Aliases for ZGPAT Gene

Aliases for ZGPAT Gene

  • Zinc Finger CCCH-Type And G-Patch Domain Containing 2 3 5
  • KIAA1847 2 3 4
  • Zinc Finger CCCH-Type With G Patch Domain-Containing Protein 3 4
  • Zinc Finger And G Patch Domain-Containing Protein 3 4
  • Zinc Finger CCCH Domain-Containing Protein 9 3 4
  • G Patch Domain-Containing Protein 6 3 4
  • GPATCH6 3 4
  • ZC3HDC9 3 4
  • GPATC6 3 4
  • ZC3H9 3 4
  • ZIP 3 4
  • Zinc Finger, CCCH-Type With G Patch Domain 3
  • Zinc Finger CCCH-Type With G-Patch Domain 2

External Ids for ZGPAT Gene

Previous HGNC Symbols for ZGPAT Gene

  • KIAA1847

Previous GeneCards Identifiers for ZGPAT Gene

  • GC20P061810
  • GC20P062338
  • GC20P059071

Summaries for ZGPAT Gene

GeneCards Summary for ZGPAT Gene

ZGPAT (Zinc Finger CCCH-Type And G-Patch Domain Containing) is a Protein Coding gene. Diseases associated with ZGPAT include Gingival Hypertrophy and Noonan Syndrome 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ENSG00000273154.

UniProtKB/Swiss-Prot Summary for ZGPAT Gene

  • Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
  • [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.

Gene Wiki entry for ZGPAT Gene

Additional gene information for ZGPAT Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZGPAT Gene

Genomics for ZGPAT Gene

GeneHancer (GH) Regulatory Elements for ZGPAT Gene

Promoters and enhancers for ZGPAT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J063705 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 510.8 +0.2 174 4 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 POLR2G NCOR1 GTF2E2 ARFRP1 ZGPAT ENSG00000273154 lnc-ZBTB46-3 DIDO1 MIR647 UCKL1 GMEB2 RTEL1 LIME1
GH20J063734 Promoter/Enhancer 1.3 EPDnew Ensembl dbSUPER 500.3 +27.1 27059 0.6 POLR2G NCOR1 SKI FOXA2 NR2F2 PCBP1 MYC SRSF1 USF1 SAP130 LIME1 NONHSAG032307.2 ZGPAT DIDO1 MIR647 ENSG00000237371 UCKL1 RTEL1 GMEB2 SLC2A4RG
GH20J063717 Promoter 0.3 EPDnew 500.4 +9.9 9898 0.1 ZGPAT ENSG00000273154 lnc-LIME1-3
GH20J063863 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 21.3 +157.7 157702 4.1 EP300 FOXK2 ZBTB40 ZNF217 CTCF SIN3A NRF1 MYC POLR2G USF1 DNAJC5 ENSG00000268858 NONHSAG032313.2 TPD52L2 DIDO1 MIR647 RTEL1 UCKL1 GMEB2 PRPF6
GH20J062898 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.5 -807.6 -807641 4.4 ZNF217 CTCF POLR2G NCOR1 ZIC2 CLOCK GABPA REST ZBTB25 TOE1 DIDO1 GMEB2 TAF4 RTEL1 GID8 RPS21 MTG2 YTHDF1 ZGPAT ENSG00000226332
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZGPAT on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZGPAT

Top Transcription factor binding sites by QIAGEN in the ZGPAT gene promoter:
  • AREB6
  • NF-kappaB1
  • STAT5B

Genomic Locations for ZGPAT Gene

Genomic Locations for ZGPAT Gene
chr20:63,707,442-63,736,142
(GRCh38/hg38)
Size:
28,701 bases
Orientation:
Plus strand
chr20:62,338,794-62,367,494
(GRCh37/hg19)
Size:
28,701 bases
Orientation:
Plus strand

Genomic View for ZGPAT Gene

Genes around ZGPAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZGPAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZGPAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZGPAT Gene

