Aliases for ZHX2 Gene
Aliases for ZHX2 Gene
External Ids for ZHX2 Gene
- HGNC: 18513
- Entrez Gene: 22882
- Ensembl: ENSG00000178764
- OMIM: 609185
- UniProtKB: Q9Y6X8
Previous GeneCards Identifiers for ZHX2 Gene
- GC08P123462
- GC08P123750
- GC08P123863
- GC08P123793
- GC08P119119
Summaries for ZHX2 Gene
-
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZHX2 Gene
ZHX2 (Zinc Fingers And Homeoboxes 2) is a Protein Coding gene. Diseases associated with ZHX2 include Smallpox and Cryptococcosis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is ZHX1.
UniProtKB/Swiss-Prot for ZHX2 Gene
-
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX2 Gene
Genomics for ZHX2 Gene
GeneHancer (GH) Regulatory Elements for ZHX2 Gene
Promoters and enhancers for ZHX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZHX2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZHX2 Gene
Genomic Locations for ZHX2 Gene
- chr8:122,781,349-122,974,515
- (GRCh38/hg38)
- Size:
- 193,167 bases
- Orientation:
- Plus strand
- chr8:123,793,633-123,986,755
- (GRCh37/hg19)
Genomic View for ZHX2 Gene
Genes around ZHX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.13 by Entrez Gene
- 8q24.13 by HGNC
- 8q24.13 by Ensembl
ZHX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZHX2 Gene
Proteins for ZHX2 Gene
-
Protein details for ZHX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6X8-ZHX2_HUMAN
- Recommended name:
- Zinc fingers and homeoboxes protein 2
- Protein Accession:
- Q9Y6X8
Protein attributes for ZHX2 Gene
- Size:
- 837 amino acids
- Molecular mass:
- 92307 Da
- Quaternary structure:
-
- Forms a homodimer (via homeobox domain). Forms a heterodimer with ZHX1 (via HD1 domain). Forms a heterodimer with ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N-terminus).
- SequenceCaution:
-
- Sequence=BAA74877.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZHX2 Gene
Post-translational modifications for ZHX2 Gene
Other Protein References for ZHX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZHX2
- Invitrogen Antibodies for ZHX2
- antibodies-online: Search results for 111 available ZHX2 Antibodies ranked by validation data
- Compare Top ZHX2 Antibodies
-
Recommended
- 83 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 15 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 83 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 15 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- GeneTex ZHX2 Antibody for ZHX2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZHX2
Protein Products
-
OriGene Purified Proteins for ZHX2
- Search Origene for MassSpec and Protein Over-expression Lysates for ZHX2
- Origene Custom Protein Services for ZHX2
- Search GeneTex for Proteins for ZHX2
Assay Products
No data available for DME Specific Peptides for ZHX2 Gene
Domains & Families for ZHX2 Gene
Gene Families for ZHX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZHX2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZHX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6X8- Family:
-
- Belongs to the ZHX family.
Function for ZHX2 Gene
Molecular function for ZHX2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.
Phenotypes From GWAS Catalog for ZHX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IDA | 12741956 |
| GO:0003714 | transcription corepressor activity | IDA | 12741956 |
Phenotypes for ZHX2 Gene
- MGI mutant phenotypes for ZHX2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZHX2:
-
- Decreased shRNA abundance (Z-score < -2)
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Increased virus production
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZHX2
-
CRISPR Products
-
OriGene CRISPR knockouts for ZHX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZHX2
- genomics-online: gRNA clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- Applied Biological Materials CRISPR for ZHX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZHX2
- GenScript: Design CRISPR guide RNA sequences for ZHX2
miRNA for ZHX2 Gene
- miRTarBase miRNAs that target ZHX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZHX2
- Browse OriGene Inhibitory RNA Products For ZHX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX2
- genomics-online: shRNA clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZHX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZHX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZHX2
- genomics-online: cdna clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- orf clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- Applied Biological Materials Clones for ZHX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZHX2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZHX2 Gene
Localization for ZHX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZHX2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 12741956 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for ZHX2 Gene
No Data Available
Interacting Proteins for ZHX2 Gene
Selected Interacting proteins:
Q9Y6X8-ZHX2_HUMAN
ENSP00000314709
for ZHX2 Gene via
IID
STRING
UniProtKB
MINT
GPS-Prot Interaction Network for ZHX2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 12741956 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006402 | mRNA catabolic process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZHX2 Gene
Drugs & Compounds for ZHX2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| regorafenib | Approved | Pharma | inhibitor | Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Sorafenib | Approved, Investigational | Pharma | inhibitors, inhibitor | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 717 |
Transcripts for ZHX2 Gene
mRNA/cDNA for ZHX2 Gene
- (121) Selected AceView cDNA sequences:
- (4) Additional mRNA sequences :
- (5) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000314393 4624 bps (uc003ypk.2)
- ENST00000534247 873 bps (uc064pwf.1)
Unigene Clusters for ZHX2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZHX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZHX2
- genomics-online: gRNA clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- Applied Biological Materials CRISPR for ZHX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZHX2
- GenScript: Design CRISPR guide RNA sequences for ZHX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZHX2
- Browse OriGene Inhibitory RNA Products For ZHX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX2
- genomics-online: shRNA clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZHX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZHX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZHX2
- genomics-online: cdna clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- orf clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- Applied Biological Materials Clones for ZHX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||
| SP3: |
Expression for ZHX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Ovary (Reproductive System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (54.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZHX2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZHX2 Gene:
ZHX2SOURCE GeneReport for Unigene cluster for ZHX2 Gene:
Hs.377090mRNA Expression by UniProt/SwissProt for ZHX2 Gene:
Q9Y6X8-ZHX2_HUMAN
Tissue specificity:
Ubiquitously expressed. Expressed in podocytes.
