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This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may functio... See more...
Aliases for ZHX3 Gene
Aliases for ZHX3 Gene
External Ids for ZHX3 Gene
- HGNC: 15935
- Entrez Gene: 23051
- Ensembl: ENSG00000174306
- OMIM: 609598
- UniProtKB: Q9H4I2
Previous HGNC Symbols for ZHX3 Gene
- TIX1
Previous GeneCards Identifiers for ZHX3 Gene
- GC20M040492
- GC20M039240
- GC20M039807
- GC20M036545
Summaries for ZHX3 Gene
-
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZHX3 Gene
ZHX3 (Zinc Fingers And Homeoboxes 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ZHX1.
UniProtKB/Swiss-Prot Summary for ZHX3 Gene
-
Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.
Additional gene information for ZHX3 Gene
- HGNC(15935)
- Entrez Gene(23051)
- Ensembl(ENSG00000174306)
- OMIM(609598)
- UniProtKB(Q9H4I2)
- Open Targets Platform(ENSG00000174306)
- Monarch Initiative
- Search for ZHX3 at DataMed
- Search for ZHX3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZHX3 Gene
Genomics for ZHX3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZHX3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZHX3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZHX3
- Top Transcription factor binding sites by QIAGEN in the ZHX3 gene promoter:
-
- AML1a
- AP-2alpha
- AP-2alphaA
- AP-2beta
- AP-2gamma
- C/EBPalpha
- E2F
- E2F-1
- p300
Genomic Locations for ZHX3 Gene
Genomic Locations for ZHX3 Gene
- chr20:41,178,448-41,317,672
- (GRCh38/hg38)
- Size:
- 139,225 bases
- Orientation:
- Minus strand
- chr20:39,807,088-39,946,312
- (GRCh37/hg19)
- Size:
- 139,225 bases
- Orientation:
- Minus strand
Genomic View for ZHX3 Gene
Genes around ZHX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q12 by HGNC
- 20q12 by Entrez Gene
- 20q12 by Ensembl
ZHX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZHX3 Gene
Proteins for ZHX3 Gene
-
Protein details for ZHX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H4I2-ZHX3_HUMAN
- Recommended name:
- Zinc fingers and homeoboxes protein 3
- Protein Accession:
- Q9H4I2
- E1P5W5
- F5H820
- O43145
- Q6NUJ7
Protein attributes for ZHX3 Gene
- Size:
- 956 amino acids
- Molecular mass:
- 104658 Da
- Quaternary structure:
-
- Homodimer (via homeobox domain 1) (PubMed:12659632, PubMed:14659886). Heterodimer with ZHX1 (via homeobox domain 1) (PubMed:12659632). Heterodimer with ZHX2 (via homeobox domain 1) (PubMed:14659886). Heterodimerization with ZHX1 is a prerequisite for repressor activity (PubMed:12659632). Interacts with NFYA (PubMed:12659632).
- SequenceCaution:
-
- Sequence=BAA23691.3; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZHX3 Gene
Post-translational modifications for ZHX3 Gene
Other Protein References for ZHX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005260398.1
- XP_005260400.1
- XP_006723811.1
- XP_006723812.1
- XP_011527003.1
- XP_011527006.1
- XP_011527007.1
- XP_011527008.1
- XP_011527009.1
- XP_011527010.1
- XP_011527011.1
- XP_011527013.1
- XP_011527015.1
- XP_011527019.1
- XP_011527020.1
- XP_016883225.1
- XP_016883226.1
- XP_016883227.1
- XP_024307628.1
- XP_024307629.1
- XP_024307630.1
- NP_001371244.1
- NP_001371245.1
- NP_001371246.1
- NP_001371247.1
- NP_001371248.1
- NP_001371249.1
- NP_001371250.1
- NP_001371251.1
- NP_001371252.1
- NP_001371253.1
- NP_001371254.1
- NP_055850.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZHX3
- Novus Biologicals Antibodies for ZHX3
-
Abcam antibodies for ZHX3
- Invitrogen Antibodies for ZHX3 (AFLGC-ZHX3)
-
Boster Bio Antibodies for ZHX3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZHX3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ZHX3
- Origene Custom Protein Services for ZHX3
- antibodies-online: Show 4 available ZHX3 Proteins ranked by validation data
- Compare Top ZHX3 Proteins
-
Quality Products:
-
Abcam proteins for ZHX3
No data available for DME Specific Peptides for ZHX3 Gene
Domains & Families for ZHX3 Gene
Gene Families for ZHX3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZHX3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZHX3 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc fingers and homeoboxes 3 (Q5JZ64_HUMAN)
- Zinc fingers and homeoboxes 3 (Q5JZ65_HUMAN)
- Zinc fingers and homeoboxes 3 (Q5JZ66_HUMAN)
- Zinc fingers and homeoboxes 3 (Q5JZ67_HUMAN)
- Zinc fingers and homeoboxes 3 (Q5JZ68_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H4I2- Family:
-
- Belongs to the ZHX family.