Proteins for ZGPAT Gene

  • Protein details for ZGPAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5A5-ZGPAT_HUMAN
    Recommended name:
    Zinc finger CCCH-type with G patch domain-containing protein
    Protein Accession:
    Q8N5A5
    Secondary Accessions:
    • E1P5K1
    • Q4VXN9
    • Q5JWI9
    • Q5JWJ0
    • Q8NC55
    • Q8WUV4
    • Q96JI0
    • Q96JU4
    • Q9H401

    Protein attributes for ZGPAT Gene

    Size:
    531 amino acids
    Molecular mass:
    57359 Da
    Quaternary structure:
    • Interacts with CHD4/Mi-2; the interaction is direct.
    SequenceCaution:
    • Sequence=BAB47476.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAC11317.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZGPAT Gene

    Alternative splice isoforms for ZGPAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZGPAT Gene

Post-translational modifications for ZGPAT Gene

  • Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZGPAT Gene

Domains & Families for ZGPAT Gene

Gene Families for ZGPAT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZGPAT Gene

Blocks:
  • D111/G-patch domain
  • Zn-finger, C-x8-C-x5-C-x3-H type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZGPAT Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, CCCH-type with G patch domain, isoform CRA_a (E1P5K2_HUMAN)
  • Zinc finger, CCCH-type with G patch domain, isoform CRA_b (E1P5K4_HUMAN)
  • Zinc finger and G patch domain-containing protein (ZGPAT_HUMAN)
genes like me logo Genes that share domains with ZGPAT: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZGPAT Gene

Function for ZGPAT Gene

Molecular function for ZGPAT Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
UniProtKB/Swiss-Prot Function:
[Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.
UniProtKB/Swiss-Prot Induction:
Down-regulated in breast carcinomas.

Phenotypes From GWAS Catalog for ZGPAT Gene

Gene Ontology (GO) - Molecular Function for ZGPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 19644445
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 19644445
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZGPAT: view
genes like me logo Genes that share phenotypes with ZGPAT: view

Animal Models for ZGPAT Gene

MGI Knock Outs for ZGPAT:
  • Zgpat Zgpat<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for ZGPAT Gene

miRTarBase miRNAs that target ZGPAT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZGPAT

Clone Products

  • Addgene plasmids for ZGPAT

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZGPAT Gene

Localization for ZGPAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZGPAT Gene

Nucleus.
[Isoform 4]: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZGPAT gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZGPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IDA,IBA 19644445
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ZGPAT: view

Pathways & Interactions for ZGPAT Gene

PathCards logo

SuperPathways for ZGPAT Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZGPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 19644445
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA 19644445
GO:0045892 negative regulation of transcription, DNA-templated IDA 19644445
genes like me logo Genes that share ontologies with ZGPAT: view

No data available for Pathways by source and SIGNOR curated interactions for ZGPAT Gene

Drugs & Compounds for ZGPAT Gene

No Compound Related Data Available

Transcripts for ZGPAT Gene

mRNA/cDNA for ZGPAT Gene

6 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZGPAT

Clone Products

  • Addgene plasmids for ZGPAT

Alternative Splicing Database (ASD) splice patterns (SP) for ZGPAT Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5: - -
SP6:
SP7:
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13: - - - -
SP14: -
SP15: -
SP16: - -

ExUns: 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4: -
SP5: - - -
SP6: - -
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ZGPAT Gene

GeneLoc Exon Structure for
ZGPAT

Expression for ZGPAT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZGPAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZGPAT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.4), NK cells (9.7), CD8 Tcells (9.3), and Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZGPAT Gene



Protein tissue co-expression partners for ZGPAT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZGPAT

SOURCE GeneReport for Unigene cluster for ZGPAT Gene:

Hs.590868

mRNA Expression by UniProt/SwissProt for ZGPAT Gene:

Q8N5A5-ZGPAT_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ZGPAT Gene

  • Nervous system(4.8)
  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with ZGPAT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZGPAT Gene

