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Aliases for ZKSCAN5 Gene

Aliases for ZKSCAN5 Gene

  • Zinc Finger With KRAB And SCAN Domains 5 2 3 5
  • Zinc Finger Protein Homologous To Zfp95 In Mouse 2 3
  • Zinc Finger Protein 95 Homolog 3 4
  • ZFP95 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 5 3
  • Zinc Finger Protein 95 Homolog (Mouse) 2
  • KIAA1015 4
  • ZSCAN37 3
  • ZFP-95 3
  • ZNF914 3
  • Zfp-95 4

External Ids for ZKSCAN5 Gene

Previous HGNC Symbols for ZKSCAN5 Gene

  • ZFP95

Previous GeneCards Identifiers for ZKSCAN5 Gene

  • GC07P098941
  • GC07P099102
  • GC07P093738

Summaries for ZKSCAN5 Gene

Entrez Gene Summary for ZKSCAN5 Gene

  • This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expressed in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for ZKSCAN5 Gene

ZKSCAN5 (Zinc Finger With KRAB And SCAN Domains 5) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF444.

UniProtKB/Swiss-Prot for ZKSCAN5 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZKSCAN5 Gene

Additional gene information for ZKSCAN5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN5 Gene

Genomics for ZKSCAN5 Gene

GeneHancer (GH) Regulatory Elements for ZKSCAN5 Gene

Promoters and enhancers for ZKSCAN5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J099504 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +4.4 4396 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZKSCAN5 ZSCAN25 TRRAP TRIM4 PTCD1 AP4M1 ZNF3 PPP1R35 ENSG00000242798 MEPCE
GH07J099497 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -1.9 -1906 3.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF394 ZKSCAN5 ZSCAN25 PPP1R35 TRRAP TRIM4 MEPCE ZNF655 PTCD1 ZNF3
GH07J099501 Enhancer 0.6 ENCODE 650.7 +0.1 56 0.2 NFATC3 NFYC SP2 ASH1L CHAMP1 CC2D1A ZNF316 ZBTB33 MAFK EMSY ZNF394 ZKSCAN5 ZNF789 GC07P099532
GH07J099502 Enhancer 0.6 ENCODE 650.7 -0.1 -57 0 NFATC3 NFYC SP2 ASH1L CC2D1A ZNF316 ZBTB33 MAFK EMSY HOMEZ ZKSCAN5 ZNF394 ZNF789
GH07J100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 31 +931.9 931902 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE ZCWPW1 PIR54054 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF3 PILRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZKSCAN5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZKSCAN5 gene promoter:

Genomic Locations for ZKSCAN5 Gene

Genomic Locations for ZKSCAN5 Gene
chr7:99,501,297-99,534,700
(GRCh38/hg38)
Size:
33,404 bases
Orientation:
Plus strand
chr7:99,102,273-99,132,323
(GRCh37/hg19)

Genomic View for ZKSCAN5 Gene

Genes around ZKSCAN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN5 Gene

Proteins for ZKSCAN5 Gene

  • Protein details for ZKSCAN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2L8-ZKSC5_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 5
    Protein Accession:
    Q9Y2L8
    Secondary Accessions:
    • A4D280
    • D6W5S9

    Protein attributes for ZKSCAN5 Gene

    Size:
    839 amino acids
    Molecular mass:
    96903 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76859.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZKSCAN5 Gene

neXtProt entry for ZKSCAN5 Gene

Post-translational modifications for ZKSCAN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZKSCAN5 Gene

Domains & Families for ZKSCAN5 Gene

Gene Families for ZKSCAN5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZKSCAN5 Gene

Suggested Antigen Peptide Sequences for ZKSCAN5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2L8

UniProtKB/Swiss-Prot:

ZKSC5_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZKSCAN5: view

Function for ZKSCAN5 Gene

Molecular function for ZKSCAN5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZKSCAN5 Gene

Gene Ontology (GO) - Molecular Function for ZKSCAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS,IEA 10585779
GO:0005515 protein binding IPI 23455924
GO:0008270 zinc ion binding NAS 10585779
genes like me logo Genes that share ontologies with ZKSCAN5: view
genes like me logo Genes that share phenotypes with ZKSCAN5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN5 Gene

