Aliases for ZIC5 Gene
External Ids for ZIC5 Gene
Previous GeneCards Identifiers for ZIC5 Gene
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated expression of this gene has been observed in various human cancers and may contribute to cancer progression. This gene is closely linked to a related family member on chromosome 13. [provided by RefSeq, Mar 2017]
GeneCards Summary for ZIC5 Gene
ZIC5 (Zic Family Member 5) is a Protein Coding gene. Diseases associated with ZIC5 include Holoprosencephaly. Among its related pathways are Mesodermal Commitment Pathway and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZIC2.
UniProtKB/Swiss-Prot for ZIC5 Gene
Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).