Evidence on tissue expression from TISSUES for ZHX2 Gene
- Liver(4.4)
- Nervous system(4.3)
- Kidney(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ZHX2
-
OriGene qPCR primer pairs for ZHX2
- genomics-online: primer clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZHX2 Gene
Orthologs for ZHX2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZHX2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZHX2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZHX2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Zhx2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zhx2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZHX2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZHX2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZHX2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zhx2 33 |
|
||
| Str.1051 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13932 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zhx2 34 33 33 |
|
OneToOne |
- Species where no ortholog for ZHX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ZHX2 Gene
- ENSEMBL:
- Gene Tree for ZHX2 (if available)
- TreeFam:
- Gene Tree for ZHX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZHX2: view image
Paralogs for ZHX2 Gene
Variants for ZHX2 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs138450443 | uncertain-significance, Hirschsprung disease 1 | 122,953,192(+) | G/A | coding_sequence_variant, missense_variant | |
| rs1000004112 | -- | 122,939,530(+) | A/G | intron_variant | |
| rs1000027319 | -- | 122,846,295(+) | G/A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000035143 | -- | 122,939,291(+) | G/A | intron_variant | |
| rs1000058693 | -- | 122,970,401(+) | GGGGGGG/GGGGGGGG | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2737525 | CNV | deletion | 23290073 |
| esv3544137 | CNV | deletion | 23714750 |
| esv3572972 | CNV | loss | 25503493 |
| nsv1032827 | CNV | gain | 25217958 |
| nsv1150054 | CNV | insertion | 26484159 |
Residual Variation Intolerance Score:
69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.93;
79.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZHX2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZHX2 Gene
Disorders for ZHX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| smallpox |
|
|
| cryptococcosis |
|
|
Search ZHX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZHX2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ZHX2 Gene
Publications for ZHX2 Gene
- Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PMID: 12741956) Kawata H … Miyamoto K (The Biochemical journal 2003) 2 3 4 58
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
- Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
Products for ZHX2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
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- Browse Human Proteins and Enzymes
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for ZHX2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ZHX2
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- OriGene qPCR primer pairs for ZHX2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZHX2
- GenScript: Next-day shipping of latest version cDNA ORF clones for ZHX2 in any vector
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- GenScript: Design CRISPR guide RNA sequences for ZHX2
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- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ZHX2
- Novus Biologicals proteins and lysates for ZHX2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for ZHX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZHX2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 111 available ZHX2 Antibodies ranked by validation data
- Compare Top ZHX2 Antibodies
- Recommended
- 83 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 15 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 83 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 15 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for 1 available ZHX2 Elisa Kits ranked by validation data
- Compare Top ZHX2 Elisa Kits
- Recommended
- antibodies-online: Search results for 4 available ZHX2 Proteins ranked by validation data
- Compare Top ZHX2 Proteins
- GeneTex ZHX2 Antibody for ZHX2
- Search GeneTex for Proteins for ZHX2
- Santa Cruz Biotechnology (SCBT) Antibodies for ZHX2
- Search Santa Cruz Biotechnology (SCBT) for ZHX2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ZHX2
- Horizon Cell Lines for ZHX2
- genomics-online: cdna clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- orf clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
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- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- genomics-online: gRNA clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- genomics-online: primer clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- genomics-online: shRNA clones - Search results for 63 available ZHX2 gene related products
- Overview of 63 available ZHX2 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-AC
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pGFP-V-RS
- pRFP-C-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZHX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZHX2
- GeneCopoeia miRNA 3'UTR Target clone products for ZHX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX2
Sources for ZHX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio