Aliases for ZKSCAN2 Gene

Aliases for ZKSCAN2 Gene

  • Zinc Finger With KRAB And SCAN Domains 2 2 3 5
  • Zinc Finger Protein 694 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 2 3 4
  • ZNF694 3 4
  • Zinc Finger And SCAN Domain Containing 31 3
  • ZSCAN31 3
  • ZSCAN34 3

External Ids for ZKSCAN2 Gene

Previous HGNC Symbols for ZKSCAN2 Gene

  • ZNF694

Previous GeneCards Identifiers for ZKSCAN2 Gene

  • GC16M025157
  • GC16M023340
  • GC16M025248

Summaries for ZKSCAN2 Gene

GeneCards Summary for ZKSCAN2 Gene

ZKSCAN2 (Zinc Finger With KRAB And SCAN Domains 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is ZSCAN29.

UniProtKB/Swiss-Prot Summary for ZKSCAN2 Gene

Additional gene information for ZKSCAN2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZKSCAN2 Gene

Genomics for ZKSCAN2 Gene

GeneHancer (GH) Regulatory Elements for ZKSCAN2 Gene

Promoters and enhancers for ZKSCAN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZKSCAN2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZKSCAN2

Top Transcription factor binding sites by QIAGEN in the ZKSCAN2 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HEN1
  • NRSF form 1
  • NRSF form 2
  • p300
  • POU2F1
  • POU2F1a
  • STAT5A
  • YY1

Genomic Locations for ZKSCAN2 Gene

Genomic Locations for ZKSCAN2 Gene
chr16:25,236,001-25,257,889
(GRCh38/hg38)
Size:
21,889 bases
Orientation:
Minus strand
chr16:25,247,322-25,269,252
(GRCh37/hg19)
Size:
21,931 bases
Orientation:
Minus strand

Genomic View for ZKSCAN2 Gene

Genes around ZKSCAN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN2 Gene

Proteins for ZKSCAN2 Gene

  • Protein details for ZKSCAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HK3-ZKSC2_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 2
    Protein Accession:
    Q63HK3
    Secondary Accessions:
    • A1L3B4
    • Q6ZN77

    Protein attributes for ZKSCAN2 Gene

    Size:
    967 amino acids
    Molecular mass:
    110941 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZKSCAN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZKSCAN2 Gene

Post-translational modifications for ZKSCAN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZKSCAN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZKSCAN2 Gene

Domains & Families for ZKSCAN2 Gene

Gene Families for ZKSCAN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZKSCAN2 Gene

Blocks:
  • Myb DNA-binding domain
  • KRAB box
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZKSCAN2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56217, highly similar to Zinc finger protein 694 (B4E0P9_HUMAN)
  • Zinc finger protein 694 (ZKSC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q63HK3

UniProtKB/Swiss-Prot:

ZKSC2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZKSCAN2: view

Function for ZKSCAN2 Gene

Molecular function for ZKSCAN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZKSCAN2 Gene

Gene Ontology (GO) - Molecular Function for ZKSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with ZKSCAN2: view
genes like me logo Genes that share phenotypes with ZKSCAN2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN2 Gene

Localization for ZKSCAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZKSCAN2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZKSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZKSCAN2: view

Pathways & Interactions for ZKSCAN2 Gene

PathCards logo

SuperPathways for ZKSCAN2 Gene

No Data Available

Interacting Proteins for ZKSCAN2 Gene

;

Gene Ontology (GO) - Biological Process for ZKSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZKSCAN2: view

No data available for Pathways by source and SIGNOR curated interactions for ZKSCAN2 Gene

Drugs & Compounds for ZKSCAN2 Gene

No Compound Related Data Available

Transcripts for ZKSCAN2 Gene

mRNA/cDNA for ZKSCAN2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN2 Gene

No ASD Table

Relevant External Links for ZKSCAN2 Gene

GeneLoc Exon Structure for
ZKSCAN2

Expression for ZKSCAN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZKSCAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZKSCAN2

SOURCE GeneReport for Unigene cluster for ZKSCAN2 Gene:

Hs.513451

Evidence on tissue expression from TISSUES for ZKSCAN2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZKSCAN2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZKSCAN2 Gene

Orthologs for ZKSCAN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN2 31 30
  • 99.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZKSCAN2 31 30
  • 87.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZKSCAN2 31 30
  • 86.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zkscan2 17 31 30
  • 83.59 (n)
rat
(Rattus norvegicus)
Mammalia Zkscan2 30
  • 83.42 (n)
oppossum
(Monodelphis domestica)
Mammalia ZKSCAN2 31
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 41 (a)
ManyToMany
Species where no ortholog for ZKSCAN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN2 Gene

ENSEMBL:
Gene Tree for ZKSCAN2 (if available)
TreeFam:
Gene Tree for ZKSCAN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZKSCAN2: view image

Paralogs for ZKSCAN2 Gene

(288) SIMAP similar genes for ZKSCAN2 Gene using alignment to 2 proteins:

  • ZKSC2_HUMAN
  • H3BQ35_HUMAN
genes like me logo Genes that share paralogs with ZKSCAN2: view

Variants for ZKSCAN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZKSCAN2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs2112811 - p.Leu253Phe
rs7197424 - p.Pro947Ser
rs8059494 - p.Glu615Asp

Additional dbSNP identifiers (rs#s) for ZKSCAN2 Gene

Variation tolerance for ZKSCAN2 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.67; 91.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZKSCAN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZKSCAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN2 Gene

Disorders for ZKSCAN2 Gene

Additional Disease Information for ZKSCAN2

No disorders were found for ZKSCAN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN2 Gene

Publications for ZKSCAN2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  3. Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. (PMID: 28218735) Kamran M … Liu Q (Oncogenesis 2017) 3 54
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  5. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 54

Products for ZKSCAN2 Gene

Sources for ZKSCAN2 Gene