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Aliases for ZKSCAN3 Gene
Aliases for ZKSCAN3 Gene
External Ids for ZKSCAN3 Gene
- HGNC: 13853
- Entrez Gene: 80317
- Ensembl: ENSG00000189298
- OMIM: 612791
- UniProtKB: Q9BRR0
Previous HGNC Symbols for ZKSCAN3 Gene
- ZNF306
- ZNF309
Previous GeneCards Identifiers for ZKSCAN3 Gene
- GC06P028426
- GC06P028317
- GC06P028124
Summaries for ZKSCAN3 Gene
GeneCards Summary for ZKSCAN3 Gene
ZKSCAN3 (Zinc Finger With KRAB And SCAN Domains 3) is a Protein Coding gene. Diseases associated with ZKSCAN3 include Non-Invasive Bladder Papillary Urothelial Neoplasm and Ureteral Benign Neoplasm. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ZKSCAN4.
UniProtKB/Swiss-Prot Summary for ZKSCAN3 Gene
-
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
Additional gene information for ZKSCAN3 Gene
- HGNC(13853)
- Entrez Gene(80317)
- Ensembl(ENSG00000189298)
- OMIM(612791)
- UniProtKB(Q9BRR0)
- Open Targets Platform(ENSG00000189298)
- Monarch Initiative
- Search for ZKSCAN3 at DataMed
- Search for ZKSCAN3 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZKSCAN3 Gene
Genomics for ZKSCAN3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZKSCAN3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZKSCAN3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZKSCAN3
- Top Transcription factor binding sites by QIAGEN in the ZKSCAN3 gene promoter:
-
- AP-2alphaA
- AP-2beta
- AP-2gamma
- c-Ets-1
- Cart-1
- GCNF
- GCNF-1
- GCNF-2
- LUN-1
Genomic Locations for ZKSCAN3 Gene
Genomic Locations for ZKSCAN3 Gene
- chr6:28,349,913-28,369,174
- (GRCh38/hg38)
- Size:
- 19,262 bases
- Orientation:
- Plus strand
- chr6:28,317,691-28,336,954
- (GRCh37/hg19)
- Size:
- 19,264 bases
- Orientation:
- Plus strand
Genomic View for ZKSCAN3 Gene
Genes around ZKSCAN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
ZKSCAN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZKSCAN3 Gene
Proteins for ZKSCAN3 Gene
-
Protein details for ZKSCAN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BRR0-ZKSC3_HUMAN
- Recommended name:
- Zinc finger protein with KRAB and SCAN domains 3
- Protein Accession:
- Q9BRR0
- B2R8W2
- B3KVC0
- H7BXX1
- Q5VXH3
- Q92972
- Q9H4T3
Protein attributes for ZKSCAN3 Gene
- Size:
- 538 amino acids
- Molecular mass:
- 60641 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZKSCAN3 Gene
Post-translational modifications for ZKSCAN3 Gene
Other Protein References for ZKSCAN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ZKSCAN3 Antibody
- GeneTex Anti-ZKSCAN3 antibody [N1C2]
- Novus Biologicals Antibodies for ZKSCAN3
-
Abcam antibodies for ZKSCAN3
- Invitrogen Antibodies for ZKSCAN3 (AFLGC-ZKSCAN3)
-
Biorbyt antibodies for ZKSCAN3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZKSCAN3
Protein Products
-
OriGene Purified Proteins for ZKSCAN3
- Search Origene for MassSpec and Protein Over-expression Lysates for ZKSCAN3
- Origene Custom Protein Services for ZKSCAN3
- antibodies-online: Show 5 available ZKSCAN3 Proteins ranked by validation data
- Compare Top ZKSCAN3 Proteins
-
Quality Products:
-
Signalway Proteins for ZKSCAN3
-
Abcam proteins for ZKSCAN3
No data available for DME Specific Peptides for ZKSCAN3 Gene
Domains & Families for ZKSCAN3 Gene
Gene Families for ZKSCAN3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZKSCAN3 Gene
- InterPro:
- Blocks:
-
- C2H2-type zinc finger signature
- KRAB box
- Transcriptional regulator SCAN
- ProtoNet:
Suggested Antigen Peptide Sequences for ZKSCAN3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ33906 fis, clone CTONG2008466, highly similar to Zinc finger protein 306 (B3KR99_HUMAN)
- Zinc finger protein 47 homolog (ZKSC3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BRR0- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZKSCAN3 Gene
Molecular function for ZKSCAN3 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
- UniProtKB/Swiss-Prot Induction:
- Overexpressed in various tumors, such as multiple myeloma, colorectal and prostate cancers (at protein level).
