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The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
ZHX2 (Zinc Fingers And Homeoboxes 2) is a Protein Coding gene. Diseases associated with ZHX2 include Cryptococcosis and Hirschsprung Disease 1. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is ZHX1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA,IDA | 12741956 |
GO:0003714 | transcription corepressor activity | IDA | 12741956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA,IDA | 12741956 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IDA | 12741956 |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
GO:0006402 | mRNA catabolic process | IEA | -- |
GO:0007399 | nervous system development | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
regorafenib | Approved | Pharma | inhibitor | Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
Sorafenib | Approved, Investigational | Pharma | inhibitors, inhibitor | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 779 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZHX2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZHX2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZHX2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Zhx2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zhx2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZHX2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZHX2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZHX2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zhx2 30 |
|
||
Str.1051 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.13932 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zhx2 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711503 | Likely Benign: not provided | 122,953,812(+) | A/G | MISSENSE_VARIANT | |
716977 | Benign: not provided | 122,952,515(+) | C/T | SYNONYMOUS_VARIANT | |
720430 | Benign: not provided | 122,953,554(+) | T/C | SYNONYMOUS_VARIANT | |
776382 | Benign: not provided | 122,952,144(+) | G/A | MISSENSE_VARIANT | |
783532 | Benign: not provided | 122,951,840(+) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2737525 | CNV | deletion | 23290073 |
esv3544137 | CNV | deletion | 23714750 |
esv3572972 | CNV | loss | 25503493 |
nsv1032827 | CNV | gain | 25217958 |
nsv1150054 | CNV | insertion | 26484159 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cryptococcosis |
|
|
hirschsprung disease 1 |
|
|