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Aliases for ZMAT5 Gene

Aliases for ZMAT5 Gene

  • Zinc Finger Matrin-Type 5 2 3 5
  • Zinc Finger CCCH-Type Containing 19 2 2 3
  • U11/U12 Small Nuclear Ribonucleoprotein 20 KDa Protein 3 4
  • U11/U12 SnRNP 20 KDa Protein 3 4
  • U11/U12 SnRNP 20K 2 3
  • U11/U12-20K 3 4
  • Zinc Finger Matrin-Type Protein 5 3
  • SNRNP20 3
  • ZC3H19 3

External Ids for ZMAT5 Gene

Previous HGNC Symbols for ZMAT5 Gene

  • ZC3H19

Previous GeneCards Identifiers for ZMAT5 Gene

  • GC22M028452
  • GC22M028456
  • GC22M030126
  • GC22M013090

Summaries for ZMAT5 Gene

GeneCards Summary for ZMAT5 Gene

ZMAT5 (Zinc Finger Matrin-Type 5) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Minor Pathway.

Additional gene information for ZMAT5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMAT5 Gene

Genomics for ZMAT5 Gene

GeneHancer (GH) Regulatory Elements for ZMAT5 Gene

Promoters and enhancers for ZMAT5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I029765 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.2 -237 2.7 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 UQCR10 ZMAT5 HORMAD2-AS1 ASCC2 MTMR3
GH22I029795 Enhancer 1.4 Ensembl ENCODE dbSUPER 6.7 -31.9 -31916 7.1 HDGF ARID4B NEUROD1 SIN3A DMAP1 IRF4 YY1 ZNF766 ZNF143 FOS HORMAD2-AS1 ASCC2 ZMAT5 CABP7 UQCR10 ENSG00000237015
GH22I030444 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.8 -678.5 -678464 1.6 ZNF76 SIN3A RAD21 YY1 ZNF335 EGR1 ZNF143 FOS ETV6 BCLAF1 SEC14L3 TUG1 TBC1D10A PATZ1 SF3A1 PES1 ENSG00000181123 SEC14L2 ENSG00000249590 LIF
GH22I029773 Enhancer 0.9 Ensembl ENCODE dbSUPER 5.8 -6.4 -6440 0.7 ZNF121 JUND ZNF362 POLR2A FOS HORMAD2-AS1 ZMAT5 UQCR10 ASCC2
GH22I029750 Enhancer 0.9 Ensembl ENCODE 0.4 +16.0 15990 1.4 ZNF189 CEBPB ZMYM3 CEBPG ELF1 RAD21 YY1 ZKSCAN1 GABPA ZNF664 MTMR3 ASCC2 GC22P029759 ZMAT5 CABP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZMAT5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZMAT5 gene promoter:

Genomic Locations for ZMAT5 Gene

Genomic Locations for ZMAT5 Gene
chr22:29,730,956-29,767,068
(GRCh38/hg38)
Size:
36,113 bases
Orientation:
Minus strand
chr22:30,126,945-30,163,000
(GRCh37/hg19)

Genomic View for ZMAT5 Gene

Genes around ZMAT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMAT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMAT5 Gene

Proteins for ZMAT5 Gene

  • Protein details for ZMAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDW3-ZMAT5_HUMAN
    Recommended name:
    Zinc finger matrin-type protein 5
    Protein Accession:
    Q9UDW3
    Secondary Accessions:
    • A8K9F6

    Protein attributes for ZMAT5 Gene

    Size:
    170 amino acids
    Molecular mass:
    19971 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Not found in the major spliceosome.

neXtProt entry for ZMAT5 Gene

Post-translational modifications for ZMAT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMAT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZMAT5 Gene

Domains & Families for ZMAT5 Gene

Gene Families for ZMAT5 Gene

Suggested Antigen Peptide Sequences for ZMAT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZMAT5: view

No data available for UniProtKB/Swiss-Prot for ZMAT5 Gene

Function for ZMAT5 Gene

Gene Ontology (GO) - Molecular Function for ZMAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMAT5: view
genes like me logo Genes that share phenotypes with ZMAT5: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMAT5 Gene

Localization for ZMAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMAT5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMAT5 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZMAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with ZMAT5: view

Pathways & Interactions for ZMAT5 Gene

genes like me logo Genes that share pathways with ZMAT5: view

Pathways by source for ZMAT5 Gene

Gene Ontology (GO) - Biological Process for ZMAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IC 15146077
genes like me logo Genes that share ontologies with ZMAT5: view

No data available for SIGNOR curated interactions for ZMAT5 Gene

Drugs & Compounds for ZMAT5 Gene

No Compound Related Data Available

Transcripts for ZMAT5 Gene

mRNA/cDNA for ZMAT5 Gene

Unigene Clusters for ZMAT5 Gene

Zinc finger, matrin-type 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1: - -
SP2: -
SP3: -

Relevant External Links for ZMAT5 Gene

GeneLoc Exon Structure for
ZMAT5
ECgene alternative splicing isoforms for
ZMAT5

Expression for ZMAT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMAT5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZMAT5 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZMAT5 Gene:

ZMAT5

SOURCE GeneReport for Unigene cluster for ZMAT5 Gene:

Hs.713647

Evidence on tissue expression from TISSUES for ZMAT5 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZMAT5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMAT5 Gene

Orthologs for ZMAT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMAT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMAT5 33 34
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia ZMAT5 33 34
  • 92.16 (n)
cow
(Bos Taurus)
Mammalia ZMAT5 33 34
  • 91.76 (n)
mouse
(Mus musculus)
Mammalia Zmat5 33 16 34
  • 90.78 (n)
rat
(Rattus norvegicus)
Mammalia Zmat5 33
  • 89.41 (n)
oppossum
(Monodelphis domestica)
Mammalia ZMAT5 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMAT5 33 34
  • 76.27 (n)
lizard
(Anolis carolinensis)
Reptilia ZMAT5 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmat5 33
  • 61.55 (n)
Str.7488 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4221 33
zebrafish
(Danio rerio)
Actinopterygii zmat5 33 34
  • 57.59 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9091 33
fruit fly
(Drosophila melanogaster)
Insecta CG31922 34
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToOne
Species where no ortholog for ZMAT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMAT5 Gene

ENSEMBL:
Gene Tree for ZMAT5 (if available)
TreeFam:
Gene Tree for ZMAT5 (if available)

Paralogs for ZMAT5 Gene

No data available for Paralogs for ZMAT5 Gene

Variants for ZMAT5 Gene

Sequence variations from dbSNP and Humsavar for ZMAT5 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000000199 -- 29,758,455(-) ACA/A intron_variant
rs1000288662 -- 29,744,189(-) G/C intron_variant
rs1000314686 -- 29,732,869(-) T/A intron_variant
rs1000363219 -- 29,740,022(-) GGGGGG/GGGGGGG intron_variant
rs1000478546 -- 29,738,474(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZMAT5 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv471194 CNV gain 18288195
nsv471195 CNV loss 18288195
nsv478346 CNV novel sequence insertion 20440878
nsv515720 CNV gain+loss 19592680

Variation tolerance for ZMAT5 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMAT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMAT5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMAT5 Gene

Disorders for ZMAT5 Gene

Additional Disease Information for ZMAT5

No disorders were found for ZMAT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZMAT5 Gene

Publications for ZMAT5 Gene

  1. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will CL … Lührmann R (RNA (New York, N.Y.) 2004) 3 4 58
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZMAT5 Gene

Sources for ZMAT5 Gene

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