Phenotypes From GWAS Catalog for ZKSCAN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18940803 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 18940803 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA,IDA | 18940803 |
| GO:0003682 | chromatin binding | IDA | 18940803 |
Phenotypes for ZKSCAN3 Gene
- MGI mutant phenotypes for ZKSCAN3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZKSCAN3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZKSCAN3 - Select products 50% OFF >
- * ZKSCAN3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZKSCAN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZKSCAN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZKSCAN3
miRNA for ZKSCAN3 Gene
- miRTarBase miRNAs that target ZKSCAN3
-
- mmu-miR-30e-5p (MIRT013441)
- hsa-miR-26b-5p (MIRT029358)
- hsa-miR-6773-5p (MIRT670249)
- hsa-miR-6724-5p (MIRT670250)
- hsa-miR-7977 (MIRT670251)
- hsa-miR-3178 (MIRT670252)
- hsa-miR-6781-5p (MIRT670253)
- hsa-miR-6877-5p (MIRT670254)
- hsa-miR-24-3p (MIRT670255)
- hsa-miR-4284 (MIRT670256)
- hsa-miR-6774-5p (MIRT670257)
- hsa-miR-635 (MIRT670258)
- hsa-miR-6499-5p (MIRT670259)
- hsa-miR-338-3p (MIRT670260)
- hsa-miR-7157-5p (MIRT670261)
- hsa-miR-4310 (MIRT670262)
- hsa-miR-6513-5p (MIRT679903)
- hsa-miR-887-5p (MIRT679904)
- hsa-miR-3913-5p (MIRT679905)
- hsa-miR-3122 (MIRT679906)
- hsa-miR-450a-1-3p (MIRT679907)
- hsa-miR-6780a-5p (MIRT679908)
- hsa-miR-6779-5p (MIRT679909)
- hsa-miR-3689c (MIRT679910)
- hsa-miR-3689b-3p (MIRT679911)
- hsa-miR-3689a-3p (MIRT679912)
- hsa-miR-30b-3p (MIRT679913)
- hsa-miR-1273h-5p (MIRT679914)
- hsa-miR-6788-5p (MIRT679915)
- hsa-miR-30c-2-3p (MIRT679916)
- hsa-miR-30c-1-3p (MIRT679917)
- hsa-miR-6799-5p (MIRT679918)
- hsa-miR-6883-5p (MIRT679919)
- hsa-miR-6785-5p (MIRT679920)
- hsa-miR-4728-5p (MIRT679921)
- hsa-miR-149-3p (MIRT679922)
- hsa-miR-7106-5p (MIRT679923)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZKSCAN3
- Browse OriGene Inhibitory RNA Products For ZKSCAN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZKSCAN3
Clone Products
- Applied Biological Materials (abm): Clones for ZKSCAN3 - Select products 50% OFF >
- * ZKSCAN3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZKSCAN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZKSCAN3
Cell Line Products
-
Horizon Cell Lines for ZKSCAN3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN3 Gene
Localization for ZKSCAN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN3 Gene
- Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| lysosome | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 18940803 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 23434374 |
Pathways & Interactions for ZKSCAN3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
Pathways by source for ZKSCAN3 Gene
2 Reactome pathways for ZKSCAN3 Gene
Interacting Proteins for ZKSCAN3 Gene
Selected Interacting proteins:
Q9BRR0-ZKSC3_HUMAN
ENSP00000366465
for ZKSCAN3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ZKSCAN3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 18940803 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006914 | autophagy | IEA | -- |
