Aliases for ZKSCAN7 Gene

Aliases for ZKSCAN7 Gene

  • Zinc Finger With KRAB And SCAN Domains 7 2 3 5
  • Zinc Finger Protein 448 2 3 4
  • Zinc Finger Protein 167 2 3 4
  • Zinc Finger Protein 64 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 7 3 4
  • ZSCAN39 2 3
  • ZNF167 3 4
  • ZNF448 3 4
  • ZNF64 3 4
  • FLJ12738 2
  • ZKSCAN7 5
  • ZFP 3

External Ids for ZKSCAN7 Gene

Previous HGNC Symbols for ZKSCAN7 Gene

  • ZNF64
  • ZNF448
  • ZNF167

Previous GeneCards Identifiers for ZKSCAN7 Gene

  • GC03P044597

Summaries for ZKSCAN7 Gene

GeneCards Summary for ZKSCAN7 Gene

ZKSCAN7 (Zinc Finger With KRAB And SCAN Domains 7) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF852.

UniProtKB/Swiss-Prot Summary for ZKSCAN7 Gene

Additional gene information for ZKSCAN7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZKSCAN7 Gene

Genomics for ZKSCAN7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZKSCAN7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZKSCAN7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZKSCAN7

Genomic Locations for ZKSCAN7 Gene

Genomic Locations for ZKSCAN7 Gene
chr3:44,555,193-44,594,173
(GRCh38/hg38)
Size:
38,981 bases
Orientation:
Plus strand
chr3:44,596,685-44,624,975
(GRCh37/hg19)
Size:
28,291 bases
Orientation:
Plus strand

Genomic View for ZKSCAN7 Gene

Genes around ZKSCAN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN7 Gene

Proteins for ZKSCAN7 Gene

  • Protein details for ZKSCAN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0L1-ZKSC7_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 7
    Protein Accession:
    Q9P0L1
    Secondary Accessions:
    • A0PJV3
    • A8K5H0
    • Q6WL09
    • Q96FQ2

    Protein attributes for ZKSCAN7 Gene

    Size:
    754 amino acids
    Molecular mass:
    85033 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZKSCAN7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZKSCAN7 Gene

Post-translational modifications for ZKSCAN7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZKSCAN7 Gene

Domains & Families for ZKSCAN7 Gene

Gene Families for ZKSCAN7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZKSCAN7 Gene

InterPro:
Blocks:
  • KRAB box
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZKSCAN7 Gene

GenScript: Design optimal peptide antigens:
  • ZNF167 protein (A7MAY2_HUMAN)
  • Zinc finger protein 167 (Q0VAN9_HUMAN)
  • ZNF167 protein (Q0VAP0_HUMAN)
  • Zinc finger protein with KRAB and SCAN domains 7 (ZN167_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P0L1

UniProtKB/Swiss-Prot:

ZKSC7_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZKSCAN7: view

Function for ZKSCAN7 Gene

Molecular function for ZKSCAN7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZKSCAN7 Gene

Gene Ontology (GO) - Molecular Function for ZKSCAN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZKSCAN7: view
genes like me logo Genes that share phenotypes with ZKSCAN7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZKSCAN7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN7 Gene

Localization for ZKSCAN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZKSCAN7 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZKSCAN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZKSCAN7: view

Pathways & Interactions for ZKSCAN7 Gene

PathCards logo

SuperPathways for ZKSCAN7 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN7: view

Pathways by source for ZKSCAN7 Gene

2 Reactome pathways for ZKSCAN7 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZKSCAN7: view

No data available for SIGNOR curated interactions for ZKSCAN7 Gene

Drugs & Compounds for ZKSCAN7 Gene

(3) Drugs for ZKSCAN7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZKSCAN7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZKSCAN7: view

Transcripts for ZKSCAN7 Gene

mRNA/cDNA for ZKSCAN7 Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZKSCAN7

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN7 Gene

No ASD Table

Relevant External Links for ZKSCAN7 Gene

GeneLoc Exon Structure for
ZKSCAN7

Expression for ZKSCAN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZKSCAN7 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZKSCAN7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZKSCAN7

SOURCE GeneReport for Unigene cluster for ZKSCAN7 Gene:

Hs.529512

Evidence on tissue expression from TISSUES for ZKSCAN7 Gene

  • Nervous system(4.5)
  • Skin(2.2)
  • Kidney(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ZKSCAN7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZKSCAN7 Gene

Orthologs for ZKSCAN7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZKSCAN7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF167 30
  • 99.42 (n)
ZKSCAN7 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF167 30
  • 84.68 (n)
-- 31
  • 81 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Zfp167 30
  • 80.21 (n)
Mouse
(Mus musculus)
Mammalia Zkscan7 30 17 31
  • 79.53 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 58 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 56 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ZNF167 30
  • 56.96 (n)
-- 31
  • 46 (a)
OneToMany
Species where no ortholog for ZKSCAN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZKSCAN7 Gene

ENSEMBL:
Gene Tree for ZKSCAN7 (if available)
TreeFam:
Gene Tree for ZKSCAN7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZKSCAN7: view image

Paralogs for ZKSCAN7 Gene

(530) SIMAP similar genes for ZKSCAN7 Gene using alignment to 3 proteins:

  • ZKSC7_HUMAN
  • C9J6L6_HUMAN
  • E7EMM9_HUMAN

Pseudogenes.org Pseudogenes for ZKSCAN7 Gene

genes like me logo Genes that share paralogs with ZKSCAN7: view

Variants for ZKSCAN7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZKSCAN7 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs13081859 - p.Phe153Ser
rs34181686 - p.Glu359Lys
rs34396823 - p.Thr342Ile
rs34437520 - p.Ser746Phe
rs35696191 - p.Arg24Cys

Additional dbSNP identifiers (rs#s) for ZKSCAN7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN7 Gene

Variant ID Type Subtype PubMed ID
nsv3790 CNV insertion 18451855
nsv965162 CNV duplication 23825009
nsv967009 CNV duplication 23825009
nsv979825 CNV duplication 23825009

Variation tolerance for ZKSCAN7 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.57; 86.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZKSCAN7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZKSCAN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN7 Gene

Disorders for ZKSCAN7 Gene

No disorders were found for ZKSCAN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN7 Gene

Publications for ZKSCAN7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. (PMID: 7814019) Calabrò V … Lania L (Human genetics 1995) 2 3
  4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZKSCAN7 Gene

Sources for ZKSCAN7 Gene