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The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of th... See more...
Aliases for ZHX2 Gene
Aliases for ZHX2 Gene
External Ids for ZHX2 Gene
- HGNC: 18513
- Entrez Gene: 22882
- Ensembl: ENSG00000178764
- OMIM: 609185
- UniProtKB: Q9Y6X8
Previous GeneCards Identifiers for ZHX2 Gene
- GC08P123462
- GC08P123750
- GC08P123863
- GC08P123793
- GC08P119119
Summaries for ZHX2 Gene
-
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZHX2 Gene
ZHX2 (Zinc Fingers And Homeoboxes 2) is a Protein Coding gene. Diseases associated with ZHX2 include Cryptococcosis and Hirschsprung Disease 1. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is ZHX1.
UniProtKB/Swiss-Prot Summary for ZHX2 Gene
-
Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Additional gene information for ZHX2 Gene
- HGNC(18513)
- Entrez Gene(22882)
- Ensembl(ENSG00000178764)
- OMIM(609185)
- UniProtKB(Q9Y6X8)
- Open Targets Platform(ENSG00000178764)
- Search for ZHX2 at DataMed
- Search for ZHX2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZHX2 Gene
Genomics for ZHX2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZHX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZHX2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZHX2
- Top Transcription factor binding sites by QIAGEN in the ZHX2 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- IRF-2
- MyoD
- SRF
- SRF (504 AA)
Genomic Locations for ZHX2 Gene
Genomic Locations for ZHX2 Gene
- chr8:122,781,655-122,974,514
- (GRCh38/hg38)
- Size:
- 192,860 bases
- Orientation:
- Plus strand
- chr8:123,793,633-123,986,755
- (GRCh37/hg19)
- Size:
- 193,123 bases
- Orientation:
- Plus strand
Genomic View for ZHX2 Gene
Genes around ZHX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.13 by HGNC
- 8q24.13 by Entrez Gene
- 8q24.13 by Ensembl
ZHX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZHX2 Gene
Proteins for ZHX2 Gene
-
Protein details for ZHX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6X8-ZHX2_HUMAN
- Recommended name:
- Zinc fingers and homeoboxes protein 2
- Protein Accession:
- Q9Y6X8
Protein attributes for ZHX2 Gene
- Size:
- 837 amino acids
- Molecular mass:
- 92307 Da
- Quaternary structure:
-
- Homodimer (via homeobox domain) (PubMed:12741956, PubMed:14659886). Heterodimer with ZHX1 (via homeobox domain 1) (PubMed:12741956). Heterodimer with ZHX3 (via homeobox domain 1) (PubMed:12741956, PubMed:14659886). Heterodimerization with ZHX1 is not necessary for repressor activity (PubMed:12741956). Interacts (via homeobox domain) with NFYA (via N-terminus) (PubMed:12741956). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (By similarity).
- SequenceCaution:
-
- Sequence=BAA74877.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for ZHX2 Gene
Post-translational modifications for ZHX2 Gene
Other Protein References for ZHX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ZHX2 / RAF Antibody (LS-B11377) and ZHX2 / RAF Antibody (LS-B13956)
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- Creative Diagnostics Anti-ZHX2 monoclonal antibody, clone 6F3
- Creative Biolabs Recombinant Anti-Human ZHX2 Antibody and Mouse Anti-ZHX2 Recombinant Antibody (CBWJZ-089)
- GeneTex Anti-ZHX2 antibody [C1C3]
- Novus Biologicals Antibodies for ZHX2
-
Abcam antibodies for ZHX2
- Invitrogen Antibodies for ZHX2 (AFLGC-ZHX2)
- antibodies-online: Show 25 available ZHX2 Antibodies ranked by validation data
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-
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- 2 IHC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 19 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 16 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZHX2
Protein Products
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-
Abcam proteins for ZHX2
No data available for DME Specific Peptides for ZHX2 Gene
Domains & Families for ZHX2 Gene
Gene Families for ZHX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZHX2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZHX2 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger and homeodomain protein 2 (ZHX2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y6X8- Family:
-
- Belongs to the ZHX family.
