Aliases for ZHX2 Gene
External Ids for ZHX2 Gene
Previous GeneCards Identifiers for ZHX2 Gene
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZHX2 Gene
ZHX2 (Zinc Fingers And Homeoboxes 2) is a Protein Coding gene. Diseases associated with ZHX2 include Cryptococcosis and Hirschsprung Disease 1. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is ZHX1.
UniProtKB/Swiss-Prot Summary for ZHX2 Gene
Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).