Orthologs for ZGPAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZGPAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZGPAT 31 30
  • 99.35 (n)
OneToMany
cow
(Bos Taurus)
Mammalia ZGPAT 31 30
  • 83.43 (n)
OneToMany
dog
(Canis familiaris)
Mammalia ZGPAT 30
  • 81.22 (n)
-- 31
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zgpat 17 31 30
  • 80.88 (n)
rat
(Rattus norvegicus)
Mammalia Zgpat 30
  • 80.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZGPAT 30
  • 68.78 (n)
-- 31
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2135 30
zebrafish
(Danio rerio)
Actinopterygii zgpat 31 30
  • 58.32 (n)
ManyToMany
CABZ01022575.1 31
  • 50 (a)
ManyToMany
-- 30
African malaria mosquito
(Anopheles gambiae)
Insecta ZGPAT_ANOGA 30
  • 48.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4709 31 30
  • 45.09 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C33H5.17 31 30
  • 38.14 (n)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G24830 30
  • 39.51 (n)
rice
(Oryza sativa)
Liliopsida Os02g0793000 30
  • 42.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 31 (a)
OneToMany
Species where no ortholog for ZGPAT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZGPAT Gene

ENSEMBL:
Gene Tree for ZGPAT (if available)
TreeFam:
Gene Tree for ZGPAT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZGPAT: view image

Paralogs for ZGPAT Gene

Paralogs for ZGPAT Gene

genes like me logo Genes that share paralogs with ZGPAT: view

Variants for ZGPAT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZGPAT Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs1291212 - p.Ser61Arg

Additional dbSNP identifiers (rs#s) for ZGPAT Gene

Structural Variations from Database of Genomic Variants (DGV) for ZGPAT Gene

Variant ID Type Subtype PubMed ID
dgv2293n106 CNV tandem duplication 24896259
dgv2453e59 CNV duplication 20981092
dgv7677n54 CNV loss 21841781
esv2661713 CNV deletion 23128226
esv2722959 CNV deletion 23290073
esv2722960 CNV deletion 23290073
esv2722961 CNV deletion 23290073
esv2722963 CNV deletion 23290073
esv2722964 CNV deletion 23290073
esv2722965 CNV deletion 23290073
esv2722966 CNV deletion 23290073
esv2758806 CNV gain+loss 17122850
esv5348 CNV loss 18987735
esv7227 CNV loss 19470904
nsv1059142 CNV gain 25217958
nsv1121583 CNV deletion 24896259
nsv1127853 CNV deletion 24896259
nsv1139762 CNV duplication 24896259
nsv1142524 CNV deletion 24896259
nsv1142997 CNV tandem duplication 24896259
nsv1160690 CNV deletion 26073780
nsv428381 CNV gain+loss 18775914
nsv470563 CNV loss 18288195
nsv586611 CNV loss 21841781
nsv586614 CNV gain 21841781
nsv586615 CNV gain 21841781
nsv586618 CNV gain 21841781
nsv828801 CNV loss 20364138
nsv953308 CNV deletion 24416366

Variation tolerance for ZGPAT Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZGPAT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZGPAT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZGPAT Gene

Disorders for ZGPAT Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZGPAT Gene - From: DISEASES

Disorder Aliases PubMed IDs
gingival hypertrophy
  • hypertrophy of gingivae
noonan syndrome 1
  • ns1
- elite association - COSMIC cancer census association via MalaCards
Search ZGPAT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZGPAT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZGPAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZGPAT Gene

Publications for ZGPAT Gene

  1. HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP. (PMID: 24116224) Maudet C … Margottin-Goguet F (PloS one 2013) 3 4 54
  2. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 41 54
  3. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 41 54
  4. sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP. (PMID: 20233718) Yu W … Shang Y (The Journal of biological chemistry 2010) 3 4 54
  5. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. (PMID: 19644445) Li R … Shang Y (The EMBO journal 2009) 3 4 54

Products for ZGPAT Gene

Sources for ZGPAT Gene