This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008] See more...

Aliases for ZIC3 Gene

Aliases for ZIC3 Gene

  • Zic Family Member 3 2 3 5
  • ZNF203 2 3 4
  • Zic Family Member 3 (Odd-Paired Homolog, Drosophila) 2 3
  • Zinc Finger Protein Of The Cerebellum 3 3 4
  • Zinc Finger Protein ZIC 3 3 4
  • Zinc Finger Protein 203 3 4
  • Heterotaxy 1 2 3
  • HTX 2 3
  • VACTERLX 3
  • HTX1 3
  • ZIC3 5

External Ids for ZIC3 Gene

Previous HGNC Symbols for ZIC3 Gene

  • HTX1

Previous GeneCards Identifiers for ZIC3 Gene

  • GC0XP131220
  • GC0XP133493
  • GC0XP134593
  • GC0XP135353
  • GC0XP136373
  • GC0XP136475
  • GC0XP136648
  • GC0XP125916

Summaries for ZIC3 Gene

Entrez Gene Summary for ZIC3 Gene

  • This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZIC3 Gene

ZIC3 (Zic Family Member 3) is a Protein Coding gene. Diseases associated with ZIC3 include Heterotaxy, Visceral, 1, X-Linked and Vacterl Association, X-Linked, With Or Without Hydrocephalus. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZIC2.

UniProtKB/Swiss-Prot Summary for ZIC3 Gene

  • Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.

Gene Wiki entry for ZIC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZIC3 Gene

Genomics for ZIC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZIC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ137563 Promoter/Enhancer 2.1 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.1 1074 9.6 POLR2A SIN3A CTBP1 SP2 CUX1 YY1 PKNOX1 MAZ TAF1 RAD51 ENSG00000224765 HSALNG0140364-002 ZIC3 SRRM1P3 ENSG00000234062 RBMX ENSG00000283692
GH0XJ137432 Enhancer 0.8 Ensembl ENCODE 11.7 -133.3 -133326 2.8 ZNF654 TRIM22 CTCF NONO SMC3 RAD21 SP1 ZNF366 SUZ12 CREB1 SRRM1P3 RBMX ENSG00000224765 ZIC3 ENSG00000234062 RAC1P4 lnc-GPR101-2 HSALNG0140364-001 GPR101
GH0XJ137551 Enhancer 0.5 FANTOM5 ENCODE dbSUPER 9.3 -15.9 -15850 0.2 HSALNG0140366 ZIC3 ENSG00000224765 HSALNG0140364-001 GPR101
GH0XJ137431 Enhancer 0.3 ENCODE 11.7 -134.9 -134930 0.2 EGR1 ZNF143 ENSG00000224765 ZIC3 RAC1P4 lnc-GPR101-2 HSALNG0140364-001 GPR101
GH0XJ137533 Enhancer 0.3 Ensembl 12.6 -32.1 -32126 0.8 RFX1 ENSG00000224765 ZIC3 HSALNG0140364-001 HSALNG0140366 GPR101
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZIC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZIC3

Top Transcription factor binding sites by QIAGEN in the ZIC3 gene promoter:
  • HOXA5
  • Ik-2
  • Sp1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • SRF
  • SRF (504 AA)

Genomic Locations for ZIC3 Gene

Latest Assembly
chrX:137,566,127-137,577,691
(GRCh38/hg38)
Size:
11,565 bases
Orientation:
Plus strand

Previous Assembly
chrX:136,648,286-136,659,850
(GRCh37/hg19 by Entrez Gene)
Size:
11,565 bases
Orientation:
Plus strand

chrX:136,648,301-136,659,850
(GRCh37/hg19 by Ensembl)
Size:
11,550 bases
Orientation:
Plus strand

Genomic View for ZIC3 Gene

Genes around ZIC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZIC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZIC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIC3 Gene

Proteins for ZIC3 Gene

  • Protein details for ZIC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60481-ZIC3_HUMAN
    Recommended name:
    Zinc finger protein ZIC 3
    Protein Accession:
    O60481
    Secondary Accessions:
    • B2CNW4
    • Q14DE5
    • Q5JY75

    Protein attributes for ZIC3 Gene

    Size:
    467 amino acids
    Molecular mass:
    50569 Da
    Quaternary structure:
    • Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity (By similarity). Interacts with KPNA1 and KPNA6. Interacts (via C2H2-type domains 3, 4 and 5) with GLI3; the interaction enhances its transcriptional activity.

