Aliases for ZIC1 Gene
External Ids for ZIC1 Gene
Previous GeneCards Identifiers for ZIC1 Gene
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZIC1 Gene
ZIC1 (Zic Family Member 1) is a Protein Coding gene. Diseases associated with ZIC1 include Craniosynostosis 6 and Structural Brain Anomalies With Impaired Intellectual Development And Craniosynostosis. Among its related pathways are Neural Crest Differentiation and Differentiation of white and brown adipocyte. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZIC2.
UniProtKB/Swiss-Prot Summary for ZIC1 Gene
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).