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Aliases for ZGRF1 Gene

Aliases for ZGRF1 Gene

  • Zinc Finger GRF-Type Containing 1 2 3 5
  • GRF-Type Zinc Finger Domain-Containing Protein 1 3 4
  • C4orf21 3 4
  • Chromosome 4 Open Reading Frame 21 2
  • Protein ZGRF1 3

External Ids for ZGRF1 Gene

Previous HGNC Symbols for ZGRF1 Gene

  • C4orf21

Previous GeneCards Identifiers for ZGRF1 Gene

  • GC04M113461

Summaries for ZGRF1 Gene

Entrez Gene Summary for ZGRF1 Gene

  • The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]

GeneCards Summary for ZGRF1 Gene

ZGRF1 (Zinc Finger GRF-Type Containing 1) is a Protein Coding gene. Diseases associated with ZGRF1 include Childhood Apraxia Of Speech and Apraxia. An important paralog of this gene is IGHMBP2.

Additional gene information for ZGRF1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZGRF1 Gene

Genomics for ZGRF1 Gene

GeneHancer (GH) Regulatory Elements for ZGRF1 Gene

Promoters and enhancers for ZGRF1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J112636 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 673.2 -0.2 -201 2.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZGRF1 LARP7 LOC105377372 ENSG00000249532 ENSG00000250966 MIR367 GC04M112615
GH04J112645 Promoter/Enhancer 1.6 EPDnew FANTOM5 ENCODE dbSUPER 654.8 -14.0 -14023 11.2 CTCF USF1 NANOG ZNF10 SIN3A ZKSCAN1 ETS1 SP1 NFIC POLR2A ZGRF1 ENSG00000249532 LOC105377372 LARP7 MIR367 MIR302D MIR302C MIR302B MIR302A GC04M112615
GH04J112566 Promoter 0.5 EPDnew 650.2 +70.3 70282 0.1 ENSG00000250966 ZGRF1 LARP7 MIR367 MIR302D MIR302C MIR302A ENSG00000249532 GC04P112588
GH04J112635 Enhancer 0.3 Ensembl 650.7 +1.7 1694 0.2 MLLT1 LARP7 ZGRF1 GC04M112615 GC04P112588
GH04J112144 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 31.3 +490.5 490522 3.3 HDGF ATF1 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF766 CBX5 ATF7 FAM241A ZGRF1 TIFA LARP7 AP1AR RPL36AP19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZGRF1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZGRF1 Gene

Genomic Locations for ZGRF1 Gene
97,663 bases
Minus strand
97,663 bases
Minus strand

Genomic View for ZGRF1 Gene

Genes around ZGRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZGRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZGRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZGRF1 Gene

Proteins for ZGRF1 Gene

  • Protein details for ZGRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ZGRF1
    Protein Accession:
    Secondary Accessions:
    • B3KQX2
    • B4DSN6
    • B4DYU8
    • E9PDE1
    • G5EA02
    • Q6ZU11
    • Q9NSW3
    • Q9NUJ4

    Protein attributes for ZGRF1 Gene

    2104 amino acids
    Molecular mass:
    236602 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC86416.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZGRF1 Gene

neXtProt entry for ZGRF1 Gene

Post-translational modifications for ZGRF1 Gene

  • Ubiquitination at posLast=183183
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZGRF1 Gene

Domains & Families for ZGRF1 Gene

Gene Families for ZGRF1 Gene

Protein Domains for ZGRF1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZGRF1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ZGRF1 Gene

Function for ZGRF1 Gene

Phenotypes From GWAS Catalog for ZGRF1 Gene

Gene Ontology (GO) - Molecular Function for ZGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZGRF1: view
genes like me logo Genes that share phenotypes with ZGRF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZGRF1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZGRF1 Gene

Localization for ZGRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZGRF1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZGRF1 gene
Compartment Confidence
plasma membrane 3
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZGRF1: view

Pathways & Interactions for ZGRF1 Gene

SuperPathways for ZGRF1 Gene

No Data Available

Interacting Proteins for ZGRF1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q86YA3-ZGRF1_HUMAN ENSP00000424737 for ZGRF1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ZGRF1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZGRF1 Gene

