio rerio)
Actinopterygii zmym2 33 32
  • 60.68 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta woc 33
  • 20 (a)
OneToMany
Species where no ortholog for ZMYM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYM2 Gene

ENSEMBL:
Gene Tree for ZMYM2 (if available)
TreeFam:
Gene Tree for ZMYM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZMYM2: view image

Paralogs for ZMYM2 Gene

(2) SIMAP similar genes for ZMYM2 Gene using alignment to 2 proteins:

  • ZMYM2_HUMAN
  • B4DZH0_HUMAN
genes like me logo Genes that share paralogs with ZMYM2: view

Variants for ZMYM2 Gene

Sequence variations from dbSNP and Humsavar for ZMYM2 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1566443543 uncertain-significance, not provided 20,067,332(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000039908 -- 20,041,807(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000051809 -- 20,077,332(+) TTTTTTT/TTTTTT genic_downstream_transcript_variant, intron_variant
rs1000054278 -- 19,957,642(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000076850 -- 19,985,983(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYM2 Gene

Variant ID Type Subtype PubMed ID
dgv1611n100 CNV gain 25217958
esv1929634 CNV deletion 18987734
esv24803 CNV loss 19812545
esv2560456 CNV deletion 19546169
esv2674061 CNV deletion 23128226
esv2761244 CNV gain 21179565
esv3383707 CNV insertion 20981092
esv3580561 CNV loss 25503493
esv3631415 CNV loss 21293372
esv3631417 CNV loss 21293372
esv3631418 CNV gain 21293372
esv3892297 CNV gain 25118596
nsv1037299 CNV gain 25217958
nsv1046946 CNV gain 25217958
nsv1054226 CNV gain 25217958
nsv1078303 OTHER inversion 25765185
nsv1131058 CNV deletion 24896259
nsv1134285 CNV deletion 24896259
nsv1140246 OTHER inversion 24896259
nsv1142725 CNV deletion 24896259
nsv1151909 OTHER inversion 26484159
nsv455828 CNV loss 19166990
nsv523961 CNV loss 19592680
nsv561215 CNV gain 21841781
nsv561216 CNV loss 21841781
nsv832557 CNV gain 17160897
nsv974234 CNV duplication 23825009

Variation tolerance for ZMYM2 Gene

Residual Variation Intolerance Score: 4.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMYM2 Gene

Human Gene Mutation Database (HGMD)
ZMYM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMYM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYM2 Gene

Disorders for ZMYM2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZMYM2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
8p11 myeloproliferative syndrome
  • chromosome 8p11 myeloproliferative syndrome
myasthenic syndrome, congenital, 6, presynaptic
  • cms6
lymphoma
  • lymphoid cancer
myeloproliferative neoplasm
  • campomelic dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search ZMYM2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ZMYM2_HUMAN
  • Note=A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. {ECO:0000269 PubMed:9716603}.

Additional Disease Information for ZMYM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZMYM2: view

No data available for Genatlas for ZMYM2 Gene

Publications for ZMYM2 Gene

  1. The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. (PMID: 9499416) Smedley D … Shipley J (Human molecular genetics 1998) 2 3 4 23 56
  2. FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. (PMID: 9425908) Xiao S … Fletcher JA (Nature genetics 1998) 2 3 4 23 56
  3. The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome. (PMID: 9889006) Kulkarni S … Cross NC (Genomics 1999) 3 4 23 56
  4. Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome. (PMID: 9716603) Reiter A … Cross NC (Blood 1998) 3 4 23 56
  5. Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13). (PMID: 9576949) Popovici C … Pébusque MJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 23 56

Products for ZMYM2 Gene

Sources for ZMYM2 Gene