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Aliases for ZMAT1 Gene

Aliases for ZMAT1 Gene

  • Zinc Finger Matrin-Type 1 2 3 5
  • KIAA1789 4

External Ids for ZMAT1 Gene

Previous GeneCards Identifiers for ZMAT1 Gene

  • GC0XM100943
  • GC0XM101023
  • GC0XM101137
  • GC0XM090944

Summaries for ZMAT1 Gene

Entrez Gene Summary for ZMAT1 Gene

  • This gene encodes a protein containing Cys2-His2 (C2H2)-type zinc fingers, which are similar to those found in the nuclear matrix protein matrin 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ZMAT1 Gene

ZMAT1 (Zinc Finger Matrin-Type 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is KRCC1.

Additional gene information for ZMAT1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMAT1 Gene

Genomics for ZMAT1 Gene

GeneHancer (GH) Regulatory Elements for ZMAT1 Gene

Promoters and enhancers for ZMAT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI101930 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.5 459 2.1 ATF1 ZNF48 YY1 ATF7 SP3 NFYC REST ZNF592 ATF4 GMEB1 ZMAT1 BEX5 TCEAL6 RNU6-345P
GH0XI101390 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 +540.2 540186 3.4 HNRNPUL1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 RPL36A BTK RPL36A-HNRNPH2 ARMCX4 ARMCX2 ARL13A ZMAT1 GLA CENPI PPIAP90
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZMAT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZMAT1 gene promoter:

Genomic Locations for ZMAT1 Gene

Genomic Locations for ZMAT1 Gene
chrX:101,882,288-101,932,135
(GRCh38/hg38)
Size:
49,848 bases
Orientation:
Minus strand
chrX:101,137,260-101,187,039
(GRCh37/hg19)

Genomic View for ZMAT1 Gene

Genes around ZMAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMAT1 Gene

Proteins for ZMAT1 Gene

  • Protein details for ZMAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9K5-ZMAT1_HUMAN
    Recommended name:
    Zinc finger matrin-type protein 1
    Protein Accession:
    Q5H9K5
    Secondary Accessions:
    • Q8NDS3
    • Q96JN6

    Protein attributes for ZMAT1 Gene

    Size:
    638 amino acids
    Molecular mass:
    74755 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47418.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMAT1 Gene

Post-translational modifications for ZMAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZMAT1 Gene

Domains & Families for ZMAT1 Gene

Gene Families for ZMAT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZMAT1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZMAT1: view

No data available for UniProtKB/Swiss-Prot for ZMAT1 Gene

Function for ZMAT1 Gene

Gene Ontology (GO) - Molecular Function for ZMAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IBA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZMAT1: view
genes like me logo Genes that share phenotypes with ZMAT1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMAT1 Gene

Localization for ZMAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMAT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMAT1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZMAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZMAT1: view

Pathways & Interactions for ZMAT1 Gene

SuperPathways for ZMAT1 Gene

No Data Available

Interacting Proteins for ZMAT1 Gene

Gene Ontology (GO) - Biological Process for ZMAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IBA --
genes like me logo Genes that share ontologies with ZMAT1: view

No data available for Pathways by source and SIGNOR curated interactions for ZMAT1 Gene

Drugs & Compounds for ZMAT1 Gene

No Compound Related Data Available

Transcripts for ZMAT1 Gene

Unigene Clusters for ZMAT1 Gene

Zinc finger, matrin-type 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT1 Gene

No ASD Table

Relevant External Links for ZMAT1 Gene

GeneLoc Exon Structure for
ZMAT1
ECgene alternative splicing isoforms for
ZMAT1

Expression for ZMAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMAT1 Gene

mRNA differential expression in normal tissues according to GTEx for ZMAT1 Gene

This gene is overexpressed in Pituitary (x4.0).

Protein differential expression in normal tissues from HIPED for ZMAT1 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZMAT1 Gene



Protein tissue co-expression partners for ZMAT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZMAT1 Gene:

ZMAT1

SOURCE GeneReport for Unigene cluster for ZMAT1 Gene:

Hs.496512

Evidence on tissue expression from TISSUES for ZMAT1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZMAT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMAT1 Gene

Orthologs for ZMAT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZMAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610936 33
  • 99.63 (n)
-- 34
  • 99 (a)
OneToMany
-- 34
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZMAT1 33 34
  • 89.89 (n)
mouse
(Mus musculus)
Mammalia Zmat1 33 16 34
  • 77.33 (n)
rat
(Rattus norvegicus)
Mammalia Zmat1 33
  • 77.05 (n)
cow
(Bos Taurus)
Mammalia ZMAT1 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZMAT1 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMAT1 34
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZMAT1 34
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ZMAT1 34
  • 26 (a)
OneToMany
Species where no ortholog for ZMAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMAT1 Gene

ENSEMBL:
Gene Tree for ZMAT1 (if available)
TreeFam:
Gene Tree for ZMAT1 (if available)

Paralogs for ZMAT1 Gene

Paralogs for ZMAT1 Gene

(13) SIMAP similar genes for ZMAT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZMAT1: view

Variants for ZMAT1 Gene

Sequence variations from dbSNP and Humsavar for ZMAT1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs138810471 benign, Abnormality of neuronal migration 101,883,614(-) G/A coding_sequence_variant, missense_variant
rs1000195964 -- 101,909,663(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000211268 -- 101,918,587(-) G/A coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant
rs1000233292 -- 101,924,407(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000351001 -- 101,902,556(-) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZMAT1 Gene

Variant ID Type Subtype PubMed ID
esv1733154 CNV deletion 17803354
esv2740363 CNV deletion 23290073
esv3241069 CNV deletion 24192839
nsv1118399 CNV deletion 24896259

Variation tolerance for ZMAT1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMAT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMAT1 Gene

Disorders for ZMAT1 Gene

Additional Disease Information for ZMAT1

No disorders were found for ZMAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZMAT1 Gene

Publications for ZMAT1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  3. Downregulation of long noncoding RNA ZMAT1 transcript variant 2 predicts a poor prognosis in patients with gastric cancer. (PMID: 26191264) Lai Y … Gao W (International journal of clinical and experimental pathology 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58

Products for ZMAT1 Gene

Sources for ZMAT1 Gene

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