Aliases for ZKSCAN3 Gene
External Ids for ZKSCAN3 Gene
Previous HGNC Symbols for ZKSCAN3 Gene
Previous GeneCards Identifiers for ZKSCAN3 Gene
GeneCards Summary for ZKSCAN3 Gene
ZKSCAN3 (Zinc Finger With KRAB And SCAN Domains 3) is a Protein Coding gene. Diseases associated with ZKSCAN3 include Non-Invasive Bladder Papillary Urothelial Neoplasm and Ureteral Benign Neoplasm. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ZKSCAN4.
UniProtKB/Swiss-Prot Summary for ZKSCAN3 Gene
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.