Aliases for ZGPAT Gene
External Ids for ZGPAT Gene
Previous HGNC Symbols for ZGPAT Gene
Previous GeneCards Identifiers for ZGPAT Gene
GeneCards Summary for ZGPAT Gene
ZGPAT (Zinc Finger CCCH-Type And G-Patch Domain Containing) is a Protein Coding gene. Diseases associated with ZGPAT include Gingival Hypertrophy and Noonan Syndrome 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ENSG00000273154.
UniProtKB/Swiss-Prot Summary for ZGPAT Gene
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
[Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.