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Aliases for ZMAT3 Gene

Aliases for ZMAT3 Gene

  • Zinc Finger Matrin-Type 3 2 3 5
  • P53-Activated Gene 608 Protein 3 4
  • PAG608 3 4
  • WIG1 3 4
  • Zinc Finger Matrin-Type Protein 3 3
  • P53 Target Zinc Finger Protein 3
  • Zinc Finger Protein WIG-1 4
  • Zinc Finger Protein WIG1 3
  • WIG-1/PAG608 Protein 3
  • WIG-1 3

External Ids for ZMAT3 Gene

Previous GeneCards Identifiers for ZMAT3 Gene

  • GC03M180225
  • GC03M178735
  • GC03M176139

Summaries for ZMAT3 Gene

Entrez Gene Summary for ZMAT3 Gene

  • This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZMAT3 Gene

ZMAT3 (Zinc Finger Matrin-Type 3) is a Protein Coding gene. Among its related pathways are DNA Damage Response. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZMAT3 Gene

  • Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.

Additional gene information for ZMAT3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMAT3 Gene

Genomics for ZMAT3 Gene

GeneHancer (GH) Regulatory Elements for ZMAT3 Gene

Promoters and enhancers for ZMAT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I179068 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 562.5 +1.6 1562 3.8 HDGF SMAD1 ARID4B SIN3A FEZF1 IRF4 ZNF143 ZNF207 ZHX2 MXD4 ZMAT3 LOC101928739 PIK3CA ZNF639 GC03M179018
GH03I179033 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +35.9 35882 5.8 FOXA2 DMAP1 TCF12 EGR2 ZNF680 SP5 SMARCA4 GLIS1 NR2C1 KDM1A LOC101928739 PIK3CA ZMAT3 KCNMB3 GC03M179018
GH03I179026 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.8 +44.9 44919 1.6 E2F5 ZBTB33 ZMAT3 ZNF639 LOC101928739 PIK3CA GC03M179018
GH03I179098 Enhancer 0.7 ENCODE 12.3 -26.4 -26407 0.6 MEIS2 CTCF PKNOX1 FOSL1 ZNF316 NFE2 FOS MAFK ZNF639 MAFG ENSG00000200616 GC03P179098 ZMAT3 PIK3CA LOC101928739 ZNF639
GH03I179045 Enhancer 1.2 Ensembl ENCODE dbSUPER 6.9 +25.8 25763 2.9 HDGF CTCF KLF1 SMAD1 RB1 BACH1 EBF1 YBX1 BATF ZIC2 ZMAT3 GC03M179018
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZMAT3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZMAT3 gene promoter:

Genomic Locations for ZMAT3 Gene

Genomic Locations for ZMAT3 Gene
chr3:179,017,223-179,072,279
(GRCh38/hg38)
Size:
55,057 bases
Orientation:
Minus strand
chr3:178,735,011-178,790,067
(GRCh37/hg19)

Genomic View for ZMAT3 Gene

Genes around ZMAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMAT3 Gene

Proteins for ZMAT3 Gene

  • Protein details for ZMAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA38-ZMAT3_HUMAN
    Recommended name:
    Zinc finger matrin-type protein 3
    Protein Accession:
    Q9HA38
    Secondary Accessions:
    • B3KVA6
    • D3DNR1
    • Q96A21

    Protein attributes for ZMAT3 Gene

    Size:
    289 amino acids
    Molecular mass:
    32059 Da
    Quaternary structure:
    • Interacts with dsRNA.

    Alternative splice isoforms for ZMAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMAT3 Gene

Post-translational modifications for ZMAT3 Gene

No Post-translational modifications

Other Protein References for ZMAT3 Gene

No data available for DME Specific Peptides for ZMAT3 Gene

Domains & Families for ZMAT3 Gene

Gene Families for ZMAT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ZMAT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZMAT3: view

No data available for UniProtKB/Swiss-Prot for ZMAT3 Gene

Function for ZMAT3 Gene

Molecular function for ZMAT3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.
UniProtKB/Swiss-Prot Induction:
By DNA damage in a p53/TP53-dependent manner. Up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines.

Phenotypes From GWAS Catalog for ZMAT3 Gene

Gene Ontology (GO) - Molecular Function for ZMAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IPI 18519039
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZMAT3: view

Phenotypes for ZMAT3 Gene

GenomeRNAi human phenotypes for ZMAT3:
genes like me logo Genes that share phenotypes with ZMAT3: view

Animal Model Products

CRISPR Products

miRNA for ZMAT3 Gene

miRTarBase miRNAs that target ZMAT3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMAT3 Gene

Localization for ZMAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMAT3 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMAT3 gene
Compartment Confidence
nucleus 5
plasma membrane 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZMAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ZMAT3: view

Pathways & Interactions for ZMAT3 Gene

SuperPathways for ZMAT3 Gene

SuperPathway Contained pathways
1 DNA Damage Response
genes like me logo Genes that share pathways with ZMAT3: view

Pathways by source for ZMAT3 Gene

1 KEGG pathway for ZMAT3 Gene

Gene Ontology (GO) - Biological Process for ZMAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006915 apoptotic process IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0015031 protein transport IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with ZMAT3: view

No data available for SIGNOR curated interactions for ZMAT3 Gene

Drugs & Compounds for ZMAT3 Gene

No Compound Related Data Available

Transcripts for ZMAT3 Gene

Unigene Clusters for ZMAT3 Gene

Zinc finger, matrin-type 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for ZMAT3 Gene

GeneLoc Exon Structure for
ZMAT3
ECgene alternative splicing isoforms for
ZMAT3

Expression for ZMAT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMAT3 Gene

Protein differential expression in normal tissues from HIPED for ZMAT3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZMAT3 Gene



Protein tissue co-expression partners for ZMAT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZMAT3 Gene:

ZMAT3

SOURCE GeneReport for Unigene cluster for ZMAT3 Gene:

Hs.371609

mRNA Expression by UniProt/SwissProt for ZMAT3 Gene:

Q9HA38-ZMAT3_HUMAN
Tissue specificity: Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.

Evidence on tissue expression from TISSUES for ZMAT3 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with ZMAT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMAT3 Gene

Orthologs for ZMAT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZMAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMAT3 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia ZMAT3 33 34
  • 93.43 (n)
cow
(Bos Taurus)
Mammalia ZMAT3 33 34
  • 92.85 (n)
mouse
(Mus musculus)
Mammalia Zmat3 33 16 34
  • 84.84 (n)
rat
(Rattus norvegicus)
Mammalia Zmat3 33
  • 84.84 (n)
oppossum
(Monodelphis domestica)
Mammalia ZMAT3 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZMAT3 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMAT3 33 34
  • 77.89 (n)
lizard
(Anolis carolinensis)
Reptilia ZMAT3 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmat3 33
  • 69.67 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC561535 33
  • 64.31 (n)
BX548160.2 34
  • 49 (a)
OneToOne
Species where no ortholog for ZMAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMAT3 Gene

ENSEMBL:
Gene Tree for ZMAT3 (if available)
TreeFam:
Gene Tree for ZMAT3 (if available)

Paralogs for ZMAT3 Gene

No data available for Paralogs for ZMAT3 Gene

Variants for ZMAT3 Gene

Sequence variations from dbSNP and Humsavar for ZMAT3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs193920814 uncertain-significance, Malignant tumor of prostate 179,067,571(-) C/T coding_sequence_variant, missense_variant
rs1000015846 -- 179,052,141(-) T/A intron_variant
rs1000028014 -- 179,063,763(-) T/C intron_variant
rs1000043681 -- 179,021,501(-) T/C 3_prime_UTR_variant
rs1000081308 -- 179,045,507(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZMAT3 Gene

Variant ID Type Subtype PubMed ID
nsv461026 CNV gain 19166990
nsv472832 CNV novel sequence insertion 20440878
nsv592649 CNV gain 21841781
nsv1009143 CNV loss 25217958
esv3598831 CNV loss 21293372

Variation tolerance for ZMAT3 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMAT3 Gene

Disorders for ZMAT3 Gene

Additional Disease Information for ZMAT3

No disorders were found for ZMAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZMAT3 Gene

Publications for ZMAT3 Gene

  1. Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung. (PMID: 11689294) Varmeh-Ziaie S … Collins VP (Cancer letters 2001) 2 3 4 58
  2. The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs. (PMID: 16844115) Méndez Vidal C … Wiman KG (FEBS letters 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein. (PMID: 11571644) Hellborg F … Wiman KG (Oncogene 2001) 3 4 58
  5. Wig-1, a new p53-induced gene encoding a zinc finger protein. (PMID: 9400996) Varmeh-Ziaie S … Wiman KG (Oncogene 1997) 2 3 58

Products for ZMAT3 Gene

Sources for ZMAT3 Gene

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