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Aliases for ZKSCAN2 Gene

Aliases for ZKSCAN2 Gene

  • Zinc Finger With KRAB And SCAN Domains 2 2 3 5
  • Zinc Finger Protein 694 2 3 4
  • ZNF694 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 2 3
  • Zinc Finger And SCAN Domain Containing 31 3
  • ZSCAN31 3
  • ZSCAN34 3

External Ids for ZKSCAN2 Gene

Previous HGNC Symbols for ZKSCAN2 Gene

  • ZNF694

Previous GeneCards Identifiers for ZKSCAN2 Gene

  • GC16M025157
  • GC16M023340
  • GC16M025248

Summaries for ZKSCAN2 Gene

GeneCards Summary for ZKSCAN2 Gene

ZKSCAN2 (Zinc Finger With KRAB And SCAN Domains 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is ZSCAN29.

UniProtKB/Swiss-Prot for ZKSCAN2 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZKSCAN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN2 Gene

Genomics for ZKSCAN2 Gene

GeneHancer (GH) Regulatory Elements for ZKSCAN2 Gene

Promoters and enhancers for ZKSCAN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I025256 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 592 +0.1 108 2.8 MLX ZFP64 FEZF1 DMAP1 IRF4 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZKSCAN2 GC16P025953 ENSG00000274925 RBBP6 LOC554206 ENSG00000261669 SCML2P2 HMGN2P3 ENSG00000263326 ARHGAP17
GH16I025047 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 36.3 +207.6 207614 5.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 SIN3A FEZF1 ZNF2 POLR2B ZNF213 RBBP6 LOC100421173 ENSG00000263326 ZKSCAN2 SCML2P2 LOC554206 ENSG00000261669 HMGN2P3 LINC02175 LCMT1
GH16I024998 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 +258.0 258048 2.2 FOXA2 MLX ARID4B ZNF213 NFYC ZHX2 MXD4 MIER2 ZNF623 PPARG GC16M024999 PIR57337 LINC02175 ENSG00000263326 SCML2P2 RBBP6 ZKSCAN2 LOC100421173 LOC554206 ENSG00000261669
GH16I025233 Enhancer 1 Ensembl ENCODE 10.3 +24.1 24146 0.4 RB1 ZNF2 RAD21 ZNF143 ZNF391 ATF7 CREM ZNF654 YY2 MXD4 ZKSCAN2 PIR35238 AQP8
GH16I025225 Enhancer 1 Ensembl ENCODE 8.4 +32.4 32431 0.6 HDGF ELF3 RB1 RAD21 SLC30A9 ZNF335 ARID2 ZNF143 ATF7 ZNF362 ZKSCAN2 AQP8 PIR35238
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZKSCAN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZKSCAN2 gene promoter:

Genomic Locations for ZKSCAN2 Gene

Genomic Locations for ZKSCAN2 Gene
21,931 bases
Minus strand

Genomic View for ZKSCAN2 Gene

Genes around ZKSCAN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN2 Gene

Proteins for ZKSCAN2 Gene

  • Protein details for ZKSCAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 2
    Protein Accession:
    Secondary Accessions:
    • A1L3B4
    • Q6ZN77

    Protein attributes for ZKSCAN2 Gene

    967 amino acids
    Molecular mass:
    110941 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZKSCAN2 Gene


neXtProt entry for ZKSCAN2 Gene

Post-translational modifications for ZKSCAN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZKSCAN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZKSCAN2 Gene

Domains & Families for ZKSCAN2 Gene

Gene Families for ZKSCAN2 Gene

Suggested Antigen Peptide Sequences for ZKSCAN2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZKSCAN2: view

Function for ZKSCAN2 Gene

Molecular function for ZKSCAN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZKSCAN2 Gene

Gene Ontology (GO) - Molecular Function for ZKSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with ZKSCAN2: view

Phenotypes for ZKSCAN2 Gene

genes like me logo Genes that share phenotypes with ZKSCAN2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN2 Gene

Localization for ZKSCAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZKSCAN2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZKSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with ZKSCAN2: view

Pathways & Interactions for ZKSCAN2 Gene

SuperPathways for ZKSCAN2 Gene

No Data Available

Interacting Proteins for ZKSCAN2 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZKSCAN2: view

No data available for Pathways by source and SIGNOR curated interactions for ZKSCAN2 Gene

Drugs & Compounds for ZKSCAN2 Gene

No Compound Related Data Available

Transcripts for ZKSCAN2 Gene

Unigene Clusters for ZKSCAN2 Gene

Zinc finger with KRAB and SCAN domains 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN2 Gene

No ASD Table

Relevant External Links for ZKSCAN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZKSCAN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZKSCAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZKSCAN2 Gene:


SOURCE GeneReport for Unigene cluster for ZKSCAN2 Gene:


Evidence on tissue expression from TISSUES for ZKSCAN2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZKSCAN2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZKSCAN2 Gene

Orthologs for ZKSCAN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZKSCAN2 33 34
  • 99.72 (n)
(Canis familiaris)
Mammalia ZKSCAN2 33 34
  • 87.09 (n)
(Bos Taurus)
Mammalia ZKSCAN2 33 34
  • 86.69 (n)
(Mus musculus)
Mammalia Zkscan2 33 16 34
  • 83.59 (n)
(Rattus norvegicus)
Mammalia Zkscan2 33
  • 83.42 (n)
(Monodelphis domestica)
Mammalia ZKSCAN2 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 41 (a)
Species where no ortholog for ZKSCAN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN2 Gene

Gene Tree for ZKSCAN2 (if available)
Gene Tree for ZKSCAN2 (if available)

Paralogs for ZKSCAN2 Gene

Paralogs for ZKSCAN2 Gene

(288) SIMAP similar genes for ZKSCAN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZKSCAN2: view

Variants for ZKSCAN2 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000024432 -- 25,258,326(-) G/T upstream_transcript_variant
rs1000094787 -- 25,247,949(-) A/T intron_variant
rs1000312680 -- 25,245,363(-) T/C intron_variant
rs1000407129 -- 25,249,010(-) G/A intron_variant
rs1000518633 -- 25,252,555(-) A/C intron_variant

Variation tolerance for ZKSCAN2 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.67; 91.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZKSCAN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN2 Gene

Disorders for ZKSCAN2 Gene

Additional Disease Information for ZKSCAN2

No disorders were found for ZKSCAN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN2 Gene

Publications for ZKSCAN2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  3. Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. (PMID: 28218735) Kamran M … Liu Q (Oncogenesis 2017) 3 58
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZKSCAN2 Gene

Sources for ZKSCAN2 Gene

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