| GO:0007040 | lysosome organization | IMP | 23434374 |
| GO:0010507 | negative regulation of autophagy | IMP | 23434374 |
No data available for SIGNOR curated interactions for ZKSCAN3 Gene
Transcripts for ZKSCAN3 Gene
mRNA/cDNA for ZKSCAN3 Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000252211 4687 nts (view in UCSC)
- ENST00000341464 1794 nts (view in UCSC)
- ENST00000377255 4799 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZKSCAN3 - Select products 50% OFF >
- * ZKSCAN3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZKSCAN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZKSCAN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZKSCAN3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZKSCAN3
- Browse OriGene Inhibitory RNA Products For ZKSCAN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZKSCAN3
Clone Products
- Applied Biological Materials (abm): Clones for ZKSCAN3 - Select products 50% OFF >
- * ZKSCAN3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZKSCAN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZKSCAN3
Relevant External Links for ZKSCAN3 Gene
- GeneLoc Exon Structure for
- ZKSCAN3
Expression for ZKSCAN3 Gene
This gene is overexpressed in Heart (66.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZKSCAN3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZKSCAN3
SOURCE GeneReport for Unigene cluster for ZKSCAN3 Gene:
Hs.380930Primer Products
-
OriGene qPCR primer pairs for ZKSCAN3
-
OriGene qPCR primer pairs and template standards for ZKSCAN3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZKSCAN3 Gene
Orthologs for ZKSCAN3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZKSCAN3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zkscan3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Zkscan3 30 17 31 |
|
ManyToMany | |
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany |
- Species where no ortholog for ZKSCAN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for ZKSCAN3 Gene
- ENSEMBL:
- Gene Tree for ZKSCAN3 (if available)
- TreeFam:
- Gene Tree for ZKSCAN3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZKSCAN3: view image
Paralogs for ZKSCAN3 Gene
Paralogs for ZKSCAN3 Gene
(426) SIMAP similar genes for ZKSCAN3 Gene using alignment to 1 proteins:
- ZKSC3_HUMAN
- ZKSCAN4
- ZNF883
- DKFZp686G16228
- ZNF502
- ZNF320
- HZF36
- ZNF98
- ZNF782
- ZNF772
- ZNF71
- ZNF585B
- ZNF253
- ZNF135
- ZNF134
- HZF30
- ZNF527
- ZNF93
- ZNF891
- ZNF773
- ZNF708
- ZNF675
- ZNF544
- ZNF519
- ZNF354C
- ZNF345
- ZNF300
- ZNF286B
- ZNF28
- ZNF271
- ZNF180
- ZNF117
- ZIM3
- ZFS-1
- KIAA1829
- DKFZp686B16128
- ZNF551
- ZNF510
- ZNF501
- ZNF879
- ZNF852
- ZNF845
- ZNF84
- ZNF813
- ZNF790
- ZNF79
- ZNF776
- ZNF765
- ZNF70
- ZNF660
- ZNF619
- ZNF616
- ZNF605
- ZNF595
- ZNF565
- ZNF479
- ZNF471
- ZNF470
- ZNF43
- ZNF429
- ZNF416
- ZNF254
- ZNF233
- ZNF23
- ZNF225
- ZNF211
- ZNF195
- ZNF16
- ZNF154
- ZNF132
- ZFP3
- ZFP2
- ZFP1
- DKFZp686H20223
- DKFZp571N1833
- DKFZp547L155
- ZNF286A
