Aliases for ZGLP1 Gene

Aliases for ZGLP1 Gene

  • Zinc Finger GATA Like Protein 1 2 3 5
  • GLP-1 2 3 4
  • GLP1 2 3 4
  • GATA Zinc Finger Domain Containing 3 2 3
  • GATA-Type Zinc Finger Protein 1 3 4
  • GATA-Like Protein 1 3 4
  • GATAD3 2 3
  • GATA Like Protein 1 2
  • ZGLP1 5

External Ids for ZGLP1 Gene

Previous GeneCards Identifiers for ZGLP1 Gene

  • GC19M010279
  • GC19M010415
  • GC19M009995

Summaries for ZGLP1 Gene

GeneCards Summary for ZGLP1 Gene

ZGLP1 (Zinc Finger GATA Like Protein 1) is a Protein Coding gene. Diseases associated with ZGLP1 include Hermaphroditism. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is GATA3.

UniProtKB/Swiss-Prot Summary for ZGLP1 Gene

  • Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independentely of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZGLP1 Gene

Genomics for ZGLP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZGLP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010304 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 600.7 +4.4 4448 1.3 IKZF1 JUND MTA2 PHF21A MTA1 NR2C1 EGR1 ZBTB2 HDAC2 E2F5 ZGLP1 lnc-ZGLP1-1 ICAM5 ENSG00000167807
GH19J010311 Enhancer 0.5 Ensembl 600.7 -1.7 -1720 0.4 HDGF ZNF316 MAFG MAFK ZNF592 ZNF384 NFE2 MAFF EMSY ZGLP1 ENSG00000167807 FDX2 lnc-RAVER1-1
GH19J010310 Promoter 0.4 EPDnew 600.7 -0.4 -437 0.1 SCRT1 ZGLP1 ICAM5 ENSG00000167807 FDX2
GH19J010309 Promoter 0.3 EPDnew 600.7 +0.8 813 0.1 ZGLP1 ICAM4 RAVER1 ICAM1 MRPL4 lnc-ZGLP1-1 ENSG00000167807 ICAM5
GH19J010308 Promoter 0.3 EPDnew 600.7 +1.6 1617 0.1 ZGLP1 ICAM4 RAVER1 ICAM1 MRPL4 lnc-ZGLP1-1 ENSG00000167807 ICAM5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZGLP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZGLP1

Genomic Locations for ZGLP1 Gene

Genomic Locations for ZGLP1 Gene
chr19:10,304,803-10,309,880
(GRCh38/hg38)
Size:
5,078 bases
Orientation:
Minus strand
chr19:10,415,479-10,420,556
(GRCh37/hg19)
Size:
5,078 bases
Orientation:
Minus strand

Genomic View for ZGLP1 Gene

Genes around ZGLP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZGLP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZGLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZGLP1 Gene

Proteins for ZGLP1 Gene

  • Protein details for ZGLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C6A0-ZGLP1_HUMAN
    Recommended name:
    GATA-type zinc finger protein 1
    Protein Accession:
    P0C6A0

    Protein attributes for ZGLP1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29628 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZGLP1 Gene

Post-translational modifications for ZGLP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZGLP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZGLP1 Gene

Domains & Families for ZGLP1 Gene

Gene Families for ZGLP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZGLP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZGLP1 Gene

GenScript: Design optimal peptide antigens:
  • GATA-like protein 1 (ZGLP1_HUMAN)
genes like me logo Genes that share domains with ZGLP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZGLP1 Gene

Function for ZGLP1 Gene

Molecular function for ZGLP1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independentely of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase.

Phenotypes From GWAS Catalog for ZGLP1 Gene

Gene Ontology (GO) - Molecular Function for ZGLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZGLP1: view
genes like me logo Genes that share phenotypes with ZGLP1: view

Animal Models for ZGLP1 Gene

MGI Knock Outs for ZGLP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZGLP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZGLP1 Gene

Localization for ZGLP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZGLP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZGLP1 gene
Compartment Confidence
nucleus 4
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZGLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZGLP1: view

Pathways & Interactions for ZGLP1 Gene

PathCards logo

SuperPathways for ZGLP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZGLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA,ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA,ISS --
GO:0045944 positive regulation of transcription by RNA polymerase II ISS --
genes like me logo Genes that share ontologies with ZGLP1: view

No data available for Pathways by source and SIGNOR curated interactions for ZGLP1 Gene

Drugs & Compounds for ZGLP1 Gene

No Compound Related Data Available

Transcripts for ZGLP1 Gene

mRNA/cDNA for ZGLP1 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZGLP1

Alternative Splicing Database (ASD) splice patterns (SP) for ZGLP1 Gene

No ASD Table

Relevant External Links for ZGLP1 Gene

GeneLoc Exon Structure for
ZGLP1

Expression for ZGLP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZGLP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZGLP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.8), Testis (24.3), and Fetal ovary (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZGLP1 Gene



Protein tissue co-expression partners for ZGLP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZGLP1

SOURCE GeneReport for Unigene cluster for ZGLP1 Gene:

Hs.709296

Evidence on tissue expression from TISSUES for ZGLP1 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZGLP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZGLP1 Gene

Orthologs for ZGLP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZGLP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZGLP1 30 31
  • 99.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZGLP1 30 31
  • 80.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZGLP1 30 31
  • 78.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zglp1 30 17 31
  • 73.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zglp1 30
  • 72.6 (n)
Zebrafish
(Danio rerio)
Actinopterygii zglp1 31
  • 24 (a)
OneToOne
Species where no ortholog for ZGLP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZGLP1 Gene

ENSEMBL:
Gene Tree for ZGLP1 (if available)
TreeFam:
Gene Tree for ZGLP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZGLP1: view image

Paralogs for ZGLP1 Gene

Paralogs for ZGLP1 Gene

genes like me logo Genes that share paralogs with ZGLP1: view

Variants for ZGLP1 Gene

Additional dbSNP identifiers (rs#s) for ZGLP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZGLP1 Gene

Variant ID Type Subtype PubMed ID
nsv470124 CNV gain 18288195

Variation tolerance for ZGLP1 Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZGLP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZGLP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZGLP1 Gene

Disorders for ZGLP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZGLP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hermaphroditism
- elite association - COSMIC cancer census association via MalaCards
Search ZGLP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZGLP1

genes like me logo Genes that share disorders with ZGLP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZGLP1 Gene

Publications for ZGLP1 Gene

  1. GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development. (PMID: 16982049) Li S … Morrisey EE (Developmental biology 2007) 2 3
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men. (PMID: 26752550) Matikainen N … Taskinen MR (PloS one 2016) 3

Products for ZGLP1 Gene

  • Signalway Proteins for ZGLP1

Sources for ZGLP1 Gene