Aliases for ZHX3 Gene
External Ids for ZHX3 Gene
Previous HGNC Symbols for ZHX3 Gene
Previous GeneCards Identifiers for ZHX3 Gene
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZHX3 Gene
ZHX3 (Zinc Fingers And Homeoboxes 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ZHX1.
UniProtKB/Swiss-Prot Summary for ZHX3 Gene
Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.