Function for ZHX3 Gene
Molecular function for ZHX3 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated during osteogenic differentiation of mesenchymal stem cells.
Phenotypes From GWAS Catalog for ZHX3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IBA,IDA | 12659632 |
Phenotypes for ZHX3 Gene
- MGI mutant phenotypes for ZHX3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZHX3:
Animal Models for ZHX3 Gene
- MGI Knock Outs for ZHX3:
-
- Zhx3 Zhx3<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZHX3 - Select products 50% OFF >
- * ZHX3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZHX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZHX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZHX3
miRNA for ZHX3 Gene
- miRTarBase miRNAs that target ZHX3
-
- mmu-miR-758-3p (MIRT007638)
- mmu-miR-301b-3p (MIRT007947)
- mmu-miR-223-3p (MIRT009685)
- mmu-miR-17-5p (MIRT010023)
- mmu-miR-19b-3p (MIRT012507)
- mmu-miR-30e-5p (MIRT013334)
- mmu-miR-24-3p (MIRT013985)
- hsa-miR-124-3p (MIRT022152)
- hsa-miR-877-3p (MIRT037094)
- hsa-miR-3171 (MIRT450195)
- hsa-miR-4778-5p (MIRT450196)
- hsa-miR-100-3p (MIRT450197)
- hsa-miR-548e-5p (MIRT450198)
- hsa-miR-574-5p (MIRT552538)
- hsa-miR-1277-5p (MIRT552539)
- hsa-miR-190a-3p (MIRT552540)
- hsa-miR-6867-5p (MIRT552541)
- hsa-miR-223-5p (MIRT552542)
- hsa-miR-511-3p (MIRT552543)
- hsa-miR-5011-5p (MIRT552544)
- hsa-miR-410-3p (MIRT552545)
- hsa-miR-1183 (MIRT552546)
- hsa-miR-4793-3p (MIRT564762)
- hsa-miR-3130-3p (MIRT564763)
- hsa-miR-6749-3p (MIRT723727)
- hsa-miR-6826-3p (MIRT723728)
- hsa-miR-3117-5p (MIRT723729)
- hsa-miR-150-5p (MIRT723730)
- hsa-miR-6887-3p (MIRT723731)
- hsa-miR-6795-3p (MIRT723732)
- hsa-miR-186-3p (MIRT723733)
- hsa-miR-483-3p (MIRT723734)
- hsa-miR-425-5p (MIRT723735)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZHX3
- Browse OriGene Inhibitory RNA Products For ZHX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX3
Clone Products
- Applied Biological Materials (abm): Clones for ZHX3 - Select products 50% OFF >
- * ZHX3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZHX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZHX3
Cell Line Products
-
Horizon Cell Lines for ZHX3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZHX3 Gene
Localization for ZHX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZHX3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 12659632 |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for ZHX3 Gene
Interacting Proteins for ZHX3 Gene
Selected Interacting proteins:
Q9H4I2-ZHX3_HUMAN
ENSP00000312222
for ZHX3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZHX3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0045669 | positive regulation of osteoblast differentiation | IMP | 21174497 |
| GO:0045892 | negative regulation of transcription, DNA-templated | IDA | 12659632 |
No data available for Pathways by source and SIGNOR curated interactions for ZHX3 Gene
Transcripts for ZHX3 Gene
mRNA/cDNA for ZHX3 Gene
- 12 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000309060 10030 nts (view in UCSC)
- ENST00000373261 657 nts (view in UCSC)
- ENST00000419740 573 nts (view in UCSC)
- ENST00000421422 8838 nts (view in UCSC)
- ENST00000432768 3551 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZHX3 - Select products 50% OFF >
- * ZHX3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZHX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZHX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZHX3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZHX3
- Browse OriGene Inhibitory RNA Products For ZHX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX3
Clone Products
- Applied Biological Materials (abm): Clones for ZHX3 - Select products 50% OFF >
- * ZHX3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZHX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZHX3
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | - |
Relevant External Links for ZHX3 Gene
- GeneLoc Exon Structure for
- ZHX3
Expression for ZHX3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
This gene is overexpressed in Adrenal (31.4) and Plasma (13.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZHX3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZHX3
SOURCE GeneReport for Unigene cluster for ZHX3 Gene:
Hs.380133mRNA Expression by UniProt/SwissProt for ZHX3 Gene:
Q9H4I2-ZHX3_HUMAN
Tissue specificity:
Widely expressed. High expression in kidney. Expressed during osteogenic differentiation.