- ZNF33B
- ZNF234
- ZNF514
- ZNF92
- ZNF888
- ZNF85
- ZNF841
- ZNF780B
- ZNF768
- ZNF729
- ZNF718
- ZNF681
- ZNF671
- ZNF606
- ZNF600
- ZNF569
- ZNF567
- ZNF480
- ZNF454
- ZNF41
- ZNF383
- ZNF347
- ZNF34
- ZNF30
- ZNF268
- ZNF214
- ZNF208
- ZNF14
- ZFP62
- ZF6
- DKFZp686J1732
- DKFZp666M039
- DKFZp666C237
- ZNF568
- ZNF473
- ZNF99
- ZNF835
- ZNF816
- ZNF814
- ZNF792
- ZNF791
- ZNF749
- ZNF720
- ZNF701
- ZNF677
- ZNF587B
- ZNF549
- ZNF546
- ZNF484
- ZNF441
- ZNF420
- ZNF415
- ZNF358
- ZNF354A
- ZNF350
- ZNF283
- ZNF273
- ZNF267
- ZNF256
- ZNF248
- ZNF182
- ZNF141
- ZNF100
- ZIK1
- ZFP28
- HZF14
- HZF11
- DKFZp762K012
- DKFZp686K03205
- DKFZp686C13142
- DKFZp434G1930
- ZNF83
- ZNF337
- ZNF285A
- ZNF257
- zf30
- ZNF836
- ZNF81
- ZNF808
- ZNF780A
- ZNF761
- ZNF736
- ZNF732
- ZNF728
- ZNF724P
- ZNF648
- ZNF614
- ZNF599
- ZNF573
- ZNF548
- ZNF530
- ZNF528
- ZNF506
- ZNF493
- ZNF468
- ZNF45
- ZNF431
- ZNF354B
- ZNF343
- ZNF333
- ZNF285
- ZNF229
- ZNF20
- ZNF175
- ZNF146
- ZNF112
- ZFP14
- ZFP112
- HZF41
- DKFZp434G1621
- PRMD9
- ZNF461
- ZNF525
- PRDM9
- ZKSCAN8
- ZNF91
- ZNF860
- ZNF726
- ZNF695
- ZNF680
- ZNF668
- ZNF611
- ZNF607
- ZNF583
- ZNF559
- ZNF497
- ZNF418
- ZNF417
- ZNF404
- ZNF391
- ZNF334
- ZNF329
- ZNF311
- ZNF264
- ZNF230
- ZNF224
- ZNF17
- ZNF133
- Nbla00121
- GD
- DKFZp572F2170
- ZNF717
- ZNF570
- ZNF626
- ZNF578
- HKR1
- ZNF323
- ZNF878
- ZNF846
- ZNF766
- ZNF737
- ZNF709
- ZNF699
- ZNF676
- ZNF665
- ZNF627
- ZNF624
- ZNF623
- ZNF621
- ZNF587
- ZNF57
- ZNF560
- ZNF492
- ZNF486
- ZNF439
- ZNF432
- ZNF35
- ZNF32
- ZNF302
- ZNF260
- ZNF26
- ZNF25
- ZNF136
- ZNF12
- ZNF107
- ZFP90
- MST154
- LOC126295
- ZNF419
- ZNF540
- ZNF823
- ZNF805
- ZNF730
- ZNF727
- ZNF678
- ZNF674
- ZNF667
- ZNF658B
- ZNF658
- ZNF615
- ZNF585A
- ZNF571
- ZNF543
- ZNF491
- ZNF322
- ZNF275
- ZNF227
- ZNF2
- ZNF160
- ZNF140
- ZFP37
- ZFP30
- RBAK
- HZF17
- ZNF44
- ZNF566
- ZNF90
- ZNF73
- ZNF721
- ZNF69
- ZNF684
- ZNF672
- ZNF664
- ZNF643
- ZNF610
- ZNF485
- ZNF442
- ZNF436
- ZNF397
- ZNF355P
- ZNF33A
- ZNF324
- ZNF226
- ZNF19
- ZFP69B
- DKFZp686D2168
- ZSCAN2
- ZNF558
- ZNF189
- ZNF80
- ZSCAN21
- ZSCAN12
- ZNF771
- ZNF735
- ZNF586
- ZNF577
- ZNF563
- ZNF529
- ZNF37A
- ZNF324B
- ZNF266
- ZNF181
- ZNF10
- DKFZp313M0722
- ZNF778
- ZNF66
- ZNF426
- ZNF331
- ZNF589
- ZNF786
- ZNF697
- ZNF630
- ZNF620
- ZNF582
- ZNF534
- ZNF443
- ZNF316
- ZNF304
- ZNF251
- ZNF184
- ZFP69
- ZFP82
- ZNF557
- ZKSCAN1
- ZSCAN30
- ZNF840
- ZNF774
- ZNF77
- ZNF75CP
- ZNF594
- ZNF555
- ZNF235
- ZNF177
- ZNF157
- ZNF121
- DKFZp686L0787
- ZNF7
- ZNF682
- ZNF669
- ZSCAN10
- ZNF829
- ZNF714
- ZNF700
- ZNF629
- ZNF596
- ZNF490
- DKFZp686O111
- ZNF165
- ZSCAN23
- ZNF837
- ZNF75D
- ZNF716
- ZNF696
- ZNF662
- ZNF3
- ZNF287
- ZNF232
- ZNF221
- ZNF213
- ZNF169
- ZNF124
- ZKSCAN7
- DKFZp451F083
- CTCFL
- ZNF263
- ZSCAN9
- ZNF550
- ZNF500
- ZSCAN16
- ZNF561
- ZSCAN31
- ZNF880
- ZNF799
- ZNF625
- ZNF613
- ZNF572
- ZNF564
- ZNF430
- ZNF250
- ZFP92
- DKFZp686N14223
- ZNF649
- ZSCAN26
- ZSCAN22
- ZNF850
- ZNF689
- ZNF670
- ZNF554
- ZNF394
- ZKSCAN5
- TIPUH1
- GLI4
- ZNF460
- ZNF8
