This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 200... See more...

Aliases for ZMPSTE24 Gene

Aliases for ZMPSTE24 Gene

  • Zinc Metallopeptidase STE24 2 3 5
  • CAAX Prenyl Protease 1 Homolog 2 3 4
  • FACE-1 2 3 4
  • STE24 2 3 4
  • Farnesylated Proteins-Converting Enzyme 1 3 4
  • Prenyl Protein-Specific Endoprotease 1 3 4
  • Zinc Metalloproteinase Ste24 Homolog 3 4
  • Ste24p 2 3
  • FACE1 3 4
  • HGPS 2 3
  • PRO1 2 3
  • Zinc Metallopeptidase STE24 Homolog (S. Cerevisiae) 2
  • Zinc Metalloproteinase (STE24 Homolog, Yeast) 2
  • Zinc Metallopeptidase (STE24 Homolog, Yeast) 2
  • Hutchinson-Gilford Progeria Syndrome 2
  • Zinc Metallopeptidase STE24 Homolog 3
  • EC 3.4.24.84 4
  • ZMPSTE24 5

External Ids for ZMPSTE24 Gene

Previous GeneCards Identifiers for ZMPSTE24 Gene

  • GC01P040758
  • GC01P039727
  • GC01P040187
  • GC01P040137
  • GC01P040392
  • GC01P040496
  • GC01P040723
  • GC01P038842

Summaries for ZMPSTE24 Gene

Entrez Gene Summary for ZMPSTE24 Gene

  • This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZMPSTE24 Gene

ZMPSTE24 (Zinc Metallopeptidase STE24) is a Protein Coding gene. Diseases associated with ZMPSTE24 include Mandibuloacral Dysplasia With Type B Lipodystrophy and Restrictive Dermopathy, Lethal. Among its related pathways are Terpenoid backbone biosynthesis and Adipogenesis. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metalloexopeptidase activity.

UniProtKB/Swiss-Prot Summary for ZMPSTE24 Gene

  • Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.

Additional gene information for ZMPSTE24 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZMPSTE24 Gene

Genomics for ZMPSTE24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZMPSTE24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZMPSTE24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZMPSTE24

Top Transcription factor binding sites by QIAGEN in the ZMPSTE24 gene promoter:
  • CUTL1
  • Nkx6-1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2C

Genomic Locations for ZMPSTE24 Gene

Genomic Locations for ZMPSTE24 Gene
chr1:40,258,078-40,294,180
(GRCh38/hg38)
Size:
36,103 bases
Orientation:
Plus strand
chr1:40,723,733-40,759,856
(GRCh37/hg19)
Size:
36,124 bases
Orientation:
Plus strand

Genomic View for ZMPSTE24 Gene

Genes around ZMPSTE24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMPSTE24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMPSTE24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMPSTE24 Gene

Proteins for ZMPSTE24 Gene

  • Protein details for ZMPSTE24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75844-FACE1_HUMAN
    Recommended name:
    CAAX prenyl protease 1 homolog
    Protein Accession:
    O75844
    Secondary Accessions:
    • B3KQI7
    • D3DPU7
    • Q8NDZ8
    • Q9UBQ2

    Protein attributes for ZMPSTE24 Gene

    Size:
    475 amino acids
    Molecular mass:
    54813 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZMPSTE24 Gene

neXtProt entry for ZMPSTE24 Gene

Post-translational modifications for ZMPSTE24 Gene

  • Ubiquitination at Lys46, Lys66, Lys251, Lys314, and Lys437
  • Modification sites at PhosphoSitePlus

Other Protein References for ZMPSTE24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZMPSTE24 Gene

Domains & Families for ZMPSTE24 Gene

Gene Families for ZMPSTE24 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for ZMPSTE24 Gene

Suggested Antigen Peptide Sequences for ZMPSTE24 Gene

GenScript: Design optimal peptide antigens:
  • Zinc metalloproteinase Ste24 homolog (FACE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75844

UniProtKB/Swiss-Prot:

FACE1_HUMAN :
  • The metalloprotease domain is constituted by the two C-terminal nuclear regions.
  • Belongs to the peptidase M48A family.
Domain:
  • The metalloprotease domain is constituted by the two C-terminal nuclear regions.
Family:
  • Belongs to the peptidase M48A family.
genes like me logo Genes that share domains with ZMPSTE24: view