Evidence on tissue expression from TISSUES for ZHX3 Gene
- Nervous system(4.8)
- Liver(4.5)
- Kidney(2.3)
Primer Products
-
OriGene qPCR primer pairs for ZHX3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZHX3 Gene
Orthologs for ZHX3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZHX3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Zhx3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zhx3 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | ZHX3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZHX3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZHX3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZHX3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZHX3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZHX3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zhx3 30 |
|
||
| Str.577 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3322 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zhx3 31 |
|
OneToOne | |
| tix1 30 |
|
- Species where no ortholog for ZHX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZHX3 Gene
- ENSEMBL:
- Gene Tree for ZHX3 (if available)
- TreeFam:
- Gene Tree for ZHX3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZHX3: view image
Paralogs for ZHX3 Gene
(2) SIMAP similar genes for ZHX3 Gene using alignment to 12 proteins:
- ZHX3_HUMAN
- F5H820_HUMAN
- F6S7L4_HUMAN
- F6UBH9_HUMAN
- F6UQN6_HUMAN
- F6XGA7_HUMAN
- F6YD28_HUMAN
- H0Y6F5_HUMAN
- H0YLR4_HUMAN
- H0YMK8_HUMAN
- H0YNY7_HUMAN
- Q6NUJ7_HUMAN
Variants for ZHX3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZHX3 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs386352383 | Uncertain Significance: not provided | 41,204,421(-) | C/A | MISSENSE_VARIANT | |
| rs17265513 | - | p.Asn310Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv700n67 | CNV | loss | 20364138 |
| dgv7571n54 | CNV | loss | 21841781 |
| dgv786e199 | CNV | deletion | 23128226 |
| esv1745872 | CNV | insertion | 17803354 |
| esv2673884 | CNV | deletion | 23128226 |
| esv27181 | CNV | gain+loss | 19812545 |
| esv2722416 | CNV | deletion | 23290073 |
| esv2722418 | CNV | deletion | 23290073 |
| esv29587 | CNV | loss | 19812545 |
| esv3557070 | CNV | deletion | 23714750 |
| esv3557071 | CNV | deletion | 23714750 |
| esv3557072 | CNV | deletion | 23714750 |
| esv3557073 | CNV | deletion | 23714750 |
| esv3567966 | CNV | loss | 25503493 |
| esv3645834 | CNV | loss | 21293372 |
| esv3645835 | CNV | loss | 21293372 |
| esv990825 | CNV | gain | 20482838 |
| nsv1064246 | CNV | loss | 25217958 |
| nsv1071696 | CNV | deletion | 25765185 |
| nsv3380 | CNV | deletion | 18451855 |
| nsv3381 | CNV | deletion | 18451855 |
| nsv498970 | CNV | loss | 21111241 |
| nsv512615 | CNV | loss | 21212237 |
| nsv585989 | CNV | loss | 21841781 |
| nsv585990 | CNV | loss | 21841781 |
| nsv585991 | CNV | loss | 21841781 |
| nsv821330 | CNV | deletion | 20802225 |
| nsv833983 | CNV | loss | 17160897 |
| nsv833984 | CNV | loss | 17160897 |
| nsv954038 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
4.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.00;
68.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZHX3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZHX3 Gene
Disorders for ZHX3 Gene
Additional Disease Information for ZHX3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for ZHX3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZHX3 Gene
Publications for ZHX3 Gene
- The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. (PMID: 14659886) Kawata H … Miyamoto K (Gene 2003) 3 4 23
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
- Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation. (PMID: 21174497) Suehiro F … Kato Y (Stem cells and development 2011) 3 4
- ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. (PMID: 17056598) Liu G … Chugh SS (The Journal of biological chemistry 2006) 3 23
- Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PMID: 12659632) Yamada K … Miyamoto K (The Biochemical journal 2003) 3 4
ExternalLinks
Products for ZHX3 Gene
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- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For ZHX3
- OriGene qPCR primer pairs for ZHX3
- OriGene CRISPR knockouts for ZHX3
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- Browse OriGene miRNA Products For ZHX3
- Sino Biological Human cDNA Clone for ZHX3
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- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ZHX3
- Novus Biologicals proteins and lysates for ZHX3
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- Abcam antibodies for ZHX3
- Abcam proteins for ZHX3
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- Browse Primary Antibodies
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- Invitrogen Antibodies for ZHX3 (AFLGC-ZHX3)
- VectorBuilder Custom and pre-made DNA vectors for ZHX3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ZHX3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ZHX3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ZHX3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ZHX3
- antibodies-online: Show 20 available ZHX3 Antibodies ranked by validation data
- Compare Top ZHX3 Antibodies
- antibodies-online: Search results for available ZHX3 related products ranked by validation data
- antibodies-online: Show 4 available ZHX3 Proteins ranked by validation data
- Compare Top ZHX3 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for ZHX3
- Search Santa Cruz Biotechnology (SCBT) for ZHX3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ZHX3
- Horizon Cell Lines for ZHX3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZHX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZHX3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ZHX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX3
- Boster Bio Antibodies for ZHX3
- Browse Boster Bio ELISA Kits
Sources for ZHX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB