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Aliases for ZHX1 Gene

Aliases for ZHX1 Gene

  • Zinc Fingers And Homeoboxes 1 2 3 5
  • Zinc-Fingers And Homeoboxes 1 2

External Ids for ZHX1 Gene

Previous GeneCards Identifiers for ZHX1 Gene

  • GC08M123375
  • GC08M124291
  • GC08M123902
  • GC08M124189
  • GC08M124217
  • GC08M124329
  • GC08M124260
  • GC08M119587

Summaries for ZHX1 Gene

Entrez Gene Summary for ZHX1 Gene

  • The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ZHX1 Gene

ZHX1 (Zinc Fingers And Homeoboxes 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ZHX2.

UniProtKB/Swiss-Prot for ZHX1 Gene

  • Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.

Gene Wiki entry for ZHX1 Gene

Additional gene information for ZHX1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX1 Gene

Genomics for ZHX1 Gene

GeneHancer (GH) Regulatory Elements for ZHX1 Gene

Promoters and enhancers for ZHX1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I123271 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.7 1668 4.3 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZHX1 ZHX1-C8orf76 RNU6-875P MIR548AA1 DUTP2 FAM83A RNU6-628P
GH08I123276 Enhancer 0.4 ENCODE 550.8 -1.5 -1495 0.2 ZNF217 NFIB ZHX1 LOC392266
GH08I123250 Enhancer 1 Ensembl ENCODE 11.4 +24.3 24259 1.4 HDAC1 HDGF RB1 CHAMP1 ZNF335 ZNF766 EGR1 ZSCAN5C ZNF143 ATF7 ZHX1 FAM83A-AS1 ATAD2 WDYHV1 RNU6-875P MIR548AA1 DUTP2 GC08M123252 C8orf76 ZHX1-C8orf76
GH08I123585 Enhancer 0.5 ENCODE 10.1 -310.6 -310560 0.6 IKZF1 BHLHE40 ATF7 ZNF112 LOC105375738 WDYHV1 KLHL38 FBXO32 TATDN1 ZHX1 RN7SKP155 ENSG00000254113
GH08I124005 Enhancer 0.9 ENCODE 4.9 -731.6 -731591 2.8 HDGF PKNOX1 ARNT NCOA2 TCF12 ZNF766 GATA2 ARID2 ATF7 NCOA1 ZHX1 GC08P124010 GC08P124011 GC08P124012 GC08P124013 PIR31943 FER1L6-AS1 GC08M123978 ENSG00000254000 FER1L6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZHX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZHX1 gene promoter:

Genomic Locations for ZHX1 Gene

Genomic Locations for ZHX1 Gene
27,092 bases
Minus strand

Genomic View for ZHX1 Gene

Genes around ZHX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZHX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZHX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZHX1 Gene

Proteins for ZHX1 Gene

  • Protein details for ZHX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc fingers and homeoboxes protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8IWD8

    Protein attributes for ZHX1 Gene

    873 amino acids
    Molecular mass:
    98098 Da
    Quaternary structure:
    • Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain).

    Three dimensional structures from OCA and Proteopedia for ZHX1 Gene

    Alternative splice isoforms for ZHX1 Gene


neXtProt entry for ZHX1 Gene

Post-translational modifications for ZHX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZHX1 Gene

No data available for DME Specific Peptides for ZHX1 Gene

Domains & Families for ZHX1 Gene

Gene Families for ZHX1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZHX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZHX family.
  • Belongs to the ZHX family.
genes like me logo Genes that share domains with ZHX1: view

Function for ZHX1 Gene

Molecular function for ZHX1 Gene

GENATLAS Biochemistry:
zing-fingers and homeo boxes 1,with two alternatived spliced isoforms,ubiquitously expressed,interacting with the nuclear transcription factor NF-Y
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.