Function for ZMPSTE24 Gene

Molecular function for ZMPSTE24 Gene

UniProtKB/Swiss-Prot Function:
Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.; EC=3.4.24.84;.
GENATLAS Biochemistry:
farnesylated protein converting enzyme 1,gluxinein subfamily of metalloproteinase ubiquitously expressed,CAAX prenyl protease S cerevisiae Ste24p homolog,catalyzing the first step of the proteolytic processing of farnesylated proteins,including Ras,also involved in NH2 terminal processing

Enzyme Numbers (IUBMB) for ZMPSTE24 Gene

Phenotypes From GWAS Catalog for ZMPSTE24 Gene

Gene Ontology (GO) - Molecular Function for ZMPSTE24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
GO:0004175 endopeptidase activity IEA --
GO:0004222 metalloendopeptidase activity IBA 21873635
GO:0005515 protein binding IPI 23539603
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with ZMPSTE24: view
genes like me logo Genes that share phenotypes with ZMPSTE24: view

Human Phenotype Ontology for ZMPSTE24 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZMPSTE24 Gene

MGI Knock Outs for ZMPSTE24:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMPSTE24

No data available for Transcription Factor Targets and HOMER Transcription for ZMPSTE24 Gene

Localization for ZMPSTE24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMPSTE24 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein. Nucleus inner membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMPSTE24 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 4
endoplasmic reticulum 4
cytosol 3
cytoskeleton 2
mitochondrion 2
golgi apparatus 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZMPSTE24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with ZMPSTE24: view

Pathways & Interactions for ZMPSTE24 Gene

PathCards logo

SuperPathways for ZMPSTE24 Gene

genes like me logo Genes that share pathways with ZMPSTE24: view

Pathways by source for ZMPSTE24 Gene

1 BioSystems pathway for ZMPSTE24 Gene
1 KEGG pathway for ZMPSTE24 Gene

Gene Ontology (GO) - Biological Process for ZMPSTE24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0001942 hair follicle development IEA --
GO:0003007 heart morphogenesis IEA --
GO:0003229 ventricular cardiac muscle tissue development IEA --
GO:0003231 cardiac ventricle development IEA --
genes like me logo Genes that share ontologies with ZMPSTE24: view

No data available for SIGNOR curated interactions for ZMPSTE24 Gene

Drugs & Compounds for ZMPSTE24 Gene

(5) Drugs for ZMPSTE24 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for ZMPSTE24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZMPSTE24: view

Transcripts for ZMPSTE24 Gene

mRNA/cDNA for ZMPSTE24 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMPSTE24

Alternative Splicing Database (ASD) splice patterns (SP) for ZMPSTE24 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5: -

Relevant External Links for ZMPSTE24 Gene

GeneLoc Exon Structure for
ZMPSTE24

Expression for ZMPSTE24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZMPSTE24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZMPSTE24 Gene

This gene is overexpressed in Nasal epithelium (56.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZMPSTE24 Gene



Protein tissue co-expression partners for ZMPSTE24 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZMPSTE24

SOURCE GeneReport for Unigene cluster for ZMPSTE24 Gene:

Hs.132642

mRNA Expression by UniProt/SwissProt for ZMPSTE24 Gene:

O75844-FACE1_HUMAN
Tissue specificity: Widely expressed. High levels in kidney, prostate, testis and ovary.

Evidence on tissue expression from TISSUES for ZMPSTE24 Gene

  • Nervous system(4.8)
  • Kidney(3.1)
  • Heart(3.1)
  • Liver(3)
  • Muscle(3)
  • Skin(2.7)
  • Blood(2.7)
  • Lung(2.6)
  • Spleen(2.6)
  • Intestine(2.5)
  • Eye(2.3)
  • Thyroid gland(2.1)
  • Adrenal gland(2.1)
  • Stomach(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMPSTE24 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • pharynx
  • skull
  • tooth
  • vocal cord
Thorax:
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • adrenal gland
  • duodenum
  • intestine
  • kidney
  • liver
  • pancreas
  • small intestine
Pelvis:
  • ovary
  • pelvis
  • penis
  • placenta
  • ureter
  • urethra
  • urinary bladder
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with ZMPSTE24: view

No data available for mRNA differential expression in normal tissues for ZMPSTE24 Gene