Localization for ZKSCAN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZKSCAN5 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZKSCAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,NAS 10585779
genes like me logo Genes that share ontologies with ZKSCAN5: view

Pathways & Interactions for ZKSCAN5 Gene

SuperPathways for ZKSCAN5 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN5: view

Pathways by source for ZKSCAN5 Gene

2 Reactome pathways for ZKSCAN5 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS,IEA 10585779
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZKSCAN5: view

No data available for SIGNOR curated interactions for ZKSCAN5 Gene

Drugs & Compounds for ZKSCAN5 Gene

No Compound Related Data Available

Transcripts for ZKSCAN5 Gene

Unigene Clusters for ZKSCAN5 Gene

Zinc finger with KRAB and SCAN domains 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - -
SP2: -
SP3: -
SP4: - - - -
SP5: -

Relevant External Links for ZKSCAN5 Gene

GeneLoc Exon Structure for
ZKSCAN5
ECgene alternative splicing isoforms for
ZKSCAN5

Expression for ZKSCAN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZKSCAN5 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN5 Gene

This gene is overexpressed in Neutrophil (25.7), Pancreatic juice (24.2), and Tlymphocyte (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZKSCAN5 Gene



Protein tissue co-expression partners for ZKSCAN5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZKSCAN5 Gene:

ZKSCAN5

SOURCE GeneReport for Unigene cluster for ZKSCAN5 Gene:

Hs.110839

Evidence on tissue expression from TISSUES for ZKSCAN5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZKSCAN5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZKSCAN5 Gene

Orthologs for ZKSCAN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZKSCAN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN5 34 33
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZKSCAN5 34 33
  • 86.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZKSCAN5 33
  • 84.6 (n)
-- 34
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zkscan5 16 34 33
  • 80.4 (n)
rat
(Rattus norvegicus)
Mammalia Zkscan5 33
  • 79.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ZKSCAN5 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 29 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo38 34
  • 17 (a)
ManyToMany
CG7368 34
  • 15 (a)
ManyToMany
Species where no ortholog for ZKSCAN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN5 Gene

ENSEMBL:
Gene Tree for ZKSCAN5 (if available)
TreeFam:
Gene Tree for ZKSCAN5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZKSCAN5: view image

Paralogs for ZKSCAN5 Gene

Paralogs for ZKSCAN5 Gene

(278) SIMAP similar genes for ZKSCAN5 Gene using alignment to 8 proteins:

  • ZKSC5_HUMAN
  • F8WBD4_HUMAN
  • J7M2K9_HUMAN
  • J7M2L3_HUMAN
  • J7M940_HUMAN
  • J7ME35_HUMAN
  • L8EAP2_HUMAN
  • Q8N718_HUMAN
genes like me logo Genes that share paralogs with ZKSCAN5: view

Variants for ZKSCAN5 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN5 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000031988 -- 99,524,869(+) A/C intron_variant
rs1000139139 -- 99,526,988(+) G/A intron_variant
rs1000171680 -- 99,508,258(+) C/T intron_variant
rs1000243877 -- 99,502,019(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000350807 -- 99,520,774(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN5 Gene

Variant ID Type Subtype PubMed ID
esv2662144 CNV deletion 23128226
esv2675875 CNV deletion 23128226
esv2734884 CNV deletion 23290073
esv3576408 CNV gain 25503493
esv3614279 CNV loss 21293372
esv3614280 CNV loss 21293372
nsv819741 CNV gain 19587683
nsv824229 CNV loss 20364138
nsv831069 CNV loss 17160897

Variation tolerance for ZKSCAN5 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZKSCAN5 Gene

Human Gene Mutation Database (HGMD)
ZKSCAN5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZKSCAN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN5 Gene

Disorders for ZKSCAN5 Gene

Additional Disease Information for ZKSCAN5

No disorders were found for ZKSCAN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN5 Gene

Publications for ZKSCAN5 Gene

  1. Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain. (PMID: 10585779) Dreyer SD … Lee B (Genomics 1999) 2 3 4 22 58
  2. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. (PMID: 21533175) Zhai G … Wallaschofski H (PLoS genetics 2011) 3 44 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZKSCAN5 Gene

Sources for ZKSCAN5 Gene

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