Drugs & Compounds for ZGRF1 Gene

No Compound Related Data Available

Transcripts for ZGRF1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZGRF1

Alternative Splicing Database (ASD) splice patterns (SP) for ZGRF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for ZGRF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZGRF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZGRF1 Gene

Protein differential expression in normal tissues from HIPED for ZGRF1 Gene

This gene is overexpressed in Plasma (45.4), Pancreatic juice (13.4), and Skin (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZGRF1 Gene

Protein tissue co-expression partners for ZGRF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZGRF1 Gene:


Evidence on tissue expression from TISSUES for ZGRF1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZGRF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZGRF1 Gene

Orthologs for ZGRF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZGRF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC461442 33
  • 99.37 (n)
(Bos Taurus)
Mammalia C4orf21 34
  • 87 (a)
ZGRF1 33
  • 85.38 (n)
(Canis familiaris)
Mammalia C4orf21 34
  • 86 (a)
(Mus musculus)
Mammalia 4930422G04Rik 34 33
  • 77.21 (n)
Zgrf1 16
(Rattus norvegicus)
Mammalia RGD1305834 33
  • 76.85 (n)
(Monodelphis domestica)
Mammalia C4orf21 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
-- 34
  • 60 (a)
(Gallus gallus)
Aves C4orf21 34
  • 68 (a)
C4H4ORF21 33
  • 64.41 (n)
(Anolis carolinensis)
Reptilia C4orf21 34
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6701 34
  • 13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for ZGRF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZGRF1 Gene

Gene Tree for ZGRF1 (if available)
Gene Tree for ZGRF1 (if available)
Evolutionary constrained regions (ECRs) for ZGRF1: view image

Paralogs for ZGRF1 Gene

Paralogs for ZGRF1 Gene

genes like me logo Genes that share paralogs with ZGRF1: view

Variants for ZGRF1 Gene

Sequence variations from dbSNP and Humsavar for ZGRF1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1057518892 uncertain-significance, Bowel incontinence, Difficulty walking, Dysarthria, Dysphagia, Progressive muscle weakness, Spastic paraplegia 112,587,460(-) AGAG/AG coding_sequence_variant, frameshift, intron_variant, non_coding_transcript_variant
rs1000044420 -- 112,559,344(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000055225 -- 112,582,649(-) G/A intron_variant
rs1000055279 -- 112,576,626(-) T/A/C intron_variant
rs1000060598 -- 112,609,635(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZGRF1 Gene

Variant ID Type Subtype PubMed ID
dgv166n6 CNV deletion 16902084
esv1001738 CNV deletion 20482838
esv1002020 CNV deletion 20482838
esv2336561 CNV deletion 18987734
esv2636867 CNV deletion 19546169
esv2728154 CNV deletion 23290073
esv3564451 CNV deletion 23714750
esv4913 CNV loss 18987735
esv9284 CNV loss 19470904
nsv1006030 CNV gain 25217958
nsv1014926 CNV gain 25217958
nsv1073366 CNV deletion 25765185
nsv1123831 CNV deletion 24896259
nsv1139298 CNV deletion 24896259
nsv435781 CNV deletion 17901297
nsv4471 CNV deletion 18451855
nsv472538 CNV novel sequence insertion 20440878
nsv499060 CNV loss 21111241
nsv513161 CNV loss 21212237
nsv525715 CNV loss 19592680
nsv950380 CNV deletion 24416366
nsv956315 CNV deletion 24416366
nsv967786 CNV duplication 23825009

Variation tolerance for ZGRF1 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZGRF1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZGRF1 Gene

Disorders for ZGRF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZGRF1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
childhood apraxia of speech
  • articulatory apraxia
  • dyspraxia
- elite association - COSMIC cancer census association via MalaCards
Search ZGRF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZGRF1

genes like me logo Genes that share disorders with ZGRF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZGRF1 Gene

Publications for ZGRF1 Gene

  1. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. (PMID: 27229929) Daakour S … Twizere JC (BMC cancer 2016) 3 58
  5. Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. (PMID: 27120335) Peter B … Raskind WH (PloS one 2016) 3 58

Products for ZGRF1 Gene

Sources for ZGRF1 Gene

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