Function for ZHX2 Gene
Molecular function for ZHX2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Phenotypes From GWAS Catalog for ZHX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IBA,IDA | 12741956 |
| GO:0003714 | transcription corepressor activity | IDA | 12741956 |
Phenotypes for ZHX2 Gene
- MGI mutant phenotypes for ZHX2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZHX2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- Strongly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in esophageal squamous lineage
- Increased virus production
- Decreased viability (cell death)
- Two nuclei (binuclear), polylobed nuclei, dynamic nuclei (hole, folded or small irregular)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
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-
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miRNA for ZHX2 Gene
- miRTarBase miRNAs that target ZHX2
miRNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for ZHX2 - Select products 50% OFF >
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Cell Line Products
-
Horizon Cell Lines for ZHX2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZHX2 Gene
Localization for ZHX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZHX2 Gene
- Nucleus. Note=Colocalizes with EFNB1 intracellular domain in the nucleus. {ECO:0000250 UniProtKB:Q8C0C0}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 12741956 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for ZHX2 Gene
Interacting Proteins for ZHX2 Gene
Selected Interacting proteins:
Q9Y6X8-ZHX2_HUMAN
ENSP00000314709
for ZHX2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZHX2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IDA | 12741956 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
| GO:0006402 | mRNA catabolic process | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZHX2 Gene
Drugs & Compounds for ZHX2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| regorafenib | Approved | Pharma | inhibitor | Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Sorafenib | Approved, Investigational | Pharma | inhibitors, inhibitor | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 779 |
Transcripts for ZHX2 Gene
mRNA/cDNA for ZHX2 Gene
- 2 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000314393 4361 nts (view in UCSC)
- ENST00000534247 873 nts (view in UCSC)
CRISPR Products
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-
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
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| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||
| SP3: |
Relevant External Links for ZHX2 Gene
- GeneLoc Exon Structure for
- ZHX2
Expression for ZHX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Ovary (Reproductive System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (54.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZHX2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZHX2
SOURCE GeneReport for Unigene cluster for ZHX2 Gene:
Hs.377090mRNA Expression by UniProt/SwissProt for ZHX2 Gene:
Q9Y6X8-ZHX2_HUMAN
Tissue specificity:
Ubiquitously expressed. Expressed in podocytes.
Evidence on tissue expression from TISSUES for ZHX2 Gene
- Nervous system(4.5)
- Liver(4.5)
- Kidney(4.4)
- Blood(2.2)
- Muscle(2.1)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for ZHX2
-
OriGene qPCR primer pairs and template standards for ZHX2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZHX2 Gene
Orthologs for ZHX2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZHX2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZHX2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZHX2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Zhx2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zhx2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZHX2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZHX2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZHX2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zhx2 30 |
|
||
| Str.1051 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13932 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zhx2 30 31 |
|
OneToOne |
- Species where no ortholog for ZHX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZHX2 Gene
- ENSEMBL:
- Gene Tree for ZHX2 (if available)
- TreeFam:
- Gene Tree for ZHX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZHX2: view image
Paralogs for ZHX2 Gene
Variants for ZHX2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZHX2 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711503 | Likely Benign: not provided | 122,953,812(+) | A/G | MISSENSE_VARIANT | |
| 716977 | Benign: not provided | 122,952,515(+) | C/T | SYNONYMOUS_VARIANT | |
| 720430 | Benign: not provided | 122,953,554(+) | T/C | SYNONYMOUS_VARIANT | |
| 776382 | Benign: not provided | 122,952,144(+) | G/A | MISSENSE_VARIANT | |
| 783532 | Benign: not provided | 122,951,840(+) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2737525 | CNV | deletion | 23290073 |
| esv3544137 | CNV | deletion | 23714750 |
| esv3572972 | CNV | loss | 25503493 |
| nsv1032827 | CNV | gain | 25217958 |
| nsv1150054 | CNV | insertion | 26484159 |
Residual Variation Intolerance Score:
69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.93;
79.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZHX2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZHX2 Gene
Disorders for ZHX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cryptococcosis |
|
|
| hirschsprung disease 1 |
|
|
Search ZHX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZHX2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ZHX2 Gene
Publications for ZHX2 Gene
- The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. (PMID: 14659886) Kawata H … Miyamoto K (Gene 2003) 3 4 23
- Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PMID: 12741956) Kawata H … Miyamoto K (The Biochemical journal 2003) 2 3 4
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
- Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
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- antibodies-online: Show 25 available ZHX2 Antibodies ranked by validation data
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Sources for ZHX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
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