    Three dimensional structures from OCA and Proteopedia for ZIC3 Gene

    Alternative splice isoforms for ZIC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZIC3 Gene

Post-translational modifications for ZIC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZIC3 Gene

No data available for DME Specific Peptides for ZIC3 Gene

Domains & Families for ZIC3 Gene

Gene Families for ZIC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZIC3 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZIC3 Gene

GenScript: Design optimal peptide antigens:
  • Zic family member 3 (Odd-paired homolog, Drosophila) (Q5JY75_HUMAN)
  • Zinc finger protein of the cerebellum 3 (ZIC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60481

UniProtKB/Swiss-Prot:

ZIC3_HUMAN :
  • The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
  • Belongs to the GLI C2H2-type zinc-finger protein family.
Domain:
  • The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZIC3: view

Function for ZIC3 Gene

Molecular function for ZIC3 Gene

UniProtKB/Swiss-Prot Function:
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
GENATLAS Biochemistry:
zinc finger protein of the cerebellum,mouse Zic homolog

Phenotypes From GWAS Catalog for ZIC3 Gene

Gene Ontology (GO) - Molecular Function for ZIC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 17764085
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 17764085
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZIC3: view
genes like me logo Genes that share phenotypes with ZIC3: view

Human Phenotype Ontology for ZIC3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZIC3 Gene

MGI Knock Outs for ZIC3:

miRNA for ZIC3 Gene

miRTarBase miRNAs that target ZIC3

Transcription Factor Targets for ZIC3 Gene

Selected GeneGlobe predicted Target genes for ZIC3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZIC3

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for ZIC3 Gene

Localization for ZIC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIC3 Gene

Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZIC3 gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZIC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with ZIC3: view

Pathways & Interactions for ZIC3 Gene

genes like me logo Genes that share pathways with ZIC3: view

Pathways by source for ZIC3 Gene

1 Qiagen pathway for ZIC3 Gene
  • Transcriptional Regulatory Network in Embryonic Stem Cell

SIGNOR curated interactions for ZIC3 Gene

Activates:

Gene Ontology (GO) - Biological Process for ZIC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping IMP 9354794
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0007368 determination of left/right symmetry IMP 9354794
GO:0007389 pattern specification process IEA --
genes like me logo Genes that share ontologies with ZIC3: view

Drugs & Compounds for ZIC3 Gene

(1) Drugs for ZIC3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 1706
genes like me logo Genes that share compounds with ZIC3: view

Transcripts for ZIC3 Gene

mRNA/cDNA for ZIC3 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZIC3

Alternative Splicing Database (ASD) splice patterns (SP) for ZIC3 Gene

No ASD Table

Relevant External Links for ZIC3 Gene

GeneLoc Exon Structure for
ZIC3

Expression for ZIC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZIC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZIC3 Gene

This gene is overexpressed in Brain - Cerebellum (x18.9) and Brain - Cerebellar Hemisphere (x18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZIC3 Gene



Protein tissue co-expression partners for ZIC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZIC3

SOURCE GeneReport for Unigene cluster for ZIC3 Gene:

Hs.111227

Evidence on tissue expression from TISSUES for ZIC3 Gene

  • Nervous system(4.7)
  • Heart(3.4)
  • Stomach(3.3)
  • Muscle(3)
  • Liver(2.7)
  • Kidney(2.7)
  • Intestine(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZIC3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • ear
  • head
  • meninges
  • skull
Thorax:
  • esophagus
  • heart
  • heart valve
  • lung
  • trachea
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • rectum
  • ureter
  • urethra
  • urinary bladder
  • uterus
Limb:
  • arm
  • digit
  • finger
  • forearm
  • hand
  • humerus
  • nail
  • radius
  • upper limb
General:
  • blood
  • blood vessel
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with ZIC3: view

Primer products for research

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZIC3 Gene

Orthologs for ZIC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZIC3 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia ZIC3 29 30
  • 94.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZIC3 29 30
  • 94.71 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zic3 29 16 30
  • 93.06 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZIC3 30
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZIC3 29 30
  • 80.85 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zic3 29
  • 72.68 (n)
African clawed frog
(Xenopus laevis)
Amphibia zic3-A 29
Zebrafish
(Danio rerio)
Actinopterygii zic3 29 30
  • 71.23 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta lmd 31
  • 43 (a)
opa 30 31
  • 31 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 37 (a)
ManyToMany
CSA.7660 30
  • 36 (a)
ManyToMany
Species where no ortholog for ZIC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZIC3 Gene

