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ZKSCAN3 (Zinc Finger With KRAB And SCAN Domains 3) is a Protein Coding gene. Diseases associated with ZKSCAN3 include Non-Invasive Bladder Papillary Urothelial Neoplasm and Ureteral Benign Neoplasm. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ZKSCAN4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18940803 |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 18940803 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA,IDA | 18940803 |
GO:0003682 | chromatin binding | IDA | 18940803 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 18940803 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 23434374 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 18940803 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006914 | autophagy | IEA | -- |
GO:0007040 | lysosome organization | IMP | 23434374 |
GO:0010507 | negative regulation of autophagy | IMP | 23434374 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZKSCAN3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zkscan3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Zkscan3 30 17 31 |
|
ManyToMany | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs13201752 | - | p.Lys200Glu | |||
rs13201753 | - | p.Lys200Thr | |||
rs17856167 | - | p.Val189Met | |||
rs213227 | - | p.His246Gln | |||
rs371085669 | - | p.Lys200Ala |
Disorder | Aliases | PubMed IDs |
---|---|---|
non-invasive bladder papillary urothelial neoplasm |
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ureteral benign neoplasm |
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chronic cervicitis |
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bladder papillary transitional cell neoplasm |
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urinary tract papillary transitional cell benign neoplasm |
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