Aliases for ZMAT3 Gene
External Ids for ZMAT3 Gene
Previous GeneCards Identifiers for ZMAT3 Gene
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZMAT3 Gene
ZMAT3 (Zinc Finger Matrin-Type 3) is a Protein Coding gene. Diseases associated with ZMAT3 include Bronchus Cancer. Among its related pathways are DNA Damage Response. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF385A.
UniProtKB/Swiss-Prot Summary for ZMAT3 Gene
Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.