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Aliases for ZIC5 Gene

Aliases for ZIC5 Gene

  • Zic Family Member 5 2 3 5
  • Zic Family Member 5 (Odd-Paired Homolog, Drosophila) 2
  • Zinc Finger Protein Of The Cerebellum 5 4

External Ids for ZIC5 Gene

Previous GeneCards Identifiers for ZIC5 Gene

  • GC13M098977
  • GC13M095004
  • GC13M099454
  • GC13M098315
  • GC13M099415
  • GC13M100615
  • GC13M081209

Summaries for ZIC5 Gene

Entrez Gene Summary for ZIC5 Gene

  • This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated expression of this gene has been observed in various human cancers and may contribute to cancer progression. This gene is closely linked to a related family member on chromosome 13. [provided by RefSeq, Mar 2017]

GeneCards Summary for ZIC5 Gene

ZIC5 (Zic Family Member 5) is a Protein Coding gene. Diseases associated with ZIC5 include Holoprosencephaly. Among its related pathways are Mesodermal Commitment Pathway and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZIC2.

UniProtKB/Swiss-Prot for ZIC5 Gene

  • Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).

Additional gene information for ZIC5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZIC5 Gene

Genomics for ZIC5 Gene

GeneHancer (GH) Regulatory Elements for ZIC5 Gene

Promoters and enhancers for ZIC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I099967 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 552.9 +2.0 1951 4.9 PKNOX1 ATF1 ARNT FEZF1 GLI4 ZNF2 ETS1 GLIS2 ZNF213 ATF7 ZIC5 PIR56949 GC13M099970 ZIC2
GH13I099974 Enhancer 0.8 ENCODE dbSUPER 550.8 -1.8 -1778 0.2 SCRT1 MAZ RNF2 ZSCAN4 OVOL3 CBX8 PRDM6 ZNF610 SCRT2 ZNF341 ZIC5 ZIC2
GH13I099972 Enhancer 0.6 ENCODE dbSUPER 550.8 -0.6 -628 0.2 ZBTB12 EZH2 ZIC5 ZIC2
GH13I099978 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.8 -11.6 -11593 10.8 HDGF ARNT SIN3A FEZF1 GLI4 ZNF2 BRCA1 ETS1 ZNF121 GLIS2 ZIC2 ZIC5 UBAC2 GC13P099996
GH13I099990 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 32.1 -18.6 -18601 0.8 ZSCAN5A SUZ12 ZSCAN4 KLF17 ZNF2 BCL11B RARA ZNF324 ZFHX2 GLIS2 ZIC5 ZIC2 GC13P099996
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZIC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZIC5 gene promoter:

Genomic Locations for ZIC5 Gene

Genomic Locations for ZIC5 Gene
8,961 bases
Minus strand

Genomic View for ZIC5 Gene

Genes around ZIC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZIC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZIC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIC5 Gene

Proteins for ZIC5 Gene

  • Protein details for ZIC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein ZIC 5
    Protein Accession:
    Secondary Accessions:
    • Q5VYB0

    Protein attributes for ZIC5 Gene

    663 amino acids
    Molecular mass:
    68448 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK55418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZIC5 Gene

Post-translational modifications for ZIC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZIC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZIC5 Gene

Domains & Families for ZIC5 Gene

Gene Families for ZIC5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZIC5 Gene

Suggested Antigen Peptide Sequences for ZIC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GLI C2H2-type zinc-finger protein family.
  • Belongs to the GLI C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZIC5: view

Function for ZIC5 Gene

Molecular function for ZIC5 Gene

UniProtKB/Swiss-Prot Function:
Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).

Phenotypes From GWAS Catalog for ZIC5 Gene

Gene Ontology (GO) - Molecular Function for ZIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZIC5: view
genes like me logo Genes that share phenotypes with ZIC5: view

Animal Models for ZIC5 Gene

MGI Knock Outs for ZIC5:

Animal Model Products

CRISPR Products

miRNA for ZIC5 Gene

miRTarBase miRNAs that target ZIC5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZIC5 Gene

Localization for ZIC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIC5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZIC5 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZIC5: view

Pathways & Interactions for ZIC5 Gene

genes like me logo Genes that share pathways with ZIC5: view

Pathways by source for ZIC5 Gene

Gene Ontology (GO) - Biological Process for ZIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZIC5: view

No data available for SIGNOR curated interactions for ZIC5 Gene

Drugs & Compounds for ZIC5 Gene

No Compound Related Data Available

Transcripts for ZIC5 Gene

mRNA/cDNA for ZIC5 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZIC5 Gene

