The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of th... See more...

Aliases for ZHX2 Gene

Aliases for ZHX2 Gene

  • Zinc Fingers And Homeoboxes 2 2 3 5
  • Zinc Fingers And Homeoboxes Protein 2 3 4
  • Zinc Finger And Homeodomain Protein 2 3 4
  • Alpha-Fetoprotein Regulator 1 3 4
  • Regulator Of AFP 3 4
  • AFP Regulator 1 3 4
  • KIAA0854 2 4
  • AFR1 3 4
  • RAF 3 4
  • Zinc-Fingers And Homeoboxes 2 2
  • Transcription Factor ZHX2 3
  • ZHX2 5

External Ids for ZHX2 Gene

Previous GeneCards Identifiers for ZHX2 Gene

  • GC08P123462
  • GC08P123750
  • GC08P123863
  • GC08P123793
  • GC08P119119

Summaries for ZHX2 Gene

Entrez Gene Summary for ZHX2 Gene

  • The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZHX2 Gene

ZHX2 (Zinc Fingers And Homeoboxes 2) is a Protein Coding gene. Diseases associated with ZHX2 include Cryptococcosis and Hirschsprung Disease 1. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is ZHX1.

UniProtKB/Swiss-Prot Summary for ZHX2 Gene

  • Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).

Gene Wiki entry for ZHX2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZHX2 Gene

Genomics for ZHX2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZHX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZHX2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZHX2

Top Transcription factor binding sites by QIAGEN in the ZHX2 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • IRF-2
  • MyoD
  • SRF
  • SRF (504 AA)

Genomic Locations for ZHX2 Gene

Genomic Locations for ZHX2 Gene
chr8:122,781,655-122,974,514
(GRCh38/hg38)
Size:
192,860 bases
Orientation:
Plus strand
chr8:123,793,633-123,986,755
(GRCh37/hg19)
Size:
193,123 bases
Orientation:
Plus strand

Genomic View for ZHX2 Gene

Genes around ZHX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZHX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZHX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZHX2 Gene

Proteins for ZHX2 Gene

  • Protein details for ZHX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X8-ZHX2_HUMAN
    Recommended name:
    Zinc fingers and homeoboxes protein 2
    Protein Accession:
    Q9Y6X8

    Protein attributes for ZHX2 Gene

    Size:
    837 amino acids
    Molecular mass:
    92307 Da
    Quaternary structure:
    • Homodimer (via homeobox domain) (PubMed:12741956, PubMed:14659886). Heterodimer with ZHX1 (via homeobox domain 1) (PubMed:12741956). Heterodimer with ZHX3 (via homeobox domain 1) (PubMed:12741956, PubMed:14659886). Heterodimerization with ZHX1 is not necessary for repressor activity (PubMed:12741956). Interacts (via homeobox domain) with NFYA (via N-terminus) (PubMed:12741956). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (By similarity).
    SequenceCaution:
    • Sequence=BAA74877.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZHX2 Gene

neXtProt entry for ZHX2 Gene

Post-translational modifications for ZHX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZHX2 Gene

No data available for DME Specific Peptides for ZHX2 Gene

Domains & Families for ZHX2 Gene

Gene Families for ZHX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZHX2 Gene

Suggested Antigen Peptide Sequences for ZHX2 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and homeodomain protein 2 (ZHX2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6X8

UniProtKB/Swiss-Prot:

ZHX2_HUMAN :
  • Belongs to the ZHX family.
Family:
  • Belongs to the ZHX family.
genes like me logo Genes that share domains with ZHX2: view

Function for ZHX2 Gene

Molecular function for ZHX2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).

