This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript ... See more...

Aliases for ZMAT3 Gene

Aliases for ZMAT3 Gene

  • Zinc Finger Matrin-Type 3 2 3 5
  • PAG608 2 3 4
  • WIG1 2 3 4
  • Zinc Finger Matrin-Type Protein 3 3 4
  • P53-Activated Gene 608 Protein 3 4
  • WIG-1 2 3
  • P53 Target Zinc Finger Protein 3
  • Zinc Finger Protein WIG-1 4
  • Zinc Finger Protein WIG1 3
  • WIG-1/PAG608 Protein 3
  • MGC10613 2
  • FLJ12296 2
  • ZMAT3 5

External Ids for ZMAT3 Gene

Previous GeneCards Identifiers for ZMAT3 Gene

  • GC03M180225
  • GC03M178735
  • GC03M176139

Summaries for ZMAT3 Gene

Entrez Gene Summary for ZMAT3 Gene

  • This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZMAT3 Gene

ZMAT3 (Zinc Finger Matrin-Type 3) is a Protein Coding gene. Diseases associated with ZMAT3 include Bronchus Cancer. Among its related pathways are DNA Damage Response. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF385A.

UniProtKB/Swiss-Prot Summary for ZMAT3 Gene

  • Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZMAT3 Gene

Genomics for ZMAT3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZMAT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J179069 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 612.4 +2.1 2099 4.4 SP1 CTCF HNRNPL PRDM10 IKZF1 ZNF692 POLR2A ZNF7 BACH1 FOXA1 ZMAT3 PIK3CA LOC101928739 ZNF639 piR-33905-062 ENSG00000275163
GH03J179074 Enhancer 0.7 Ensembl ENCODE 600.7 -1.9 -1888 2.4 IKZF2 YY1 RUNX3 EBF1 HLF CBFA2T3 SPI1 ZMAT3 ENSG00000200616 PIK3CA
GH03J179612 Enhancer 1 Ensembl ENCODE 10.2 -542.1 -542088 3.6 LEF1 IKZF1 JUND REST NR2C1 BRD9 ZNF24 DPF2 HDAC1 SOX6 ENSG00000239096 USP13 ZMAT3 NDUFB5 MRPL47
GH03J179100 Enhancer 0.8 Ensembl 12.2 -28.3 -28288 0.4 JUND FOXA1 DPF2 HDAC1 SOX6 FOXJ2 EP300 ZNF766 HMBOX1 MTA3 ZMAT3 PIK3CA LOC101928739 ZNF639 KCNMB3 ENSG00000200616 piR-55657-185
GH03J179033 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +36.4 36388 6.9 ZNF512 LEF1 FOXA1 NR2C1 SOX6 TCF12 SOX13 MGA NFE2 HES1 PIK3CA LOC101928739 ZMAT3 ZNF639 KCNMB3 piR-39401-022 lnc-ZMAT3-4 ENSG00000275163
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZMAT3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZMAT3

Top Transcription factor binding sites by QIAGEN in the ZMAT3 gene promoter:
  • AREB6
  • E47
  • Elk-1
  • FOXF2
  • FOXL1
  • GATA-1
  • Msx-1
  • Nkx2-2
  • PPAR-alpha
  • Sox5

Genomic Locations for ZMAT3 Gene

Genomic Locations for ZMAT3 Gene
chr3:178,960,121-179,072,513
(GRCh38/hg38)
Size:
112,393 bases
Orientation:
Minus strand
chr3:178,735,011-178,790,067
(GRCh37/hg19)
Size:
55,057 bases
Orientation:
Minus strand

Genomic View for ZMAT3 Gene

Genes around ZMAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMAT3 Gene

Proteins for ZMAT3 Gene

  • Protein details for ZMAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA38-ZMAT3_HUMAN
    Recommended name:
    Zinc finger matrin-type protein 3
    Protein Accession:
    Q9HA38
    Secondary Accessions:
    • B3KVA6
    • D3DNR1
    • Q96A21

    Protein attributes for ZMAT3 Gene

    Size:
    289 amino acids
    Molecular mass:
    32059 Da
    Quaternary structure:
    • Interacts with dsRNA.

    Alternative splice isoforms for ZMAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMAT3 Gene

Post-translational modifications for ZMAT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZMAT3 Gene

Domains & Families for ZMAT3 Gene

Gene Families for ZMAT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZMAT3 Gene

Suggested Antigen Peptide Sequences for ZMAT3 Gene

GenScript: Design optimal peptide antigens:
  • p53-activated gene 608 protein (ZMAT3_HUMAN)
genes like me logo Genes that share domains with ZMAT3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZMAT3 Gene

Function for ZMAT3 Gene

Molecular function for ZMAT3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.
UniProtKB/Swiss-Prot Induction:
By DNA damage in a p53/TP53-dependent manner. Up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines.

