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Aliases for ZHX1-C8orf76 Gene

Aliases for ZHX1-C8orf76 Gene

  • ZHX1-C8orf76 Readthrough 2 3 5
  • ZHX1-C8orf76 Readthrough Transcript Protein 3 4
  • Zinc Fingers And Homeoboxes Protein 1, Isoform 2 3
  • C8orf76 4

External Ids for ZHX1-C8orf76 Gene

Previous GeneCards Identifiers for ZHX1-C8orf76 Gene

  • GC08M124239

Summaries for ZHX1-C8orf76 Gene

Entrez Gene Summary for ZHX1-C8orf76 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring zinc fingers and homeoboxes 1 (ZHX1) and chromosome 8 open reading frame 76 (C8orf76) genes. The read-through transcript encodes a protein that shares sequence identity with the downstream gene, but it has a distinct N-terminus encoded by exon structure from the upstream gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ZHX1-C8orf76 Gene

ZHX1-C8orf76 (ZHX1-C8orf76 Readthrough) is a Protein Coding gene. An important paralog of this gene is C8orf76.

Additional gene information for ZHX1-C8orf76 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX1-C8orf76 Gene

Genomics for ZHX1-C8orf76 Gene

GeneHancer (GH) Regulatory Elements for ZHX1-C8orf76 Gene

Promoters and enhancers for ZHX1-C8orf76 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J123271 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.6 614 4.3 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZHX1 ZHX1-C8orf76 FAM91A1 RNU6-875P MIR548AA1 DUTP2 FAM83A RNU6-628P
GH08J123240 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.3 +33.4 33403 1.9 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 C8orf76 WDYHV1 FAM83A UBA52P5 ZHX1-C8orf76
GH08J123251 Enhancer 1 Ensembl ENCODE 0.3 +23.2 23205 1.4 HDAC1 HDGF RB1 CHAMP1 ZNF335 ZNF766 EGR1 ZSCAN5C ZNF143 ATF7 ZHX1 FAM83A-AS1 WDYHV1 ATAD2 RNU6-875P MIR548AA1 DUTP2 GC08M123252 C8orf76 ZHX1-C8orf76
GH08J123269 Enhancer 0.7 Ensembl ENCODE 0.4 +5.4 5386 0.2 MEIS2 STAT1 PKNOX1 POLR2A STAT2 RNU6-628P ZHX1 ZHX1-C8orf76
GH08J123254 Promoter 0.7 EPDnew 0.3 +20.6 20613 0.1 EHMT2 ZBTB33 ZHX1 GC08M123252 FAM83A-AS1 RNU6-875P MIR548AA1 DUTP2 TRF-GAA12-1 ZHX1-C8orf76
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZHX1-C8orf76 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZHX1-C8orf76 Gene

Genomic Locations for ZHX1-C8orf76 Gene
48,299 bases
Minus strand
48,299 bases
Minus strand

Genomic View for ZHX1-C8orf76 Gene

Genes around ZHX1-C8orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZHX1-C8orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZHX1-C8orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZHX1-C8orf76 Gene

Proteins for ZHX1-C8orf76 Gene

  • Protein details for ZHX1-C8orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc fingers and homeoboxes protein 1, isoform 2
    Protein Accession:

    Protein attributes for ZHX1-C8orf76 Gene

    292 amino acids
    Molecular mass:
    33285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZHX1-C8orf76 Gene


neXtProt entry for ZHX1-C8orf76 Gene

Post-translational modifications for ZHX1-C8orf76 Gene

No Post-translational modifications

Other Protein References for ZHX1-C8orf76 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZHX1-C8orf76 Gene

Domains & Families for ZHX1-C8orf76 Gene

Gene Families for ZHX1-C8orf76 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZHX1-C8orf76 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZHX1-C8orf76: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ZHX1-C8orf76 Gene

Function for ZHX1-C8orf76 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX1-C8orf76

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZHX1-C8orf76 Gene

Localization for ZHX1-C8orf76 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZHX1-C8orf76 Gene

Pathways & Interactions for ZHX1-C8orf76 Gene

SuperPathways for ZHX1-C8orf76 Gene

No Data Available

Interacting Proteins for ZHX1-C8orf76 Gene

Gene Ontology (GO) - Biological Process for ZHX1-C8orf76 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZHX1-C8orf76 Gene

Drugs & Compounds for ZHX1-C8orf76 Gene

No Compound Related Data Available

Transcripts for ZHX1-C8orf76 Gene

mRNA/cDNA for ZHX1-C8orf76 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZHX1-C8orf76

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX1-C8orf76 Gene

No ASD Table

Relevant External Links for ZHX1-C8orf76 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZHX1-C8orf76 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZHX1-C8orf76 Gene

Orthologs for ZHX1-C8orf76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX1-C8orf76 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 34
  • 81 (a)
(Bos Taurus)
Mammalia -- 34
  • 63 (a)
(Mus musculus)
Mammalia 9130401M01Rik 34
  • 50 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
(Gallus gallus)
Aves -- 34
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
(Danio rerio)
Actinopterygii C16H8orf76 34
  • 26 (a)
Species where no ortholog for ZHX1-C8orf76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZHX1-C8orf76 Gene

Gene Tree for ZHX1-C8orf76 (if available)
Gene Tree for ZHX1-C8orf76 (if available)

Paralogs for ZHX1-C8orf76 Gene

Paralogs for ZHX1-C8orf76 Gene

(1) SIMAP similar genes for ZHX1-C8orf76 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZHX1-C8orf76: view

Variants for ZHX1-C8orf76 Gene

Sequence variations from dbSNP and Humsavar for ZHX1-C8orf76 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000020950 -- 123,272,139(-) C/T intron_variant
rs1000074255 -- 123,258,737(-) T/C intron_variant
rs1000117185 -- 123,234,140(-) A/G intron_variant
rs1000151804 -- 123,241,124(-) C/A intron_variant
rs1000187769 -- 123,232,800(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZHX1-C8orf76 Gene

Variant ID Type Subtype PubMed ID
nsv1032827 CNV gain 25217958
nsv1124373 CNV deletion 24896259
nsv831449 CNV loss 17160897
nsv981978 CNV duplication 23825009

Additional Variant Information for ZHX1-C8orf76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZHX1-C8orf76 Gene

Disorders for ZHX1-C8orf76 Gene

Additional Disease Information for ZHX1-C8orf76

No disorders were found for ZHX1-C8orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZHX1-C8orf76 Gene

Publications for ZHX1-C8orf76 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZHX1-C8orf76 Gene

Sources for ZHX1-C8orf76 Gene

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