- ZNF547
- ZNF449
- ZNF396
- ZNF274
- ZNF24
- ZNF239
- ZNF223
- ZNF584
- ZNF517
- ZNF793
- ZSCAN20
- ZNF74
- ZNF483
- ZNF222
- ZNF174
- ZNF155
Variants for ZKSCAN3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZKSCAN3 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs13201752 | - | p.Lys200Glu | |||
| rs13201753 | - | p.Lys200Thr | |||
| rs17856167 | - | p.Val189Met | |||
| rs213227 | - | p.His246Gln | |||
| rs371085669 | - | p.Lys200Ala |
Residual Variation Intolerance Score:
21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.13;
75.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZKSCAN3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZKSCAN3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN3 Gene
Disorders for ZKSCAN3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| non-invasive bladder papillary urothelial neoplasm |
|
|
| ureteral benign neoplasm |
|
|
| chronic cervicitis |
|
|
| bladder papillary transitional cell neoplasm |
|
|
| urinary tract papillary transitional cell benign neoplasm |
|
|
Search ZKSCAN3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZKSCAN3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ZKSCAN3 Gene
Publications for ZKSCAN3 Gene
- The zinc finger transcription factor ZKSCAN3 promotes prostate cancer cell migration. (PMID: 22531714) Zhang X … Yang L (The international journal of biochemistry & cell biology 2012) 2 3 4
- Computer sequence analysis of human highly conserved zinc finger modules. (PMID: 10520746) Petroni D … Comi P (DNA sequence : the journal of DNA sequencing and mapping 1998) 2 3 4
- ZKSCAN3 is a master transcriptional repressor of autophagy. (PMID: 23434374) Chauhan S … Boyd DD (Molecular cell 2013) 3 4
- Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma. (PMID: 21057542) Yang L … Orlowski RZ (Oncogene 2011) 3 4
- Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 41
ExternalLinks
Products for ZKSCAN3 Gene
- Custom Antibody Services
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- antibodies-online: Show 8 available ZKSCAN3 Antibodies ranked by validation data
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- Quality Products:
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- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZKSCAN3
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- Biorbyt antibodies for ZKSCAN3
- Signalway Proteins for ZKSCAN3
Sources for ZKSCAN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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- (36) Pseudogene
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- (38) dbSNP
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- (44) Atlas
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- (48) IMGT
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- (50) miRBase
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- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
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- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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