ENSEMBL:
Gene Tree for ZIC3 (if available)
TreeFam:
Gene Tree for ZIC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZIC3: view image
Alliance of Genome Resources:
Additional Orthologs for ZIC3

Paralogs for ZIC3 Gene

Paralogs for ZIC3 Gene

(7) SIMAP similar genes for ZIC3 Gene using alignment to 1 proteins:

  • ZIC3_HUMAN
genes like me logo Genes that share paralogs with ZIC3: view

Variants for ZIC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZIC3 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
1020263 Uncertain Significance: Heterotaxy, visceral, 1, X-linked 137,569,052(+) G/T
NM_003413.4(ZIC3):c.1211G>T (p.Arg404Leu)
MISSENSE
1033580 Uncertain Significance: Heterotaxy, visceral, 1, X-linked 137,566,796(+) G/A
NM_003413.4(ZIC3):c.105G>A (p.Met35Ile)
MISSENSE
1044413 Uncertain Significance: Heterotaxy, visceral, 1, X-linked 137,567,017(+) C/G
NM_003413.4(ZIC3):c.326C>G (p.Ser109Cys)
MISSENSE
11440 Pathogenic: Heterotaxy, visceral, 1, X-linked 137,567,663(+) C/CTT
NM_003413.4(ZIC3):c.972_973insTT (p.Glu325fs)
FRAMESHIFT
853122 Uncertain Significance: Heterotaxy, visceral, 1, X-linked 137,568,999(+) GC/G
NM_003413.4(ZIC3):c.1161del (p.Tyr388fs)
FRAMESHIFT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZIC3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZIC3 Gene

Variant ID Type Subtype PubMed ID
nsv522544 CNV gain 19592680

Variation tolerance for ZIC3 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZIC3 Gene

Human Gene Mutation Database (HGMD)
ZIC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZIC3
Leiden Open Variation Database (LOVD)
ZIC3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZIC3 Gene

Disorders for ZIC3 Gene

MalaCards: The human disease database

(44) MalaCards diseases for ZIC3 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search ZIC3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ZIC3_HUMAN
  • Heterotaxy, visceral, 1, X-linked (HTX1) [MIM:306955]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can be associated with a variety of congenital defects including cardiac malformations. {ECO:0000269 PubMed:14681828, ECO:0000269 PubMed:17295247, ECO:0000269 PubMed:17764085, ECO:0000269 PubMed:18716025, ECO:0000269 PubMed:24123890, ECO:0000269 PubMed:9354794}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • VACTERL association X-linked with or without hydrocephalus (VACTERLX) [MIM:314390]: A syndrome characterized by a non-random association of congenital defects. Affected individuals manifest vertebral anomalies (V), anal atresia (A), cardiac malformations (C), tracheoesophageal fistula (TE), renal anomalies (R) such as urethral atresia with hydronephrosis, and limb anomalies (L) such as hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb. Some patients may have hydrocephalus. Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement. {ECO:0000269 PubMed:20452998, ECO:0000269 PubMed:24123890}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Congenital heart defects, multiple types, 1, X-linked (CHTD1) [MIM:306955]: A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. The etiology of CHTD is complex, with contributions from environmental exposure, chromosomal abnormalities, and gene defects. Some patients with CHTD also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions. {ECO:0000269 PubMed:14681828, ECO:0000269 PubMed:17764085, ECO:0000269 PubMed:24123890}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for ZIC3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZIC3: view

No data available for Genatlas for ZIC3 Gene

Publications for ZIC3 Gene

  1. Characterization of the interactions of human ZIC3 mutants with GLI3. (PMID: 17764085) Zhu L … Belmont JW (Human mutation 2008) 3 4 22 72
  2. Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects. (PMID: 14681828) Ware SM … Belmont JW (American journal of human genetics 2004) 3 4 22 72
  3. Polyalanine expansion in the ZIC3 gene leading to X-linked heterotaxy with VACTERL association: a new polyalanine disorder? (PMID: 20452998) Wessels MW … Casey B (Journal of medical genetics 2010) 4 22 72
  4. Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain. (PMID: 17295247) Chhin B … Bouvagnet P (Human mutation 2007) 3 4 22
  5. Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans. (PMID: 14679585) Klootwijk R … Franke B (American journal of medical genetics. Part A 2004) 3 22 40

Products for ZIC3 Gene

Sources for ZIC3 Gene