Aliases for ZKSCAN4 Gene

Aliases for ZKSCAN4 Gene

  • Zinc Finger With KRAB And SCAN Domains 4 2 3 5
  • Zinc Finger Protein 307 2 3 4
  • Zinc Finger Protein 427 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 4 3 4
  • ZNF307 3 4
  • ZNF427 3 4
  • P373c6.1 (Novel C2H2 Type Zinc Finger Protein) 3
  • EC 54
  • EC 54
  • P1P373C6 3
  • P373c6.1 4
  • ZSCAN36 3

External Ids for ZKSCAN4 Gene

Previous HGNC Symbols for ZKSCAN4 Gene

  • ZNF307
  • ZNF427

Previous GeneCards Identifiers for ZKSCAN4 Gene

  • GC06M028324
  • GC06M028212
  • GC06M028021
  • GC06M028244

Summaries for ZKSCAN4 Gene

GeneCards Summary for ZKSCAN4 Gene

ZKSCAN4 (Zinc Finger With KRAB And SCAN Domains 4) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZKSCAN3.

UniProtKB/Swiss-Prot Summary for ZKSCAN4 Gene

  • May be involved in the transcriptional activation of MDM2 and EP300 genes.

Additional gene information for ZKSCAN4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZKSCAN4 Gene

Genomics for ZKSCAN4 Gene

GeneHancer (GH) Regulatory Elements for ZKSCAN4 Gene

Promoters and enhancers for ZKSCAN4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZKSCAN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZKSCAN4 gene promoter:
  • AREB6
  • Brachyury
  • c-Ets-1
  • C/EBPalpha
  • GATA-1
  • LCR-F1
  • LUN-1
  • p300
  • p53
  • Roaz

Genomic Locations for ZKSCAN4 Gene

Genomic Locations for ZKSCAN4 Gene
17,575 bases
Minus strand
14,611 bases
Minus strand

Genomic View for ZKSCAN4 Gene

Genes around ZKSCAN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN4 Gene

Proteins for ZKSCAN4 Gene

  • Protein details for ZKSCAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 4
    Protein Accession:
    Secondary Accessions:
    • B2RE32
    • Q5U7L4

    Protein attributes for ZKSCAN4 Gene

    545 amino acids
    Molecular mass:
    61579 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZKSCAN4 Gene

Selected DME Specific Peptides for ZKSCAN4 Gene


Post-translational modifications for ZKSCAN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZKSCAN4 Gene

Gene Families for ZKSCAN4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZKSCAN4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57654, highly similar to Zinc finger protein 307 (B7Z7H3_HUMAN)
  • Zinc finger protein 427 (ZKSC4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZKSCAN4: view

Function for ZKSCAN4 Gene

Molecular function for ZKSCAN4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the transcriptional activation of MDM2 and EP300 genes.

Enzyme Numbers (IUBMB) for ZKSCAN4 Gene

Phenotypes From GWAS Catalog for ZKSCAN4 Gene

Gene Ontology (GO) - Molecular Function for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZKSCAN4: view
genes like me logo Genes that share phenotypes with ZKSCAN4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN4 Gene

Localization for ZKSCAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZKSCAN4 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZKSCAN4: view

Pathways & Interactions for ZKSCAN4 Gene

PathCards logo

SuperPathways for ZKSCAN4 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN4: view

Pathways by source for ZKSCAN4 Gene

2 Reactome pathways for ZKSCAN4 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZKSCAN4: view

No data available for SIGNOR curated interactions for ZKSCAN4 Gene

Drugs & Compounds for ZKSCAN4 Gene

No Compound Related Data Available

Transcripts for ZKSCAN4 Gene

mRNA/cDNA for ZKSCAN4 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN4 Gene

No ASD Table

Relevant External Links for ZKSCAN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZKSCAN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZKSCAN4 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN4 Gene

This gene is overexpressed in Pancreas (20.2), Tlymphocyte (19.6), Rectum (13.1), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZKSCAN4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZKSCAN4 Gene:


SOURCE GeneReport for Unigene cluster for ZKSCAN4 Gene:


mRNA Expression by UniProt/SwissProt for ZKSCAN4 Gene:

Tissue specificity: Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.

Evidence on tissue expression from TISSUES for ZKSCAN4 Gene

  • Heart(4.1)
genes like me logo Genes that share expression patterns with ZKSCAN4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZKSCAN4 Gene

Orthologs for ZKSCAN4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZKSCAN4 33 32
  • 99.51 (n)
(Bos Taurus)
Mammalia LOC539620 32
  • 86.32 (n)
-- 33
  • 82 (a)
(Canis familiaris)
Mammalia ZKSCAN4 32
  • 82.9 (n)
-- 33
  • 76 (a)
(Mus musculus)
Mammalia Zkscan4 33
  • 75 (a)
Species where no ortholog for ZKSCAN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN4 Gene

Gene Tree for ZKSCAN4 (if available)
Gene Tree for ZKSCAN4 (if available)
Evolutionary constrained regions (ECRs) for ZKSCAN4: view image

Paralogs for ZKSCAN4 Gene

(487) SIMAP similar genes for ZKSCAN4 Gene using alignment to 2 proteins:

  • B7Z7H3_HUMAN
genes like me logo Genes that share paralogs with ZKSCAN4: view

Variants for ZKSCAN4 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000536019 -- 28,241,303(-) C/T downstream_transcript_variant
rs1000768753 -- 28,248,840(-) A/G intron_variant
rs1000926885 -- 28,249,095(-) A/G intron_variant
rs1000943690 -- 28,256,441(-) A/G genic_upstream_transcript_variant, intron_variant
rs1001245941 -- 28,257,706(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN4 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV loss 17160897

Variation tolerance for ZKSCAN4 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZKSCAN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN4 Gene

Disorders for ZKSCAN4 Gene

Additional Disease Information for ZKSCAN4

No disorders were found for ZKSCAN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN4 Gene

Publications for ZKSCAN4 Gene

  1. A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein. (PMID: 19008334) Ecker K … Helmberg A (Journal of molecular endocrinology 2009) 2 3 56
  2. ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway. (PMID: 17910948) Li J … Wu X (Biochemical and biophysical research communications 2007) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56

Products for ZKSCAN4 Gene

Sources for ZKSCAN4 Gene