Orthologs for ZMPSTE24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZMPSTE24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZMPSTE24 30 31
  • 99.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZMPSTE24 30 31
  • 94.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZMPSTE24 30 31
  • 94.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zmpste24 30
  • 90.15 (n)
Mouse
(Mus musculus)
Mammalia Zmpste24 30 17 31
  • 90.08 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZMPSTE24 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZMPSTE24 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZMPSTE24 30 31
  • 80.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-5401 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zmpste24 30
  • 75.84 (n)
Str.6615 30
Zebrafish
(Danio rerio)
Actinopterygii zmpste24 30 31
  • 69.74 (n)
OneToOne
wufi45a02 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004470 30
  • 55.86 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta ste24a 30 31
  • 54.55 (n)
OneToMany
CG9000 32
  • 49 (a)
ste24b 31
  • 32 (a)
OneToMany
ste24c 31
  • 30 (a)
OneToMany
CG30461 32
  • 30 (a)
CG9001 32
  • 30 (a)
CG9002 32
  • 30 (a)
CG7573 31
  • 21 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea fce-1 30 31
  • 51.71 (n)
OneToOne
C04F12.10 32
  • 41 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE24 30 31 33
  • 48.94 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10846g 30
  • 47.01 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ATSTE24 30
  • 53.68 (n)
Soybean
(Glycine max)
eudicotyledons Gma.17905 30
Rice
(Oryza sativa)
Liliopsida Os02g0680400 30
  • 54.15 (n)
Os.13475 30
Barley
(Hordeum vulgare)
Liliopsida Hv.11857 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3H1.05 30
  • 50.24 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU03637 30
  • 50.16 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.646 30
Species where no ortholog for ZMPSTE24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZMPSTE24 Gene

ENSEMBL:
Gene Tree for ZMPSTE24 (if available)
TreeFam:
Gene Tree for ZMPSTE24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZMPSTE24: view image

Paralogs for ZMPSTE24 Gene

No data available for Paralogs for ZMPSTE24 Gene

Variants for ZMPSTE24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZMPSTE24 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
667032 Uncertain Significance: not specified 40,285,924(+) G/A SPLICE_ACCEPTOR_VARIANT
707844 Likely Benign: not provided 40,258,290(+) C/T SYNONYMOUS_VARIANT
721469 Likely Benign: not provided 40,260,958(+) A/G SYNONYMOUS_VARIANT
724164 Benign: not provided 40,270,035(+) T/C SYNONYMOUS_VARIANT
725823 Conflicting Interpretations: Lethal tight skin contracture syndrome; Mandibuloacral dysplasia with type B lipodystrophy; not provided 40,290,959(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZMPSTE24 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZMPSTE24 Gene

Variant ID Type Subtype PubMed ID
esv2658928 CNV deletion 23128226
esv3561094 CNV deletion 23714750
esv3561105 CNV deletion 23714750
nsv1126993 CNV deletion 24896259
nsv829660 CNV gain+loss 17160897

Variation tolerance for ZMPSTE24 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMPSTE24 Gene

Human Gene Mutation Database (HGMD)
ZMPSTE24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMPSTE24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMPSTE24 Gene

Disorders for ZMPSTE24 Gene

MalaCards: The human disease database

(26) MalaCards diseases for ZMPSTE24 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

UniProtKB/Swiss-Prot

FACE1_HUMAN
  • Mandibuloacral dysplasia with type B lipodystrophy (MADB) [MIM:608612]: A disorder characterized by mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, joint contractures, and generalized lipodystrophy with loss of subcutaneous fat from the extremities, face, neck and trunk. {ECO:0000269 PubMed:12913070, ECO:0000269 PubMed:17152860, ECO:0000269 PubMed:18435794, ECO:0000269 PubMed:20814950}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Lethal tight skin contracture syndrome (LTSCS) [MIM:275210]: Rare disorder mainly characterized by intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and epidermal hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia, multiple joint contractures and an early neonatal lethal course. Liveborn children usually die within the first week of life. The overall prevalence of consanguineous cases suggested an autosomal recessive inheritance. {ECO:0000269 PubMed:15317753}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ZMPSTE24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZMPSTE24: view

No data available for Genatlas for ZMPSTE24 Gene

Publications for ZMPSTE24 Gene

  1. Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins. (PMID: 10373325) Freije JM … López-Otín C (Genomics 1999) 2 3 4 23
  2. Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing. (PMID: 9700155) Tam A … Michaelis S (The Journal of cell biology 1998) 2 3 4 23
  3. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PMID: 19841875) Fontaine-Bisson B … Morange PE (Journal of molecular medicine (Berlin, Germany) 2010) 3 23 41
  4. Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings. (PMID: 18435794) Miyoshi Y … Ozono K (Clinical genetics 2008) 3 4 23
  5. Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency. (PMID: 17152860) Agarwal AK … Garg A (Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2006) 3 4 23

Products for ZMPSTE24 Gene

  • Signalway Proteins for ZMPSTE24

Sources for ZMPSTE24 Gene