Phenotypes From GWAS Catalog for ZMAT3 Gene

Gene Ontology (GO) - Molecular Function for ZMAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI 18519039
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMAT3: view
genes like me logo Genes that share phenotypes with ZMAT3: view

Animal Model Products

CRISPR Products

miRNA for ZMAT3 Gene

miRTarBase miRNAs that target ZMAT3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMAT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMAT3 Gene

Localization for ZMAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMAT3 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMAT3 gene
Compartment Confidence
nucleus 5
plasma membrane 4
mitochondrion 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZMAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ZMAT3: view

Pathways & Interactions for ZMAT3 Gene

PathCards logo

SuperPathways for ZMAT3 Gene

SuperPathway Contained pathways
1 DNA Damage Response
genes like me logo Genes that share pathways with ZMAT3: view

Pathways by source for ZMAT3 Gene

1 KEGG pathway for ZMAT3 Gene

Gene Ontology (GO) - Biological Process for ZMAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0015031 protein transport IEA --
GO:0040008 regulation of growth IEA --
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with ZMAT3: view

No data available for SIGNOR curated interactions for ZMAT3 Gene

Drugs & Compounds for ZMAT3 Gene

No Compound Related Data Available

Transcripts for ZMAT3 Gene

mRNA/cDNA for ZMAT3 Gene

8 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZMAT3

Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for ZMAT3 Gene

GeneLoc Exon Structure for
ZMAT3

Expression for ZMAT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZMAT3 Gene

Protein differential expression in normal tissues from HIPED for ZMAT3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZMAT3 Gene



Protein tissue co-expression partners for ZMAT3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZMAT3

SOURCE GeneReport for Unigene cluster for ZMAT3 Gene:

Hs.371609

mRNA Expression by UniProt/SwissProt for ZMAT3 Gene:

Q9HA38-ZMAT3_HUMAN
Tissue specificity: Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.

Evidence on tissue expression from TISSUES for ZMAT3 Gene

  • Nervous system(3.7)
  • Skin(2.6)
genes like me logo Genes that share expression patterns with ZMAT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMAT3 Gene

Orthologs for ZMAT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZMAT3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZMAT3 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZMAT3 30 31
  • 93.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZMAT3 30 31
  • 92.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zmat3 30 17 31
  • 84.84 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zmat3 30
  • 84.84 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZMAT3 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZMAT3 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZMAT3 30 31
  • 77.89 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZMAT3 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zmat3 30
  • 69.67 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC561535 30
  • 64.31 (n)
BX548160.2 31
  • 49 (a)
OneToOne
Species where no ortholog for ZMAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZMAT3 Gene

ENSEMBL:
Gene Tree for ZMAT3 (if available)
TreeFam:
Gene Tree for ZMAT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZMAT3: view image

Paralogs for ZMAT3 Gene

Paralogs for ZMAT3 Gene

genes like me logo Genes that share paralogs with ZMAT3: view

Variants for ZMAT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZMAT3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs193920814 Uncertain Significance: Malignant tumor of prostate 179,067,571(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZMAT3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZMAT3 Gene

Variant ID Type Subtype PubMed ID
esv3598831 CNV loss 21293372
nsv1009143 CNV loss 25217958
nsv461026 CNV gain 19166990
nsv472832 CNV novel sequence insertion 20440878
nsv592649 CNV gain 21841781

Variation tolerance for ZMAT3 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMAT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMAT3 Gene

Disorders for ZMAT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMAT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bronchus cancer
  • malignant neoplasm of bronchus and lung
- elite association - COSMIC cancer census association via MalaCards
Search ZMAT3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZMAT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMAT3 Gene

Publications for ZMAT3 Gene

  1. Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung. (PMID: 11689294) Varmeh-Ziaie S … Collins VP (Cancer letters 2001) 2 3 4
  2. The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs. (PMID: 16844115) Méndez Vidal C … Wiman KG (FEBS letters 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein. (PMID: 11571644) Hellborg F … Wiman KG (Oncogene 2001) 3 4
  5. Wig-1, a new p53-induced gene encoding a zinc finger protein. (PMID: 9400996) Varmeh-Ziaie S … Wiman KG (Oncogene 1997) 2 3

Products for ZMAT3 Gene

Sources for ZMAT3 Gene