Zic family member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZIC5 Gene

No ASD Table

Relevant External Links for ZIC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZIC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZIC5 Gene

mRNA differential expression in normal tissues according to GTEx for ZIC5 Gene

This gene is overexpressed in Brain - Cerebellum (x21.9) and Brain - Cerebellar Hemisphere (x18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZIC5 Gene

Protein tissue co-expression partners for ZIC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZIC5 Gene:


SOURCE GeneReport for Unigene cluster for ZIC5 Gene:

genes like me logo Genes that share expression patterns with ZIC5: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZIC5 Gene

Orthologs for ZIC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZIC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZIC5 34
  • 100 (a)
(Canis familiaris)
Mammalia ZIC5 33 34
  • 93.55 (n)
(Rattus norvegicus)
Mammalia Zic5 33
  • 92.7 (n)
(Ornithorhynchus anatinus)
Mammalia ZIC5 34
  • 91 (a)
(Mus musculus)
Mammalia Zic5 33 16 34
  • 89.96 (n)
(Bos Taurus)
Mammalia ZIC5 34
  • 89 (a)
(Monodelphis domestica)
Mammalia ZIC5 34
  • 76 (a)
(Anolis carolinensis)
Reptilia ZIC5 34
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia zic5-A 33
(Danio rerio)
Actinopterygii zic5 34
  • 67 (a)
Dr.27091 33
fruit fly
(Drosophila melanogaster)
Insecta opa 35 34
  • 62 (a)
lmd 35
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4381 34
  • 33 (a)
Species where no ortholog for ZIC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZIC5 Gene

Gene Tree for ZIC5 (if available)
Gene Tree for ZIC5 (if available)

Paralogs for ZIC5 Gene

Paralogs for ZIC5 Gene

(7) SIMAP similar genes for ZIC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZIC5: view

Variants for ZIC5 Gene

Sequence variations from dbSNP and Humsavar for ZIC5 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000539945 -- 99,972,288(-) G/A upstream_transcript_variant
rs1000611457 -- 99,971,341(-) G/A coding_sequence_variant, missense_variant
rs1001017851 -- 99,967,940(-) T/C intron_variant
rs1001131290 -- 99,967,117(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZIC5 Gene

Variant ID Type Subtype PubMed ID
dgv345n67 CNV gain 20364138
dgv346n67 CNV gain 20364138
dgv347n67 CNV gain 20364138
esv2747875 CNV deletion 23290073
nsv1069768 CNV deletion 25765185
nsv1118272 CNV deletion 24896259
nsv1121866 CNV deletion 24896259
nsv456093 CNV loss 19166990
nsv510622 CNV deletion 20534489
nsv562952 CNV loss 21841781
nsv562953 CNV loss 21841781
nsv562954 CNV loss 21841781
nsv826757 CNV loss 20364138
nsv826766 CNV gain 20364138
nsv832697 CNV loss 17160897

Variation tolerance for ZIC5 Gene

Gene Damage Index Score: 3.67; 57.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZIC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZIC5 Gene

Disorders for ZIC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZIC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • holoprosencephaly sequence
- elite association - COSMIC cancer census association via MalaCards
Search ZIC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZIC5

genes like me logo Genes that share disorders with ZIC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZIC5 Gene

Publications for ZIC5 Gene

  1. Identification of zinc finger protein of the cerebellum 5 as a survival factor of prostate and colorectal cancer cells. (PMID: 29024195) Satow R … Fukami K (Cancer science 2017) 3 58
  2. MAGI2 Mutations Cause Congenital Nephrotic Syndrome. (PMID: 27932480) Bierzynska A … UK study of Nephrotic Syndrome (Journal of the American Society of Nephrology : JASN 2017) 4 58
  3. ZIC5 Drives Melanoma Aggressiveness by PDGFD-Mediated Activation of FAK and STAT3. (PMID: 27671679) Satow R … Fukami K (Cancer research 2017) 3 58
  4. Overexpression of ZIC5 promotes proliferation in non-small cell lung cancer. (PMID: 27663664) Sun Q … Ren B (Biochemical and biophysical research communications 2016) 3 58
  5. Gene-expression analysis of gleason grade 3 tumor glands embedded in low- and high-risk prostate cancer. (PMID: 27191985) Hoogland AM … van Leenders GJ (Oncotarget 2016) 3 58

Products for ZIC5 Gene

Sources for ZIC5 Gene

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