Phenotypes From GWAS Catalog for ZHX2 Gene

Gene Ontology (GO) - Molecular Function for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA,IDA 12741956
GO:0003714 transcription corepressor activity IDA 12741956
genes like me logo Genes that share ontologies with ZHX2: view
genes like me logo Genes that share phenotypes with ZHX2: view

Animal Model Products

CRISPR Products

miRNA for ZHX2 Gene

miRTarBase miRNAs that target ZHX2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZHX2 Gene

Localization for ZHX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZHX2 Gene

Nucleus. Note=Colocalizes with EFNB1 intracellular domain in the nucleus. {ECO:0000250 UniProtKB:Q8C0C0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZHX2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
mitochondrion 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,IDA 12741956
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZHX2: view

Pathways & Interactions for ZHX2 Gene

PathCards logo

SuperPathways for ZHX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA,IDA 12741956
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0006402 mRNA catabolic process IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZHX2: view

No data available for Pathways by source and SIGNOR curated interactions for ZHX2 Gene

Drugs & Compounds for ZHX2 Gene

(2) Drugs for ZHX2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 779
genes like me logo Genes that share compounds with ZHX2: view

Transcripts for ZHX2 Gene

mRNA/cDNA for ZHX2 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX2

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1:
SP2: - - - - - -
SP3:

Relevant External Links for ZHX2 Gene

GeneLoc Exon Structure for
ZHX2

Expression for ZHX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZHX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZHX2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (54.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZHX2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZHX2

SOURCE GeneReport for Unigene cluster for ZHX2 Gene:

Hs.377090

mRNA Expression by UniProt/SwissProt for ZHX2 Gene:

Q9Y6X8-ZHX2_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed in podocytes.

Evidence on tissue expression from TISSUES for ZHX2 Gene

  • Nervous system(4.5)
  • Liver(4.5)
  • Kidney(4.4)
  • Blood(2.2)
  • Muscle(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ZHX2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZHX2 Gene

Orthologs for ZHX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZHX2 30 31
  • 99.24 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZHX2 30 31
  • 88.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZHX2 30 31
  • 86.94 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zhx2 30 17 31
  • 84.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zhx2 30
  • 84.45 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ZHX2 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZHX2 30 31
  • 69.85 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZHX2 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zhx2 30
  • 62.87 (n)
Str.1051 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.13932 30
Zebrafish
(Danio rerio)
Actinopterygii zhx2 30 31
  • 56.85 (n)
OneToOne
Species where no ortholog for ZHX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZHX2 Gene

ENSEMBL:
Gene Tree for ZHX2 (if available)
TreeFam:
Gene Tree for ZHX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZHX2: view image

Paralogs for ZHX2 Gene

Paralogs for ZHX2 Gene

(2) SIMAP similar genes for ZHX2 Gene using alignment to 2 proteins:

  • ZHX2_HUMAN
  • H0YKA3_HUMAN
genes like me logo Genes that share paralogs with ZHX2: view

Variants for ZHX2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZHX2 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
711503 Likely Benign: not provided 122,953,812(+) A/G MISSENSE_VARIANT
716977 Benign: not provided 122,952,515(+) C/T SYNONYMOUS_VARIANT
720430 Benign: not provided 122,953,554(+) T/C SYNONYMOUS_VARIANT
776382 Benign: not provided 122,952,144(+) G/A MISSENSE_VARIANT
783532 Benign: not provided 122,951,840(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZHX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZHX2 Gene

Variant ID Type Subtype PubMed ID
esv2737525 CNV deletion 23290073
esv3544137 CNV deletion 23714750
esv3572972 CNV loss 25503493
nsv1032827 CNV gain 25217958
nsv1150054 CNV insertion 26484159

Variation tolerance for ZHX2 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZHX2 Gene

Human Gene Mutation Database (HGMD)
ZHX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZHX2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZHX2 Gene

Disorders for ZHX2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZHX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cryptococcosis
  • busse-buschke's disease
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search ZHX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZHX2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZHX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZHX2 Gene

Publications for ZHX2 Gene

  1. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. (PMID: 14659886) Kawata H … Miyamoto K (Gene 2003) 3 4 23
  2. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PMID: 12741956) Kawata H … Miyamoto K (The Biochemical journal 2003) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 41
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

Products for ZHX2 Gene

Sources for ZHX2 Gene