Gene Ontology (GO) - Molecular Function for ZHX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IDA 12237128
GO:0003714 transcription corepressor activity IDA 17303076
GO:0005515 protein binding IPI 10571058
genes like me logo Genes that share ontologies with ZHX1: view
genes like me logo Genes that share phenotypes with ZHX1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZHX1 Gene

Localization for ZHX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZHX1 Gene

Nucleus. Note=Colocalized in the nucleus with DNMT3B.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZHX1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZHX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12237128
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZHX1: view

Pathways & Interactions for ZHX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZHX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 17303076
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 12237128
genes like me logo Genes that share ontologies with ZHX1: view

No data available for Pathways by source and SIGNOR curated interactions for ZHX1 Gene

Drugs & Compounds for ZHX1 Gene

(1) Drugs for ZHX1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
genes like me logo Genes that share compounds with ZHX1: view

Transcripts for ZHX1 Gene

Unigene Clusters for ZHX1 Gene

Zinc fingers and homeoboxes 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX1 Gene

No ASD Table

Relevant External Links for ZHX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZHX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZHX1 Gene

Protein differential expression in normal tissues from HIPED for ZHX1 Gene

This gene is overexpressed in Breast (39.1) and Cervix (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZHX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZHX1 Gene:


SOURCE GeneReport for Unigene cluster for ZHX1 Gene:


mRNA Expression by UniProt/SwissProt for ZHX1 Gene:

Tissue specificity: Ubiquitously expressed. Expressed in podocytes.

Evidence on tissue expression from TISSUES for ZHX1 Gene

  • Kidney(4.4)
  • Liver(4.4)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZHX1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZHX1 Gene

Orthologs for ZHX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZHX1 33 34
  • 99.85 (n)
(Canis familiaris)
Mammalia ZHX1 33 34
  • 93.55 (n)
(Bos Taurus)
Mammalia ZHX1 33 34
  • 91.83 (n)
(Rattus norvegicus)
Mammalia Zhx1 33
  • 89.73 (n)
(Mus musculus)
Mammalia Zhx1 33 16 34
  • 89.5 (n)
(Monodelphis domestica)
Mammalia ZHX1 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia ZHX1 34
  • 51 (a)
(Gallus gallus)
Aves ZHX1 33 34
  • 77.61 (n)
(Anolis carolinensis)
Reptilia ZHX1 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zhx1 33
  • 67.28 (n)
Species where no ortholog for ZHX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZHX1 Gene

Gene Tree for ZHX1 (if available)
Gene Tree for ZHX1 (if available)

Paralogs for ZHX1 Gene

Paralogs for ZHX1 Gene

(2) SIMAP similar genes for ZHX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZHX1: view

Variants for ZHX1 Gene

Sequence variations from dbSNP and Humsavar for ZHX1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000020950 -- 123,272,139(-) C/T intron_variant
rs1000074255 -- 123,258,737(-) T/C intron_variant
rs1000194978 -- 123,269,329(-) C/T intron_variant
rs1000208535 -- 123,276,385(-) G/A upstream_transcript_variant
rs1000245260 -- 123,273,453(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZHX1 Gene

Variant ID Type Subtype PubMed ID
nsv1032827 CNV gain 25217958
nsv1124373 CNV deletion 24896259
nsv831449 CNV loss 17160897

Variation tolerance for ZHX1 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZHX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZHX1 Gene

Disorders for ZHX1 Gene

Additional Disease Information for ZHX1

No disorders were found for ZHX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZHX1 Gene

Publications for ZHX1 Gene

  1. Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y. (PMID: 10441475) Yamada K … Granner DK (Biochemical and biophysical research communications 1999) 2 3 4 22 58
  2. Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains. (PMID: 20509910) Bird LE … Stammers DK (BMC structural biology 2010) 3 4 58
  3. The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension. (PMID: 19348505) Wienk H … Folkers GE (Biochemistry 2009) 3 4 58
  4. BS69, a corepressor interacting with ZHX1, is a bifunctional transcription factor. (PMID: 17127430) Ogata-Kawata H … Miyamoto K (Frontiers in bioscience : a journal and virtual library 2007) 3 22 58
  5. Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. (PMID: 17303076) Kim SH … Kim TY (Biochemical and biophysical research communications 2007) 3 4 58

Products for ZHX1 Gene

Sources for ZHX1 Gene

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